Novel paradigm in drug development: Understanding resistance mechanisms to targeted protein degradation
Targeted protein degradation (TPD) is a new paradigm in drug discovery that could lead to the development of new medicines to treat diseases such as cancer more effectively. A recent study by researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences reveals global and drug-specific cellular effectors needed for TPD. The results have now been published in the scientific journal Molecular Cell. Traditional…
CeMM International Postdoc Program (Vienna, Austria)
Pre-ERC Postdoc Program in Cellular, Molecular and Digital Medicine We are recruiting a group of postdocs (13 positions available) who are eager to pursue groundbreaking biomedical research, and we will help them to establish themselves as future scientific leaders. This postdoc program is designed to prepare postdoctoral researchers for a successful ERC Starting Grant application and for an independent research career in top research…
BAFfling cancer growth strategies: new targets for chromatin remodeling mutations identified
More than one-fifth of all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for Molecule Medicine of the Austrian Academy of Sciences to identify new approaches to target BAF mutant cancers. The study describing these findings has now…
Nature podcast with CeMM PI Georg Winter
On 27 June 2019, the ceremony for the Eppendorf Award took place at the EMBL Advanced Training Centre in Heidelberg. The laudation honoring Georg’s achievements was held by Award Jury Chairman Reinhard Jahn, Director of the Max Planck Institute for Biophysical Chemistry, Göttingen. Georg received the € 20.000 prize for his pioneering work developing a method for targeting specific proteins for degradation using heterobifunctional chemical…
An unexpected developmental hierarchy in an unusual disease
Langerhans cell histiocytosis (LCH) is a rare disease affecting primarily young children. While LCH may heal by itself without treatment in some patients, others require intensive chemotherapy and suffer from long-term consequences, or may even succumb to the disease. The reasons for these differences in disease severity are poorly understood. In a new study published in Cancer Discovery, researchers from the St. Anna Children’s Cancer Research…
A public statement by numerous European institutes calls for the amendment of the EU's almost 20-year-old GMO legislation
One year after the European Court of Justice (ECJ) ruling on genome editing: Scientists call on EU politicians to amend legislation to secure our food supply and promote sustainable agriculture. On Thursday, July 25th, 2019, numerous renowned European scientists appealed to the EU to simplify the use of new precision breeding methods to improve crops. This should enable the sustainable development of agriculture and food production in the face…
Identifying genetic causes for immune diseases as a way to uncover immune regulatory pathways
Human DEF6 deficiency underlies a novel immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis A single gene affected in a young girl resulted in serious autoimmune diseases. By deciphering the underlying mechanism, an international research team led by LBI-RUD Director Kaan Boztug was able to shed some light on the mechanism of autoimmunity in the human body. Based on these findings, an already approved drug has…
CeMM statement about constructive feedback
We are grateful for any constructive criticism and advice to improve CeMM as employer, as collaboration partner and as institute as a whole. Also positive feedback can be helpful as a confirmation for areas that work well, and deserve further investments. There are several channels and platforms to give feedback, and we urge you to do it in a professional and respectful way. Unfortunately, there has been an incident where our standards of open…
Loss of the IL-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses
The human immune system is essential for the prevention of infections and the detection of tumor cells, and severe congenital allergic (atopic) diseases can be the result of a genetic disorder effecting the immune system. An international team of researchers from the USA, UK and Kaan Boztug's research group at the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) in Vienna has now discovered a novel genetic defect that leads…
Mitochondria: when friends become enemies
A research group from MedUni Vienna and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has discovered a new mechanism by which cells communicate in inflammatory processes. This involves endogenous mitochondria released from white blood cells turning into initiators of inflammation. It is as if friends turn into enemies. The results have been published in the journal Circulation Research. In collaboration with…
Machine Learning in Medicine & Biology
On June 5, 2019, the “1st Vienna Symposium on Machine Learning in Medicine & Biology” took place at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences bringing together the diverse crowd of Austrian researchers in this rapidly growing field. The event was organized by Georg Langs (Medical University of Vienna) and Christoph Bock (CeMM), with support by the Austrian Platform for Personalized Medicine. Invited…
2nd RESOLUTE Consortium Meeting 3-5 June 2019
RESOLUTE, an European Union IMI2 funded project with 13 partners, CeMM as academic coordinator and Pfizer as EFPIA leader, celebrated the 2nd RESOLUTE consortium meeting from June 3-5, 2019 in Krems an der Donau, near Vienna. More than 65 participants coming from all over Europe and the US joined the meeting. This was a great chance to review the current status of the RESOLUTE project right before completing the first year of collaborations.…
Petition #DEALFORSCIENCE: Keep the EU and UK collaborating in science
EU-LIFE, EuroScience and Wellcome launched a campaign to urge the EU and UK to continue supporting scientific collaboration and to asap sign a research and innovation agreement: #dealforscience Researchers need certainty on scientific collaboration between the UK and EU. Science has been a key success of the EU and must remain a priority to keep Europe competitive. International collaboration makes science stronger and we should not let Brexit…
Robert Kralovics becoming CeMM Adjunct Principal Investigator
On June 1st 2019, Robert Kralovics and team members moved to the Medical University of Vienna, to join the Department of Laboratory Medicine (KILM) at the Anna Spiegel Building, which means Robert is now becoming an Adjunct Principal Investigator of CeMM. Robert Kralovics was one of the very first internationally recruited Principal Investigators who started at CeMM in June 2006. At that time CeMM was still a virtual institute, with rented lab…
EU-LIFE Strategy Meeting 2019
Thanks to the Babraham Institute for hosting the annual EU-LIFE Strategy Meeting, bringing together directors and main representatives from the 13 member institutes. CeMM is a proud member of EU-LIFE, profiting from the exchange of best practices and contributing to European research policy. #EULIFEScience #researchexcellence #sciencepolicy >7000 scientists and support personnel, >500 group leaders, >4000 publications, >100 running ERC…
