2026
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
Valentina A Spiteri,
Dmitri Segal,
Alejandro Correa-Sáez,
Kentaro Iso,
Ryan Casement,
Miquel Muñoz I Ordoño,
Mark A Nakasone,
Gajanan Sathe,
Caroline Schätz,
Hannah E Peters,
Mark Doward,
Lisa Kainacher,
Angus D Cowan,
Alessio Ciulli,
Georg E Winter.
Nat Chem Biol. 2026 May 12. doi: 10.1038/s41589-026-02224-y. Online ahead of print.
2026
Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization
Antonio José Cabrera-Serrano,
María Carretero-Fernández,
Begoña Pérez-Rojo,
Rob Ter Horst,
Marisa Cañadas-Garre,
Helena Canhão,
Luca Quartuccio,
Signe B Sorensen,
Bente Glintborg,
Ileana Filipescu,
Eva Pérez-Pampin,
Pablo Conesa-Zamora,
Jerzy Swierkot,
Alfons A den Broeder,
Salvatore de Vita,
Eva Rabing Brix Petersen,
Yang Li,
Marieke J H Coenen,
Katarzyna Bogunia-Kubik,
Vibeke Andersen,
João Eurico Fonseca,
Merete Lund Hetland,
Miguel Ángel López Nevot,
Clementina López-Medina,
Fernando Jesús Reyes-Zurita,
Mihai G Netea,
Alejandro Escudero,
Rafael Cáliz,
Eduardo Collantes-Estévez,
José Manuel Sánchez-Maldonado,
Juan Sainz.
Front Immunol. 2026 Apr 23;17:1637735. doi: 10.3389/fimmu.2026.1637735. eCollection 2026.
2026
Comparative insights into the apoptosome, inflammasomes and PIDDosome
Mohamed Lamkanfi,
Lieselotte Vande Walle,
Felix Eichin,
Andreas Villunger.
Nat Rev Immunol. 2026 May 6. doi: 10.1038/s41577-026-01304-3. Online ahead of print.
2026
Target-agnostic SAR mapping and immunological evaluation of (-)-FR252921 and analogs against primary human immune cells
Iakovos Saridakis,
Manuel Schupp,
Haoqi Zhang,
Thomas Leischner,
Laura Marie Gail,
Konstantin Günther,
Martina Drescher,
Florian Doubek,
Daniel Kaiser,
Georg Stary,
Nuno Maulide.
Chem Sci. 2026 Apr 27. doi: 10.1039/d5sc09554a. Online ahead of print.
2026
A network-based map of the chemical exposome connects molecular interactions to public health
Salvo D Lombardo,
Christiane V R Hütter,
Miriam M Unterlass,
Jörg Menche.
Nat Commun. 2026 Apr 27. doi: 10.1038/s41467-026-72402-y. Online ahead of print.
2026
Unexplained bleeding tendency and scleroderma-like skin changes: a diagnostic journey to vitamin C deficiency
Florian Winkler,
Peter Maximilian Heil,
Johannes Thaler,
Wolfgang R Sperr,
Cihan Ay,
Johanna Strobl,
Johanna Gebhart,
Dino Mehic.
Res Pract Thromb Haemost. 2026 Mar 25;10(3):103424. doi: 10.1016/j.rpth.2026.103424. eCollection 2026 Mar.
2026
Disruption of the SAGA CORE triggers collateral degradation of KAT2A
Paul Batty,
Hannah Beneder,
Caroline Schätz,
Gabriel Onea,
Maciej Zaczek,
Ana P Kutschat,
Miriam Abele,
Sophie Müller,
Giulio Superti-Furga,
Georg E Winter,
Davide Seruggia.
Nat Commun. 2026 Apr 20;17(1):3410. doi: 10.1038/s41467-026-71613-7.
2026
Preclinical models of hepatosplenic γδ T-cell lymphoma with an activating STAT5B mutation display sensitivity to JAK inhibitor upadacitinib
Myint Myat Khine Aung,
Susann Schönefeldt,
Sophie Pfalz-Kraupp,
Tamara Wais,
Tobias Suske,
Safia Zahma,
Stefan Franz,
Andrea Müllebner,
Gabriela Feurstein,
Christina Wagner,
Thomas Eder,
Tea Pemovska,
Christiane Agreiter,
Alexander Pichler,
Philipp B Staber,
Martin Hofer,
Ralf Steinborn,
Svenja-Verena Strohmer,
Ingrid Simonitsch-Klupp,
Marcus Bauer,
Andreas Wilfer,
Thomas Weber,
Swapnil Potdar,
Tero Aittokallio,
Dennis Jungherz,
Tony A Müller,
Julia List,
Dagmar Gotthardt,
Florian Grebien,
Vasileios Bekiaris,
Marco Herling,
Richard Moriggl,
Heidi A Neubauer.
Hemasphere. 2026 Apr 16;10(4):e70345. doi: 10.1002/hem3.70345. eCollection 2026 Apr.
2026
Impact of pharmacological sGC stimulation with Riociguat in experimental models of liver disease regression
Katharina Bonitz,
Philipp Königshofer,
Henriette Horstmeier,
Thomas Sorz-Nechay,
Vlad Taru,
Katharina Bareiner,
Oleksander Petrenko,
Benedikt Simbrunner,
Benedikt Silvester Hofer,
Georg Kramer,
Katja Sommer,
Kerstin Zinober,
Katharina Regnat,
Hubert Scharnagl,
Peng Sun,
Eric Simon,
Stefan Kauscke,
Michael Trauner,
Thomas Reiberger,
Philipp Schwabl.
Hepatol Int. 2026 Apr 15. doi: 10.1007/s12072-026-11086-4. Online ahead of print.
2026
Radiomics-Based Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic Patients Using Routine CT Scans
Celine Sin,
Martin Luther Watzenboeck,
Eugenia Iofinova,
Lorenz Balcar,
Georg Semmler,
Bernhard Scheiner,
Katharina Lampichler,
Mattias Mandorfer,
Lucile Moga,
Pierre-Emmanuel Rautou,
Maxime Ronot,
Jörg Menche,
Thomas Reiberger,
Martina Scharitzer.
Liver Int. 2026 May;46(5):e70633. doi: 10.1111/liv.70633.
