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Nuno Maulide

Nuno Maulide

Precision Design Enabled by Organic Synthesis

Research Focus

The research of Nuno Maulide's group in organic chemistry has mostly focused on unusual or "unconventional" reactivity profiles of organic compounds. His group has taken particular interest in high-energy reactive intermediates that can be generated under mild conditions and subsequently lead to complex molecular rearrangements, domino reaction sequences, or catalytic asymmetric transformations. A broad scope of research activities has resulted from these efforts, spanning a large subset of key areas within modern synthetic organic chemistry.

Main Research Interests

  • Development of new synthetic methodologies in organic chemistry
  • Total synthesis of complex natural products
  • "Precision modification" of C-H bonds, with the vision of systematically exploiting such modifications in specific chemical and biological contexts
  • Design of new chemical probes, developed in close collaboration with computational chemistry methods
  • Drug design and synthesis with applications in medicinal chemistry and chemical biology

Biosketch

Nuno Maulide is a trained chemist. He underwent doctoral studies in the Université Catholique de Louvain and, in 2007, obtained his PhD under the supervision of Prof. István Markó, working on the application of functionalized orthoesters in organic synthesis. He then moved to Stanford University for a postdoctoral stay in the group of Prof. Barry Trost. Nuno started his independent career in 2009, when he was appointed group leader at the Max- Planck-Institut für Kohlenforschung in Mülheim an der Ruhr. In 2013, at age 33, he was appointed Full Professor of Organic Synthesis at the University of Vienna and is currently Head of the Institute of Organic Chemistry. He is the holder of an ERC Consolidator Grant (2017–2021)   and an ERC Proof of Concept Grant (awarded 2018), after having held an ERC Starting Grant (2011–2016). Nuno also leads the Christian Doppler Laboratory for Entropy-Oriented Drug Design and was named “Austria’s Scientist of the  Year 2018”. Nuno Maulide joined CeMM as Adjunct PI in November 2018 and has since been awarded the Ignaz L. Lieben Award of the Austrian Academy of Sciences (2019) as well as the 2020 Tetrahedron Young Investigator Award.

Top 5 Publications

  1. Grant PS, Vavrík M, Porte V, Meyrelles R, Maulide N. Remote proton elimination: C–H activation enabled by distal acidification. Science. 2024;384(6697):815-820. doi:10.1126/science.adi8997. (published paper)

  2. Brutiu BR, Iannelli G, Riomet M, Kaiser D, Maulide N. Stereodivergent 1,3-difunctionalization of alkenes by charge relocation. Nature. 2024;626(7997):92-97. doi:10.1038/s41586-023-06938-0. (published paper)

  3. Klose I, Di Mauro G, Kaldre D, Maulide N. Inverse hydride shuttle catalysis enables the stereoselective one-step synthesis of complex frameworks. Nat Chem. 2022;14(11):1306-1310. doi:10.1038/s41557-022-00991-4. (published paper)

  4. Adler P, Teskey CJ, Kaiser D, Holy M, Sitte HH, Maulide N. α-Fluorination of carbonyls with nucleophilic fluorine. Nat Chem. 2019;11(4):329-334. doi:10.1038/s41557-019-0215-z. (published paper)

  5. Kaldre D, Klose I, Maulide N. Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge-accelerated sulfonium rearrangement. Science. 2018;361(6403):664-667. doi:10.1126/science.aat5883. (published paper)

 

Please visit Nuno Maulide's Google Scholar profile for a complete list of publications.

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