2026
What are the limits to biomedical research acceleration through general-purpose AI?
Konstantin Hebenstreit,
Constantin Convalexius,
Stephan Reichl,
Stefan Huber,
Christoph Bock,
Matthias Samwald.
Sci Rep. 2026 Jan 12;16(1):1304. doi: 10.1038/s41598-025-32583-w.
2026
KRAS mutated lung adenocarcinoma responds to pan-ERBB and Aurora kinase inhibitors
Iris Z Uras,
Marija V Trkulja,
Abdelrahman K A A Salama,
Jaqueline Horvath,
Khushi Asnani,
Christoph Trenk,
Stefan Kubicek,
Martin Bilban,
Herwig P Moll,
Emilio Casanova.
NPJ Precis Oncol. 2026 Jan 12;10(1):14. doi: 10.1038/s41698-025-01242-8.
2026
The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
M Leone,
N Kinz,
F Eichin,
D Obwegs,
V C Sladky,
V Z Braun,
R Hirschberger,
D Rizzotto,
L Englmaier,
C Manzl,
K Moos,
J Mergner,
P Giansanti,
N Martinez-Garcia,
M M Marques,
E D Jacotot,
L Eblahed,
R Yousif,
M K Wright,
D Dawood,
L S Maupome,
C Savko,
M Boerries,
M A Sussman,
A Villunger.
Cell Death Differ. 2026 Jan 12. doi: 10.1038/s41418-025-01645-x. Online ahead of print.
2026
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Sofia Rossini,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Siska Führer,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Ciriana Orabona,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
Nat Chem. 2026 Jan 7. doi: 10.1038/s41557-025-02021-5. Online ahead of print.
2026
Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis
Katharina Hoppe,
Johannes Woelk,
Julia Benz,
Sarah Spoeck,
William J Olson,
Andreas Villunger,
Natascha Hermann-Kleiter,
Verena Labi.
FEBS J. 2026 Jan 6. doi: 10.1111/febs.70387. Online ahead of print.
2026
Mitotic errors as triggers of cell death and inflammation
Dario Rizzotto,
Christian Zierhut,
Andreas Villunger.
Nat Cell Biol. 2026 Jan 6. doi: 10.1038/s41556-025-01785-9. Online ahead of print.
2025
Editorial: Extracellular Matrix Biomarkers Illuminate the Architecture of Portal Hypertension in End-Stage Liver Disease-Authors' Reply
Mattias Mandorfer,
Benedikt Simbrunner,
Diana Julie Leeming.
Aliment Pharmacol Ther. 2025 Dec 21. doi: 10.1111/apt.70499. Online ahead of print.
2025
Type I interferon at the crossroads of metastatic dissemination
Teresa Neuwirth,
Barbara B Maier.
Nat Rev Immunol. 2025 Dec 8. doi: 10.1038/s41577-025-01259-x. Online ahead of print.
2025
Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain
Sabrina Grundtner,
Feng Xian,
Daniel Malzl,
Tina Radits,
Allison Marie Barry,
Julia Regina Sondermann,
Jörg Menche,
David Gómez-Varela,
Manuela Schmidt.
Biomed Pharmacother. 2025 Dec;193:118855. doi: 10.1016/j.biopha.2025.118855. Epub 2025 Dec 4.
2025
Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission
Johanna Strobl,
Lisa Kleissl,
Julia Eder,
Sally Connolly,
Tobias Frey,
Laura Marie Gail,
Aglaja Kopf,
Sophie Weninger,
Mateusz Markowicz,
Pavlína Bartíková,
Christian Freystätter,
Klaus Schmetterer,
Herbert Strobl,
Hannes Stockinger,
Michiel Wijnveld,
Georg Stary.
Nat Commun. 2025 Nov 28;16(1):11715. doi: 10.1038/s41467-025-66821-6.
