DE EN
Andreas Bergthaler

Andreas Bergthaler

Systemic Immunometabolism in Viral Infection and Advanced Pathogen Surveillance on the Population Level

2020

Repression of the B cell identity factor Pax5 is not required for plasma cell development.

Liu GJ, Jaritz M, Wöhner M, Agerer B, Bergthaler A, Malin SG, Busslinger M.
J Exp Med. 2020 Nov 2;217(11):e20200147. doi: 10.1084/jem.20200147.
2020

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.

Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM.
J Exp Med. 2021 Jan 4;218(1):e20200559. doi: 10.1084/jem.20200559.
2020

Systemic Immunometabolism: Challenges and Opportunities.

Lercher A, Baazim H, Bergthaler A.
Immunity. 2020 Sep 15;53(3):496-509. doi: 10.1016/j.immuni.2020.08.012.
2020

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation.

Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W.
Cell Rep. 2020 Feb 4;30(5):1542-1552.e7. doi: 10.1016/j.celrep.2020.01.011.
2019

AIF-regulated oxidative phosphorylation supports lung cancer development.

Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM.
Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27.
2019

CD8(+) T cells induce cachexia during chronic viral infection.

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, AliA, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D,Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.
Nat Immunol. 2019Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID:31110314;
2019

A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.

Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GA.
Sci Rep. 2019 May 27;9(1):7901. doi:10.1038/s41598-019-44359-0.
2019

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P,Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H,de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A.
Cancer Cell. 2019Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.
2019

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.

Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A.
 Immunity. 2019;51(6):1074–1087.e9. doi:10.1016/j.immuni.2019.10.014
2019

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.

Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M,Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J, Bergthaler A, Steiner G, Blüml S.
Front Immunol. 2019 Jun 13;10:1367. doi:10.3389/fimmu.2019.01367. eCollection 2019.