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Year
Paper
2021
Achyutuni S, Nivarthi H, Majoros A, Hug E, Schueller C, Jia R, Varga C, Schuster M, Senekowitsch M, Tsiantoulas D, Kavirayani A, Binder CJ, Bock C, Zagrijtschuk O, Kralovics R. Hematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivo. Am J Hematol. 2021 Mar 24. doi: 10.1002/ajh.26171. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33761144/
2021
Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33664060/
2021
Agerer B, Lercher A, Bergthaler A. The serine's call: Suppressing interferon responses. Cell Metab. 2021 May 4;33(5):849-850. doi: 10.1016/j.cmet.2021.04.012.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33951468/
2021
Akkari L, Finley SD, Ho PC, Jenkins M, Maier BB, McGranahan N, Mutebi M, Perera RM, Robles-Espinoza CD, Vardhana S, Wan L, Xu MM. Challenges and opportunities in 2021. Nat Cancer. 2021 Dec;2(12):1278-1283. doi: 10.1038/s43018-021-00294-6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35121916/
2021
Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 Nov;9(11):1245-1251. doi: 10.1158/2326-6066.CIR-21-0519. Epub 2021 Sep 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34544686/
2021
Amaya-García F, Caldera M, Koren A, Kubicek S, Menche J, Unterlass MM. Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives. ChemSusChem. 2021 Apr 22;14(8):1780. doi: 10.1002/cssc.202100607.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33855809/ _blank
2021
Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nat Rev Immunol. 2021 Oct 4:1-13. doi: 10.1038/s41577-021-00624-w. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34608281/
2021
Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nat Rev Immunol. 2021 Oct 4;1-13. doi: 10.1038/s41577-021-00624-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34608281/ _blank
2021
Balcar L, Semmler G, Pomej K, Simbrunner B, Bauer D, Hartl L, Jachs M, Paternostro R, Bucsics T, Pinter M, Trauner M, Mandorfer M, Reiberger T, Scheiner B. Patterns of acute decompensation in hospitalized patients with cirrhosis and course of acute-on-chronic liver failure. United European Gastroenterol J. 2021 May;9(4):427-437. doi: 10.1002/ueg2.12089.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34050619/
2021
Bangert C, Rindler K, Krausgruber T, Alkon N, Thaler FM, Kurz H, Ayub T, Demirtas D, Fortelny N, Vorstandlechner V, Bauer WM, Quint T, Mildner M, Jonak C, Elbe-Bürger A, Griss J, Bock C, Brunner PM. Persistence of mature dendritic cells, T(H)2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade. Sci Immunol. 2021 Jan 22;6(55):eabe2749. doi: 10.1126/sciimmunol.abe2749.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33483337/
2021
Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P, Moser D, Haller F, Hof F, Beer A, Orgler E, Frick A, Khare V, Evstatiev R, Strohmaier S, Primas C, Dolak W, Köcher T, Klavins K, Rath T, Neurath MF, Berry D, Makristathis A, Muttenthaler M, Gasche C. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology. 2021 Oct;161(4):1245-1256.e20. doi: 10.1053/j.gastro.2021.06.024.2021 Jun 17.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34146566/
2021
Bayram O, Haskologlu S, Bayrakoğlu D, Bal SK, Islamoglu C, Cipe FE, Kendirli T, Kursun N, Guner SN, Yildiran A, Bozdogan G, Yuksek M, Reisli I, Dalva K, Aytekin C, Boztug K, Dogu F, Ikinciogullari A. Single-Center Study of 72 Patients with Severe Combined Immunodeficiency: Clinical and Laboratory Features and Outcomes. J Clin Immunol. 2021 Oct;41(7):1563-1573. doi: 10.1007/s10875-021-01062-y. Epub 2021 Jun 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34114123/
2021
Berg JL, Perfler B, Hatzl S, Uhl B, Reinisch A, Pregartner G, Berghold A, Penz T, Schuster M, Geissler K, Prokesch A, Müller-Tidow C, Hoefler G, Kashofer K, Wölfler A, Sill H, Caraffini V, Zebisch A. EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity. Leukemia. 2021 Feb 15. doi: 10.1038/s41375-021-01161-0. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33589750/
2021
Bernardo S, Meyenberg M, Loizou JI. Decomposing the mutational landscape of cancer genomes with RepairSig. Cell Syst. 2021 Oct 20;12(10):953-955. doi: 10.1016/j.cels.2021.09.009.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34672958/
2021
Besse L, Besse A, Stolze SC, Sobh A, Zaal EA, van der Ham AJ, Ruiz M, Phuyal S, Büchler L, Sathianathan M, Florea BI, Borén J, Ståhlman M, Huber J, Bolomsky A, Ludwig H, Hannich JT, Loguinov A, Everts B, Berkers CR, Pilon M, Farhan H, Vulpe CD, Overkleeft HS, Driessen C. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma. Cancer Res. 2021 Sep 1;81(17):4581-4593. doi: 10.1158/0008-5472.CAN-20-3323. Epub 2021 Jun 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34158378/
2021
Beumer J., Geurts M.H., Lamers M.M., Puschhof J., Zhang J., van der Vaart J., Mykytyn A.Z., Breugem T.I., Riesebosch S., Schipper D., van den Doel P.B., de Lau W., Pleguezuelos-Manzano C., Busslinger G.A., Haagmans B.L., Clevers H. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nat Commun. 2021 Sep 17;12(1):5498. doi: 10.1038/s41467-021-25729-7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34535662/
2021
Bock C, Boutros M, Camp JG, Clarke L, Clevers H, Knoblich JA, Liberali P, Regev A, Rios AC, Stegle O, Stunnenberg HG, Teichmann SA, Treutlein B, Vries RGJ; Human Cell Atlas ‘Biological Network’ Organoids. The Organoid Cell Atlas. Nat Biotechnol. 2021 Jan;39(1):13-17. doi: 10.1038/s41587-020-00762-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33384458/
2021
Boehm T, Ristl R, Joseph S, Petroczi K, Klavins K, Valent P, Jilma B. Metabolome and lipidome derangements during a severe mast cell activation event in a patient with indolent systemic mastocytosis. J Allergy Clin Immunol. 2021 Apr 14:S0091-6749(21)00607-2. doi: 10.1016/j.jaci.2021.03.043. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33864889/
2021
Bolomsky A, Miettinen JJ, Malyutina A, Besse A, Huber J, Fellinger S, Breid H, Parsons A, Klavins K, Hannich JT, Kubicek S, Caers J, Hübl W, Schreder M, Zojer N, Driessen C, Tang J, Besse L, Heckman CA, Ludwig H. Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma. Blood Adv. 2021 Oct 26;5(20):4125-4139. doi: 10.1182/bloodadvances.2020003826.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34478517/
2021
Buchta C, Camp JV, Jovanovic J, Chiba P, Puchhammer-Stöckl E, Mayerhofer M, Plicka H, Lercher A, Popa AM, Endler L, Bergthaler A, Huf W, Benka B, Delatour V, Müller MM, Griesmacher A, Aberle SW, Görzer I. The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria. Clin Chem Lab Med. 2021 Jun 29. DOI: 10.1515/cclm-2021-0604. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34187131/ _blank
2021
Buchta C, Camp JV, Jovanovic J, Chiba P, Puchhammer-Stöckl E, Mayerhofer M, Plicka H, Lercher A, Popa AM, Endler L, Bergthaler A, Huf W, Benka B, Delatour V, Müller MM, Griesmacher A, Aberle SW, Görzer I. The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria. Clin Chem Lab Med. 2021 Jun 30;59(10):1735-1744. doi: 10.1515/cclm-2021-0604. Print 2021 Sep 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34187131/
2021
Buphamalai P, Kokotovic T, Nagy V, Menche J. Network analysis reveals rare disease signatures across multiple levels of biological organization. Nat Commun. 2021 Nov 9;12(1):6306. doi: 10.1038/s41467-021-26674-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34753928/ _blank
