Publications

Former Groups

Year

Paper

2023

Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy
Jana Slyskova, Alba Muniesa-Vargas, Israel Tojal da Silva, Rodrigo Drummond, Jiyeong Park, David Häckes, Isabella Poetsch, Cristina Ribeiro-Silva, Amandine Moretton, Petra Heffeter, Orlando D Schärer, Wim Vermeulen, Hannes Lans, Joanna I Loizou.
NAR Cancer. 2023 Dec 5;5(4):zcad057. doi: 10.1093/narcan/zcad057. eCollection 2023 Dec.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38058548/

2023

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet
Mathilde Meyenberg, Anna Hakobyan, Nikolina Papac-Milicevic, Laura Göderle, Franziska L Langner, Mateo Markovic, Ji-Hyun Lee, Bon-Kyoung Koo, Georg A Busslinger, Israel Tojal da Silva, Christoph J Binder, Jörg Menche, Joanna I Loizou.
Sci Rep. 2023 Aug 26;13(1):13964. doi: 10.1038/s41598-023-41123-3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37633982/

2023

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability
Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual-Reguant, Natalia Pardo-Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci.
Mol Syst Biol. 2023 Jul 11;19(7):e11267. doi: 10.15252/msb.202211267. Epub 2023 Jun 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37259925/

2022

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
Anna Schrempf, Sara Bernardo, Emili A Arasa Verge, Miguel A Ramirez Otero, Jordan Wilson, Dominik Kirchhofer, Gerald Timelthaler, Anna M Ambros, Atilla Kaya, Marcus Wieder, Gerhard F Ecker, Georg E Winter, Vincenzo Costanzo, Joanna I Loizou.
Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. Epub 2022 Nov 17.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36400033/

2022

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy
Amandine Moretton, Jana Slyskova, Marwan E Simaan, Emili A Arasa-Verge, Mathilde Meyenberg, D Alonso Cerrón-Infantes, Miriam M Unterlass, Joanna I Loizou.
Front Oncol. 2022 Jun 2;12:874201. doi: 10.3389/fonc.2022.874201. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35719993/

2022

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens
Jordan Wilson, Joanna I Loizou.
Mol Oncol. 2022 Nov;16(21):3778-3791. doi: 10.1002/1878-0261.13272. Epub 2022 Jun 29.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35708734/

2022

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair
J Ferreira da Silva, G P Oliveira, E A Arasa-Verge, C Kagiou, A Moretton, G Timelthaler, J Jiricny, J I Loizou.
Nat Commun. 2022 Feb 9;13(1):760. doi: 10.1038/s41467-022-28442-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35140211/

Year

Paper

2021

Jia R, Kutzner L, Koren A, Runggatscher K, Májek P, Müller AC, Schuster M, Bock C, Loizou JI, Kubicek S, Kralovics R. High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells. Blood Cancer J. 2021 Jul 31;11(7):137. doi: 10.1038/s41408-021-00531-2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34333533/

2021

Vulliard L, Hancock J, Kamnev A, Fell CW, Ferreira da Silva J, Loizou JI, Nagy V, Dupré L, Menche J. BioProfiling.jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations. Bioinformatics. 2021 Dec 22;38(6):1692-9. doi: 10.1093/bioinformatics/btab853. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34935929/

2021

Meyenberg M, Ferreira da Silva J, Loizou JI. Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing. Front Genet. 2021 Sep 3;12:728520. doi: 10.3389/fgene.2021.728520. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34539755/

2021

Ferreira da Silva J, Meyenberg M, Loizou JI. Tissue specificity of DNA repair: the CRISPR compass. Trends Genet. 2021 Nov;37(11):958-962. doi: 10.1016/j.tig.2021.07.010. Epub 2021 Aug 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34392967/

2021

Schrempf A, Slyskova J, Loizou JI. Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy. Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33109489/

2021

Buttura JR, Provisor Santos MN, Valieris R, Drummond RD, Defelicibus A, Lima JP, Calsavara VF, Freitas HC, Cordeiro de Lima VC, Fernanda Bartelli T, Wiedner M, Rosales R, Gollob KJ, Loizou J, Dias-Neto E, Nunes DN, da Silva IT. Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention. Cancers (Basel). 2021 Jan 27;13(3):490. doi: 10.3390/cancers13030490.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33513945/

