Publications
2019
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL.
Schmidl C,
Vladimer GI,
Rendeiro AF,
Schnabl S,
Krausgruber T,
Taubert C,Krall N,
Pemovska T,
Araghi M,
Snijder B,
Hubmann R,
Ringler A,
Runggatscher K,Demirtas D,
de la Fuente OL,
Hilgarth M,
Skrabs C,
Porpaczy E,
Gruber M,
HoermannG,
Kubicek S,
Staber PB,
Shehata M,
Superti-Furga G,
Jäger U,
Bock C.
Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.
2019
Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia (T-PLL).
Staber PB,
Herling M,
Bellido M,
Jacobsen ED,
Davids MS,
Kadia TM,
Shustov A,Tournilhac O,
Bachy E,
Zaja F,
Porkka K,
Hoermann G,
Simonitsch I,
Haferlach C,Kubicek S,
Mayerhoefer M,
Hopfinger G,
Jaeger U,
Dearden C.
Blood. 2019 Jul 10. pii: blood.2019000402. doi: 10.1182/blood.2019000402. [Epub ahead of print]
2019
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Maurer B,
Nivarthi H,
Wingelhofer B,
Pham HTT,
Schlederer M,
Suske T,Grausenburger R,
Schiefer AI,
Prchal-Murphy M,
Chen D,
Winkler S,
Merkel O,Kornauth C,
Hofbauer M,
Hochgatterer B,
Hoermann G,
Hoelbl-Kovacic A,
ProchazkovaJ,
Lobello C,
Cumaraswamy AA,
Latzka J,
Kitzwögerer M,
Chott A,
Janikova A,Pospíšilova Š,
Loizou JI,
Kubicek S,
Valent P,
Kolbe T,
Grebien F,
Kenner L,Gunning PT,
Kralovics R,
Herling M,
Müller M,
Rülicke T,
Sexl V,
Moriggl R.
Haematologica. 2019 May 23. pii: haematol.2019.216986. doi:10.3324/haematol.2019.216986. [Epub ahead of print]
2019
The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway.
Chien J,
Wolf FW,
Grosche S,
Yosef N,
Garriga G,
Mörck C.
Genetics. 2019 Dec;213(4):1465-1478. doi: 10.1534/genetics.119.302628.
2019
Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers.
Schick S,
Rendeiro AF,
Runggatscher K,
Ringler A,
Boidol B,
Hinkel M,
Májek P,
Vulliard L,
Penz T,
Parapatics K,
Schmidl C,
Menche J,
Boehmelt G,
Petronczki M,
Müller AC, Bock C,
Kubicek S.
Nat Genet. 2019;51(9):1399–1410. doi:10.1038/s41588-019-0477-9
2018
Ldlr(-)(/)(-) and ApoE(-)(/)(-) mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
Saulnier-Blache JS,
Wilson R,
Klavins K,
Graham D,
Alesutan I,
Kastenmüller G,
Wang-Sattler R,
Adamski J,
Roden M,
Rathmann W,
Seissler J,
Meisinger C,
Koenig W,
Thiery J,
Suhre K,
Peters A,
Kuro-O M,
Lang F,
Dallmann G,
Delles C,
Voelkl J,
Waldenberger M,
Bascands JL,
Klein J,
Schanstra JP.
Atherosclerosis. 2018 Sep;276:140-147. doi: 10.1016/j.atherosclerosis.2018.07.024. Epub 2018 Jul 21.
2018
Lymphatic exosomes promote dendritic cell migration along guidance cues.
Brown M,
Johnson LA,
Leone DA,
Majek P,
Vaahtomeri K,
Senfter D,
Bukosza N,
Schachner H,
Asfour G,
Langer B,
Hauschild R,
Parapatics K,
Hong YK,
Bennett KL,
Kain R,
Detmar M,
Sixt M,
Jackson DG,
Kerjaschki D.
J Cell Biol. 2018 Jun 4;217(6):2205-2221. doi: 10.1083/jcb.201612051. Epub 2018 Apr 12.
2018
CDK6 antagonizes p53-induced responses during tumorigenesis.
Bellutti F,
Tigan AS,
Nebenfuehr S,
Dolezal M,
Zojer M,
Grausenburger R,
Hartenberger S,
Kollmann S,
Doma E,
Prchal-Murphy M,
Uras IZ,
Höllein A,
Neuberg DS,
Ebert BL,
Ringler A,
Mueller AC,
Loizou JI,
Hinds PW,
Vogl C,
Heller G,
Kubicek S,
Zuber J,
Malumbres M,
Farlik M,
Villunger A,
Kollmann K,
Sexl V.
Cancer Discov. 2018 Jun 13. pii: CD-17-0912. doi: 10.1158/2159-8290.CD-17-0912. [Epub ahead of print]
2018
Pharmacologic inhibition of STAT5 in acute myeloid leukemia.
Wingelhofer B,
Maurer B,
Heyes EC,
Cumaraswamy AA,
Berger-Becvar A,
de Araujo ED,
Orlova A,
Freund P,
Ruge F,
Park J,
Tin G,
Ahmar S,
Lardeau CH,
Sadovnik I,
Bajusz D,
Keserű GM,
Grebien F,
Kubicek S,
Valent P,
Gunning PT,
Moriggl R.
Leukemia. 2018 May;32(5):1135-1146. doi: 10.1038/s41375-017-0005-9. Epub 2018 Feb 2.
2017
First in human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.
Boidol B,
Kornauth C,
van der Kouwe E,
Prutsch N,
Kazianka L,
Gültekin S,
Hoermann G,
Mayerhoefer ME,
Hopfinger G,
Hauswirth A,
Panny M,
Aretin MB,
Hilgarth B,
Sperr WR,
Valent P,
Simonitsch-Klupp I,
Moriggl R,
Merkel O,
Kenner L,
Jäger U,
Kubicek S,
Staber PB.
Blood. 2017 Sep 27. pii: blood-2017-05-785683. doi: 10.1182/blood-2017-05-785683. [Epub ahead of print]