Publications
Year
Paper
2019
Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld OB, Altelaar M, Nieuwenhuis J, Celie PHN, Brummelkamp TR, Perrakis A. Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nat Struct Mol Biol. 2019 Jul;26(7):567-570. doi: 10.1038/s41594-019-0254-6. Epub 2019 Jul 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31270470
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31270470
2019
Robinson-Garcia L, Ferreira da Silva J, Loizou JI.Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics. Cancer Res. 2019 Aug 6. doi: 10.1158/0008-5472.CAN-19-1364. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31387919
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31387919
2019
Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A. Checkpoint kinase 1 is essential for fetal and adult hematopoiesis. EMBO Rep. 2019 Aug;20(8):e47026. doi: 10.15252/embr.201847026. Epub 2019 Jun 17.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31379128
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31379128
2019
Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T, Penninger JM, Pauler FM, Hudson QJ. The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS Genet. 2019 Jul 22;15(7):e1008268. doi: 10.1371/journal.pgen.1008268.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31329595/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31329595/
2019
Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T,Penninger JM, Pauler FM, Hudson QJ. The Airn lncRNA does not require any DNAelements within its locus to silence distant imprinted genes. PLoS Genet. 2019Jul 22;15(7):e1008268. doi: 10.1371/journal.pgen.1008268. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31329595
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31329595
2019
Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells. Cell Rep. 2019;29(13):4447–4459.e6. doi:10.1016/j.celrep.2019.11.089
Abstract: https://pubmed.ncbi.nlm.nih.gov/31875552/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31875552/
2019
Asp J, Skov V, Bellosillo B, Kristensen T, Lippert E, Dicker F, Schwarz J,Wojtaszewska M, Palmqvist L, Akiki S, Aggerholm A, Tolstrup Andersen M, GirodonF, Kjær L, Oppliger Leibundgut E, Pancrazzi A, Vorland M, Andrikovics H,Kralovics R, Cassinat B, Coucelo M, Eftimov A, Haslam K, Kusec R, Link-LenczowskaD, Lodé L, Matiakowska K, Naguib D, Navaglia F, Novotny GW, Percy MJ, SudarikovA, Hermouet S, Pallisgaard N. International external quality assurance of JAK2V617F quantification. Ann Hematol. 2019 May;98(5):1111-1118. doi:10.1007/s00277-018-3570-8. Epub 2018 Dec 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30535576
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30535576
2019
Asslaber D, Wacht N, Leisch M, Qi Y, Maeding N, Hufnagl C, Jansko B, Zaborsky N, Villunger A, Hartmann TN, Greil R, Egle A. BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation. Clin Cancer Res. 2019 Mar 15;25(6):1901-1912. doi:10.1158/1078-0432.CCR-18-1548. Epub 2018 Nov 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30487125
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30487125
2019
Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, AliA, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D,Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. CD8(+) T cells induce cachexia during chronic viral infection. Nat Immunol. 2019Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID:31110314;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31110314.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31110314.
2019
Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M,Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, BinderCJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi:10.1161/ATVBAHA.118.312272. Epub 2019 May 16.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31092015
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31092015
2019
Balligand T, Achouri Y, Pecquet C, Gaudray G, Colau D, Hug E, Rahmani Y, Stroobant V, Plo I, Vainchenker W, Kralovics R, Van den Eynde BJ, Defour JP, Constantinescu SN. Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development. Leukemia. 2019 Aug 30. doi: 10.1038/s41375-019-0538-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31471561/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31471561/
2019
Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW; GLASS Consortium. Barthel FP, Johnson KC, Varn FS, et al. Longitudinal molecular trajectories of diffuse glioma in adults. Nature. 2019;576(7785):112–120. doi:10.1038/s41586-019-1775-1
Abstract: https://pubmed.ncbi.nlm.nih.gov/31748746/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31748746/
2019
Bier J, Rao G, Payne K, Brigden H, French E, Pelham SJ, Lau A, Lenthall H,Edwards ESJ, Smart JM, Cole TS, Choo S, Joshi AY, Abraham RS, O'Sullivan M, Boztug K, Meyts I, Gray PE, Berglund LJ, Hsu P, Wong M, Holland SM, NotarangeloLD, Uzel G, Ma CS, Brink R, Tangye SG, Deenick EK. Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells. JAllergy Clin Immunol. 2019 Jul;144(1):236-253. doi: 10.1016/j.jaci.2019.01.033.Epub 2019 Feb 6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30738173
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30738173
2019
Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B,Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP,Karonitsch T. IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs. Exp Mol Med. 2019 Jul 8;51(7):75. doi:10.1038/s12276-019-0267-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31285419
