Publications
2019
Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.
Unterhauser K,
Pöltl L,
Schneditz G,
Kienesberger S,
Glabonjat RA,
Kitsera M,
Pletz J,
Josa-Prado F,
Dornisch E,
Lembacher-Fadum C,
Roier S,
Gorkiewicz G,
Lucena D,
Barasoain I,
Kroutil W,
Wiedner M,
Loizou JI,
Breinbauer R,
Díaz JF,
Schild S,
Högenauer C,
Zechner EL.
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116.
2019
Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.
Ferreira da Silva J,
Salic S,
Wiedner M,
Datlinger P,
Essletzbichler P,
Hanzl A,
Superti-Furga G,
Bock C,
Winter G,
Loizou JI.
Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
2019
Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.
Conde CD,
Petronczki ÖY,
Baris S,
Willmann KL,
Girardi E,
Salzer E,
Weitzer S,
Ardy RC,
Krolo A,
Ijspeert H,
Kiykim A,
Karakoc-Aydiner E,
Förster-Waldl E,
Kager L,
Pickl WF,
Superti-Furga G,
Martínez J,
Loizou JI,
Ozen A,
van der Burg M,
Boztug K.
J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903.
2019
Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics.
Robinson-Garcia L,
Ferreira da Silva J,
Loizou JI.
Cancer Res. 2019 Aug 6. doi: 10.1158/0008-5472.CAN-19-1364. [Epub ahead of print]
2018
CDK6 antagonizes p53-induced responses during tumorigenesis.
Bellutti F,
Tigan AS,
Nebenfuehr S,
Dolezal M,
Zojer M,
Grausenburger R,
Hartenberger S,
Kollmann S,
Doma E,
Prchal-Murphy M,
Uras IZ,
Höllein A,
Neuberg DS,
Ebert BL,
Ringler A,
Mueller AC,
Loizou JI,
Hinds PW,
Vogl C,
Heller G,
Kubicek S,
Zuber J,
Malumbres M,
Farlik M,
Villunger A,
Kollmann K,
Sexl V.
Cancer Discov. 2018 Jun 13. pii: CD-17-0912. doi: 10.1158/2159-8290.CD-17-0912. [Epub ahead of print]
2018
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.
Velimezi G,
Robinson-Garcia L,
Muñoz-Martínez F,
Wiegant WW,
Ferreira da Silva J,
Owusu M,
Moder M,
Wiedner M,
Rosenthal SB,
Fisch KM,
Moffat J,
Menche J,
van Attikum H,
Jackson SP,
Loizou JI.
Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.
2018
Validating the concept of mutational signatures with isogenic cell models.
Zou X,
Owusu M,
Harris R,
Jackson SP,
Loizou JI,
Nik-Zainal S.
Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8.
2017
Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH.
Mazouzi A,
Battistini F,
Moser SC,
Ferreira da Silva J,
Wiedner M,
Owusu M,
Lardeau CH,
Ringler A,
Weil B,
Neesen J,
Orozco M,
Kubicek S,
Loizou JI.
Mol Cell. 2017 Nov 16;68(4):797-807.e7. doi: 10.1016/j.molcel.2017.10.021
2017
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
Moder M,
Velimezi G,
Owusu M,
Mazouzi A,
Wiedner M,
Ferreira da Silva J,
Robinson-Garcia L,
Schischlik F,
Slavkovsky R,
Kralovics R,
Schuster M,
Bock C,
Ideker T,
Jackson SP,
Menche J,
Loizou JI.
Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.
2016
A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.
Mazouzi A,
Stukalov A,
Müller AC,
Chen D,
Wiedner M,
Prochazkova J,
Chiang S-C,
Schuster M,
Breitwieser FP,
Pichlmair A,
El-Khamisy SF,
Bock C,
Kralovics R,
Colinge J,
Bennett K,
Loizou JI.
In press, Cell Reports 2016.
