Publications
2023
Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy
Jana Slyskova,
Alba Muniesa-Vargas,
Israel Tojal da Silva,
Rodrigo Drummond,
Jiyeong Park,
David Häckes,
Isabella Poetsch,
Cristina Ribeiro-Silva,
Amandine Moretton,
Petra Heffeter,
Orlando D Schärer,
Wim Vermeulen,
Hannes Lans,
Joanna I Loizou.
NAR Cancer. 2023 Dec 5;5(4):zcad057. doi: 10.1093/narcan/zcad057. eCollection 2023 Dec.
2023
Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet
Mathilde Meyenberg,
Anna Hakobyan,
Nikolina Papac-Milicevic,
Laura Göderle,
Franziska L Langner,
Mateo Markovic,
Ji-Hyun Lee,
Bon-Kyoung Koo,
Georg A Busslinger,
Israel Tojal da Silva,
Christoph J Binder,
Jörg Menche,
Joanna I Loizou.
Sci Rep. 2023 Aug 26;13(1):13964. doi: 10.1038/s41598-023-41123-3.
2023
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability
Amandine Moretton,
Savvas Kourtis,
Antoni Gañez Zapater,
Chiara Calabrò,
Maria Lorena Espinar Calvo,
Frédéric Fontaine,
Evangelia Darai,
Etna Abad Cortel,
Samuel Block,
Laura Pascual-Reguant,
Natalia Pardo-Lorente,
Ritobrata Ghose,
Matthew G Vander Heiden,
Ana Janic,
André C Müller,
Joanna I Loizou,
Sara Sdelci.
Mol Syst Biol. 2023 Jul 11;19(7):e11267. doi: 10.15252/msb.202211267. Epub 2023 Jun 1.
2022
POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
Anna Schrempf,
Sara Bernardo,
Emili A Arasa Verge,
Miguel A Ramirez Otero,
Jordan Wilson,
Dominik Kirchhofer,
Gerald Timelthaler,
Anna M Ambros,
Atilla Kaya,
Marcus Wieder,
Gerhard F Ecker,
Georg E Winter,
Vincenzo Costanzo,
Joanna I Loizou.
Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. Epub 2022 Nov 17.
2021
High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells.
Jia R,
Kutzner L,
Koren A,
Runggatscher K,
Májek P,
Müller AC,
Schuster M,
Bock C,
Loizou JI,
Kubicek S,
Kralovics R.
Blood Cancer J. 2021 Jul 31;11(7):137. doi: 10.1038/s41408-021-00531-2.
2021
Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations.
Vulliard L,
Hancock J,
Kamnev A,
Fell CW,
Ferreira da Silva J,
Loizou JI,
Nagy V,
Dupré L,
Menche J.
jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations. Bioinformatics. 2021 Dec 22;38(6):1692-9. doi: 10.1093/bioinformatics/btab853. Online ahead of print.
2021
Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing.
Meyenberg M,
Ferreira da Silva J,
Loizou JI.
Front Genet. 2021 Sep 3;12:728520. doi: 10.3389/fgene.2021.728520. eCollection 2021.
2021
Tissue specificity of DNA repair: the CRISPR compass.
Ferreira da Silva J,
Meyenberg M,
Loizou JI.
Trends Genet. 2021 Nov;37(11):958-962. doi: 10.1016/j.tig.2021.07.010. Epub 2021 Aug 12.
2022
Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy
Amandine Moretton,
Jana Slyskova,
Marwan E Simaan,
Emili A Arasa-Verge,
Mathilde Meyenberg,
D Alonso Cerrón-Infantes,
Miriam M Unterlass,
Joanna I Loizou.
Front Oncol. 2022 Jun 2;12:874201. doi: 10.3389/fonc.2022.874201. eCollection 2022.
2022
Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens
Jordan Wilson,
Joanna I Loizou.
Mol Oncol. 2022 Nov;16(21):3778-3791. doi: 10.1002/1878-0261.13272. Epub 2022 Jun 29.