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31285419
2019
Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC,Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi:10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30595531
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30595531
2019
Brand M, Winter GE. Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies. Methods Mol Biol. 2019;1953:105-119. doi:10.1007/978-1-4939-9145-7_7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30912018
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30912018
2019
Brand M, Winter GE. Stick it to E3s. Nat Chem Biol. 2019 Jul;15(7):655-656.doi: 10.1038/s41589-019-0312-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31209352
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31209352
2019
Brandstetter B, Dalwigk K, Platzer A, Niederreiter B, Kartnig F, Fischer A,Vladimer GI, Byrne RA, Sevelda F, Holinka J, Pap T, Steiner G, Superti-Furga G,Smolen JS, Kiener HP, Karonitsch T. FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes. Lab Invest. 2019 May;99(5):648-658. doi: 10.1038/s41374-018-0184-7. Epub 2019 Jan 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30679758
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30679758
2019
Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen S1. 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30770553/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30770553/
2019
Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, Zusinaite E, Dumpis U, Vitkauskiene A, Cox RJ, Kallio-Kokko H, Bergqvist A, Tenson T, Merits A, Oksenych V, Bjørås M, Anthonsen MW, Shum D, Kaarbø M, Vapalahti O, Windisch MP, Superti-Furga G, Snijder B, Kainov D, Kandasamy RK. Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis. Front Immunol. 2019 Oct 4;10:2186. doi: 10.3389/fimmu.2019.02186.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31636628/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31636628/
2019
Cagdas D, Halaçlı SO, Tan Ç, Lo B, Çetinkaya PG, Esenboğa S, Karaatmaca B, Matthews H, Balcı-Hayta B, Arıkoğlu T, Ezgü F, Aladağ E, Saltık-Temizel İN, Demir H, Kuşkonmaz B, Okur V, Gümrük F, Göker H, Çetinkaya D, Boztuğ K, Lenardo M, Sanal Ö, Tezcan İ. A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects. J Clin Immunol. 2019 Oct;39(7):726-738. doi: 10.1007/s10875-019-00677-6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31432443/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31432443/
2019
Caldera M, Müller F, Kaltenbrunner I, Licciardello MP, Lardeau CH, Kubicek S, Menche J. Mapping the perturbome network of cellular perturbations. Nat Commun. 2019 Nov 13;10(1):5140. doi: 10.1038/s41467-019-13058-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31723137/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31723137/
2019
Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F,Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, NotarangeloLD. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019Jun;143(6):2317-2321.e12. doi: 10.1016/j.jaci.2019.02.014. Epub 2019 Feb 26.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30822429
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30822429
2019
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R1, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation. 2019 May 21;139(21):2466-2482. doi: 10.1161/CIRCULATIONAHA.118.038534.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30894016/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30894016/
2019
Chen Y, Coussanes G, Souris C, Aillard P, Kaldre D, Runggatscher K, Kubicek S, Di Mauro G, Maryasin B, Maulide N. A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants. J Am Chem Soc. 2019 Sep 4;141(35):13772-13777. doi: 10.1021/jacs.9b07185.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31436963/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31436963/
2019
Chien J, Wolf FW, Grosche S, Yosef N, Garriga G, Mörck C. The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway. Genetics. 2019 Dec;213(4):1465-1478. doi: 10.1534/genetics.119.302628.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31619445/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31619445/
2019
Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH, Binder CJ, Kaser A, Mallat Z. Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice. Circ Res. 2019;125(11):1019–1034. doi:10.1161/CIRCRESAHA.119.315248
Abstract: https://pubmed.ncbi.nlm.nih.gov/31610723/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31610723/
2019
Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K. Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31449058/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31449058/
2019
Connolly P, Garcia-Carpio I, Villunger A. Cell-Cycle Cross Talk with Caspases and Their Substrates. Cold Spring Harb Perspect Biol. 2019 Nov 14. pii: a036475. doi: 10.1101/cshperspect.a036475.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31727679/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31727679/
2019
Di Giacomo AM, Covre A, Finotello F, Rieder D, Danielli R, Sigalotti L, Giannarelli D, Petitprez F, Lacroix L, Valente M, Cutaia O, Fazio C, Amato G, Lazzeri A, Monterisi S, Miracco C, Coral S, Anichini A, Bock C, Nemc A, Oganesian A, Lowder J, Azab M, Fridman WH, Sautès-Fridman C, Trajanoski Z, Maio M. Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial. Clin Cancer Res. 2019;25(24):7351–7362. doi:10.1158/1078-0432.CCR-19-1335
