Publications
2025
Inhibitors supercharge kinase turnover through native proteolytic circuits
Natalie S Scholes,
Martino Bertoni,
Arnau Comajuncosa-Creus,
Katharina Kladnik,
Xuefei Guo,
Fabian Frommelt,
Matthias Hinterndorfer,
Hlib Razumkov,
Polina Prokofeva,
Martin P Schwalm,
Florian Born,
Sandra Roehm,
Hana Imrichova,
Brianda L Santini,
Eleonora Barone,
Caroline Schätz,
Miquel Muñoz I Ordoño,
Severin Lechner,
Andrea Rukavina,
Iciar Serrano,
Miriam Abele,
Anna Koren,
Stefan Kubicek,
Stefan Knapp,
Nathanael S Gray,
Giulio Superti-Furga,
Bernhard Kuster,
Yigong Shi,
Patrick Aloy,
Georg E Winter.
Nature. 2025 Nov 26. doi: 10.1038/s41586-025-09763-9. Online ahead of print.
2025
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Tuan-Anh Nguyen,
Jung-Ming G Lin,
Anne-Sophie M C Marques,
Maximilian Fottner,
Ludwig G Bauer,
Andreas Reicher,
Diana Daum,
Lorenzo Scrofani,
Yusi Liu,
Carol Cheng,
Luna D'Angelo L D D,
Juan Sanchez,
Christoph Bueschl,
Nara Marella,
Pisanu Buphamalai,
Florian Traversi,
Maša Bereš,
Herwig P Moll,
Marton Siklos,
Jakob-Wendelin Genger,
Gerald Hofstaetter,
Ludovica Villanti,
Monika Malik,
Christoph Klimek,
Kathrin Runggatscher,
Bettina Guertl,
Jesper S Hansen,
Sarah Dobner,
Olga Babosova,
Tina Becirovic,
Laura P M H de Rooij,
Emilio Casanova,
Anna Koren,
D Sean Froese,
David S Rosenblatt,
Kristaps Klavins,
Andreas Bergthaler,
Jörg Menche,
J Thomas Hannich,
Miriam Abele,
Sara Sdelci,
Kathrin Lang,
Kilian V M Huber,
Stefan Kubicek.
Science. 2025 Dec 11;390(6778):1143-1150. doi: 10.1126/science.adv4257. Epub 2025 Nov 6.
2025
The human proteome with direct physical access to DNA
Jakob Trendel,
Simon Trendel,
Shuyao Sha,
Franziska Greulich,
Sandra Goll,
Susanne I Wudy,
Karin Kleigrewe,
Stefan Kubicek,
N Henriette Uhlenhaut,
Bernhard Kuster.
Cell. 2025 Aug 7;188(16):4424-4440.e17. doi: 10.1016/j.cell.2025.04.037. Epub 2025 May 22.
2024
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis
Laura Gebetsberger,
Zahra Malekshahi,
Aron Teutsch,
Gabor Tajti,
Frédéric Fontaine,
Nara Marella,
André Mueller,
Lena Prantl,
Hannes Stockinger,
Heribert Stoiber,
Anna Ohradanova-Repic.
Emerg Microbes Infect. 2024 Dec;13(1):2417868. doi: 10.1080/22221751.2024.2417868. Epub 2024 Oct 28.
2024
Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection
Katja Knapp,
Romana Klasinc,
Anna Koren,
Magdalena Siller,
Ruth Dingelmaier-Hovorka,
Mathias Drach,
Juan Sanchez,
David Chromy,
Marlene Kranawetter,
Christoph Grimm,
Andreas Bergthaler,
Stefan Kubicek,
Hannes Stockinger,
Georg Stary.
Cell Rep Med. 2024 Jul 16;5(7):101643. doi: 10.1016/j.xcrm.2024.101643. Epub 2024 Jul 8.
2024
Monitoring subcellular protein localization at scale in live cells
Jiří Reiniš,
Andreas Reicher.
Nat Rev Mol Cell Biol. 2024 Sep;25(9):673. doi: 10.1038/s41580-024-00749-5.
2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Fabian Offensperger,
Gary Tin,
Miquel Duran-Frigola,
Elisa Hahn,
Sarah Dobner,
Christopher W Am Ende,
Joseph W Strohbach,
Andrea Rukavina,
Vincenth Brennsteiner,
Kevin Ogilvie,
Nara Marella,
Katharina Kladnik,
Rodolfo Ciuffa,
Jaimeen D Majmudar,
S Denise Field,
Ariel Bensimon,
Luca Ferrari,
Evandro Ferrada,
Amanda Ng,
Zhechun Zhang,
Gianluca Degliesposti,
Andras Boeszoermenyi,
Sascha Martens,
Robert Stanton,
André C Müller,
J Thomas Hannich,
David Hepworth,
Giulio Superti-Furga,
Stefan Kubicek,
Monica Schenone,
Georg E Winter.
Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
2024
Pooled multicolour tagging for visualizing subcellular protein dynamics
Andreas Reicher,
Jiří Reiniš,
Maria Ciobanu,
Pavel Růžička,
Monika Malik,
Marton Siklos,
Victoria Kartysh,
Tatjana Tomek,
Anna Koren,
André F Rendeiro,
Stefan Kubicek.
Nat Cell Biol. 2024 May;26(5):745-756. doi: 10.1038/s41556-024-01407-w. Epub 2024 Apr 19.
2024
Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
Tayma Handal,
Sarah Juster,
Manar Abu Diab,
Shira Yanovsky-Dagan,
Fouad Zahdeh,
Uria Aviel,
Roni Sarel-Gallily,
Shir Michael,
Ester Bnaya,
Shulamit Sebban,
Yosef Buganim,
Yotam Drier,
Vincent Mouly,
Stefan Kubicek,
Walther J A A van den Broek,
Derick G Wansink,
Silvina Epsztejn-Litman,
Rachel Eiges.
Nat Commun. 2024 Apr 16;15(1):3270. doi: 10.1038/s41467-024-47217-4.
2024
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Maria Weyh,
Marie-Lena Jokisch,
Tuan-Anh Nguyen,
Maximilian Fottner,
Kathrin Lang.
Nat Chem. 2024 Jun;16(6):913-921. doi: 10.1038/s41557-024-01500-5. Epub 2024 Mar 26.
