Publications
2025
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Tuan-Anh Nguyen,
Jung-Ming G Lin,
Anne-Sophie M C Marques,
Maximilian Fottner,
Ludwig G Bauer,
Andreas Reicher,
Diana Daum,
Lorenzo Scrofani,
Yusi Liu,
Carol Cheng,
Luna D'Angelo L D D,
Juan Sanchez,
Christoph Bueschl,
Nara Marella,
Pisanu Buphamalai,
Florian Traversi,
Maša Bereš,
Herwig P Moll,
Marton Siklos,
Jakob-Wendelin Genger,
Gerald Hofstaetter,
Ludovica Villanti,
Monika Malik,
Christoph Klimek,
Kathrin Runggatscher,
Bettina Guertl,
Jesper S Hansen,
Sarah Dobner,
Olga Babosova,
Tina Becirovic,
Laura P M H de Rooij,
Emilio Casanova,
Anna Koren,
D Sean Froese,
David S Rosenblatt,
Kristaps Klavins,
Andreas Bergthaler,
Jörg Menche,
J Thomas Hannich,
Miriam Abele,
Sara Sdelci,
Kathrin Lang,
Kilian V M Huber,
Stefan Kubicek.
Science. 2025 Nov 6:eadv4257. doi: 10.1126/science.adv4257. Online ahead of print.
2025
Artificial Intelligence and Network Medicine: Path to Precision Medicine
Lucia Altucci,
Lina Badimon,
Jean-Luc Balligand,
Jan Baumbach,
Alberico L Catapano,
Feixong Cheng,
Dawn DeMeo,
Rajat Gupta,
Marcus Hacker,
Yang-Yu Liu,
Joseph Loscalzo,
Sabrina Maniscalco,
Jörg Menche,
Giulia Menichetti,
Paolo Parini,
Harald H H W Schmidt,
Marinka Zitnik.
NEJM AI. 2025 Sep;2(9):10.1056/aira2401229. doi: 10.1056/aira2401229. Epub 2025 Aug 28.
2025
Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
Mariem Radhouani,
Asma Farhat,
Anna Hakobyan,
Sophie Zahalka,
Lisabeth Pimenov,
Alina Fokina,
Anastasiya Hladik,
Karin Lakovits,
Jessica Brösamlen,
Vojtech Dvorak,
Natalia Nunes,
Andreas Zech,
Marco Idzko,
Thomas Krausgruber,
Jörg Köhl,
Ozge Uluckan,
Jiri Kovarik,
Kai Hoehlig,
Axel Vater,
Margret Eckhard,
Andy Sombke,
Nikolaus Fortelny,
Jörg Menche,
Sylvia Knapp,
Philipp Starkl.
Sci Immunol. 2025 Apr 4;10(106):eadp6231. doi: 10.1126/sciimmunol.adp6231. Epub 2025 Apr 4.
2025
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation
Teresa Neuwirth,
Daniel Malzl,
Katja Knapp,
Panagiota Tsokkou,
Lisa Kleissl,
Anna Gabriel,
Baerbel Reininger,
Christian Freystätter,
Nara Marella,
Ana P Kutschat,
Elisabeth Ponweiser,
Arvand Haschemi,
Davide Seruggia,
Jörg Menche,
Erwin F Wagner,
Georg Stary.
Immunity. 2025 Mar 11;58(3):632-647.e12. doi: 10.1016/j.immuni.2025.02.011. Epub 2025 Feb 28.
2024
Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia
Sabrina Grundtner,
Julia R Sondermann,
Feng Xian,
Daniel Malzl,
Daniel Segelcke,
Esther M Pogatzki-Zahn,
Jörg Menche,
David Gómez-Varela,
Manuela Schmidt.
Pharmacol Res. 2025 Jan;211:107552. doi: 10.1016/j.phrs.2024.107552. Epub 2024 Dec 16.
2024
Pan-cancer analysis of the interplay between mutational signatures and cellular signaling
Anna Hakobyan,
Mathilde Meyenberg,
Nelli Vardazaryan,
Joel Hancock,
Loan Vulliard,
Joanna I Loizou,
Jörg Menche.
iScience. 2024 May 2;27(6):109873. doi: 10.1016/j.isci.2024.109873. eCollection 2024 Jun 21.
2024
Network cartographs for interpretable visualizations
Christiane V R Hütter,
Celine Sin,
Felix Müller,
Jörg Menche.
Nat Comput Sci. 2022 Feb;2(2):84-89. doi: 10.1038/s43588-022-00199-z. Epub 2022 Feb 24.
2023
RIF1 regulates early replication timing in murine B cells
Daniel Malzl,
Mihaela Peycheva,
Ali Rahjouei,
Stefano Gnan,
Kyle N Klein,
Mariia Nazarova,
Ursula E Schoeberl,
David M Gilbert,
Sara C B Buonomo,
Michela Di Virgilio,
Tobias Neumann,
Rushad Pavri.
Nat Commun. 2023 Dec 11;14(1):8049. doi: 10.1038/s41467-023-43778-y.
2023
Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model
Alex Horánszky,
Bachuki Shashikadze,
Radwa Elkhateib,
Salvo Danilo Lombardo,
Federica Lamberto,
Melinda Zana,
Jörg Menche,
Thomas Fröhlich,
András Dinnyés.
Front Cell Dev Biol. 2023 Aug 16;11:1236243. doi: 10.3389/fcell.2023.1236243. eCollection 2023.
2023
Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients
Kumar Sharma,
Guanshi Zhang,
Jens Hansen,
Petter Bjornstad,
Hak Joo Lee,
Rajasree Menon,
Leila Hejazi,
Jian-Jun Liu,
Anthony Franzone,
Helen C Looker,
Byeong Yeob Choi,
Roman Fernandez,
Manjeri A Venkatachalam,
Luxcia Kugathasan,
Vikas S Sridhar,
Loki Natarajan,
Jing Zhang,
Varun S Sharma,
Brian Kwan,
Sushrut S Waikar,
Jonathan Himmelfarb,
Katherine R Tuttle,
Bryan Kestenbaum,
Tobias Fuhrer,
Harold I Feldman,
Ian H de Boer,
Fabio C Tucci,
John Sedor,
Hiddo Lambers Heerspink,
Jennifer Schaub,
Edgar A Otto,
Jeffrey B Hodgin,
Matthias Kretzler,
Christopher R Anderton,
Theodore Alexandrov,
David Cherney,
Su Chi Lim,
Robert G Nelson,
Jonathan Gelfond,
Ravi Iyengar,
Kidney Precision Medicine Project.
J Clin Invest. 2023 Oct 16;133(20):e170341. doi: 10.1172/JCI170341.