2021
Buphamalai P, Kokotovic T, Nagy V, Menche J. Network analysis reveals rare disease signatures across multiple levels of biological organization. Nat Commun. 2021 Nov 9;12(1):6306. doi: 10.1038/s41467-021-26674-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34753928/
2021
Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A, Maffini S, Fava LL. Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. EMBO J. 2021 Feb 15;40(4):e104844. doi: 10.15252/embj.2020104844. Epub 2020 Dec 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33350486/
2021
Busslinger G, Weusten BLA, Bogte A, Begthel H, Brosens LAA, Clevers H. Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution. Cell Rep. 2021 Mar 9;34(10):108819.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33691112/
2021
Busslinger G.A., de Barbanson B., Oka R., Weusten B.L.A., de Maat M., van Hillegersberg R., Brosens L.A.A., van Boxtel R., van Oudenaarden A. and Clevers H. Molecular characterization of Barrett’s esophagus at single-cell resolution. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2113061118. doi: 10.1073/pnas.2113061118.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34795059/
2021
Busslinger GA, de Barbanson B, Oka R, Weusten BLA, de Maat M, van Hillegersberg R, Brosens LAA, van Boxtel R, van Oudenaarden A, Clevers H. Molecular characterization of Barrett's esophagus at single-cell resolution. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2113061118. doi: 10.1073/pnas.2113061118.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34795059/
2021
Buttura JR, Provisor Santos MN, Valieris R, Drummond RD, Defelicibus A, Lima JP, Calsavara VF, Freitas HC, Cordeiro de Lima VC, Fernanda Bartelli T, Wiedner M, Rosales R, Gollob KJ, Loizou J, Dias-Neto E, Nunes DN, da Silva IT. Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention. Cancers (Basel). 2021 Jan 27;13(3):490. doi: 10.3390/cancers13030490.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33513945/
2021
Cadena Del Castillo CE, Hannich JT, Kaech A, Chiyoda H, Brewer J, Fukuyama M, Færgeman NJ, Riezman H, Spang A. Patched regulates lipid homeostasis by controlling cellular cholesterol levels. Nat Commun. 2021 Aug 12;12(1):4898. doi: 10.1038/s41467-021-24995-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34385431/
2021
Cagdas D, Halacli SO, Tan C, Esenboga S, Karaatmaca B, Cetinkaya PG, Balcı-Hayta B, Ayhan A, Uner A, Orhan D, Boztug K, Ozen S, Topaloglu R, Sanal O, Tezcan I. Diversity in Serine/Threonine Protein Kinase-4 Deficiency and Review of the Literature. J Allergy Clin Immunol Pract. 2021 Oct;9(10):3752-3766.e4. doi: 10.1016/j.jaip.2021.05.032. Epub 2021 Jun 17.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34146746/
2021
Cagdas D, Mayr D, Baris S, Worley L, Langley DB, Metin A, Aytekin ES, Atan R, Kasap N, Bal SK, Dmytrus J, Heredia RJ, Karasu G, Torun SH, Toyran M, Karakoc-Aydiner E, Christ D, Kuskonmaz B, Uçkan-Çetinkaya D, Uner A, Oberndorfer F, Schiefer AI, Uzel G, Deenick EK, Keller B, Warnatz K, Neven B, Durandy A, Sanal O, Ma CS, Özen A, Stepensky P, Tezcan I, Boztug K, Tangye SG. Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency. J Clin Immunol. 2021 Apr 30. doi: 10.1007/s10875-021-01031-5. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33929673/
2021
Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021 Jul;595(7868):578-584. doi: 10.1038/s41586-021-03651-8. Epub 2021 Jun 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34135508/
2021
Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021 Jul;595(7868):578-584. doi: 10.1038/s41586-021-03651-8. Epub 2021 Jun 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34135508/
2021
Casiraghi A, Bensimon A, Superti-Furga G. Recent developments in ligands and chemical probes targeting solute carrier transporters. Curr Opin Chem Biol. 2021 Mar 6;62:53-63. doi: 10.1016/j.cbpa.2021.01.012. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33689964/
2021
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S. An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Mol Metab. 2021 Dec;54:101329. doi: 10.1016/j.molmet.2021.101329. Epub 2021 Aug 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34454092/
2021
Chausheva S, Redwan B, Sharma S, Marella N, Schossleitner K, Mueller AC, Petzelbauer P, Morris T, Lang IM. Synthetic Fibrin-Derived Bβ(15-42) Peptide Delays Thrombus Resolution in a Mouse Model. Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2168-2180. doi: 10.1161/ATVBAHA.121.316404. Epub 2021 Jun 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34078093/
2021
Chuang HY, Schupp M, Meyrelles R, Maryasin B, Maulide N. Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols. Angew Chem Int Ed Engl. 2021 Mar 24. doi: 10.1002/anie.202100801. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33760338/
2021
Ciulli A, Hamann L, Jahnke W, Kalgutkar AS, Magauer T, Ritter T, Steadman V, Williams SD, Winter G, Hoegenauer K, Krawinkler KH, Stepan AF. The 2(nd) Alpine Winter Conference on Medicinal and Synthetic Chemistry. ChemMedChem. 2021 Aug 5;16(15):2417-2423. doi: 10.1002/cmdc.202100372. Epub 2021 Jun 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34114371/
2021
Costa D, Simbrunner B, Jachs M, Hartl L, Bauer D, Paternostro R, Schwabl P, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T. Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality. J Hepatol. 2021 Apr;74(4):819-828. doi: 10.1016/j.jhep.2020.10.004. Epub 2020 Oct 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33075344/
2021
Costa D, Simbrunner B, Reiberger T. Reply to: "Prognostic role of systemic inflammatory biomarkers in advanced chronic liver disease". J Hepatol. 2021 Apr;74(4):1000-1001. doi: 10.1016/j.jhep.2021.01.026. Epub 2021 Jan 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33497763/
2021
Datlinger P, Rendeiro AF, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing. Nat Methods . 2021 Jun;18(6):635-642. doi: 10.1038/s41592-021-01153-z. Epub 2021 May 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34059827/ _blank
2021
Datlinger P, Rendeiro AF, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing. Nat Methods. 2021 Jun;18(6):635-642. doi: 10.1038/s41592-021-01153-z. Epub 2021 May 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34059827/
2021
Demiroz D, Platanitis E, Bryant M, Fischer P, Prchal-Murphy M, Lercher A, Lassnig C, Baccarini M, Müller M, Bergthaler A, Sexl V, Dolezal M, Decker T. Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons. PLoS Pathog. 2021 Jul 8;17(7):e1009697. doi: 10.1371/journal.ppat.1009697. eCollection 2021 Jul.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34237114/
2021
Dupré L, Boztug K, Pfajfer L. Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies. Front Cell Dev Biol. 2021 Jun 24;9:665519. doi: 10.3389/fcell.2021.665519. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34249918/
2021
Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Bärenz F, Bender E, Digles D, Dürrenberger F, Heitman LH, IJzerman AP, Kell DB, Kickinger S, Körzö D, Leippe P, Licher T, Manolova V, Rizzetto R, Sassone F, Scarabottolo L, Schlessinger A, Schneider V, Sijben HJ, Steck AL, Sundström H, Tremolada S, Wilhelm M, Wright Muelas M, Zindel D, Steppan CM, Superti-Furga G. An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters. Front Pharmacol. 2021 Aug 10;12:722889. doi: 10.3389/fphar.2021.722889. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34447313/
