Publications
2022
A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation
Lena Hess,
Verena Moos,
Arnel A Lauber,
Wolfgang Reiter,
Michael Schuster,
Natascha Hartl,
Daniel Lackner,
Thorina Boenke,
Anna Koren,
Paloma M Guzzardo,
Brigitte Gundacker,
Anna Riegler,
Petra Vician,
Claudia Miccolo,
Susanna Leiter,
Mahesh B Chandrasekharan,
Terezia Vcelkova,
Andrea Tanzer,
Jun Qi Jun,
James Bradner,
Gerald Brosch,
Markus Hartl,
Christoph Bock,
Tilmann Bürckstümmer,
Stefan Kubicek,
Susanna Chiocca,
Srividya Bhaskara,
Christian Seiser.
PLoS Genet. 2022 Aug 22;18(8):e1010376. doi: 10.1371/journal.pgen.1010376. eCollection 2022 Aug.
2022
Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound
Iris E Ertl,
Ursula Lemberger,
Dafina Ilijazi,
Melanie R Hassler,
Andreas Bruchbacher,
Robert Brettner,
Hannah Kronabitter,
Michael Gutmann,
Petra Vician,
Gerhard Zeitler,
Anna Koren,
Charles-Hugues Lardeau,
Thomas Mohr,
Andrea Haitel,
Eva Compérat,
André Oszwald,
Gabriel Wasinger,
Thomas Clozel,
Olivier Elemento,
Stefan Kubicek,
Walter Berger,
Shahrokh F Shariat.
Eur Urol. 2022 Sep;82(3):261-270. doi: 10.1016/j.eururo.2022.03.009. Epub 2022 Apr 4.
2022
Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
Katharina Woess,
Sabine Macho-Maschler,
Dorette S Van Ingen Schenau,
Miriam Butler,
Caroline Lassnig,
Daniel Valcanover,
Andrea Poelzl,
Katrin Meissl,
Barbara Maurer,
Tania Brandstoetter,
Claus Vogl,
Anna Koren,
Stefan Kubicek,
Anna Orlova,
Richard Moriggl,
Birgit Strobl,
Veronika Sexl,
Frank N Van Leeuwen,
Roland P Kuiper,
Mathias Mueller.
Haematologica. 2022 Jan 13. doi: 10.3324/haematol.2021.279848. Online ahead of print.
2021
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche S,
Marenholz I,
Esparza-Gordillo J,
Arnau-Soler A,
Pairo-Castineira E,
Rüschendorf F,
Ahluwalia TS,
Almqvist C,
Arnold A; Australian Asthma Genetics Consortium (AAGC),
Baurecht H,
Bisgaard H,
Bønnelykke K,
Brown SJ,
Bustamante M,
Curtin JA,
Custovic A,
Dharmage SC,
Esplugues A,
Falchi M,
Fernandez-Orth D,
Ferreira MAR,
Franke A,
Gerdes S,
Gieger C,
Hakonarson H,
Holt PG,
Homuth G,
Hubner N,
Hysi PG,
Jarvelin MR,
Karlsson R,
Koppelman GH,
Lau S,
Lutz M,
Magnusson PKE,
Marks GB,
Müller-Nurasyid M,
Nöthen MM,
Paternoster L,
Pennell CE,
Peters A,
Rawlik K,
Robertson CF,
Rodriguez E,
Sebert S,
Simpson A,
Sleiman PMA,
Standl M,
Stölzl D,
Strauch K,
Szwajda A,
Tenesa A,
Thompson PJ,
Ullemar V,
Visconti A,
Vonk JM,
Wang CA,
Weidinger S,
Wielscher M,
Worth CL,
Xu CJ,
Lee YA.
Nat Commun. 2021 Nov 16;12(1):6618. doi: 10.1038/s41467-021-26783-x.
2021
Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma.
Bolomsky A,
Miettinen JJ,
Malyutina A,
Besse A,
Huber J,
Fellinger S,
Breid H,
Parsons A,
Klavins K,
Hannich JT,
Kubicek S,
Caers J,
Hübl W,
Schreder M,
Zojer N,
Driessen C,
Tang J,
Besse L,
Heckman CA,
Ludwig H.
Blood Adv. 2021 Oct 26;5(20):4125-4139. doi: 10.1182/bloodadvances.2020003826.
2021
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.
Casteels T,
Zhang Y,
Frogne T,
Sturtzel C,
Lardeau CH,
Sen I,
Liu X,
Hong S,
Pauler FM,
Penz T,
Brandstetter M,
Barbieux C,
Berishvili E,
Heuser T,
Bock C,
Riedel CG,
Meyer D,
Distel M,
Hecksher-Sørensen J,
Li J,
Kubicek S.
Mol Metab. 2021 Dec;54:101329. doi: 10.1016/j.molmet.2021.101329. Epub 2021 Aug 25.
2021
Patched regulates lipid homeostasis by controlling cellular cholesterol levels.
Cadena Del Castillo CE,
Hannich JT,
Kaech A,
Chiyoda H,
Brewer J,
Fukuyama M,
Færgeman NJ,
Riezman H,
Spang A.
Nat Commun. 2021 Aug 12;12(1):4898. doi: 10.1038/s41467-021-24995-9.
2021
Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis.
Baumgartner M,
Lang M,
Holley H,
Crepaz D,
Hausmann B,
Pjevac P,
Moser D,
Haller F,
Hof F,
Beer A,
Orgler E,
Frick A,
Khare V,
Evstatiev R,
Strohmaier S,
Primas C,
Dolak W,
Köcher T,
Klavins K,
Rath T,
Neurath MF,
Berry D,
Makristathis A,
Muttenthaler M,
Gasche C.
Gastroenterology. 2021 Oct;161(4):1245-1256.e20. doi: 10.1053/j.gastro.2021.06.024.2021 Jun 17.
2021
Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives.
Amaya-García F,
Caldera M,
Koren A,
Kubicek S,
Menche J,
Unterlass MM.
ChemSusChem. 2021 Apr 22;14(8):1780. doi: 10.1002/cssc.202100607.
2021
5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines.
Subtelna I,
Kryshchyshyn-Dylevych A,
Jia R,
Lelyukh M,
Ringler A,
Kubicek S,
Zagrijtschuk O,
Kralovics R,
Lesyk R.
Arch Pharm (Weinheim). 2021 Apr;354(4):e2000342. doi: 10.1002/ardp.202000342. Epub 2020 Nov 25.
