CeMM Adjunct Principal Investigator
Precision Design Enabled by Organic Synthesis
Nuno Maulide has a broadly documented expertise in state-of-the-art innovations in organic synthesis. One of his research goals is translating the “precision design” that is enabled by synthesis, whereby modification and tailoring of organic molecules can be done with atomic precision, to the realm of biomedical research with an impact on medical practice. A showcase of these possibilities is an interest in “precision fluorination” of C-H bonds, with the vision of systematically exploiting such modifications in particular contexts, whereby the possible benefits shall be first interrogated using in silico techniques prior to actual synthesis. The Adjunct PI position at CeMM will allow close collaboration with pharmacologists, neuroscientists and molecular biologists and holds the promise for several new discoveries.
Nuno Maulide is a trained chemist. He underwent doctoral studies in the Université Catholique de Louvain and, in 2007, obtained his PhD under the supervision of Prof. István Markó, working on the application of functionalized orthoesters in organic synthesis. He then moved to Stanford University for a postdoctoral stay in the group of Prof. Barry Trost. Nuno started his independent career in 2009, when he was appointed group leader at the Max- Planck-Institut für Kohlenforschung in Mülheim an der Ruhr. In 2013, at age 33, he was appointed Full Professor of Organic Synthesis at the University of Vienna and is currently Head of the Institute of Organic Chemistry. He is the holder of an ERC Consolidator Grant (2017–2021) and an ERC Proof of Concept Grant (awarded 2018), after having held an ERC Starting Grant (2011–2016). Nuno also leads the Christian Doppler Laboratory for Entropy-Oriented Drug Design and was named “Austria’s Scientist of the Year 2018”. Nuno Maulide joined CeMM as Adjunct PI in November 2018 and has since been awarded the Ignaz L. Lieben Award of the Austrian Academy of Sciences (2019) as well as the 2020 Tetrahedron Young Investigator Award.
Kaiser D, et al. A general acid-mediated hydroaminomethylation of unactivated alkenes and alkynes. Angewandte Chemie International Edition 2019, 58, 14639-14643. Angewandte Chemie. 2019, 131, 14781-14785. (abstract)
Chen Y, et al. A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants. Journal of the American Chemical Society. 2019, 141, 13772-13777. (abstract)
Adler P, et al. α-Fluorination of carbonyls with nucleophilic fluorine. Nature Chemistry. 2019, 11, 329-334. (abstract)
Pauline Adler, Amandine Pons, Jing Li, Jörg Heider, Bogdan R. Brutiu and Nuno Maulide. Chemoselective Activation of Diethyl Phosphonates: A Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds. Angewandte Chemie International Edition 2018, Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13330-13334. (abstract)
Dainis Kaldre, Immo Klose and Nuno Maulide. Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge–accelerated sulfonium rearrangement. Science 2018, 361, 664–667. (abstract)
Daniel H. O' Donovan, Paul Aillard, Martin Berger, Aurélien de la Torre, Desislava Petkova, Christian Knittl-Frank, Danny Geerdink, Marcel Kaiser and Nuno Maulide. C−H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity. Angewandte Chemie International Edition 2018, 57, 10737–10741. Angewandte Chemie 2018, 130, 10897–10901. (abstract)
Aurélien de la Torre, Daniel Kaiser and Nuno Maulide. Flexible and Chemoselective Oxidation of Amides to α-Keto Amides and α-Hydroxy Amides. Journal of the American Chemical Society 2017, 139, 6578–6581. (abstract)
Lan-Gui Xie, Supaporn Niyomchon, Antonio J. Mota, Leticia Gonzalez and Nuno Maulide. Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles. Nature Communications 2016, 7, 10914. (abstract)