2021
Edgar L, Akbar N, Braithwaite AT, Krausgruber T, Gallart-Ayala H, Bailey J, Corbin AL, Khoyratty TE, Chai JT, Alkhalil M, Rendeiro AF, Ziberna K, Arya R, Cahill TJ, Bock C, Laurencikiene J, Crabtree MJ, Lemieux ME, Riksen NP, Netea MG, Wheelock CE, Channon KM, Rydén M, Udalova IA, Carnicer R, Choudhury RP. Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis. Circulation. 2021 Sep 21;144(12):961-982. doi: 10.1161/CIRCULATIONAHA.120.046464. Epub 2021 Jul 13.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34255973/
2021
Fell CW, Nagy V. Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability. Trends Mol Med. 2021 Mar;27(3):220-230. doi: 10.1016/j.molmed.2020.12.003. Epub 2021 Jan 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33397633/
2021
Ferreira da Silva J, Meyenberg M, Loizou JI. Tissue specificity of DNA repair: the CRISPR compass. Trends Genet. 2021 Nov;37(11):958-962. doi: 10.1016/j.tig.2021.07.010. Epub 2021 Aug 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34392967/
2021
Freyberger F, Kokotović T, Krnjak G, Frković SH, Nagy V. Expanding the known phenotype of Mullegama-Klein-Martinez syndrome in male patients. Hum Genome Var. 2021 Sep 27;8(1):37. doi: 10.1038/s41439-021-00169-3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34580287/
2021
Garrison H, Agostinho M, Alvarez L, Bekaert S, Bengtsson L, Broglio E, Couso D, Araújo Gomes R, Ingram Z, Martinez E, Mena AL, Nickel D, Norman M, Pinheiro I, Solís-Mateos M, Bertero MG. Involving society in science: Reflections on meaningful and impactful stakeholder engagement in fundamental research. EMBO Rep. 2021 Nov 4;22(11):e54000. doi: 10.15252/embr.202154000.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34734669/
2021
German Y, Vulliard L, Kamnev A, Pfajfer L, Huemer J, Mautner AK, Rubio A, Kalinichenko A, Boztug K, Ferrand A, Menche J, Dupré L. Morphological profiling of human T and NK lymphocytes by high-content cell imaging. Cell Rep. 2021 Jul 6;36(1):109318. doi: 10.1016/j.celrep.2021.109318.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34233185/
2021
Giobbe G., Bonfante F., Jones B., Gagliano O., Luni C., Zambaiti E., Perin S., Laterza C., Busslinger G.A., Stuart H., Pagliari M., Bortolami A., Mazzetto E., Manfredi A., Colantuono C., Di Filippo L., Pellegata A., Panzarin V., Thapar N., Li V., Eaton S., Cacchiarelli D., Clevers H., Elvassore N., and De Coppi P. SARS-CoV-2 infection and replication in human gastric organoids. Nat Commun. 2021 Nov 16;12(1):6610. doi: 10.1038/s41467-021-26762-2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34785679/
2021
Grosche S, Marenholz I, Esparza-Gordillo J, Arnau-Soler A, Pairo-Castineira E, Rüschendorf F, Ahluwalia TS, Almqvist C, Arnold A; Australian Asthma Genetics Consortium (AAGC), Baurecht H, Bisgaard H, Bønnelykke K, Brown SJ, Bustamante M, Curtin JA, Custovic A, Dharmage SC, Esplugues A, Falchi M, Fernandez-Orth D, Ferreira MAR, Franke A, Gerdes S, Gieger C, Hakonarson H, Holt PG, Homuth G, Hubner N, Hysi PG, Jarvelin MR, Karlsson R, Koppelman GH, Lau S, Lutz M, Magnusson PKE, Marks GB, Müller-Nurasyid M, Nöthen MM, Paternoster L, Pennell CE, Peters A, Rawlik K, Robertson CF, Rodriguez E, Sebert S, Simpson A, Sleiman PMA, Standl M, Stölzl D, Strauch K, Szwajda A, Tenesa A, Thompson PJ, Ullemar V, Visconti A, Vonk JM, Wang CA, Weidinger S, Wielscher M, Worth CL, Xu CJ, Lee YA. Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4. Nat Commun. 2021 Nov 16;12(1):6618. doi: 10.1038/s41467-021-26783-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34785669/
2021
Grzes KM, Sanin DE, Kabat AM, Stanczak MA, Edwards-Hicks J, Matsushita M, Hackl A, Hässler F, Knoke K, Zahalka S, Villa M, Kofler DM, Voll RE, Zigrino P, Fabri M, Pearce EL, Pearce EJ. Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity. 2021 Nov 9;54(11):2514-2530.e7. doi: 10.1016/j.immuni.2021.10.009. Epub 2021 Oct 29.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34717796/
2021
Gülich AF, Rica R, Tizian C, Viczenczova C, Khamina K, Faux T, Hainberger D, Penz T, Bosselut R, Bock C, Laiho A, Elo LL, Bergthaler A, Ellmeier W, Sakaguchi S. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. Front Immunol. 2021 Mar 17;12:535039. doi: 10.3389/fimmu.2021.535039. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33815354/
2021
Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM. A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. J Exp Med. 2021 Jan 4;218(1):e20200559. doi: 10.1084/jem.20200559.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32930709/
2021
Haimel H, Pazmandi J, Jiménez Heredia R, Dmytrus J, Köstel Bal S, Zoghi S, van Daele P, Briggs TA, Wouters C, Bader-Meunier B, Aeschlimann FA, Caorsi R, Eleftheriou D, Hoppenreijs E, Salzer E, Bakhtiar S, Derfalvi B, Saettini F, Kusters MAA, Elfeky R, Trück J, Rivière JQ, van der Burg M, Gattorno M, Seidel MG, Burns S, Warnatz K, Hauck F, Brogan P, Gilmour KC, Schuetz C, Simon A, Bock C, Hambleton S, de Vries E, Robinson PN, van Gijn M, Boztug K. Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity. J Allergy Clin Immunol . 2021 May 12;S0091-6749(21)00732-6. doi: 10.1016/j.jaci.2021.04.033. Online ahead of print.
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2021
Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. Histone deacetylase 1 controls CD4(+) T cell trafficking in autoinflammatory diseases. J Autoimmun. 2021 May;119:102610. doi: 10.1016/j.jaut.2021.102610. Epub 2021 Feb 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33621930/
2021
Helderman RFCPA, Löke DR, Tanis PJ, Tuynman JB, Ceelen W, de Hingh IH, van der Speeten K, Franken NAP, Oei AL, Kok HP, Crezee J. Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges. Cancers (Basel). 2021 Jul 8;13(14):3430. doi: 10.3390/cancers13143430.
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2021
Hoffman JM, Kiklevich JV, Klavins K, Valencak TG, Austad SN. Alterations of Lipid Metabolism With Age and Weight in Companion Dogs. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):400-405. doi: 10.1093/gerona/glaa186.
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2021
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S. Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. FEBS J. 2021 Mar;288(5):1533-1545. doi: 10.1111/febs.15493. Epub 2020 Aug 4.
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2021
Jaeger MG, Winter GE. Fast-acting chemical tools to delineate causality in transcriptional control. Mol Cell. 2021 Apr 15;81(8):1617-1630. doi: 10.1016/j.molcel.2021.02.015. Epub 2021 Mar 8.
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2021
Jia R, Balligand T, Atamanyuk V, Nivarthi H, Xu E, Kutzner L, Weinzierl J, Nedelec A, Kubicek S, Lesyk R, Zagrijtschuk O, Constantinescu SN, Kralovics R. Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor. Blood. 2021 Apr 8;137(14):1920-1931. doi: 10.1182/blood.2020006264.
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2021
Jia R, Kutzner L, Koren A, Runggatscher K, Májek P, Müller AC, Schuster M, Bock C, Loizou JI, Kubicek S, Kralovics R. High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells. Blood Cancer J. 2021 Jul 31;11(7):137. doi: 10.1038/s41408-021-00531-2.
