The Metabolomics Facility at CeMM aims to provide highest quality metabolomics analyses on biological and biomedical research samples to its customers. This includes method development for detection and quantification of novel metabolites, systematic screening of established metabolites in the classes of amino acids, central carbon metabolism and TCA cycle metabolites, nucleotides, folates and lipids, and more focused analyses of selected metabolites. We aim to constantly develop and improve methods to more comprehensively cover the entire human metabolome and decrease the required sample amounts, while at the same time maintaining rigorous standards in data analysis and quantitation.
Thomas Hannich is a biochemist by training with a profound knowledge of different metabolomics workflows. Before joining CeMM, he studied the role of amino acids and lipids in development and disease. As Head for Metabolomics, he and his team develop workflows for the analysis of a wide range of metabolites and lipids in various biological systems. At the facility, they use a targeted metabolite profiling approach as it provides high selectivity, greater accuracy, reproducibility, and robustness. Moreover, it can be used for hypothesis generating or hypothesis testing studies. All established methods are suitable for high throughput analysis.
Thomas Hannich was fascinated by the chemistry of life since high school, which is the reason why he went on to study biochemistry in Tübingen and Munich (Germany). Combining genetics and biochemistry, he investigated SUMOylation in the Hochstrasser laboratory at Yale University (USA). During his thesis with Temo Kurzchalia at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden (Germany), and afterwards in Howard Riezman’s group at Geneva University (Switzerland), he developed lipidomics and metabolomics approaches to explore the role of metabolites in biology. In September 2020, he joined CeMM as Head of the Metabolomics Facility to help unravel novel functions of metabolites in health and disease.