Publications
2020
Profiling of inhibitory immune checkpoints in glioblastoma: Potential pathogenetic players.
Lombardo SD,
Bramanti A,
Ciurleo R,
Basile MS,
Pennisi M,
Bella R,
Mangano K,
Bramanti P,
Nicoletti F,
Fagone P.
Oncol Lett. 2020 Dec;20(6):332. doi: 10.3892/ol.2020.12195. Epub 2020 Oct 7.
2020
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS,
Vogel A,
Lercher A,
Caldera M,
Korosec A,
Pühringer M,
Hofmann M,
Hajto A,
Kieler M,
Garrido LQ,
Kerndl M,
Kuttke M,
Mesteri I,
Górna MW,
Kulik M,
Dominiak PM,
Brandon AE,
Estevez E,
Egan CL,
Gruber F,
Schweiger M,
Menche J,
Bergthaler A,
Weichhart T,
Klavins K,
Febbraio MA,
Sharif O,
Schabbauer G.
Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16.
2020
Environmental arginine controls multinuclear giant cell metabolism and formation.
Brunner JS,
Vulliard L,
Hofmann M,
Kieler M,
Lercher A,
Vogel A,
Russier M,
Brüggenthies JB,
Kerndl M,
Saferding V,
Niederreiter B,
Junza A,
Frauenstein A,
Scholtysek C,
Mikami Y,
Klavins K,
Krönke G,
Bergthaler A,
O'Shea JJ,
Weichhart T,
Meissner F,
Smolen JS,
Cheng P,
Yanes O,
Menche J,
Murray PJ,
Sharif O,
Blüml S,
Schabbauer G.
Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1.
2019
Mapping the perturbome network of cellular perturbations.
Caldera M,
Müller F,
Kaltenbrunner I,
Licciardello MP,
Lardeau CH,
Kubicek S,
Menche J.
Nat Commun. 2019 Nov 13;10(1):5140. doi: 10.1038/s41467-019-13058-9.
2019
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Sdelci S,
Rendeiro AF,
Rathert P,
You W,
Lin JG,
Ringler A,
Hofstätter G,Moll HP,
Gürtl B,
Farlik M,
Schick S,
Klepsch F,
Oldach M,
Buphamalai P,Schischlik F,
Májek P,
Parapatics K,
Schmidl C,
Schuster M,
Penz T,
Buckley DL,Hudecz O,
Imre R,
Wang SY,
Maric HM,
Kralovics R,
Bennett KL,
Müller AC,
MechtlerK,
Menche J,
Bradner JE,
Winter GE,
Klavins K,
Casanova E,
Bock C,
Zuber J,Kubicek S.
Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
2019
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.
Lercher A,
Bhattacharya A,
Popa AM,
Caldera M,
Schlapansky MF,
Baazim H,
Agerer B,
Gürtl B,
Kosack L,
Májek P,
Brunner JS,
Vitko D,
Pinter T,
Genger JW,
Orlova A,
Pikor N,
Reil D,
Ozsvár-Kozma M,
Kalinke U,
Ludewig B,
Moriggl R,
Bennett KL,
Menche J,
Cheng PN,
Schabbauer G,
Trauner M,
Klavins K,
Bergthaler A.
Immunity. 2019;51(6):1074–1087.e9. doi:10.1016/j.immuni.2019.10.014
2019
HACE1 deficiency leads to structural and functional neurodevelopmental defects.
Nagy V,
Hollstein R,
Pai TP,
Herde MK,
Buphamalai P,
Moeseneder P,Lenartowicz E,
Kavirayani A,
Korenke GC,
Kozieradzki I,
Nitsch R,
Cicvaric A,Monje Quiroga FJ,
Deardorff MA,
Bedoukian EC,
Li Y,
Yigit G,
Menche J,
Perçin EF,Wollnik B,
Henneberger C,
Kaiser FJ,
Penninger JM.
Neurol Genet. 2019 Apr29;5(3):e330. doi: 10.1212/NXG.0000000000000330. eCollection 2019 Jun. PubMedPMID: 31321300;
2019
Mapping the Human Kinome in Response to DNA Damage.
Owusu M,
Bannauer P,
Ferreira da Silva J,
Mourikis TP,
Jones A,
Májek P,Caldera M,
Wiedner M,
Lardeau CH,
Mueller AC,
Menche J,
Kubicek S,
Ciccarelli FD,Loizou JI.
Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
2019
Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.
Schischlik F,
Jäger R,
Rosebrock F,
Hug E,
Schuster M,
Holly R,
Fuchs E,Milosevic Feenstra JD,
Bogner E,
Gisslinger B,
Schalling M,
Rumi E,
Pietra D,Fischer G,
Faé I,
Vulliard L,
Menche J,
Haferlach T,
Meggendorfer M,
Stengel A,Bock C,
Cazzola M,
Gisslinger H,
Kralovics R.
Blood. 2019 Jul 11;134(2):199-210. doi: 10.1182/blood.2019000519. Epub2019 May 7.
2019
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.
Mayor-Ruiz C,
Jaeger MG,
Bauer S,
Brand M,
Sin C,
Hanzl A,
Mueller AC,
Menche J,
Winter GE.
Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