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2021
Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM. The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. Immunity. 2021 Jan 12;54(1):132-150.e9. doi: 10.1016/j.immuni.2020.11.003. Epub 2020 Dec 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33271119/
2021
Jäger R, Gisslinger H, Fuchs E, Bogner E, Milosevic Feenstra JD, Weinzierl J, Schischlik F, Gisslinger B, Schalling M, Zörer M, Krejcy K, Klade C, Kralovics R. Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera. Blood. 2021 Jan 21;137(3):387-391. doi: 10.1182/blood.2020005792.
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2021
Jühling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Gut. 2021 Jan;70(1):157-169. doi: 10.1136/gutjnl-2019-318918. Epub 2020 Mar 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32217639/
2021
Kalinichenko A, Perinetti Casoni G, Dupré L, Trotta L, Huemer J, Galgano D, German Y, Haladik B, Pazmandi J, Thian M, Yüce Petronczki Ö, Chiang SC, Taskinen M, Hekkala A, Kauppila S, Lindgren O, Tapiainen T, Kraakman MJ, Vettenranta K, Lomakin AJ, Saarela J, Seppänen MRJ, Bryceson YT, Boztug K. RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis. Blood. 2021 Apr 15;137(15):2033-2045. doi: 10.1182/blood.2020008738.
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2021
Keuenhof K, Heimel P, Zopf LM, Raigel M, Turyanskaya A, Kavirayani A, Reier S, Glösmann M, Schöfer C, Kralovics R, Streli C, Weninger WJ, Geyer SH, Slezak P, Macfelda K, Jäger R, Wanek T, Walter A. Multimodality imaging beyond CLEM: Showcases of combined in-vivo preclinical imaging and ex-vivo microscopy to detect murine mural vascular lesions. Methods Cell Biol. 2021;162:389-415. doi: 10.1016/bs.mcb.2020.10.002. Epub 2020 Dec 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33707020/
2021
Kiely-Collins H, Winter GE, Bernardes GJL. The role of reversible and irreversible covalent chemistry in targeted protein degradation. Cell Chem Biol. 2021 Mar 25:S2451-9456(21)00144-6. doi: 10.1016/j.chembiol.2021.03.005. Online ahead of print.
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2021
Kilic G, Bulut O, Jaeger M, Ter Horst R, Koeken VACM, Moorlag SJCFM, Mourits VP, de Bree C, Domínguez-Andrés J, Joosten LAB, Netea MG. The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men. Front Immunol. 2021 Aug 9;12:720090. doi: 10.3389/fimmu.2021.720090. eCollection 2021.
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2021
Klein K, Witalisz-Siepracka A, Gotthardt D, Agerer B, Locker F, Grausenburger R, Knab VM, Bergthaler A, Sexl V. T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo. Front Immunol. 2021 Jun 24;12:650977. doi: 10.3389/fimmu.2021.650977. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34248938/
2021
Kogler H, Novak W, Vécsei A, Zachbauer C, Huber WD, Lakatos K, Woeran K, Stift J, Boztug K, Kager L. Occurrence of autoimmune pancreatitis after chronic immune thrombocytopenia in a Caucasian adolescent. Clin J Gastroenterol. 2021 Mar 20. doi: 10.1007/s12328-021-01383-w. Online ahead of print.
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2021
Kokotović T, Langeslag M, Lenartowicz EM, Manion J, Fell CW, Alehabib E, Tafakhori A, Darvish H, Bellefroid EJ, Neely GG, Kress M, Penninger JM, Nagy V. PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life. Front Mol Neurosci. 2021 Sep 27;14:720973. doi: 10.3389/fnmol.2021.720973. eCollection 2021.
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2021
Kollmann S, Grausenburger R, Klampfl T, Prchal-Murphy M, Bastl K, Pisa H, Knab VM, Brandstoetter T, Doma E, Sperr WR, Lagger S, Farlik M, Moriggl R, Valent P, Halbritter F, Kollmann K, Heller G, Maurer B, Sexl V. A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells. Blood. 2021 Dec 9;138(23):2347-2359. doi: 10.1182/blood.2021010980.
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2021
Kopf A, Kiermaier E. Dynamic Microtubule Arrays in Leukocytes and Their Role in Cell Migration and Immune Synapse Formation. Front Cell Dev Biol. 2021 Feb 9;9:635511. doi: 10.3389/fcell.2021.635511. eCollection 2021.
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2021
Kornauth C, Pemovska T, Vladimer GI, Bayer G, Bergmann M, Eder S, Eichner R, Erl M, Esterbauer H, Exner R, Felsleitner-Hauer V, Forte M, Gaiger A, Geissler K, Greinix HT, Gstöttner W, Hacker M, Hartmann BL, Hauswirth AW, Heinemann T, Heintel D, Hoda MA, Hopfinger G, Jaeger U, Kazianka L, Kenner L, Kiesewetter B, Krall N, Krajnik G, Kubicek S, Le T, Lubowitzki S, Mayerhoefer ME, Menschel E, Merkel O, Miura K, Müllauer L, Neumeister P, Noesslinger T, Ocko K, Öhler L, Panny M, Pichler A, Porpaczy E, Prager GW, Raderer M, Ristl R, Ruckser R, Salamon J, Schiefer AI, Schmolke AS, Schwarzinger I, Selzer E, Sillaber C, Skrabs C, Sperr WR, Srndic I, Thalhammer R, Valent P, van der Kouwe E, Vanura K, Vogt S, Waldstein C, Wolf D, Zielinski CC, Zojer N, Simonitsch-Klupp I, Superti-Furga G, Snijder B, Staber PB. Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematological Cancers and Identifies Exceptional Responders. Cancer Discov. 2021 Oct 11:candisc.0538.2021. doi: 10.1158/2159-8290.CD-21-0538.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34635570/ _blank
2021
Kretzmer H, Biran A, Purroy N, Lemvigh C, Clement K, Gruber M, Gu H, Rassenti L, Mohammad AW, Lesnick C, Slager SL, Braggio E, Shanafelt TD, Kay NE, Fernandes S, Brown JR, Wang L, Li S, Livak KJ, Neuberg DS, Klages S, Timmermann B, Kipps TJ, Campo E, Gnirke A, Wu CJ, Meissner A. Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy. Blood Cancer Discov. 2021 Jan;2(1):54-69. doi: 10.1158/2643-3230.BCD-19-0058. Epub 2020 Dec 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33604581/
2021
Kuehn HS, Niemela JE, Stoddard J, Mannurita SC, Shahin T, Goel S, Hintermeyer M, Heredia RJ, Garofalo M, Lucas L, Singh S, Tondo A, Jacobs Z, Gahl WA, Latour S, Verbsky J, Routes J, Cunningham-Rundles C, Boztug K, Gambineri E, Fleisher TA, Chandrakasan S, Rosenzweig SD. Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies. Blood. 2021 Jan 21;137(3):349-363. doi: 10.1182/blood.2020007292.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32845957/
2021
Köhler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA, Danis D, Balagura G, Baynam G, Brower AM, Callahan TJ, Chute CG, Est JL, Galer PD, Ganesan S, Griese M, Haimel M, Pazmandi J, Hanauer M, Harris NL, Hartnett MJ, Hastreiter M, Hauck F, He Y, Jeske T, Kearney H, Kindle G, Klein C, Knoflach K, Krause R, Lagorce D, McMurry JA, Miller JA, Munoz-Torres MC, Peters RL, Rapp CK, Rath AM, Rind SA, Rosenberg AZ, Segal MM, Seidel MG, Smedley D, Talmy T, Thomas Y, Wiafe SA, Xian J, Yüksel Z, Helbig I, Mungall CJ, Haendel MA, Robinson PN. The Human Phenotype Ontology in 2021. Nucleic Acids Res. 2021 Jan 8;49(D1):D1207-D1217. doi: 10.1093/nar/gkaa1043.
