CeMM Adjunct Principal Investigator
Translational immunology of the skin and mucous membranes
The research projects of Georg Stary are focusing on different aspects of host-pathogen interactions and the contribution of tissue-resident leukocytes to physiologic and pathologic immune responses. Georg’s research interest lies in the biology, longevity, turnover and function of tissue-resident leukocytes in peripheral tissue with the skin being an optimal and accessible organ to perform meaningful human experiments. Georg Stary is a member of the Immuno-Board for Rare and Undiagnosed Diseases organized by LBI-RUD and CeRUD Director Kaan Boztug, and the Stary laboratory is applying omics technologies in collaboration with research groups at CeMM and LBI-RUD.
Georg Stary is a fully trained dermatovenereologist with direct contact to patients and ample experience in research in organ-specific immunological processes. After a four-year fellowship in the von Andrian Laboratory at Harvard Medical School, he became senior physician and principal investigator to the Department of Dermatology of the Medical University of Vienna in 2014. He was appointed assistant professor in 2015 and associate professor in 2016. Since November 2018, he has been an adjunct principal investigator at LBI-RUD and CeMM and has since been named co-director of LBI-RUD. His research projects focus on different aspects of host-pathogen interactions and the contribution of tissue-resident leukocytes to physiological and pathological immune responses. His research projects are in the areas of biology, immune cell longevity, and turnover and function of tissue-resident leukocytes in peripheral tissue. The skin often serves as model tissue, as it is accessible for translational experimental setups. He is a member of the Immuno-Board for Rare and Undiagnosed Diseases organized by LBI-RUD and CeRUD, a board member of the Society of Dermatological Research for Germany, Austria, and Switzerland (ADF), a board member of the Austrian Society of Dermatology and Venerology (ÖGDV), chair of the Austrian Society of Sexually Transmitted Diseases and Dermatological Microbiology (ÖGSTD), treasurer of the Austrian Society for Allergy and Immunology (ÖGAI), and member of various other national and international societies. In 2022, Georg Stary was awarded the Ferdinand von Hebra Prize by the ÖGDV. He received the prize for his comprehensive research on the role of immune cells in host-pathogen interactions in physiological and pathological conditions of the skin and mucous membranes that has led to significant progress in the field of dermatological research.
Strobl J et al. Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission. J Clin Invest. 2022 Nov 1;132(21):e161188. (abstract)
Saluzzo S et al. Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin- and mucosa-resident memory T cells. Immunity. 2021 Dec 14;54(12):2842-2858.e5.
Strobl J, Gail LM, et al. Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation. J Exp Med. 2021 Nov 1;218(11):e20210417. (abstract)
Stary V et al. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses. Sci Immunol. 2020 Oct 16;5(52):eaba6232. (abstract)
Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19;348(6241):aaa8205. (abstract)
Brüggen MC, Petzelbauer P, Greinix H, Contassot E, Jankovic D, French L, Socié G, Rabitsch W, Kuzmina Z, Kalhs P, Knobler R, Stingl G, Stary G. Epidermal elafin expression is an indicator of poor prognosis in cutaneous graft-versus-host disease. J Invest Dermatol. 2015 Apr;135(4):999-1006. (abstract)
Brüggen MC, Klein I, Greinix H, Bauer W, Kuzmina Z, Rabitsch W, Kalhs P, Petzelbauer P, Knobler R, Stingl G, Stary G. Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease. Blood. 2014 Jan 9;123(2):290-9. (abstract)
Stary G, Klein I, Kohlhofer S, Koszik F, Scherzer T, Müllauer L, Quendler H, Kohrgruber N, Stingl G. Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood. 2009 Oct 29;114(18):3854-63. (abstract)
Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med. 2007 Jun 11;204(6):1441-51.(abstract)