Abstract: https://pubmed.ncbi.nlm.nih.gov/31530631/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31530631/
2019
Doukas A, Karena E, Botou M, Papakostas K, Papadaki A, Tziouvara O, Xingi E, Frillingos S, Boleti H. Heterologous expression of the mammalian sodium-nucleobase transporter rSNBT1 in Leishmania tarentolae. Biochim Biophys Acta Biomembr. 2019 Sep 1;1861(9):1546-1557. doi: 10.1016/j.bbamem.2019.07.001.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31283918/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31283918/
2019
Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ; NIHR BioResource, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. 2019 Dec 5;134(23):2082-2091. doi: 10.1182/blood.2018891192.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31064749/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31064749/
2019
Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A,Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, DeenickEK, Uzel G, Tangye SG. Activating PIK3CD mutations impair human cytotoxiclymphocyte differentiation and function and EBV immunity. J Allergy Clin Immunol.2019 Jan;143(1):276-291.e6. doi: 10.1016/j.jaci.2018.04.030. Epub 2018 May 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29800648
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29800648
2019
Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, SchuetzC, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C,Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG,Lycopoulou L, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, DbaiboG, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM,Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C,Wolska-Kuśnierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, ChandrakasanS, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O,Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B,Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR,Notarangelo LD, Walter JE. Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1970-1985.e4. doi: 10.1016/j.jaip.2019.02.038. Epub 2019 Mar 12.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30877075
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30877075
2019
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW,Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K,Superti-Furga G. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30237509
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30237509
2019
Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells. Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/
2019
Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M,Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J, Bergthaler A, Steiner G, Blüml S. MicroRNA-155 Controls T Helper Cell Activation During Viral Infection. Front Immunol. 2019 Jun 13;10:1367. doi:10.3389/fimmu.2019.01367. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31275315
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31275315
2019
Goyal G, Zheng J, Adam E, Steffes G, Jain M, Klavins K, Hummel T. Sphingolipid-dependent Dscam sorting regulates axon segregation. Nat Commun. 2019 Feb 18;10(1):813. doi: 10.1038/s41467-019-08765-2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30778062/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30778062/
2019
Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, Maurer-Granofszky M, Roka F, Penz T, Bock C, Zhang G, Herlyn M, Glatz K, Läubli H, Mertz KD, Petzelbauer P, Wiesner T, Hartl M, Pickl WF, Somasundaram R, Steinberger P, Wagner SN. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun. 2019;10(1):4186. Published 2019 Sep 13. doi:10.1038/s41467-019-12160-2
Abstract: https://pubmed.ncbi.nlm.nih.gov/31519915/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31519915/
2019
Gruber M, Bozic I, Leshchiner I, Livitz D, Stevenson K, Rassenti L, RosebrockD, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, BrownJR, Neuberg D, Kipps TJ, Nowak MA, Getz G, Wu CJ. Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019 Jun;570(7762):474-479.doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31142838
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31142838
2019
Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10(1):5573. doi: 10.1038/s41467-019-13348-2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31811124/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31811124/
2019
Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih H-Y, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M. Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun. 2019;102379. doi:10.1016/j.jaut.2019.102379
Abstract: https://pubmed.ncbi.nlm.nih.gov/31883829/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31883829/
2019
Göschl L, Winkler S, Dmytrus J, Heredia RJ, Lagler H, Ramharter M, Scheinecker C, Bonelli M, Schmetterer K, Pickl WF, Grabmeier-Pfistershammer K, Hershfield MS, Boztug K, Förster-Waldl E, Gualdoni GA. Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle. J Clin Immunol. 2019 Nov 4. doi: 10.1007/s10875-019-00700-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31686313/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31686313/
2019
Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GA. A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52. Sci Rep. 2019 May 27;9(1):7901. doi:10.1038/s41598-019-44359-0.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133683
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133683
2019
