The CeMM Proteomics and Metabolomics Facility (Pro-Met-) provides state-of-the-art technologies hosted in a specifically designed laboratory. The mass spectrometry laboratory has been designed to the highest standards with individual air-conditioned cubicles that ensure the highest quality of mass spectometry (MS)-based analysis with minimized impact of temperature variation or background chemical noise.
The instrument park consists of triple quadrupole MS systems as well as high-end Orbitrap-based MS instruments. The combination of mass spectrometers with ultra-high-performance liquid chromatography (UHPLC) and nanoflow liquid chromatography (nano-LC) enables unsurpassed performance in terms of flexibility of application, sensitivity and speed of analysis. The robust proteomic and metabolomic platforms incorporate modern industrial and academic concepts, i.e. quality control procedures and automated data processing pipelines. A highly skilled and motivated team is providing the service analysis with the goal to go beyond sample measurements and be an active part of your research quest.
André C. Müller
Head of the Proteomics and Metabolomics Facility
André C. Müller is an expert for various preoteomics tools both in academic and industrial settings. Currently he is responsible for maintanence of standard workflows as well as implementation of new tools for a wide range of proteomics applications. It can span from highly sensitive targeted assays to discovery approaches with comprehensive analyte coverage and sample throughput. Established standard workflows enable the determination of protein-protein interactions, drug-protein interactions, quantitative protein expression profiling and post-translational modifications in cell signalling pathways.
André C. Müller obtained his Master’s degree in biochemistry at the University of Cologne, Germany. He worked as an adjunct research associate in the Biocatalysis lab of Dr. Bettina Rosche at the School of Biotechnology and Biomolecular Sciences (BABS), University of New South Wales in Sydney, Australia before moving to Austria. André joined the mass spectrometry and proteomic research group of Dr. Keiryn Bennett in 2007 before joining the ‘Life Science and Mass Spectrometry’ based European Application Support Specialist team of Thermo Fisher Scientific. In June 2017, he returned to CeMM as head of the Proteomics and Metabolomics Facility.
Deputy Head for Metabolomics
Kristaps Klavins is an analytical chemist with a profound expertise in different mass spectrometry and separation techniques. His research focus for the last 7 years has been development of novel workflows for targeted metabolomics. As Deputy Head for Metabolomics, he and his team are developing workflows for the analysis of wide range metabolites and lipids in various biological systems. At the facility, targeted metabolite profiling approach is employed as it provides high selectivity, greater accuracy, reproducibility, and robustness. Moreover, it can be used for hypothesis generating or hypothesis testing studies. It should be noted that all established methods are suitable for high throughput analysis.
Kristaps Klavins studied Analytical Chemistry at the University of Latvia. He undertook his graduate studies with Gunda Koellensperger at University of Natural Resources and Life Sciences, Vienna followed by an analytical scientist and senior scientist positions in R&D Department at Biocrates Life Sciences. He joined CeMM in 2017.