Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet

Mathilde Meyenberg, Anna Hakobyan, Nikolina Papac-Milicevic, Laura Göderle, Franziska L Langner, Mateo Markovic, Ji-Hyun Lee, Bon-Kyoung Koo, Georg A Busslinger, Israel Tojal da Silva, Christoph J Binder, Jörg Menche, Joanna I Loizou.
Sci Rep. 2023 Aug 26;13(1):13964. doi: 10.1038/s41598-023-41123-3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37633982/

Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome

Benedikt Simbrunner, Ida Falk Villesen, Bernhard Scheiner, Rafael Paternostro, Philipp Schwabl, Albert Friedrich Stättermayer, Rodrig Marculescu, Matthias Pinter, Peter Quehenberger, Michael Trauner, Morten Karsdal, Ton Lisman, Thomas Reiberger, Diana Julie Leeming, Mattias Mandorfer.
Hepatol Int. 2023 Aug 21. doi: 10.1007/s12072-023-10577-y. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37605068/

Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels

Anka Güldenpfennig, Ann-Katrin Hopp, Lukas Muskalla, Patrick Manetsch, Fabio Raith, Lars Hellweg, Cyril Dördelmann, Deena M Leslie Pedrioli, Kai Johnsson, Giulio Superti-Furga, Michael O Hottiger.
Nucleic Acids Res. 2023 Aug 17:gkad659. doi: 10.1093/nar/gkad659. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37587695/

Pharmacological perturbation of the phase-separating protein SMNDC1

Lennart Enders, Marton Siklos, Jan Borggräfe, Stefan Gaussmann, Anna Koren, Monika Malik, Tatjana Tomek, Michael Schuster, Jiří Reiniš, Elisa Hahn, Andrea Rukavina, Andreas Reicher, Tamara Casteels, Christoph Bock, Georg E Winter, J Thomas Hannich, Michael Sattler, Stefan Kubicek.
Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37587144/

GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2^-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling

Claudia D Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner.
Cell Mol Gastroenterol Hepatol. 2023 Aug 10:S2352-345X(23)00147-9. doi: 10.1016/j.jcmgh.2023.08.003. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37572734/

Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model

Federica Lamberto, Bachuki Shashikadze, Radwa Elkhateib, Salvo Danilo Lombardo, Alex Horánszky, Andrea Balogh, Kornél Kistamás, Melinda Zana, Jörg Menche, Thomas Fröhlich, András Dinnyés.
Environ Pollut. 2023 Aug 9;335:122359. doi: 10.1016/j.envpol.2023.122359. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37567409/

Structural and functional annotation of solute carrier transporters: implication for drug discovery

Vojtech Dvorak, Giulio Superti-Furga.
Expert Opin Drug Discov. 2023 Aug 10:1-17. doi: 10.1080/17460441.2023.2244760. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37563933/

Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance

Irmina Garcia-Carpio, Vincent Z Braun, Elias S Weiler, Marina Leone, Sergio Niñerola, Angel Barco, Luca L Fava, Andreas Villunger.
EMBO J. 2023 Aug 2:e113510. doi: 10.15252/embj.2023113510. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37530438/

Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter.
Protein Cell. 2023 Aug 1;14(8):560-578. doi: 10.1093/procel/pwac064.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37526344/

Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors

Vojtech Dvorak, Andrea Casiraghi, Claire Colas, Anna Koren, Tatjana Tomek, Fabian Offensperger, Andrea Rukavina, Gary Tin, Elisa Hahn, Sarah Dobner, Fabian Frommelt, Andras Boeszoermenyi, Viktoriia Bernada, J Thomas Hannich, Gerhard F Ecker, Georg E Winter, Stefan Kubicek, Giulio Superti-Furga.
Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37516113/

Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis

Máté G Kiss, Nikolina Papac-Miličević, Florentina Porsch, Dimitrios Tsiantoulas, Tim Hendrikx, Minoru Takaoka, Huy Q Dinh, Marie-Sophie Narzt, Laura Göderle, Mária Ozsvár-Kozma, Michael Schuster, Nikolaus Fortelny, Anastasiya Hladik, Sylvia Knapp, Florian Gruber, Matthew C Pickering, Christoph Bock, Filip K Swirski, Klaus Ley, Alma Zernecke, Clément Cochain, Claudia Kemper, Ziad Mallat, Christoph J Binder.
Immunity. 2023 Aug 8;56(8):1809-1824.e10. doi: 10.1016/j.immuni.2023.06.026. Epub 2023 Jul 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37499656/