Halbritter F, Farlik M, Schwentner R, Jug G, Fortelny N, Schnöller T, Pisa H, Schuster LC, Reinprecht A, Czech T, Gojo J, Holter W, Minkov M, Bauer W, Simonitsch-Klupp I, Bock C, Hutter C. Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis. Cancer Discov. 2019 Oct;9(10):1406-1421. doi: 10.1158/2159-8290.CD-19-0138.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31345789/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31345789/
2019
Hamdane N, Jühling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, BandieraS, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I,Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoël M,Piardi T, Sommacale D, Imamura M, Uchida T, Ohdan H, Aikata H, Chayama K,Boldanova T, Pessaux P, Fuchs BC, Hoshida Y, Zeisel MB, Duong FHT, Baumert TF. HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response. Gastroenterology. 2019 Jun;156(8):2313-2329.e7.doi: 10.1053/j.gastro.2019.02.038. Epub 2019 Mar 2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30836093
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30836093
2019
Heijink AM, Talens F, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM. BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. NatCommun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. PubMed PMID:30626869;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6327059
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6327059
2019
Houben T, Magro Dos Reis I, Oligschlaeger Y, Steinbusch H, Gijbels MJJ, Hendrikx T, Binder CJ, Cassiman D, Westerterp M, Prickaerts J, Shiri-Sverdlov R. Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease. Front Immunol. 2019 Jan 7;9:3089. doi: 10.3389/fimmu.2018.03089. eCollection 2018.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30666257/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30666257/
2019
Jia R, Kralovics R. Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions. Int J Hematol. 2019 Nov 18. doi: 10.1007/s12185-019-02778-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31741139/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31741139/
2019
Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK. Colocalization analysesof genomic elements: approaches, recommendations and challenges. Bioinformatics. 2019 May 1;35(9):1615-1624. doi: 10.1093/bioinformatics/bty835. PubMed PMID:30307532;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6499241
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6499241
2019
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T. Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. JCI Insight. 2019;4(20):e124164. Published 2019 Oct 17. doi:10.1172/jci.insight.124164
Abstract: https://pubmed.ncbi.nlm.nih.gov/31619583/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31619583/
2019
Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C,Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res. 2019 Jul 1;115(9):1385-1392. doi:10.1093/cvr/cvz166.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31228191
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31228191
2019
Kiss MG, Ozsvár-Kozma M, Porsch F, Göderle L, Papac-Miličević N, Bartolini-Gritti B, Tsiantoulas D, Pickering MC, Binder CJ. Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production. Front Immunol. 2019;10:1607. Published 2019 Jul 11. doi:10.3389/fimmu.2019.01607
Abstract: https://pubmed.ncbi.nlm.nih.gov/31354740/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31354740/
2019
Klufa J, Bauer T, Hanson B, Herbold C, Starkl P, Lichtenberger B, Srutkova D, Schulz D, Vujic I, Mohr T, Rappersberger K, Bodenmiller B, Kozakova H, Knapp S, Loy A, Sibilia M. Klufa J, Bauer T, Hanson B, et al. Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy. Sci Transl Med. 2019;11(522):eaax2693. doi:10.1126/scitranslmed.aax2693
Abstract: https://pubmed.ncbi.nlm.nih.gov/31826981/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31826981/
2019
Kocacik Uygun DF, Uygun V, Daloğlu H, Öztürkmen S, Karasu G, Reisli İ, Sayar E, Yüksekkaya HA, Glocker EO, Boztuğ K, Yeşilipek A. Hematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement? J Pediatr Hematol Oncol. 2019Jan;41(1):64-66. doi: 10.1097/MPH.0000000000001165.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29683948
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29683948
2019
Korchynska S, Krassnitzer M, Malenczyk K, Prasad RB, Tretiakov EO, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger SN, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak DD, Romanov RA, Pifl C, Groop L, Hökfelt TG, Harkany T. Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants [published online ahead of print, 2019 Nov 21]. EMBO J. 2019;e100882. doi:10.15252/embj.2018100882
Abstract: https://pubmed.ncbi.nlm.nih.gov/31750562/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31750562/
2019
Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P,Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H,de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease. Cancer Cell. 2019Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30645971
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30645971
2019
Kral-Pointner JB, Schrottmaier WC, Salzmann M, Mussbacher M, Schmidt GJ, Moser B, Heber S, Birnecker B, Paar H, Zellner M, Knapp S, Assinger A, Schabbauer G. Platelet PI3K Modulates Innate Leukocyte Extravasation during Acid-Induced Acute Lung Inflammation. Thromb Haemost. 2019;19(10):1642–1654. doi:10.1055/s-0039-1693693
Abstract: https://pubmed.ncbi.nlm.nih.gov/31370072/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31370072/