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2021
Königshofer P, Brusilovskaya K, Petrenko O, Hofer BS, Schwabl P, Trauner M, Reiberger T. Nuclear receptors in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166235. doi: 10.1016/j.bbadis.2021.166235. Epub 2021 Jul 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34339839/
2021
Lahnsteiner M, Caldera M, Moura HM, Cerrón-Infantes DA, Roeser J, Konegger T, Thomas A, Menche J, Unterlass MM. Hydrothermal polymerization of porous aromatic polyimide networks and machine learning-assisted computational morphology evolution interpretation. J Mater Chem A Mater. 2021 Sep 8;9(35):19754-19769. doi: 10.1039/d1ta01253c.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34589226/ _blank
2021
Lahnsteiner M, Caldera M, Moura HM, Cerrón-Infantes DA, Roeser J, Konegger T, Thomas A, Menche J, Unterlass MM. Hydrothermal polymerization of porous aromatic polyimide networks and machine learning-assisted computational morphology evolution interpretation. J Mater Chem A Mater. 2021 Sep 8;9(35):19754-19769. doi: 10.1039/d1ta01253c. eCollection 2021 Sep 14.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34589226/
2021
Leader AM, Grout JA, Maier BB, Nabet BY, Park MD, Tabachnikova A, Chang C, Walker L, Lansky A, Le Berichel J, Troncoso L, Malissen N, Davila M, Martin JC, Magri G, Tuballes K, Zhao Z, Petralia F, Samstein R, Roy D'Amore N, Thurston G, Kamphorst AO, Wolf A, Flores R, Wang P, Müller S, Mellman I, Beasley MB, Salmon H, Rahman AH, Marron TU, Kenigsberg E, Merad M. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell. 2021 Nov 2;S1535-6108(21)00560-2. doi: 10.1016/j.ccell.2021.10.009. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34767762/
2021
Leber W, Lammel O, Redlberger-Fritz M, Mustafa-Korninger ME, Glehr RC, Camp J, Agerer B, Lercher A, Popa A, Genger JW, Penz T, Aberle S, Bock C, Bergthaler A, Stiasny K, Hochstrasser EM, Hoellinger C, Siebenhofer A, Griffiths C, Panovska-Griffiths J. Rapid, early and accurate SARS-CoV-2 detection using RT-qPCR in primary care: a prospective cohort study (REAP-1). BMJ Open. 2021 Aug 2;11(8):e045225. doi: 10.1136/bmjopen-2020-045225.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34341034/
2021
Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33972798/ _blank
2021
Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8. Epub 2021 May 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33972798/
2021
Martins AMA, Paiva MUB, Paiva DVN, de Oliveira RM, Machado HL, Alves LJSR, Picossi CRC, Faccio AT, Tavares MFM, Barbas C, Giraldez VZR, Santos RD, Monte GU, Atik FA. Innovative Approaches to Assess Intermediate Cardiovascular Risk Subjects: A Review From Clinical to Metabolomics Strategies. Front Cardiovasc Med. 2021 Dec 22;8:788062. doi: 10.3389/fcvm.2021.788062. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35004898/
2021
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2021 Mar;17(3):361. doi: 10.1038/s41589-021-00735-4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33452497/
2021
Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Downes K, Haimel M, Pabinger I, Gebhart J. Thrombomodulin in patients with mild to moderate bleeding tendency. Haemophilia. 2021 Nov;27(6):1028-1036. doi: 10.1111/hae.14433. Epub 2021 Oct 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34628704/
2021
Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Rejtö J, Ouwehand WH, Downes K, Haimel M, Pabinger I, Gebhart J. Elevated levels of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency. Blood Adv. 2021 Jan 26;5(2):391-398. doi: 10.1182/bloodadvances.2020003464.
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2021
Meyenberg M, Ferreira da Silva J, Loizou JI. Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing. Front Genet. 2021 Sep 3;12:728520. doi: 10.3389/fgene.2021.728520. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34539755/
2021
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, Bretherick AD, Richardson TG, Klughammer J, Iotchkova V, Sharp G, Al Khleifat A, Shatunov A, Iacoangeli A, McArdle WL, Ho KM, Kumar A, Söderhäll C, Soriano-Tárraga C, Giralt-Steinhauer E, Kazmi N, Mason D, McRae AF, Corcoran DL, Sugden K, Kasela S, Cardona A, Day FR, Cugliari G, Viberti C, Guarrera S, Lerro M, Gupta R, Bollepalli S, Mandaviya P, Zeng Y, Clarke TK, Walker RM, Schmoll V, Czamara D, Ruiz-Arenas C, Rezwan FI, Marioni RE, Lin T, Awaloff Y, Germain M, Aïssi D, Zwamborn R, van Eijk K, Dekker A, van Dongen J, Hottenga JJ, Willemsen G, Xu CJ, Barturen G, Català-Moll F, Kerick M, Wang C, Melton P, Elliott HR, Shin J, Bernard M, Yet I, Smart M, Gorrie-Stone T; BIOS Consortium, Shaw C, Al Chalabi A, Ring SM, Pershagen G, Melén E, Jiménez-Conde J, Roquer J, Lawlor DA, Wright J, Martin NG, Montgomery GW, Moffitt TE, Poulton R, Esko T, Milani L, Metspalu A, Perry JRB, Ong KK, Wareham NJ, Matullo G, Sacerdote C, Panico S, Caspi A, Arseneault L, Gagnon F, Ollikainen M, Kaprio J, Felix JF, Rivadeneira F, Tiemeier H, et al. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet. 2021 Sep;53(9):1311-1321. doi: 10.1038/s41588-021-00923-x. Epub 2021 Sep 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34493871/
2021
Molteni R, Biavasco R, Stefanoni D, Nemkov T, Domínguez-Andrés J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal IW, Maksud P, Piras F, Cesana D, Cassina L, Distefano G, Loffreda A, Gnani D, De Luca G, Tomelleri A, Campochiaro C, Joosten LAB, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Doglioni C, Ferrarini M, Ferrero E, Boletta A, D'Alessandro A, Montini E, Netea MG, Cavalli G. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood. 2021 Oct 28;138(17):1554-1569. doi: 10.1182/blood.2020009594.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34077954/
2021
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab. 2021 Feb;3(2):149-165. doi: 10.1038/s42255-021-00347-1. Epub 2021 Feb 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33536639/
2021
Müller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell JB, Beck H, Beedie S, Betz UAK, Bezerra GA, Brennan PE, Brown D, Brown PJ, Bullock AN, Carter AJ, Chaikuad A, Chaineau M, Ciulli A, Collins I, Dreher J, Drewry D, Edfeldt K, Edwards AM, Egner U, Frye SV, Fuchs SM, Hall MD, Hartung IV, Hillisch A, Hitchcock SH, Homan E, Kannan N, Kiefer JR, Knapp S, Kostic M, Kubicek S, Leach AR, Lindemann S, Marsden BD, Matsui H, Meier JL, Merk D, Michel M, Morgan MR, Mueller-Fahrnow A, Owen DR, Perry BG, Rosenberg SH, Saikatendu KS, Schapira M, Scholten C, Sharma S, Simeonov A, Sundström M, Superti-Furga G, Todd MH, Tredup C, Vedadi M, von Delft F, Willson TM, Winter GE, Workman P, Arrowsmith CH. Target 2035 - update on the quest for a probe for every protein. RSC Med Chem. 2021 Dec 3;13(1):13-21. doi: 10.1039/d1md00228g. eCollection 2022 Jan 27.