You only waste twice: T cells in parasite-induced organ wasting

Felix Clemens Richter, Andreas Bergthaler.
Cell Rep. 2023 Aug 29;42(8):112829. doi: 10.1016/j.celrep.2023.112829. Epub 2023 Jul 24.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37490906/

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma

Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira Dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti-Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli.
EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37435859/

Complex interactions of cellular players in chronic Graft-versus-Host Disease

Laura Marie Gail, Kimberly Julia Schell, Piotr Łacina, Johanna Strobl, Steven J Bolton, Emilie Steinbakk Ulriksen, Katarzyna Bogunia-Kubik, Hildegard Greinix, Rachel Emily Crossland, Marit Inngjerdingen, Georg Stary.
Front Immunol. 2023 Jun 26;14:1199422. doi: 10.3389/fimmu.2023.1199422. eCollection 2023.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37435079/

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

Bachuki Shashikadze, Libera Valla, Salvo Danilo Lombardo, Cornelia Prehn, Mark Haid, Fabien Riols, Jan Bernd Stöckl, Radwa Elkhateib, Simone Renner, Birgit Rathkolb, Jörg Menche, Martin Hrabĕ de Angelis, Eckhard Wolf, Elisabeth Kemter, Thomas Fröhlich.
Mol Metab. 2023 Sep;75:101768. doi: 10.1016/j.molmet.2023.101768. Epub 2023 Jul 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37414142/

Phosphomevalonate kinase deficiency expands the genetic spectrum of systemic autoinflammatory diseases

Jakob Berner, Cheryl van de Wetering, Raul Jimenez Heredia, Christina Rashkova, Sacha Ferdinandusse, Janet Koster, Johannes G Weiss, Alexandra Frohne, Sarah Giuliani, Hans R Waterham, Irinka Castanon, Jürgen Brunner, Kaan Boztug.
J Allergy Clin Immunol. 2023 Jun 25:S0091-6749(23)00809-6. doi: 10.1016/j.jaci.2023.06.013. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37364720/

Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

Irfete S Fetahu, Wolfgang Esser-Skala, Rohit Dnyansagar, Samuel Sindelar, Fikret Rifatbegovic, Andrea Bileck, Lukas Skos, Eva Bozsaky, Daria Lazic, Lisa Shaw, Marcus Tötzl, Dora Tarlungeanu, Marie Bernkopf, Magdalena Rados, Wolfgang Weninger, Eleni M Tomazou, Christoph Bock, Christopher Gerner, Ruth Ladenstein, Matthias Farlik, Nikolaus Fortelny, Sabine Taschner-Mandl.
Nat Commun. 2023 Jun 26;14(1):3620. doi: 10.1038/s41467-023-39210-0.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37365178/

Urethane functions can reduce metal salts under hydrothermal conditions: synthesis of noble metal nanoparticles on flexible sponges applied in semi-automated organic reduction

Olivier Gazil, Johannes Bernardi, Arthur Lassus, Nick Virgilio, Miriam M Unterlass.
J Mater Chem A Mater. 2023 Feb 24;11(24):12703-12712. doi: 10.1039/d2ta09405c. eCollection 2023 Jun 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37346738/

Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency

Jana Block, Christina Rashkova, Irinka Castanon, Samaneh Zoghi, Jessica Platon, Rico C Ardy, Mitsuhiro Fujiwara, Beatriz Chaves, Rouven Schoppmeyer, Caspar I van der Made, Raul Jimenez Heredia, Frederike L Harms, Samin Alavi, Laia Alsina, Paula Sanchez Moreno, Rainiero Ávila Polo, Rocío Cabrera-Pérez, Sevgi Kostel Bal, Laurène Pfajfer, Bernhard Ransmayr, Anna-Katharina Mautner, Ryohei Kondo, Anna Tinnacher, Michael Caldera, Michael Schuster, Cecilia Domínguez Conde, René Platzer, Elisabeth Salzer, Thomas Boyer, Han G Brunner, Judith E Nooitgedagt-Frons, Estíbaliz Iglesias, Angela Deyà-Martinez, Marisol Camacho-Lovillo, Jörg Menche, Christoph Bock, Johannes B Huppa, Winfried F Pickl, Martin Distel, Jeffrey A Yoder, David Traver, Karin R Engelhardt, Tobias Linden, Leo Kager, J Thomas Hannich, Alexander Hoischen, Sophie Hambleton, Sabine Illsinger, Lydie Da Costa, Kerstin Kutsche, Zahra Chavoshzadeh, Jaap D van Buul, Jordi Antón, Joan Calzada-Hernández, Olaf Neth, Julien Viaud, Akihiko Nishikimi, Loïc Dupré, Kaan Boztug.
N Engl J Med. 2023 Aug 10;389(6):527-539. doi: 10.1056/NEJMoa2210054. Epub 2023 Jun 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37342957/

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis

Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Müller, Teresa Preglej, Leonhard X Heinz, Elisabeth Simader, Lisa Göschl, Stephan E Puchner, Sebastian Weiss, Lisa E Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S Smolen, Guenter Steiner, Daniel Aletaha, Hans P Kiener, Myles J Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli.
Ann Rheum Dis. 2023 Sep;82(9):1142-1152. doi: 10.1136/ard-2022-223396. Epub 2023 Jun 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37344156/

Prioritization and functional validation of target genes from single-cell transcriptomics studies

Liliana Sokol, Anne Cuypers, Anh-Co K Truong, Ann Bouché, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P M H de Rooij, Peter Carmeliet.
Commun Biol. 2023 Jun 17;6(1):648. doi: 10.1038/s42003-023-05006-7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37330599/

Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Julian Petersen, Lukas Englmaier, Artem V Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko.
Nat Commun. 2023 Jun 15;14(1):3565. doi: 10.1038/s41467-023-39373-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37322005/

Buffy coat signatures of breast cancer risk in a prospective cohort study

Felicia Fei-Lei Chung, Sandra González Maldonado, Amelie Nemc, Liacine Bouaoun, Vincent Cahais, Cyrille Cuenin, Aurelie Salle, Theron Johnson, Bekir Ergüner, Marina Laplana, Paul Datlinger, Jana Jeschke, Elisabete Weiderpass, Vessela Kristensen, Suzette Delaloge, François Fuks, Angela Risch, Akram Ghantous, Christoph Plass, Christoph Bock, Rudolf Kaaks, Zdenko Herceg.
Clin Epigenetics. 2023 Jun 12;15(1):102. doi: 10.1186/s13148-023-01509-6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37309009/

Screening newborns for low T cell receptor excision circles (TRECs) Fails to Detect Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome

Olga Staudacher, Jeanette Klein, Stephanie Thee, Jan Ullrich, Volker Wahn, Nadine Unterwalder, Uwe Kölsch, Erwin Lankes, Anna Stittrich, Cinzia Dedieu, Sarah Dinges, Mirjam Völler, Catharina Schuetz, Johannes Schulte, Kaan Boztug, Christian Meisel, Jörn-Sven Kuehl, Renate Krüger, Oliver Blankenstein, Horst von Bernuth.
J Allergy Clin Immunol Pract. 2023 Jun 9:S2213-2198(23)00649-9. doi: 10.1016/j.jaip.2023.06.006. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37302792/

Severe congenital neutropenia due to G6PC3 deficiency: early and delayed phenotype of a patient

Negar Moradian, Samaneh Zoghi, Elham Rayzan, Simin Seyedpour, Raul Jimenez Heredia, Kaan Boztug, Nima Rezaei.
Allergy Asthma Clin Immunol. 2023 Jun 9;19(1):51. doi: 10.1186/s13223-023-00804-4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37296469/

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual-Reguant, Natalia Pardo-Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci.
Mol Syst Biol. 2023 Jul 11;19(7):e11267. doi: 10.15252/msb.202211267. Epub 2023 Jun 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37259925/

Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis

Sevgi Kostel Bal, Sarah Giuliani, Jana Block, Peter Repiscak, Christoph Hafemeister, Tala Shahin, Nurhan Kasap, Bernhard Ransmayr, Yirun Miao, Cheryl van de Wetering, Alexandra Frohne, Raul Jimenez Heredia, Michael Schuster, Samaneh Zoghi, Vanessa Hertlein, Marini Thian, Aleksandr Bykov, Royala Babayeva, Sevgi Bilgic Eltan, Elif Karakoc-Aydiner, Lisa E Shaw, Iftekhar Chowdhury, Markku Varjosalo, Rafael J Argüello, Matthias Farlik, Ahmet Ozen, Edgar Serfling, Loïc Dupré, Christoph Bock, Florian Halbritter, J Thomas Hannich, Irinka Castanon, Michael J Kraakman, Safa Baris, Kaan Boztug.
Blood. 2023 Aug 31;142(9):827-845. doi: 10.1182/blood.2022018303.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37249233/

PRPF19 modulates morphology and growth behavior in a cell culture model of human skin

Lisa Kleissl, Regina Weinmüllner, Ingo Lämmermann, Ruth Dingelmaier-Hovorka, Mohammad Jafarmadar, Abdoelwaheb El Ghalbzouri, Georg Stary, Johannes Grillari, Hanna Dellago.
Front Aging. 2023 May 5;4:1154005. doi: 10.3389/fragi.2023.1154005. eCollection 2023.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37214773/

Novel patients with NHLRC2 variants expand the phenotypic spectrum of FINCA disease

Antti Tallgren, Leo Kager, Gina O'Grady, Hannu Tuominen, Jarmo Körkkö, Outi Kuismin, Martha Feucht, Callum Wilson, Jana Behunova, Eleina England, Mitja I Kurki, Aarno Palotie, Mikko Hallman, Riitta Kaarteenaho, Franco Laccone, Kaan Boztug, Reetta Hinttala, Johanna Uusimaa.
Front Neurosci. 2023 Apr 27;17:1123327. doi: 10.3389/fnins.2023.1123327. eCollection 2023.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37179546/

Genotype-phenotype correlation in contactin-associated protein-like 2 (CNTNAP-2) developmental disorder

Gianluca D'Onofrio, Andrea Accogli, Mariasavina Severino, Haluk Caliskan, Tomislav Kokotović, Antonela Blazekovic, Kristina Gotovac Jercic, Silvana Markovic, Tamara Zigman, Krnjak Goran, Nina Barišić, Vlasta Duranovic, Ana Ban, Fran Borovecki, Danijela Petković Ramadža, Ivo Barić, Walid Fazeli, Peter Herkenrath, Carla Marini, Roberta Vittorini, Vykuntaraju Gowda, Arjan Bouman, Clarissa Rocca, Issam Azmi Alkhawaja, Bibi Nazia Murtaza, Malik Mujaddad Ur Rehman, Chadi Al Alam, Gisele Nader, Maria Margherita Mancardi, Thea Giacomini, Siddharth Srivastava, Javeria Raza Alvi, Hoda Tomoum, Sara Matricardi, Michele Iacomino, Antonella Riva, Marcello Scala, Francesca Madia, Angela Pistorio, Vincenzo Salpietro, Carlo Minetti, Jean-Baptiste Rivière, Myriam Srour, Stephanie Efthymiou, Reza Maroofian, Henry Houlden, Sonja Catherine Vernes, Federico Zara, Pasquale Striano, Vanja Nagy.
Hum Genet. 2023 Jul;142(7):909-925. doi: 10.1007/s00439-023-02552-2. Epub 2023 May 14.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37183190/

Functional heterogeneity of human skin-resident memory T cells in health and disease

Johanna Strobl, Muzlifah Haniffa.
Immunol Rev. 2023 Jul;316(1):104-119. doi: 10.1111/imr.13213. Epub 2023 May 5.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37144705/

