Publications
2025
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation
Peter Traxler,
Stephan Reichl,
Lukas Folkman,
Lisa Shaw,
Victoria Fife,
Amelie Nemc,
Djurdja Pasajlic,
Anna Kusienicka,
Daniele Barreca,
Nikolaus Fortelny,
André F Rendeiro,
Florian Halbritter,
Wolfgang Weninger,
Thomas Decker,
Matthias Farlik,
Christoph Bock.
Cell Syst. 2025 Aug 20;16(8):101346. doi: 10.1016/j.cels.2025.101346. Epub 2025 Aug 8.
2025
Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions
Zhenhua Zhang,
Wenchao Li,
Qiuyao Zhan,
Michelle Aillaud,
Javier Botey-Bataller,
Martijn Zoodsma,
Rob Ter Horst,
Leo A B Joosten,
Christoph Bock,
Leon N Schulte,
Cheng-Jian Xu,
Mihai G Netea,
Marc Jan Bonder,
Yang Li.
Nat Commun. 2025 Aug 4;16(1):7134. doi: 10.1038/s41467-025-61192-4.
2025
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
Ramona Rica,
Monika Waldherr,
Emi Miyakoda,
Ana Patricia Kutschat,
Marlene Schülein,
Jing Zhang,
Ricardo Alfredo Orbegozo-Medina,
Lisa Sandner,
Valentina Stolz,
Darina Waltenberger,
Thomas Krausgruber,
Christoph Bock,
Nicole Boucheron,
Davide Seruggia,
Wilfried Ellmeier,
Shinya Sakaguchi.
J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4.
2025
Mast cells activated in vitro can modulate macrophage polarization and antibacterial responses
Dorothea B Holter,
Sophie Zahalka,
Jessica Brösamlen,
Mariem Radhouani,
Martin L Watzenboeck,
Tyler J Artner,
Asma Farhat,
Riem Gawish,
Karin Lakovits,
Anastasiya Hladik,
Federica Quattrone,
Wolfgang Weninger,
Thomas Krausgruber,
Shane J F Cronin,
Shweta Tikoo,
Rohit Jain,
Sylvia Knapp,
Nikolaus Fortelny,
Philipp Starkl.
J Allergy Clin Immunol. 2025 Sep;156(3):754-773. doi: 10.1016/j.jaci.2025.02.040. Epub 2025 May 26.
2025
Protecting centrosomes from fracturing enables efficient cell navigation
Madeleine T Schmitt,
Janina Kroll,
Mauricio J A Ruiz-Fernandez,
Robert Hauschild,
Shaunak Ghosh,
Petra Kameritsch,
Jack Merrin,
Johanna Schmid,
Kasia Stefanowski,
Andreas W Thomae,
Jingyuan Cheng,
Gamze Naz Öztan,
Peter Konopka,
Germán Camargo Ortega,
Thomas Penz,
Luisa Bach,
Dirk Baumjohann,
Christoph Bock,
Tobias Straub,
Felix Meissner,
Eva Kiermaier,
Jörg Renkawitz.
Sci Adv. 2025 Apr 25;11(17):eadx4047. doi: 10.1126/sciadv.adx4047. Epub 2025 Apr 25.
2025
Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma
Matarr Khan,
Marlis Alteneder,
Wolfgang Reiter,
Thomas Krausgruber,
Lina Dobnikar,
Moritz Madern,
Monika Waldherr,
Christoph Bock,
Markus Hartl,
Wilfried Ellmeier,
Johan Henriksson,
Nicole Boucheron.
Nat Commun. 2025 Mar 15;16(1):2565. doi: 10.1038/s41467-025-57590-3.
2025
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation
Ci Zhu,
Nicole Boucheron,
Osamah Al-Rubaye,
Brian K Chung,
Liv Wenche Thorbjørnsen,
Thomas Köcher,
Michael Schuster,
Thierry Claudel,
Emina Halilbasic,
Victoria Kunczer,
Fanziska Muscate,
Lois L Cavanagh,
Darina Waltenberger,
Alexander Lercher,
Anna Ohradanova-Repic,
Philipp Schatzlmaier,
Tatjana Stojakovic,
Hubert Scharnagl,
Andreas Bergthaler,
Hannes Stockinger,
Samuel Huber,
Christoph Bock,
Lukas Kenner,
Tom H Karlsen,
Wilfried Ellmeier,
Michael Trauner.
Gut. 2025 Jun 6;74(7):1079-1093. doi: 10.1136/gutjnl-2024-333297.
2025
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions
Anzhelika Karjalainen,
Agnieszka Witalisz-Siepracka,
Michaela Prchal-Murphy,
David Martin,
Felix Sternberg,
Milica Krunic,
Marlies Dolezal,
Nikolaus Fortelny,
Matthias Farlik,
Sabine Macho-Maschler,
Caroline Lassnig,
Katrin Meissl,
Lena Amenitsch,
Therese Lederer,
Elena Pohl,
Dagmar Gotthardt,
Christoph Bock,
Thomas Decker,
Birgit Strobl,
Mathias Müller.
Cell Mol Life Sci. 2025 Mar 2;82(1):98. doi: 10.1007/s00018-025-05625-9.
2025
Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring
Takaya Saito,
Marit Espe,
Maren Mommens,
Christoph Bock,
Jorge M O Fernandes,
Kaja Helvik Skjærven.
PLoS One. 2025 Feb 24;20(2):e0317770. doi: 10.1371/journal.pone.0317770. eCollection 2025.
2025
Single-cell CRISPR screening in mouse brain
Eugenia V Pankevich,
Christoph Bock.
Nat Protoc. 2025 Jul;20(7):1731-1732. doi: 10.1038/s41596-024-01128-2.
