Research Focus
The research of Nuno Maulide's group in organic chemistry focuses mainly on unusual or "unconventional" reactivity profiles of organic compounds. His group has taken particular interest in high-energy reactive intermediates that can be generated under mild conditions and subsequently, often through precise charge control, lead to complex molecular rearrangements, domino reaction sequences, or catalytic asymmetric transformations. A broad scope of research activities has resulted from these efforts, spanning a large subset of key areas within modern synthetic organic chemistry.
Main Research Interests
- Development of new synthetic methodology
- “Precision modification” of C–H bonds, particularly through charge control, with the vision of systematically exploiting such modifications in particular contexts
- Design of new chemical probes in close collaboration with computational methods
- Total synthesis of natural products
- Drug design and synthesis
Biosketch
Nuno Maulide is a trained chemist. He undertook doctoral studies at the Université Catholique de Louvain and, in 2007, obtained his PhD under the supervision of Professor István Markó, working on the application of functionalized orthoesters in organic synthesis. He then moved to Stanford University for a postdoctoral stay in the group of Professor Barry Trost. Maulide started his independent career in 2009, when he was appointed group leader at the Max Planck Institute for Coal Research in Mülheim an der Ruhr. In 2013, at age 33, he was appointed full professor of organic synthesis at the University of Vienna. He has held a number of prestigious grants, including an ERC Advanced Grant (awarded 2024), ERC Consolidator Grant (2017–2022), an ERC Starting Grant (2011–2016), and two ERC Proof of Concept Grants (awarded 2018 and 2023). Maulide also led the Christian Doppler Laboratory for Entropy-Oriented Drug Design and was named “Austria’s Scientist of the Year 2018.” Nuno Maulide joined CeMM as adjunct PI in November 2018 and has since been awarded the Ignaz L. Lieben Award of the Austrian Academy of Sciences (2019) as well as the Tetrahedron Young Investigator Award (2020) and the Arthur C. Cope Scholar Award (2025). He has been a full member of the Austrian Academy of Sciences since 2021.
Top 5 Publications
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Grant PS, Vavrík M, Porte V, Meyrelles R, Maulide N. Remote proton elimination: C–H activation enabled by distal acidification. Science. 2024;384(6697):815-820. doi:10.1126/science.adi8997. (published paper)
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Brutiu BR, Iannelli G, Riomet M, Kaiser D, Maulide N. Stereodivergent 1,3-difunctionalization of alkenes by charge relocation. Nature. 2024;626(7997):92-97. doi:10.1038/s41586-023-06938-0. (published paper)
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Klose I, Di Mauro G, Kaldre D, Maulide N. Inverse hydride shuttle catalysis enables the stereoselective one-step synthesis of complex frameworks. Nat Chem. 2022;14(11):1306-1310. doi:10.1038/s41557-022-00991-4. (published paper)
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Adler P, Teskey CJ, Kaiser D, Holy M, Sitte HH, Maulide N. α-Fluorination of carbonyls with nucleophilic fluorine. Nat Chem. 2019;11(4):329-334. doi:10.1038/s41557-019-0215-z. (published paper)
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Kaldre D, Klose I, Maulide N. Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge-accelerated sulfonium rearrangement. Science. 2018;361(6403):664-667. doi:10.1126/science.aat5883. (published paper)
Please visit Nuno Maulide's Google Scholar profile for a complete list of publications.