Apoptotic cell death in disease-Current understanding of the NCCD 2023

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Rami I Aqeilan, Eli Arama, Eric H Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A Barlev, Jiri Bartek, Nicolas G Bazan, Christoph Becker, Francesca Bernassola, Mathieu J M Bertrand, Marco E Bianchi, Mikhail V Blagosklonny, J Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H Chen, Emily H Cheng, Jerry E Chipuk, John A Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R Cubillos-Ruiz, Peter E Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M Dawson, Valina L Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J Dixon, Brian D Dynlacht, Wafik S El-Deiry, John W Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J Garcia-Saez, Abhishek D Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R Green, Lloyd A Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J Marie Hardwick, Ygal Haupt, Sudan He, David M Heery, Michael O Hengartner, Claudio Hetz, David A Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L Kelly, Oliver Kepp, Adi Kimchi, Richard N Kitsis, Daniel J Klionsky, Ruth Kluck, Dmitri V Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N Lavrik, John J Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A Lipton, Richard A Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J Martin, Jean-Claude Martinou, Pier G Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A Miao, Ute M Moll, Cristina Muñoz-Pinedo, Daniel J Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M Penninger, Francesca Pentimalli, David M Pereira, Shazib Pervaiz, Marcus E Peter, Paolo Pinton, Giovanni Porta, Jochen H M Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Krishnaraj Rajalingam, Kodi S Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M P Rodrigues, Barak Rotblat, Carla V Rothlin, David C Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M Ryan, Kristopher A Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W G Tait, Daolin Tang, Nektarios Tavernarakis, Carol M Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G Vander Heiden, Jacqueline L Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K Voss, Karen H Vousden, Domagoj Vucic, Daniela Vuri, Erwin F Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi.
Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37100955/

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer

Matthew D Park, Ivan Reyes-Torres, Jessica LeBerichel, Pauline Hamon, Nelson M LaMarche, Samarth Hegde, Meriem Belabed, Leanna Troncoso, John A Grout, Assaf Magen, Etienne Humblin, Achuth Nair, Martina Molgora, Jinchao Hou, Jenna H Newman, Adam M Farkas, Andrew M Leader, Travis Dawson, Darwin D'Souza, Steven Hamel, Alfonso Rodriguez Sanchez-Paulete, Barbara Maier, Nina Bhardwaj, Jerome C Martin, Alice O Kamphorst, Ephraim Kenigsberg, Maria Casanova-Acebes, Amir Horowitz, Brian D Brown, Lucas Ferrari De Andrade, Marco Colonna, Thomas U Marron, Miriam Merad.
Nat Immunol. 2023 May;24(5):792-801. doi: 10.1038/s41590-023-01475-4. Epub 2023 Apr 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37081148/

Dysregulated biomarkers of innate and adaptive immunity predict infections and disease progression in cirrhosis

Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David J M Bauer, Bernhard Scheiner, Benedikt Silvester Hofer, Albert Friedrich Stättermayer, Rodrig Marculescu, Michael Trauner, Mattias Mandorfer, Thomas Reiberger.
JHEP Rep. 2023 Feb 24;5(5):100712. doi: 10.1016/j.jhepr.2023.100712. eCollection 2023 May.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37035457/

Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger.
Nat Metab. 2023 Apr;5(4):711. doi: 10.1038/s42255-023-00791-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37024756/

Disturbances in sodium and chloride homeostasis predict outcome in stable and critically ill patients with cirrhosis

Georg Semmler, Bernhard Scheiner, Lorenz Balcar, Rafael Paternostro, Benedikt Simbrunner, Matthias Pinter, Michael Trauner, Marta Bofill Roig, Elias Laurin Meyer, Benedikt Silvester Hofer, Mattias Mandorfer, David James Pinato, Christian Zauner, Thomas Reiberger, Georg-Christian Funk.
Aliment Pharmacol Ther. 2023 Jul;58(1):71-79. doi: 10.1111/apt.17507. Epub 2023 Apr 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37016513/

WAVES (Web-based tool for Analysis and Visualization of Environmental Samples)-a web application for visualization of wastewater pathogen sequencing results

Petr Triska, Fabian Amman, Lukas Endler, Andreas Bergthaler.
Bioinformatics. 2023 Apr 3;39(4):btad160. doi: 10.1093/bioinformatics/btad160.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37018136/

A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade

Carolina Mangana, Barbara B Maier.
Cancer Cell. 2023 Apr 10;41(4):653-655. doi: 10.1016/j.ccell.2023.02.020. Epub 2023 Mar 30.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37001525/

Assessment of community efforts to advance network-based prediction of protein-protein interactions

Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P Wytock, István A Kovács, Olivér M Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu.
Nat Commun. 2023 Mar 22;14(1):1582. doi: 10.1038/s41467-023-37079-7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36949045/

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger.
Nat Metab. 2023 Mar;5(3):495-515. doi: 10.1038/s42255-023-00766-2. Epub 2023 Mar 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36941451/

Good or bad cops: immune cells in aGVHD

Georg Stary.
Blood. 2023 Mar 16;141(11):1238-1240. doi: 10.1182/blood.2022018226.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36929436/

Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response

Benedikt Simbrunner, Esther Caparrós, Teresa Neuwirth, Philipp Schwabl, Philipp Königshofer, David Bauer, Rodrig Marculescu, Michael Trauner, Bernhard Scheiner, Georg Stary, Mattias Mandorfer, Thomas Reiberger, Rubén Francés.
Hepatol Int. 2023 Aug;17(4):1045-1056. doi: 10.1007/s12072-023-10496-y. Epub 2023 Mar 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36881247/

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers

Ines Bojanic, Nina Worel, Carolina P Pacini, Georg Stary, Agnieszka Piekarska, Aisling M Flinn, Kimberly J Schell, Andrew R Gennery, Robert Knobler, João F Lacerda, Hildegard T Greinix, Drazen Pulanic, Rachel E Crossland.
Front Immunol. 2023 Feb 17;14:1086006. doi: 10.3389/fimmu.2023.1086006. eCollection 2023.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36875063/

Polymerase-δ-deficiency as a novel cause of inborn cancer predisposition associated with human papillomavirus infection

Johanna Strobl, Bettina Huber, Raul Jimenez Heredia, Reinhard Kirnbauer, Kaan Boztug, Georg Stary.
Br J Dermatol. 2023 Apr 20;188(5):684-685. doi: 10.1093/bjd/ljad021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36787285/

Correction: Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer

Nadine Bayer, Bela Hausmann, Ram Vinay Pandey, Florian Deckert, Laura-Marie Gail, Johanna Strobl, Petra Pjevac, Christoph Krall, Luisa Unterluggauer, Anna Redl, Victoria Bachmayr, Lisa Kleissl, Marion Nehr, Rasmus Kirkegaard, Athanasios Makristathis, Martin L Watzenboeck, Robert Nica, Clement Staud, Lukas Hammerl, Philipp Wohlfarth, Rupert C Ecker, Sylvia Knapp, Werner Rabitsch, David Berry, Georg Stary.
Leukemia. 2023 Mar;37(3):724. doi: 10.1038/s41375-023-01839-7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36788337/

In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target

Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A Yee, Sampath K Loganathan, Lina Liu, Derek C H Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E Dick, Mark D Minden, Daniel Schramek, Gene W Yeo, Kristin J Hope.
Blood Cancer Discov. 2023 Feb 10:BCD-22-0086. doi: 10.1158/2643-3230.BCD-22-0086. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36763002/

Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

Thomas Krausgruber, Anna Redl, Daniele Barreca, Konstantin Doberer, Daria Romanovskaia, Lina Dobnikar, Maria Guarini, Luisa Unterluggauer, Lisa Kleissl, Denise Atzmüller, Carolina Mayerhofer, Aglaja Kopf, Simona Saluzzo, Clarice X Lim, Praveen Rexie, Thomas Weichhart, Christoph Bock, Georg Stary.
Immunity. 2023 Feb 14;56(2):289-306.e7. doi: 10.1016/j.immuni.2023.01.014. Epub 2023 Feb 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36750099/

Macrophage and monocyte subsets as new therapeutic targets in cancer immunotherapy

B Fendl, A S Berghoff, M Preusser, B Maier.
ESMO Open. 2023 Feb;8(1):100776. doi: 10.1016/j.esmoop.2022.100776. Epub 2023 Feb 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36731326/

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

Patrick Essletzbichler, Vitaly Sedlyarov, Fabian Frommelt, Didier Soulat, Leonhard X Heinz, Adrijana Stefanovic, Benedikt Neumayer, Giulio Superti-Furga.
Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36725334/

Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence

Miquel Duran-Frigola, Marko Cigler, Georg E Winter.
J Am Chem Soc. 2023 Feb 8;145(5):2711-2732. doi: 10.1021/jacs.2c11098. Epub 2023 Jan 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36706315/

LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data

Peter Peneder, Christoph Bock, Eleni M Tomazou.
Bioinform Adv. 2022 Mar 23;2(1):vbac017. doi: 10.1093/bioadv/vbac017. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36699368/

Epigenetic regulation of T cell lineages in skin and blood following hematopoietic stem cell transplantation

Ram Vinay Pandey, Johanna Strobl, Anna Redl, Luisa Unterluggauer, Laura Gail, Lisa Kleissl, Sophie Müller, Denise Atzmüller, Victoria Fife-Gernedl, Thomas Krausgruber, Hanna Knaus, Margit Mitterbauer, Philipp Wohlfarth, Werner Rabitsch, Christoph Bock, Georg Stary.
Clin Immunol. 2023 Mar;248:109245. doi: 10.1016/j.clim.2023.109245. Epub 2023 Jan 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36702179/

Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species

Johanna Klughammer, Daria Romanovskaia, Amelie Nemc, Annika Posautz, Charlotte A Seid, Linda C Schuster, Melissa C Keinath, Juan Sebastian Lugo Ramos, Lindsay Kosack, Ann Evankow, Dieter Printz, Stefanie Kirchberger, Bekir Ergüner, Paul Datlinger, Nikolaus Fortelny, Christian Schmidl, Matthias Farlik, Kaja Skjærven, Andreas Bergthaler, Miriam Liedvogel, Denise Thaller, Pamela A Burger, Marcela Hermann, Martin Distel, Daniel L Distel, Anna Kübber-Heiss, Christoph Bock.
Nat Commun. 2023 Jan 16;14(1):232. doi: 10.1038/s41467-022-34828-y.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36646694/

Dual redox-active porous polyimides as high performance and versatile electrode material for next-generation batteries

Nicolas Goujon, Marianne Lahnsteiner, Daniel A Cerrón-Infantes, Hipassia M Moura, Daniele Mantione, Miriam M Unterlass, David Mecerreyes.
Mater Horiz. 2023 Mar 6;10(3):967-976. doi: 10.1039/d2mh01335e.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36633135/

Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

Bradley M Wertheim, Rui-Sheng Wang, Christelle Guillermier, Christiane Vr Hütter, William M Oldham, Jörg Menche, Matthew L Steinhauser, Bradley A Maron.
JCI Insight. 2023 Feb 22;8(4):e163932. doi: 10.1172/jci.insight.163932.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36626231/

Apoptosis as a Barrier against CIN and Aneuploidy

Johannes G Weiss, Filip Gallob, Patricia Rieder, Andreas Villunger.
Cancers (Basel). 2022 Dec 21;15(1):30. doi: 10.3390/cancers15010030.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36612027/

The 2000HIV study: Design, multi-omics methods and participant characteristics

Wilhelm A J W Vos, Albert L Groenendijk, Marc J T Blaauw, Louise E van Eekeren, Adriana Navas, Maartje C P Cleophas, Nadira Vadaq, Vasiliki Matzaraki, Jéssica C Dos Santos, Elise M G Meeder, Janeri Fröberg, Gert Weijers, Yue Zhang, Jingyuan Fu, Rob Ter Horst, Christoph Bock, Rainer Knoll, Anna C Aschenbrenner, Joachim Schultze, Linos Vanderkerckhove, Talent Hwandih, Elizabeth R Wonderlich, Sai V Vemula, Mike van der Kolk, Sterre C P de Vet, Willem L Blok, Kees Brinkman, Casper Rokx, Arnt F A Schellekens, Quirijn de Mast, Leo A B Joosten, Marvin A H Berrevoets, Janneke E Stalenhoef, Annelies Verbon, Jan van Lunzen, Mihai G Netea, Andre J A M van der Ven.
Front Immunol. 2022 Dec 20;13:982746. doi: 10.3389/fimmu.2022.982746. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36605197/

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter.
J Am Chem Soc. 2023 Jan 18;145(2):1176-1184. doi: 10.1021/jacs.2c10784. Epub 2023 Jan 5.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36602777/