Publications
2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Fabian Offensperger,
Gary Tin,
Miquel Duran-Frigola,
Elisa Hahn,
Sarah Dobner,
Christopher W Am Ende,
Joseph W Strohbach,
Andrea Rukavina,
Vincenth Brennsteiner,
Kevin Ogilvie,
Nara Marella,
Katharina Kladnik,
Rodolfo Ciuffa,
Jaimeen D Majmudar,
S Denise Field,
Ariel Bensimon,
Luca Ferrari,
Evandro Ferrada,
Amanda Ng,
Zhechun Zhang,
Gianluca Degliesposti,
Andras Boeszoermenyi,
Sascha Martens,
Robert Stanton,
André C Müller,
J Thomas Hannich,
David Hepworth,
Giulio Superti-Furga,
Stefan Kubicek,
Monica Schenone,
Georg E Winter.
Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
2024
Pooled multicolour tagging for visualizing subcellular protein dynamics
Andreas Reicher,
Jiří Reiniš,
Maria Ciobanu,
Pavel Růžička,
Monika Malik,
Marton Siklos,
Victoria Kartysh,
Tatjana Tomek,
Anna Koren,
André F Rendeiro,
Stefan Kubicek.
Nat Cell Biol. 2024 May;26(5):745-756. doi: 10.1038/s41556-024-01407-w. Epub 2024 Apr 19.
2024
Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
Tayma Handal,
Sarah Juster,
Manar Abu Diab,
Shira Yanovsky-Dagan,
Fouad Zahdeh,
Uria Aviel,
Roni Sarel-Gallily,
Shir Michael,
Ester Bnaya,
Shulamit Sebban,
Yosef Buganim,
Yotam Drier,
Vincent Mouly,
Stefan Kubicek,
Walther J A A van den Broek,
Derick G Wansink,
Silvina Epsztejn-Litman,
Rachel Eiges.
Nat Commun. 2024 Apr 16;15(1):3270. doi: 10.1038/s41467-024-47217-4.
2024
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Maria Weyh,
Marie-Lena Jokisch,
Tuan-Anh Nguyen,
Maximilian Fottner,
Kathrin Lang.
Nat Chem. 2024 Jun;16(6):913-921. doi: 10.1038/s41557-024-01500-5. Epub 2024 Mar 26.
2023
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling
Amanda Ng,
Fabian Offensperger,
Jose A Cisneros,
Natalie S Scholes,
Monika Malik,
Ludovica Villanti,
Andrea Rukavina,
Evandro Ferrada,
J Thomas Hannich,
Anna Koren,
Stefan Kubicek,
Giulio Superti-Furga,
Georg E Winter.
ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21.
2023
2,4-Dichlorophenoxyacetic Acid Induces Degeneration of mDA Neurons In Vitro
Tamara Russ,
Lennart Enders,
Julia M Zbiegly,
Phani Sankar Potru,
Johannes Wurm,
Björn Spittau.
Biomedicines. 2023 Oct 24;11(11):2882. doi: 10.3390/biomedicines11112882.
2023
A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
Andras Boeszoermenyi,
Léa Bernaleau,
Xudong Chen,
Felix Kartnig,
Min Xie,
Haobo Zhang,
Sensen Zhang,
Maeva Delacrétaz,
Anna Koren,
Ann-Katrin Hopp,
Vojtech Dvorak,
Stefan Kubicek,
Daniel Aletaha,
Maojun Yang,
Manuele Rebsamen,
Leonhard X Heinz,
Giulio Superti-Furga.
Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3.
2023
Pharmacological perturbation of the phase-separating protein SMNDC1
Lennart Enders,
Marton Siklos,
Jan Borggräfe,
Stefan Gaussmann,
Anna Koren,
Monika Malik,
Tatjana Tomek,
Michael Schuster,
Jiří Reiniš,
Elisa Hahn,
Andrea Rukavina,
Andreas Reicher,
Tamara Casteels,
Christoph Bock,
Georg E Winter,
J Thomas Hannich,
Michael Sattler,
Stefan Kubicek.
Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0.
2022
Metabolic modulation of transcription: The role of one-carbon metabolism
Jung-Ming G Lin,
Savvas Kourtis,
Ritobrata Ghose,
Natalia Pardo Lorente,
Stefan Kubicek,
Sara Sdelci.
Cell Chem Biol. 2022 Dec 1:S2451-9456(22)00415-9. doi: 10.1016/j.chembiol.2022.11.009. Online ahead of print.
2022
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Tamara Casteels,
Simon Bajew,
Jiří Reiniš,
Lennart Enders,
Michael Schuster,
Frédéric Fontaine,
André C Müller,
Bridget K Wagner,
Christoph Bock,
Stefan Kubicek.
Cell Rep. 2022 Aug 30;40(9):111288. doi: 10.1016/j.celrep.2022.111288.