2019
Kutluǧ Ş, Boztuǧ K, Yıldıran A. Development of multiple gallstones in a child with lipopolysaccharide-responsive beige-like anchor protein mutation. Cent Eur J Immunol. 2019;44(3):332-335. doi: 10.5114/ceji.2019.89613.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31871423/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31871423/
2019
Lee NJ, Clarke IM, Zengin A, Enriquez RF, Nagy V, Penninger JM, Baldock PA,Herzog H. RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. J Neuroendocrinol. 2019 Feb;31(2):e12687. doi:10.1111/jne.12687. Epub 2019 Feb 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30633834
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30633834
2019
Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A. Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. Immunity. 2019;51(6):1074–1087.e9. doi:10.1016/j.immuni.2019.10.014
Abstract: https://pubmed.ncbi.nlm.nih.gov/31784108/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31784108/
2019
Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T,Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O,Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, ProchazkovaJ, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A,Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L,Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.Haematologica. 2019 May 23. pii: haematol.2019.216986. doi:10.3324/haematol.2019.216986. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31123029
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31123029
2019
Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31442425/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31442425/
2019
Mayor-Ruiz C, Winter GE. Identification and characterization of cancer vulnerabilities via targeted protein degradation. Drug Discov Today Technol. 2019Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31200863.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31200863.
2019
McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L,Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M,Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb13.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30760925
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30760925
2019
Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA,Brummelkamp TR, Schumacher TN. SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. PLoS One. 2019 Feb 12;14(2):e0212053. doi:10.1371/journal.pone.0212053. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30753225
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30753225
2019
Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M,Ottmann OG, Hantschel O. The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis. Leukemia. 2019 Apr 8. doi:10.1038/s41375-019-0468-y. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30962580
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30962580
2019
Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA. Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation. Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30737144/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30737144/
2019
Moik F, Riedl JM, Winder T, Terbuch A, Rossmann CH, Szkandera J, Bauernhofer T, Kasparek AK, Schaberl-Moser R, Reicher A, Prinz F, Pichler M, Stöger H, Stotz M, Gerger A, Posch F. Benefit of second-line systemic chemotherapy for advanced biliary tract cancer: A propensity score analysis. Sci Rep. 2019 Apr 3;9(1):5548.doi: 10.1038/s41598-019-42069-1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30944390
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30944390
2019
Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G,Girardi E, Superti-Furga G. The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Sci Rep. 2019 Jul 18;9(1):10471.doi: 10.1038/s41598-019-46952-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31320712
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31320712
2019
Muller A, Gasch J, Albring KF, Aberger F, Nivarthi H, Khemeri M, Moriggl R, Friedrich KH. Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells. Neoplasma. 2019 May 23;66(3):357-366. doi: 10.4149/neo_2018_180731N560.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30569725/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30569725/
2019
Müller F, Scherer M, Assenov Y, Lutsik P, Walter J, Lengauer T, Bock C. RnBeads 2.0: comprehensive analysis of DNA methylation data. Genome Biol. 2019Mar 14;20(1):55. doi: 10.1186/s13059-019-1664-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30871603
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30871603
2019
Nagy V, Hollstein R, Pai TP, Herde MK, Buphamalai P, Moeseneder P,Lenartowicz E, Kavirayani A, Korenke GC, Kozieradzki I, Nitsch R, Cicvaric A,Monje Quiroga FJ, Deardorff MA, Bedoukian EC, Li Y, Yigit G, Menche J, Perçin EF,Wollnik B, Henneberger C, Kaiser FJ, Penninger JM. HACE1 deficiency leads to structural and functional neurodevelopmental defects. Neurol Genet. 2019 Apr29;5(3):e330. doi: 10.1212/NXG.0000000000000330. eCollection 2019 Jun. PubMedPMID: 31321300;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6561753
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6561753
2019
Nieuwenhuis J, Brummelkamp TR. The Tubulin Detyrosination Cycle: Function andEnzymes. Trends Cell Biol. 2019 Jan;29(1):80-92. doi: 10.1016/j.tcb.2018.08.003. Epub 2018 Sep 10. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30213517
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30213517