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2021
Neehus AL, Moriya K, Nieto-Patlán A, Le Voyer T, Lévy R, Özen A, Karakoc-Aydiner E, Baris S, Yildiran A, Altundag E, Roynard M, Haake K, Migaud M, Dorgham K, Gorochov G, Abel L, Lachmann N, Dogu F, Haskologlu S, İnce E, El-Benna J, Uzel G, Kiykim A, Boztug K, Roderick MR, Shahrooei M, Brogan PA, Abolhassani H, Hancioglu G, Parvaneh N, Belot A, Ikinciogullari A, Casanova JL, Puel A, Bustamante J. Impaired respiratory burst contributes to infections in PKCδ-deficient patients. J Exp Med. 2021 Sep 6;218(9):e20210501. doi: 10.1084/jem.20210501. Epub 2021 Jul 15.
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2021
Nicholson MD, Endler L, Popa A, Genger JW, Bock C, Michor F, Bergthaler A. Response to comment on "Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2". Sci Transl Med. 2021 Oct 27;13(617):eabj3222. doi: 10.1126/scitranslmed.abj3222. Epub 2021 Oct 27.
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2021
Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM, Pryor M, Yang ZH, Remaley AT, Mollnes TE, Hewitt SM, Yan B, Kazemian M, Kiss MG, Binder CJ, Halvorsen B, Espevik T, Kemper C. Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation. Sci Immunol. 2021 Dec 24;6(66):eabf2489. doi: 10.1126/sciimmunol.abf2489. Epub 2021 Dec 24.
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2021
Obermayer G, Afonyushkin T, Göderle L, Puhm F, Schrottmaier W, Taqi S, Schwameis M, Ay C, Pabinger I, Jilma B, Assinger A, Mackman N, Binder C. Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis. Blood . 2021 Mar 11;137(10):1406-1415. doi: 10.1182/blood.2020007155.
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2021
Paolino M, Koglgruber R, Cronin SJF, Uribesalgo I, Rauscher E, Harreiter J, Schuster M, Bancher-Todesca D, Pranjic B, Novatchkova M, Fededa JP, White AJ, Sigl V, Dekan S, Penz T, Bock C, Kenner L, Holländer GA, Anderson G, Kautzky-Willer A, Penninger JM. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 2021 Jan;589(7842):442-447. doi: 10.1038/s41586-020-03071-0. Epub 2020 Dec 23.
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2021
Pemovska T, Bigenzahn JW, Srndic I, Lercher A, Bergthaler A, César-Razquin A, Kartnig F, Kornauth C, Valent P, Staber PB, Superti-Furga G. Metabolic drug survey highlights cancer cell dependencies and vulnerabilities. Nat Commun. 2021 Dec 14;12(1):7190. doi: 10.1038/s41467-021-27329-x.
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2021
Peneder P, Stütz AM, Surdez D, Krumbholz M, Semper S, Chicard M, Sheffield NC, Pierron G, Lapouble E, Tötzl M, Ergüner B, Barreca D, Rendeiro AF, Agaimy A, Boztug H, Engstler G, Dworzak M, Bernkopf M, Taschner-Mandl S, Ambros IM, Myklebost O, Marec-Bérard P, Burchill SA, Brennan B, Strauss SJ, Whelan J, Schleiermacher G, Schaefer C, Dirksen U, Hutter C, Boye K, Ambros PF, Delattre O, Metzler M, Bock C, Tomazou EM. Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden. Nat Commun. 2021 May 28;12(1):3230. doi: 10.1038/s41467-021-23445-w.
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2021
Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w.
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2021
Pezzè L, Meškytė EM, Forcato M, Pontalti S, Badowska KA, Rizzotto D, Skvortsova II, Bicciato S, Ciribilli Y. ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes. Cell Death Dis. 2021 Jul 27;12(8):742. doi: 10.1038/s41419-021-04005-y.
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2021
Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ. Correction: Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2021 Jul 23. doi: 10.1038/s41418-021-00831-x. Online ahead of print.
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2021
Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A. Mutations and variants of ONECUT1 in diabetes. Nat Med. 2021 Nov;27(11):1928-1940. doi: 10.1038/s41591-021-01502-7. Epub 2021 Oct 18.
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2021
Pirch S, Müller F, Iofinova E, Pazmandi J, Hütter CVR, Chiettini M, Sin C, Boztug K, Podkosova I, Kaufmann H, Menche J. The VRNetzer platform enables interactive network analysis in Virtual Reality. Nat Commun. 2021 Apr 23;12(1):2432. doi: 10.1038/s41467-021-22570-w.
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2021
Pirch S, Müller F, Iofinova E, Pazmandi J, Hütter CVR, Chiettini M, Sin C, Boztug K, Podkosova I, Kaufmann H, Menche J. The VRNetzer platform enables interactive network analysis in Virtual Reality. Nat Commun. 2021 Apr 23;12(1):2432. doi: 10.1038/s41467-021-22570-w.
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2021
Pizzagalli MD, Bensimon A, Superti-Furga G. A guide to plasma membrane solute carrier proteins. FEBS J. 2021 May;288(9):2784-2835. doi: 10.1111/febs.15531. Epub 2020 Sep 18.
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2021
Rahman MR, Islam T, Shahjaman M, Islam MR, Lombardo SD, Bramanti P, Ciurleo R, Bramanti A, Tchorbanov A, Fisicaro F, Fagone P, Nicoletti F, Pennisi M. Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis. Brief Bioinform. 2021 Nov 5;22(6):bbab262. doi: 10.1093/bib/bbab262.
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2021
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. 2021 Apr;592(7852):E8. doi: 10.1038/s41586-021-03287-8.
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2021
Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis. Life Sci Alliance. 2020 Dec 11;4(2):e202000794. doi: 10.26508/lsa.202000794. Print 2021 Feb.
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2021
Reitermaier R, Krausgruber T, Fortelny N, Ayub T, Vieyra-Garcia PA, Kienzl P, Wolf P, Scharrer A, Fiala C, Kölz M, Hiess M, Vierhapper M, Schuster C, Spittler A, Worda C, Weninger W, Bock C, Eppel W, Elbe-Bürger A. αβγδ T cells play a vital role in fetal human skin development and immunity. J Exp Med. 2021 Apr 5;218(4):e20201189. doi: 10.1084/jem.20201189.
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2021
Revilla-I-Domingo R, Rajan VBV, Waldherr M, Prohaczka G, Musset H, Orel L, Gerrard E, Smolka M, Stockinger A, Farlik M, Lucas RJ, Raible F, Tessmar-Raible K. Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution. Elife. 2021 Aug 5;10:e66144. doi: 10.7554/eLife.66144.
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2021
Rindler K, Krausgruber T, Thaler FM, Alkon N, Bangert C, Kurz H, Fortelny N, Rojahn TB, Jonak C, Griss J, Bock C, Brunner PM. Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct From Healthy Control Skin. Front Immunol. 2021 Feb 24;12:630892. doi: 10.3389/fimmu.2021.630892. eCollection 2021.
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2021
Rizzotto D, Englmaier L, Villunger A. At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity. Int J Mol Sci. 2021 Oct 8;22(19):10883. doi: 10.3390/ijms221910883.
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2021
Rizzotto D, Villunger A. P53 clears aneuploid cells by entosis. Cell Death Differ. 2021 Feb;28(2):818-820. doi: 10.1038/s41418-020-00659-x. Epub 2020 Nov 4.
