Publications
2026
What are the limits to biomedical research acceleration through general-purpose AI?
Konstantin Hebenstreit,
Constantin Convalexius,
Stephan Reichl,
Stefan Huber,
Christoph Bock,
Matthias Samwald.
Sci Rep. 2026 Jan 12;16(1):1304. doi: 10.1038/s41598-025-32583-w.
2025
Interleukin-38 is a negative regulator of trained immunity-A retrospective multi-omics study
Lisa U Teufel,
Vasiliki Matzaraki,
Lukas Folkman,
Dennis M de Graaf,
Rob Ter Horst,
Simone J C F M Moorlag,
Jéssica C Dos Santos,
Catharina M Mulders-Manders,
Thomas Krausgruber,
Charles Dinarello,
Mihai G Netea,
Leo A B Joosten,
Rob J W Arts.
iScience. 2025 Oct 14;28(11):113758. doi: 10.1016/j.isci.2025.113758. eCollection 2025 Nov 21.
2025
Multimodal learning enables chat-based exploration of single-cell data
Moritz Schaefer,
Peter Peneder,
Daniel Malzl,
Salvo Danilo Lombardo,
Mihaela Peycheva,
Jake Burton,
Anna Hakobyan,
Varun Sharma,
Thomas Krausgruber,
Celine Sin,
Jörg Menche,
Eleni M Tomazou,
Christoph Bock.
Nat Biotechnol. 2025 Nov 11. doi: 10.1038/s41587-025-02857-9. Online ahead of print.
2025
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard
Yu-Yu Lin,
Kersten Breuer,
Dieter Weichenhan,
Pascal Lafrenz,
Antonella Sarnataro,
Agata Wilk,
Maryna Chepeleva,
Oliver Mücke,
Maximilian Schönung,
Franziska Petermann,
Philip Reiner Kensche,
Lena Weiser,
Frank Thommen,
Gideon Giacomelli,
Karl Nordstroem,
Edahi Gonzalez-Avalos,
Angelika Merkel,
Helene Kretzmer,
Jonas Fischer,
Stephen Krämer,
Murat Iskar,
Stephan Wolf,
Ivo Buchhalter,
Manel Esteller,
Christian Lawerenz,
Sven Twardziok,
Marc Zapatka,
Volker Hovestadt,
Matthias Schlesner,
Marcel H Schulz,
Steve Hoffmann,
Clarissa Gerhauser,
Jörn Walter,
Mark Hartmann,
Daniel B Lipka,
Yassen Assenov,
Christoph Bock,
Christoph Plass,
Reka Toth,
Pavlo Lutsik.
Nucleic Acids Res. 2025 Oct 14;53(19):gkaf970. doi: 10.1093/nar/gkaf970.
2025
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
Paul Datlinger,
Eugenia V Pankevich,
Cosmas D Arnold,
Nicole Pranckevicius,
Jenny Lin,
Daria Romanovskaia,
Moritz Schaefer,
Francesco Piras,
Anne-Christine Orts,
Amelie Nemc,
Paulina N Biesaga,
Michelle Chan,
Teresa Neuwirth,
Artem V Artemov,
Wentao Li,
Sabrina Ladstätter,
Thomas Krausgruber,
Christoph Bock.
Nature. 2025 Oct;646(8086):963-972. doi: 10.1038/s41586-025-09507-9. Epub 2025 Sep 24.
2025
A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers
Antonio José Cabrera-Serrano,
Lucía Ruiz-Durán,
Juan Francisco Gutiérrez-Bautista,
María Carretero-Fernández,
Rob Ter Horst,
Yang Li,
Fernando Jesús Reyes-Zurita,
Francisco José García-Verdejo,
Mihai G Netea,
Pedro Sánchez-Rovira,
Miguel Ángel López-Nevot,
Antonio Sampedro,
Juan Sainz.
Front Immunol. 2025 Aug 18;16:1639825. doi: 10.3389/fimmu.2025.1639825. eCollection 2025.
2025
Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia
Antonio José Cabrera-Serrano,
José Manuel Sánchez-Maldonado,
Juan José Rodríguez-Sevilla,
Fernando Jesús Reyes-Zurita,
Rosa Collado,
Anna Puiggros,
Elena Cornejo-Calvo,
Paloma García-Martín,
Rob Ter Horst,
Yolanda Benavente,
Andrés Jerez,
Stefano Landi,
Blanca Espinet,
Rossana Maffei,
Miguel Ángel López-Nevot,
Silvia Ramos-Campoy,
Carmen González-Olmedo,
Tzu-Hua Chen-Liang,
Víctor Moreno,
Fatin Jannus,
Rafael Marcos-Gragera,
María Carretero-Fernández,
Belém Sampaio-Marques,
Irene Gámez,
María García-Álvarez,
Nicola J Camp,
Trinidad Dierssen-Sotos,
Joanna Kamaso,
Eva María Pérez,
Aaron D Norman,
Mario Luppi,
Yang Li,
Miguel Alcoceba,
Daniele Campa,
Silvia de San José,
Roberto Marasca,
Paula Ludovico,
Alyssa Clay-Gilmour,
Federico Canzian,
Marian Ibañez,
Mihai G Netea,
James McKay,
Delphine Casabonne,
Sonja I Berndt,
Susan L Slager,
Juan Sainz.
Blood Adv. 2025 Dec 9;9(23):6076-6089. doi: 10.1182/bloodadvances.2025017345.
2025
Bacillus Calmette-Guérin-induced trained immunity potentiates TH17 responses in vitro
Leonie S Helder,
Laszlo A Groh,
Vasiliki Matzaraki,
Rob Ter Horst,
Gert Jan Scheffer,
Leo A B Joosten,
Mihai G Netea,
Anaisa V Ferreira.
J Leukoc Biol. 2025 Sep 1;117(9):qiaf123. doi: 10.1093/jleuko/qiaf123.
2025
Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines
Julia Naas,
Meritxell Balmaña,
Laurenz Holcik,
Maria Novatchkova,
Lina Dobnikar,
Thomas Krausgruber,
Sabrina Ladstätter,
Christoph Bock,
Arndt von Haeseler,
Christopher Esk,
Jürgen A Knoblich.
Cell Rep. 2025 Sep 23;44(9):116168. doi: 10.1016/j.celrep.2025.116168. Epub 2025 Aug 26.
2025
Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features
Zhijun Yu,
Merel Derksen,
Brigit M Te Pas,
Sabrina Ladstätter,
Rene Overmeer,
Peter Brazda,
Marc van de Wetering,
Farzin Pourfarzad,
Robert G J Vries,
Wout Megchelenbrink,
Christoph Bock,
Lucia Altucci,
Hendrik G Stunnenberg.
Int J Cancer. 2025 Dec 15;157(12):2619-2634. doi: 10.1002/ijc.70103. Epub 2025 Aug 23.