2019
Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P,Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD,Loizou JI. Mapping the Human Kinome in Response to DNA Damage. Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30650350
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30650350
2019
Patra V, Strobl J, Gruber-Wackernagel A, Vieyra-Garcia P, Stary G, Wolf P. CD11b(+) cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption. Br J Dermatol. 2019 May 3. doi: 10.1111/bjd.18092. [Epub ahead ofprint]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31049931
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31049931
2019
Pazmandi J, Kalinichenko A, Ardy RC, Boztug K. Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms. Immunol Rev. 2019 Jan;287(1):162-185. doi: 10.1111/imr.12726. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30565237
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30565237
2019
Pecquet C, Chachoua I, Roy A, Balligand T, Vertenoeil G, Leroy E, Albu RI,Defour JP, Nivarthi H, Hug E, Xu E, Ould-Amer Y, Mouton C, Colau D, Vertommen D, Shwe MM, Marty C, Plo I, Vainchenker W, Kralovics R, Constantinescu SN. Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants. Blood. 2019 Jun 20;133(25):2669-2681. doi:10.1182/blood-2018-09-874578. Epub 2019 Mar 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30902807
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30902807
2019
Piper CJM, Rosser EC, Oleinika K, Nistala K, Krausgruber T, Rendeiro AF, Banos A, Drozdov I, Villa M, Thomson S, Xanthou G, Bock C, Stockinger B, Mauri C. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells. Cell Rep. 2019;29(7):1878–1892.e7. doi:10.1016/j.celrep.2019.10.018
Abstract: https://pubmed.ncbi.nlm.nih.gov/31722204/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31722204/
2019
Porsch F, Binder CJ. Impact of B-Cell-Targeted Therapies on Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Jul 18:ATVBAHA119311996. doi:10.1161/ATVBAHA.119.311996. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31315439
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31315439
2019
Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M,Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N,Boilard E, Binder CJ. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells. Circ Res. 2019 Jun 21;125(1):43-52. doi:10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31219742
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31219742
2019
Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31133695/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31133695/
2019
Robinson-Garcia L, Ferreira da Silva J, Loizou JI. Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics. Cancer Res. 2019 Nov 15;79(22):5693-5698. doi: 10.1158/0008-5472.CAN-19-1364.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31387919/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31387919/
2019
Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M,Reichardt HM, Villunger A, Tischner D, Wiegers GJ. Glucocorticoid Receptor-Deficient Foxp3(+) Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease. Front Immunol. 2019 Mar 18;10:472. doi:10.3389/fimmu.2019.00472. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30936873
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30936873
2019
Sage AP, Tsiantoulas D, Binder CJ, Mallat Z. The role of B cells inatherosclerosis. Nat Rev Cardiol. 2019 Mar;16(3):180-196. doi:10.1038/s41569-018-0106-9. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30410107
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30410107
2019
Scalise M, Galluccio M, Pochini L, Cosco J, Trotta M, Rebsamen M,Superti-Furga G, Indiveri C. Insights into the transport side of the human SLC38A9 transceptor. Biochim Biophys Acta Biomembr. 2019 Jul 8;1861(9):1558-1567.doi: 10.1016/j.bbamem.2019.07.006. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31295473
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31295473
2019
Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Májek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Müller AC, Bock C, Kubicek S. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019;51(9):1399–1410. doi:10.1038/s41588-019-0477-9
Abstract: https://pubmed.ncbi.nlm.nih.gov/31427792/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31427792/
2019
Schiefer AI, Salzer E, Füreder A, Szepfalusi Z, Müller-Sacherer T, Huber WD, Michel-Behnke I, Lawitschka A, Pichler H, Mann G, Hutter C, Simonitsch-Klupp I,Attarbaschi A. PD-L1 and PD1 expression in post-transplantation lymphoproliferative disease (PTLD) of childhood and adolescence: An inter- and intra-individual descriptive study covering the whole spectrum of PTLD categories. Cancer Med. 2019 Jul 3. doi: 10.1002/cam4.2394. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31269329
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31269329
2019
Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E,Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D,Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A,Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. Blood. 2019 Jul 11;134(2):199-210. doi: 10.1182/blood.2019000519. Epub2019 May 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31064751
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31064751
2019
Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C,Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K,Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, HoermannG, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C. Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL. Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692684
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692684
2019
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A,Rajewsky K, Labi V. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J. 2019 May 23. doi:10.1111/febs.14934. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31120187
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31120187
2019
Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N,Villunger A, Labi V. CHK1 dosage in germinal center B cells controls humoral immunity. Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5. [Epubahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30894677
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30894677
2019
Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G,Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P,Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL,Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, MechtlerK, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J,Kubicek S. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133746
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133746
2019
Semmler G, Simbrunner B, Scheiner B, Schwabl P, Paternostro R, Bucsics T,Stättermayer AF, Bauer D, Pinter M, Ferenci P, Trauner M, Mandorfer M, Reiberger T. Impact of farnesoid X receptor single nucleotide polymorphisms on hepatic decompensation and mortality in cirrhotic patients with portal hypertension. JGastroenterol Hepatol. 2019 May 6. doi: 10.1111/jgh.14700. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31062417
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31062417
2019
Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nat Immunol. 2019 Nov;20(11):1435-1443. doi: 10.1038/s41590-019-0493-z.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31591569/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31591569/
2019
Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Loizou JI, Kain R,Bidmon-Fliegenschnee B, Schickel JN, Glauzy S, Huemer J, Garncarz W, Salzer E,Pierides I, Bilic I, Thiel J, Priftakis P, Banerjee PP, Förster-Waldl E, MedgyesiD, Huber WD, Orange JS, Meffre E, Sansom DM, Bryceson YT, Altman A, Boztug K. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019 Jul 15;10(1):3106.doi: 10.1038/s41467-019-10812-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31308374
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31308374
2019
Shabani M, Aleyasin S, Kashef S, Zoghi S, Deswarte C, Casanova JL, BustamanteJ, Rezaei N. A Novel Recessive Mutation of Interferon-γ Receptor 1 in a Patient with Mycobacterium tuberculosis in Bone Marrow Aspirate. J Clin Immunol. 2019Feb;39(2):127-130. doi: 10.1007/s10875-019-00595-7. Epub 2019 Feb 5.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30719685
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30719685
2019
Shahin T, Aschenbrenner D, Cagdas D, Bal SK, Conde CD, Garncarz W, MedgyesiD, Schwerd T, Karaatmaca B, Cetinkaya PG, Esenboga S, Twigg SRF, Cant A, WilkieAOM, Tezcan I, Uhlig HH, Boztug K. Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function. Haematologica. 2019 Mar;104(3):609-621. doi:10.3324/haematol.2018.194233. Epub 2018 Oct 11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30309848
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30309848
2019
Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019 Mar 15;202(6):1724-1734. doi: 10.4049/jimmunol.1701649.Epub 2019 Feb 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718299
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718299
2019
Singh DD, Hawkins RD, Lahesmaa R, Tripathi SK. CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases. Semin Cell Dev Biol. 2019 Jun 19. pii: S1084-9521(18)30111-3. doi:10.1016/j.semcdb.2019.05.007. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31112800
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31112800
2019
Skucha A, Ebner J, Grebien F. Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond. Int J Mol Sci. 2019 Feb 27;20(5). pii: E1029. doi:10.3390/ijms20051029. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30818762
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30818762
2019
Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L,Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML,Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L,Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019 Jun 7;364(6444). pii: eaas9536. doi:10.1126/science.aas9536.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31171666
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31171666
2019
Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K. CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis. Blood. 2019 Oct 31;134(18):1510-1516. doi: 10.1182/blood.2019000644.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31501153/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31501153/
2019
Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M,Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M,Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD,Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD,Thaventhiran JED. Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. J Exp Med. 2019 Jun 24. pii:jem.20190344. doi: 10.1084/jem.20190344. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31235509
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31235509