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2021
Saluzzo S, Pandey RV, Gail LM, Dingelmaier-Hovorka R, Kleissl L, Shaw L, Reininger B, Atzmüller D, Strobl J, Touzeau-Römer V, Beer A, Staud C, Rieger A, Farlik M, Weninger W, Stingl G, Stary G. Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin- and mucosa-resident memory T cells. Immunity. 2021 Nov 16;S1074-7613(21)00459-3. doi: 10.1016/j.immuni.2021.10.021. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34813775/
2021
Saluzzo S, Pandey RV, Gail LM, Dingelmaier-Hovorka R, Kleissl L, Shaw L, Reininger B, Atzmüller D, Strobl J, Touzeau-Römer V, Beer A, Staud C, Rieger A, Farlik M, Weninger W, Stingl G, Stary G. Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin- and mucosa-resident memory T cells. Immunity. 2021 Dec 14;54(12):2842-2858.e5. doi: 10.1016/j.immuni.2021.10.021. Epub 2021 Nov 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34813775/
2021
Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, Ramesmayer J, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer A, Perry ACF, Leeb M. Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. Nat Commun. 2021 Jun 21;12(1):3804. doi: 10.1038/s41467-021-23510-4.
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2021
Sarbanes SL, Blomen VA, Lam E, Heissel S, Luna JM, Brummelkamp TR, Falck-Pedersen E, Hoffmann HH, Rice CM. E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015794118. doi: 10.1073/pnas.2015794118. Epub 2020 Dec 21.
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2021
Schick S, Grosche S, Kohl KE, Drpic D, Jaeger MG, Marella NC, Imrichova H, Lin JG, Hofstätter G, Schuster M, Rendeiro AF, Koren A, Petronczki M, Bock C, Müller AC, Winter GE, Kubicek S. Acute BAF perturbation causes immediate changes in chromatin accessibility. Nat Genet. 2021 Mar;53(3):269-278. doi: 10.1038/s41588-021-00777-3. Epub 2021 Feb 8.
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2021
Scholes NS, Mayor-Ruiz C, Winter GE. Identification and selectivity profiling of small-molecule degraders via multi-omics approaches. Cell Chem Biol. 2021 Mar 29:S2451-9456(21)00146-X. doi: 10.1016/j.chembiol.2021.03.007. Online ahead of print.
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2021
Schrempf A, Slyskova J, Loizou JI. Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy. Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24.
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2021
Schwabl P, Hambruch E, Budas GR, Supper P, Burnet M, Liles JT, Birkel M, Brusilovskaya K, Königshofer P, Peck-Radosavljevic M, Watkins WJ, Trauner M, Breckenridge DG, Kremoser C, Reiberger T. The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model. Biomedicines. 2021 Jan 9;9(1):60. doi: 10.3390/biomedicines9010060.
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2021
Shafeghat M, Esmaeilzadeh H, Sadeghalvad M, Rayzan E, Zoghi S, Shahkarami S, Heredia Jimenez R, Krolo A, Boztug K, Rezaei N. A novel homozygous RAG1 mutation is associated with severe combined immunodeficiency and neurological presentations. Allergol Immunopathol (Madr). 2021 Jul 1;49(4):91-97. doi: 10.15586/aei.v49i4.194. eCollection 2021.
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2021
Shahin T, Kuehn HS, Shoeb MR, Gawriyski L, Giuliani S, Repiscak P, Hoeger B, Yüce Petronczki O, Köstel Bal S, Zoghi S, Dmytrus J, Seruggia D, Castanon I, Rezaei N, Varjosalo M, Halbritter F, Rosenzweig SD, Boztug K. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity. Sci Immunol. 2021 Nov 26;6(65):eabe3981. doi: 10.1126/sciimmunol.abe3981. Epub 2021 Nov 26.
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2021
Shahin T, Kuehn HS, Shoeb MR, Gawriyski L, Giuliani S, Repiscak P, Hoeger B, Yüce Petronczki Ö, Bal SK, Zoghi S, Dmytrus J, Seruggia D, Castanon I, Rezaei N, Varjosalo M, Halbritter F, Rosenzweig SD, Boztug K. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity. Sci Immunol. 2021 Nov 26;6(65):eabe3981. doi: 10.1126/sciimmunol.abe3981. Epub 2021 Nov 26.
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2021
Shaka Z, Mojtabavi H, Rayzan E, Zoghi S, Shahkarami S, Raul JH, Sedighi I, Boztug K, Rezaei N. Novel BTK mutation in X-linked agammaglobulinemia: Report of a 17-year-old male. Allergol Immunopathol (Madr). 2021 Mar 1;49(2):80-83. doi: 10.15586/aei.v49i2.62. eCollection 2021.
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2021
Sheikh TI, Vasli N, Pastore S, Kharizi K, Harripaul R, Fattahi Z, Pande S, Naeem F, Hussain A, Mir A, Islam O, Girisha KM, Irfan M, Ayub M, Schwarzer C, Najmabadi H, Shukla A, Sladky VC, Braun VZ, Garcia-Carpio I, Villunger A, Vincent JB. Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability. Transl Psychiatry. 2021 Jan 5;11(1):1. doi: 10.1038/s41398-020-01158-w.
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2021
Simbrunner B, Costa D, Reiberger T. Reply to: "Presepsin as a biomarker of inflammation and prognosis in decompensated liver disease". J Hepatol. 2021 Apr 20:S0168-8278(21)00233-6. doi: 10.1016/j.jhep.2021.03.027. Online ahead of print.
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2021
Singh DD, Verma R, Tripathi SK, Sahu R, Trivedi P, Yadav DK. Breast Cancer Transcriptional Regulatory Network Reprogramming by using the CRISPR/Cas9 System: An Oncogenetics Perspective. Curr Top Med Chem. 2021;21(31):2800-2813. doi: 10.2174/1568026621666210902120754.
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2021
Sladky VC, Eichin F, Reiberger T, Villunger A. Polyploidy control in hepatic health and disease. J Hepatol. 2021 Nov;75(5):1177-1191. doi: 10.1016/j.jhep.2021.06.030. Epub 2021 Jul 3.
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2021
Smyth M, Khamina K, Popa A, Gudipati V, Agerer B, Lercher A, Kosack L, Endler L, Baazim H, Viczenczova C, Huppa JB, Bergthaler A. Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus. Front Immunol. 2021 Jun 14;12:638485. doi: 10.3389/fimmu.2021.638485. eCollection 2021.
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2021
Starkl P, Gaudenzio N, Marichal T, Reber LL, Sibilano R, Watzenboeck ML, Fontaine F, Mueller AC, Tsai M, Knapp S, Galli SJ. IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells. Allergy. 2021 Apr 11. doi: 10.1111/all.14852. Online ahead of print.
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2021
Steindl A, Alpar D, Heller G, Mair MJ, Gatterbauer B, Dieckmann K, Widhalm G, Hainfellner JA, Schmidinger M, Bock C, Müllauer L, Preusser M, Berghoff AS. Tumor mutational burden and immune infiltrates in renal cell carcinoma and matched brain metastases. ESMO Open. 2021 Apr;6(2):100057. doi: 10.1016/j.esmoop.2021.100057. Epub 2021 Feb 12.
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2021
Strobl J, Gail LM, Kleissl L, Pandey RV, Smejkal V, Huber J, Puxkandl V, Unterluggauer L, Dingelmaier-Hovorka R, Atzmüller D, Krausgruber T, Bock C, Wohlfarth P, Rabitsch W, Stary G. Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation. J Exp Med. 2021 Nov 1;218(11):e20210417. doi: 10.1084/jem.20210417. Epub 2021 Oct 13.
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2021
Strobl J, Pandey RV, Krausgruber T, Bayer N, Kleissl L, Reininger B, Vieyra-Garcia P, Wolf P, Jentus MM, Mitterbauer M, Wohlfarth P, Rabitsch W, Stingl G, Bock C, Stary G. Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease. Sci Transl Med. 2020 Nov 18;12(570):eabb7028. doi: 10.1126/scitranslmed.abb7028.
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2021
Subtelna I, Kryshchyshyn-Dylevych A, Jia R, Lelyukh M, Ringler A, Kubicek S, Zagrijtschuk O, Kralovics R, Lesyk R. 5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines. Arch Pharm (Weinheim). 2021 Apr;354(4):e2000342. doi: 10.1002/ardp.202000342. Epub 2020 Nov 25.