2020

Moretton A, Loizou JI. Interplay between Cellular Metabolism and the DNA Damage Response in Cancer. Cancers (Basel). 2020 Jul 25;12(8):2051. doi: 10.3390/cancers12082051.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32722390/

2020

Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia. Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31123029

2019

Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL. Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30808763/

2019

Robinson-Garcia L, Ferreira da Silva J, Loizou JI. Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics. Cancer Res. 2019 Nov 15;79(22):5693-5698. doi: 10.1158/0008-5472.CAN-19-1364.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31387919/

2019

Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells. Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/

2019

Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K. Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31449058/

2019

Robinson-Garcia L, Ferreira da Silva J, Loizou JI.Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics. Cancer Res. 2019 Aug 6. doi: 10.1158/0008-5472.CAN-19-1364. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31387919

2019

Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Loizou JI, Kain R,Bidmon-Fliegenschnee B, Schickel JN, Glauzy S, Huemer J, Garncarz W, Salzer E,Pierides I, Bilic I, Thiel J, Priftakis P, Banerjee PP, Förster-Waldl E, MedgyesiD, Huber WD, Orange JS, Meffre E, Sansom DM, Bryceson YT, Altman A, Boztug K. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019 Jul 15;10(1):3106.doi: 10.1038/s41467-019-10812-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31308374

2019

Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P,Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD,Loizou JI. Mapping the Human Kinome in Response to DNA Damage. Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30650350

2019

Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T,Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O,Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, ProchazkovaJ, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A,Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L,Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.Haematologica. 2019 May 23. pii: haematol.2019.216986. doi:10.3324/haematol.2019.216986. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31123029

2018

Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29717121

2018

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI. Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29891926

2018

Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V. CDK6 antagonizes p53-induced responses during tumorigenesis. Cancer Discov. 2018 Jun 13. pii: CD-17-0912. doi: 10.1158/2159-8290.CD-17-0912. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29899063

2017

Mazouzi A, Battistini F, Moser SC, Ferreira da Silva J, Wiedner M, Owusu M, Lardeau CH, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JI. Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. Mol Cell. 2017 Nov 16;68(4):797-807.e7. doi: 10.1016/j.molcel.2017.10.021
Abstract: http://www.cell.com/molecular-cell/comments/S1097-2765(17)30796-7

2017

Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29089570

2016

Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI. A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Rep. 2016 Apr 14. pii: S2211-1247(16)30366-7. doi: 10.1016/j.celrep.2016.03.077.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27149854

2016

Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou & Sebastian M. B. Nijman. MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated. Nature Communications 2016 Dec 6. doi:10.1038/NCOMMS13701
Abstract: http://www.nature.com/articles/ncomms13701

2016

Anjos-Afonso F, Loizou JI, Bradburn A, Kanu N, Purewal S, Da Costa C, Bonnet D, Behrens A. Perturbed hematopoiesis in mice lacking ATMIN. Blood 2016 Sep. doi:10.1182/blood-2015-09-672980.
Abstract: http://www.bloodjournal.org/content/early/2016/08/31/blood-2015-09-67298

2015

Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, Moder M, Turchinovich G, Hladik A, Gurnhofer E, Hayday A, Behrens A, Knapp S, Kenner L, Ellmeier W, Loizou JI. DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS Genet. 2015 Nov 6;11(11):e1005645. doi: 10.1371/journal.pgen.1005645. eCollection 2015.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26544571

2015

Prochazkova J, Loizou JI. Programmed DNA breaks in lymphoid cells: Repair mechanisms and consequences in human disease. Immunology. 2015 Oct 12. doi: 10.1111/imm.12547.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26455503

2014

ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, Loizou JI. DNA Repair (Amst). 2014 Sep 24. pii: S1568-7864(14)00223-7. doi: 10.1016/j.dnarep.2014.09.001. [Epub ahead of print] PMID: 25262557.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25262557

2014

DNA replication stress: Causes, resolution and disease.Mazouzi A, Velimezi G, Loizou JI.Exp Cell Res. 2014 Sep 30. pii: S0014-4827(14)00435-2. doi: 10.1016/j.yexcr.2014.09.030. [Epub ahead of print] Review.PMID: 25281304.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25281304

2014

Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24695225