2019
Staber PB, Herling M, Bellido M, Jacobsen ED, Davids MS, Kadia TM, Shustov A,Tournilhac O, Bachy E, Zaja F, Porkka K, Hoermann G, Simonitsch I, Haferlach C,Kubicek S, Mayerhoefer M, Hopfinger G, Jaeger U, Dearden C. Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia (T-PLL). Blood. 2019 Jul 10. pii: blood.2019000402. doi: 10.1182/blood.2019000402. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31292114
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31292114
2019
Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Mol Cell. 2019 Nov 7;76(3):485-499.e8. doi: 10.1016/j.molcel.2019.07.034.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31495563/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31495563/
2019
Tesch VK, Abolhassani H, Shadur B, Zobel J, Mareika Y, Sharapova S, Karakoc-Aydiner E, Rivière JG, Garcia-Prat M, Moes N, Haerynck F, Gonzales-Granado LI, Santos Pérez JL, Mukhina A, Shcherbina A, Aghamohammadi A, Hammarström L, Dogu F, Haskologlu S, İkincioğulları AI, Bal SK, Baris S, Kilic SS, Karaca NE, Kutukculer N, Girschick H, Kolios A, Keles S, Uygun V, Stepensky P, Worth A, van Montfrans JM, Peters AMJ, Meyts I, Adeli M, Marzollo A, Padem N, Khojah AM, Chavoshzadeh Z, Stefanija MA, Bakhtiar S, Florkin B, Meeths M, Gamez L, Grimbacher B, Seppänen MR, Lankester A, Gennery AR, Seidel MG; Inborn Errors, Clinical, and Registry Working Parties of the European Society for Blood and Marrow Transplantation (EBMT) and the European Society of Immunodeficiencies (ESID). Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score. J Allergy Clin Immunol. 2019 Dec 27. pii: S0091-6749(19)32603-X. doi: 10.1016/j.jaci.2019.12.896.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31887391/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31887391/
2019
Ulz P, Perakis S, Zhou Q, Moser T, Belic J, Lazzeri I, Wölfler A, Zebisch A, Gerger A, Pristauz G, Petru E, White B, Roberts CES, John JS, Schimek MG, Geigl JB, Bauernhofer T, Sill H, Bock C, Heitzer E, Speicher MR. Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection. Nat Commun. 2019;10(1):4666. Published 2019 Oct 11. doi:10.1038/s41467-019-12714-4
Abstract: https://pubmed.ncbi.nlm.nih.gov/31604930/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31604930/
2019
Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL. Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30808763/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30808763/
2019
Unterleuthner D, Neuhold P, Schwarz K, Janker L, Neuditschko B, Nivarthi H, Crncec I, Kramer N, Unger C, Hengstschläger M, Eferl R, Moriggl R, Sommergruber W, Gerner C, Dolznig H. Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer. Angiogenesis. 2019 Oct 30. doi: 10.1007/s10456-019-09688-8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31667643/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31667643/
2019
Uras IZ, Maurer B, Nivarthi H, Jodl P, Kollmann K, Prchal-Murphy M, Milosevic Feenstra JD, Zojer M, Lagger S, Grausenburger R, Grabner B, Holly R, Kavirayani A, Bock C, Gisslinger H, Valent P, Kralovics R, Sexl V. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks. Blood. 2019;133(15):1677–1690. doi:10.1182/blood-2018-08-872648
Abstract: https://pubmed.ncbi.nlm.nih.gov/30635286/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30635286/
2019
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM. Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions. Haematologica. 2019 Oct;104(10):1935-1949. doi: 10.3324/haematol.2019.222059.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31048353/
Abstract: https://pubmed.ncbi.nlm.nih.gov/31048353/
2019
Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A, Merkel A, Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH, Clarke L, Heath S, van der Reijden BA, Flicek P, Yaspo ML, Gut I, Bock C, Schuringa JJ, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes. Cell Rep. 2019;26(4):1059–1069.e6. doi:10.1016/j.celrep.2018.12.098
Abstract: https://pubmed.ncbi.nlm.nih.gov/30673601/
Abstract: https://pubmed.ncbi.nlm.nih.gov/30673601/
2019
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S,Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T,Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, HabenichtAJR. ApoE attenuates unresolvable inflammation by complex formation withactivated C1q. Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8.Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Feb 4;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692699
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692699
2019
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S,Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T,Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, HabenichtAJR. Publisher Correction: ApoE attenuates unresolvable inflammation by complexformation with activated C1q. Nat Med. 2019 Mar;25(3):529. doi:10.1038/s41591-019-0378-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718908
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718908
2019
van Mierlo G, Dirks RAM, De Clerck L, Brinkman AB, Huth M, Kloet SL, Saksouk N, Kroeze LI, Willems S, Farlik M, Bock C, Jansen JH, Deforce D, Vermeulen M,Déjardin J, Dhaenens M, Marks H. Integrative Proteomic Profiling RevealsPRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. CellStem Cell. 2019 Jan 3;24(1):123-137.e8. doi: 10.1016/j.stem.2018.10.017. Epub2018 Nov 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30472157
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30472157