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2021
Swoboda A, Soukup R, Eckel O, Kinslechner K, Wingelhofer B, Schörghofer D, Sternberg C, Pham HTT, Vallianou M, Horvath J, Stoiber D, Kenner L, Larue L, Poli V, Beermann F, Yokota T, Kubicek S, Krausgruber T, Rendeiro AF, Bock C, Zenz R, Kovacic B, Aberger F, Hengstschläger M, Petzelbauer P, Mikula M, Moriggl R. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway. Oncogene. 2021 Feb;40(6):1091-1105. doi: 10.1038/s41388-020-01584-6. Epub 2020 Dec 15.
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2021
Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V'kovski P, Hörmann K, Müller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R. Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun. 2021 Dec 14;12(1):7276. doi: 10.1038/s41467-021-27511-1.
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2021
Terlecki-Zaniewicz S, Humer T, Eder T, Schmoellerl J, Heyes E, Manhart G, Kuchynka N, Parapatics K, Liberante FG, Müller AC, Tomazou EM, Grebien F. Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression. Nat Struct Mol Biol. 2021 Feb;28(2):190-201. doi: 10.1038/s41594-020-00550-w. Epub 2021 Jan 21.
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2021
Thomas HF, Kotova E, Jayaram S, Pilz A, Romeike M, Lackner A, Penz T, Bock C, Leeb M, Halbritter F, Wysocka J, Buecker C. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements. Mol Cell. 2021 Mar 4;81(5):969-982.e13. doi: 10.1016/j.molcel.2020.12.047. Epub 2021 Jan 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33482114/
2021
Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer FJ, Kiss MG, Enders L, Weißer J, Göderle L, Lambert J, Frommlet F, Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L, Afonyushkin T, Murphy JE, Fogelstrand P, Donzé O, Pasterkamp G, Hoke M, Kubicek S, Jørgensen HF, Danchin N, Simon T, Scharnagl H, März W, Borén J, Hess H, Mallat Z, Schneider P, Binder CJ. APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. Nature. 2021 Sep;597(7874):92-96. doi: 10.1038/s41586-021-03818-3. Epub 2021 Aug 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34433968/
2021
Unterluggauer L, Pospischil I, Krall C, Saluzzo S, Kimeswenger S, Karolyi M, Wenisch C, Lamprecht B, Guenova E, Winkler S, Viczenczova C, Bergthaler A, Weninger W, Hoetzenecker W, Stary G. Cutaneous manifestations of SARS-CoV-2: A 2-center, prospective, case-controlled study. J Am Acad Dermatol. 2021 Jul;85(1):202-204. doi: 10.1016/j.jaad.2021.03.064. Epub 2021 Mar 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33771589/ _blank
2021
Unterluggauer L, Pospischil I, Krall C, Saluzzo S, Kimeswenger S, Karolyi M, Wenisch C, Lamprecht B, Guenova E, Winkler S, Viczenczova C, Bergthaler A, Weninger W, Hoetzenecker W, Stary G. Cutaneous manifestations of SARS-CoV-2: A 2-center, prospective, case-controlled study. J Am Acad Dermatol. 2021 Mar 23:S0190-9622(21)00619-8. doi: 10.1016/j.jaad.2021.03.064. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33771589/
2021
Untersmayr E, Förster-Waldl E, Bonelli M, Boztug K, Brunner PM, Eiwegger T, Eller K, Göschl L, Grabmeier-Pfistershammer K, Hötzenecker W, Jordakieva G, Moschen AR, Pfaller B, Pickl W, Reinisch W, Wiedermann U, Klimek L, Bergmann KC, Brehler R, Pfützner W, Novak N, Merk H, Rabe U, Schlenter W, Ring J, Wehrmann W, Mülleneisen N, Wrede H, Fuchs T, Jensen-Jarolim E. Immunologically relevant aspects of the new COVID-19 vaccines-an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper. Allergo J Int. 2021;30(5):155-168. doi: 10.1007/s40629-021-00178-2. Epub 2021 Jun 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34178577/
2021
Valent P, Orfao A, Kubicek S, Staber P, Haferlach T, Deininger M, Kollmann K, Lion T, Virgolini I, Winter G, Hantschel O, Kenner L, Zuber J, Grebien F, Moriggl R, Hoermann G, Hermine O, Andreeff M, Bock C, Mughal T, Constantinescu SN, Kralovics R, Sexl V, Skoda R, Superti-Furga G, Jäger U. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions. Hemasphere. 2021 Feb 17;5(3):e536. doi: 10.1097/HS9.0000000000000536. eCollection 2021 Mar.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33623882/
2021
Vulliard L, Hancock J, Kamnev A, Fell CW, Ferreira da Silva J, Loizou JI, Nagy V, Dupré L, Menche J. BioProfiling.jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations. Bioinformatics. 2021 Dec 22;38(6):1692-9. doi: 10.1093/bioinformatics/btab853. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34935929/
2021
Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, Capitani M, Warner N, Pan J, Wang L, Li Q, Zuo T, Cohen-Kedar S, Lu J, Ardy RC, Mulder DJ, Dissanayake D, Peng K, Huang Z, Li X, Wang Y, Wang X, Li S, Bullers S, Gammage AN, Warnatz K, Schiefer AI, Krivan G, Goda V, Kahr WHA, Lemaire M; Genomics England Research Consortium, Lu CY, Siddiqui I, Surette MG, Kotlarz D, Engelhardt KR, Griffin HR, Rottapel R, Decaluwe H, Laxer RM, Proietti M, Hambleton S, Elcombe S, Guo CH, Grimbacher B, Dotan I, Ng SC, Freeman SA, Snapper SB, Klein C, Boztug K, Huang Y, Li D, Uhlig HH, Muise AM. Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet. 2021 Apr;53(4):500-510. doi: 10.1038/s41588-021-00803-4. Epub 2021 Mar 29.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33782605/
2021
Watzenboeck ML, Drobits B, Zahalka S, Gorki AD, Farhat A, Quattrone F, Hladik A, Lakovits K, Richard GM, Lederer T, Strobl B, Versteeg GA, Boon L, Starkl P, Knapp S. Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner. PLoS Pathog. 2021 Apr 27;17(4):e1009487. doi: 10.1371/journal.ppat.1009487. eCollection 2021 Apr.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33905460/
2021
Xu HC, Wang R, Shinde PV, Walotka L, Huang A, Poschmann G, Huang J, Liu W, Stühler K, Schaal H, Bergthaler A, Pandyra AA, Hardt C, Lang KS, Lang PA. Slow viral propagation during initial phase of infection leads to viral persistence in mice. Commun Biol. 2021 Apr 29;4(1):508. doi: 10.1038/s42003-021-02028-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33927339/
2021
Yucel E, Karakus IS, Krolo A, Kiykim A, Heredia RJ, Tamay Z, Cipe FE, Karakoc-Aydiner E, Ozen A, Karaman S, Boztug K, Baris S. Novel Frameshift Autosomal Recessive Loss-of-Function Mutation in SMARCD2 Encoding a Chromatin Remodeling Factor Mediates Granulopoiesis. J Clin Immunol. 2021 Jan;41(1):59-65. doi: 10.1007/s10875-020-00878-4. Epub 2020 Oct 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33025377/
2021
Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. 24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation. J Hepatol. 2021 Nov;75(5):1164-1176. doi: 10.1016/j.jhep.2021.06.036. Epub 2021 Jul 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34242699/
2021
Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P. Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. Mol Cell. 2021 Aug 5;81(15):3096-3109.e8. doi: 10.1016/j.molcel.2021.05.028. Epub 2021 Jun 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34146481/