Publications
2022
Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair
J Ferreira da Silva,
G P Oliveira,
E A Arasa-Verge,
C Kagiou,
A Moretton,
G Timelthaler,
J Jiricny,
J I Loizou.
Nat Commun. 2022 Feb 9;13(1):760. doi: 10.1038/s41467-022-28442-1.
2020
Interplay between Cellular Metabolism and the DNA Damage Response in Cancer.
Moretton A,
Loizou JI.
Cancers (Basel). 2020 Jul 25;12(8):2051. doi: 10.3390/cancers12082051.
2020
Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy.
Schrempf A,
Slyskova J,
Loizou JI.
Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24.
2021
Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy.
Schrempf A,
Slyskova J,
Loizou JI.
Trends Cancer. 2021 Feb;7(2):98-111. doi: 10.1016/j.trecan.2020.09.007. Epub 2020 Oct 24.
2021
Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention.
Buttura JR,
Provisor Santos MN,
Valieris R,
Drummond RD,
Defelicibus A,
Lima JP,
Calsavara VF,
Freitas HC,
Cordeiro de Lima VC,
Fernanda Bartelli T,
Wiedner M,
Rosales R,
Gollob KJ,
Loizou J,
Dias-Neto E,
Nunes DN,
da Silva IT.
Cancers (Basel). 2021 Jan 27;13(3):490. doi: 10.3390/cancers13030490.
2020
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Maurer B,
Nivarthi H,
Wingelhofer B,
Pham HTT,
Schlederer M,
Suske T,
Grausenburger R,
Schiefer AI,
Prchal-Murphy M,
Chen D,
Winkler S,
Merkel O,
Kornauth C,
Hofbauer M,
Hochgatterer B,
Hoermann G,
Hoelbl-Kovacic A,
Prochazkova J,
Lobello C,
Cumaraswamy AA,
Latzka J,
Kitzwögerer M,
Chott A,
Janikova A,
Pospíšilova Š,
Loizou JI,
Kubicek S,
Valent P,
Kolbe T,
Grebien F,
Kenner L,
Gunning PT,
Kralovics R,
Herling M,
Müller M,
Rülicke T,
Sexl V,
Moriggl R.
Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986.
2019
Mapping the Human Kinome in Response to DNA Damage.
Owusu M,
Bannauer P,
Ferreira da Silva J,
Mourikis TP,
Jones A,
Májek P,Caldera M,
Wiedner M,
Lardeau CH,
Mueller AC,
Menche J,
Kubicek S,
Ciccarelli FD,Loizou JI.
Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
2019
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
Serwas NK,
Hoeger B,
Ardy RC,
Stulz SV,
Sui Z,
Memaran N,
Meeths M,
Krolo A,
Yüce Petronczki Ö,
Pfajfer L,
Hou TZ,
Halliday N,
Santos-Valente E,
Kalinichenko A,
Kennedy A,
Mace EM,
Mukherjee M,
Tesi B,
Schrempf A,
Loizou JI,
Kain R,Bidmon-Fliegenschnee B,
Schickel JN,
Glauzy S,
Huemer J,
Garncarz W,
Salzer E,Pierides I,
Bilic I,
Thiel J,
Priftakis P,
Banerjee PP,
Förster-Waldl E,
MedgyesiD,
Huber WD,
Orange JS,
Meffre E,
Sansom DM,
Bryceson YT,
Altman A,
Boztug K.
Nat Commun. 2019 Jul 15;10(1):3106.doi: 10.1038/s41467-019-10812-x.
2019
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Maurer B,
Nivarthi H,
Wingelhofer B,
Pham HTT,
Schlederer M,
Suske T,Grausenburger R,
Schiefer AI,
Prchal-Murphy M,
Chen D,
Winkler S,
Merkel O,Kornauth C,
Hofbauer M,
Hochgatterer B,
Hoermann G,
Hoelbl-Kovacic A,
ProchazkovaJ,
Lobello C,
Cumaraswamy AA,
Latzka J,
Kitzwögerer M,
Chott A,
Janikova A,Pospíšilova Š,
Loizou JI,
Kubicek S,
Valent P,
Kolbe T,
Grebien F,
Kenner L,Gunning PT,
Kralovics R,
Herling M,
Müller M,
Rülicke T,
Sexl V,
Moriggl R.
Haematologica. 2019 May 23. pii: haematol.2019.216986. doi:10.3324/haematol.2019.216986. [Epub ahead of print]
2019
Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics.
Robinson-Garcia L,
Ferreira da Silva J,
Loizou JI.
Cancer Res. 2019 Nov 15;79(22):5693-5698. doi: 10.1158/0008-5472.CAN-19-1364.
