Publications
2025
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
Paul Datlinger,
Eugenia V Pankevich,
Cosmas D Arnold,
Nicole Pranckevicius,
Jenny Lin,
Daria Romanovskaia,
Moritz Schaefer,
Francesco Piras,
Anne-Christine Orts,
Amelie Nemc,
Paulina N Biesaga,
Michelle Chan,
Teresa Neuwirth,
Artem V Artemov,
Wentao Li,
Sabrina Ladstätter,
Thomas Krausgruber,
Christoph Bock.
Nature. 2025 Oct;646(8086):963-972. doi: 10.1038/s41586-025-09507-9. Epub 2025 Sep 24.
2025
A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers
Antonio José Cabrera-Serrano,
Lucía Ruiz-Durán,
Juan Francisco Gutiérrez-Bautista,
María Carretero-Fernández,
Rob Ter Horst,
Yang Li,
Fernando Jesús Reyes-Zurita,
Francisco José García-Verdejo,
Mihai G Netea,
Pedro Sánchez-Rovira,
Miguel Ángel López-Nevot,
Antonio Sampedro,
Juan Sainz.
Front Immunol. 2025 Aug 18;16:1639825. doi: 10.3389/fimmu.2025.1639825. eCollection 2025.
2025
Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia
Antonio José Cabrera-Serrano,
José Manuel Sánchez-Maldonado,
Juan José Rodríguez-Sevilla,
Fernando Jesús Reyes-Zurita,
Rosa Collado,
Anna Puiggros,
Elena Cornejo-Calvo,
Paloma García-Martín,
Rob Ter Horst,
Yolanda Benavente,
Andrés Jerez,
Stefano Landi,
Blanca Espinet,
Rossana Maffei,
Miguel Ángel López-Nevot,
Silvia Ramos-Campoy,
Carmen González-Olmedo,
Tzu-Hua Chen-Liang,
Víctor Moreno,
Fatin Jannus,
Rafael Marcos-Gragera,
María Carretero-Fernández,
Belém Sampaio-Marques,
Irene Gámez,
María García-Álvarez,
Nicola J Camp,
Trinidad Dierssen-Sotos,
Joanna Kamaso,
Eva María Pérez,
Aaron D Norman,
Mario Luppi,
Yang Li,
Miguel Alcoceba,
Daniele Campa,
Silvia de San José,
Roberto Marasca,
Paula Ludovico,
Alyssa Clay-Gilmour,
Federico Canzian,
Marian Ibañez,
Mihai G Netea,
James McKay,
Delphine Casabonne,
Sonja I Berndt,
Susan L Slager,
Juan Sainz.
Blood Adv. 2025 Dec 9;9(23):6076-6089. doi: 10.1182/bloodadvances.2025017345.
2025
Bacillus Calmette-Guérin-induced trained immunity potentiates TH17 responses in vitro
Leonie S Helder,
Laszlo A Groh,
Vasiliki Matzaraki,
Rob Ter Horst,
Gert Jan Scheffer,
Leo A B Joosten,
Mihai G Netea,
Anaisa V Ferreira.
J Leukoc Biol. 2025 Sep 1;117(9):qiaf123. doi: 10.1093/jleuko/qiaf123.
2025
Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines
Julia Naas,
Meritxell Balmaña,
Laurenz Holcik,
Maria Novatchkova,
Lina Dobnikar,
Thomas Krausgruber,
Sabrina Ladstätter,
Christoph Bock,
Arndt von Haeseler,
Christopher Esk,
Jürgen A Knoblich.
Cell Rep. 2025 Sep 23;44(9):116168. doi: 10.1016/j.celrep.2025.116168. Epub 2025 Aug 26.
2025
Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features
Zhijun Yu,
Merel Derksen,
Brigit M Te Pas,
Sabrina Ladstätter,
Rene Overmeer,
Peter Brazda,
Marc van de Wetering,
Farzin Pourfarzad,
Robert G J Vries,
Wout Megchelenbrink,
Christoph Bock,
Lucia Altucci,
Hendrik G Stunnenberg.
Int J Cancer. 2025 Dec 15;157(12):2619-2634. doi: 10.1002/ijc.70103. Epub 2025 Aug 23.
2025
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation
Peter Traxler,
Stephan Reichl,
Lukas Folkman,
Lisa Shaw,
Victoria Fife,
Amelie Nemc,
Djurdja Pasajlic,
Anna Kusienicka,
Daniele Barreca,
Nikolaus Fortelny,
André F Rendeiro,
Florian Halbritter,
Wolfgang Weninger,
Thomas Decker,
Matthias Farlik,
Christoph Bock.
Cell Syst. 2025 Aug 20;16(8):101346. doi: 10.1016/j.cels.2025.101346. Epub 2025 Aug 8.
2025
Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions
Zhenhua Zhang,
Wenchao Li,
Qiuyao Zhan,
Michelle Aillaud,
Javier Botey-Bataller,
Martijn Zoodsma,
Rob Ter Horst,
Leo A B Joosten,
Christoph Bock,
Leon N Schulte,
Cheng-Jian Xu,
Mihai G Netea,
Marc Jan Bonder,
Yang Li.
Nat Commun. 2025 Aug 4;16(1):7134. doi: 10.1038/s41467-025-61192-4.
2025
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
Ramona Rica,
Monika Waldherr,
Emi Miyakoda,
Ana Patricia Kutschat,
Marlene Schülein,
Jing Zhang,
Ricardo Alfredo Orbegozo-Medina,
Lisa Sandner,
Valentina Stolz,
Darina Waltenberger,
Thomas Krausgruber,
Christoph Bock,
Nicole Boucheron,
Davide Seruggia,
Wilfried Ellmeier,
Shinya Sakaguchi.
J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4.
2025
Mast cells activated in vitro can modulate macrophage polarization and antibacterial responses
Dorothea B Holter,
Sophie Zahalka,
Jessica Brösamlen,
Mariem Radhouani,
Martin L Watzenboeck,
Tyler J Artner,
Asma Farhat,
Riem Gawish,
Karin Lakovits,
Anastasiya Hladik,
Federica Quattrone,
Wolfgang Weninger,
Thomas Krausgruber,
Shane J F Cronin,
Shweta Tikoo,
Rohit Jain,
Sylvia Knapp,
Nikolaus Fortelny,
Philipp Starkl.
J Allergy Clin Immunol. 2025 Sep;156(3):754-773. doi: 10.1016/j.jaci.2025.02.040. Epub 2025 May 26.
