Publications

2022

CIDE-stepping E3s

Gary Tin, Georg E Winter.
Nat Chem Biol. 2023 Jan;19(1):3-4. doi: 10.1038/s41589-022-01217-x.
2022

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Alexander Hanzl, Ryan Casement, Hana Imrichova, Scott J Hughes, Eleonora Barone, Andrea Testa, Sophie Bauer, Jane Wright, Matthias Brand, Alessio Ciulli, Georg E Winter.
Nat Chem Biol. 2023 Mar;19(3):323-333. doi: 10.1038/s41589-022-01177-2. Epub 2022 Nov 3.
2022

BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia

Barbara Peter, Gregor Eisenwort, Irina Sadovnik, Karin Bauer, Michael Willmann, Thomas Rülicke, Daniela Berger, Gabriele Stefanzl, Georg Greiner, Gregor Hoermann, Alexandra Keller, Dominik Wolf, Martin Čulen, Georg E Winter, Thomas Hoffmann, Ana-Iris Schiefer, Wolfgang R Sperr, Johannes Zuber, Jiří Mayer, Peter Valent.
Am J Hematol. 2022 Sep;97(9):1215-1225. doi: 10.1002/ajh.26650. Epub 2022 Jul 18.
2021

Target 2035 - update on the quest for a probe for every protein.

Müller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell JB, Beck H, Beedie S, Betz UAK, Bezerra GA, Brennan PE, Brown D, Brown PJ, Bullock AN, Carter AJ, Chaikuad A, Chaineau M, Ciulli A, Collins I, Dreher J, Drewry D, Edfeldt K, Edwards AM, Egner U, Frye SV, Fuchs SM, Hall MD, Hartung IV, Hillisch A, Hitchcock SH, Homan E, Kannan N, Kiefer JR, Knapp S, Kostic M, Kubicek S, Leach AR, Lindemann S, Marsden BD, Matsui H, Meier JL, Merk D, Michel M, Morgan MR, Mueller-Fahrnow A, Owen DR, Perry BG, Rosenberg SH, Saikatendu KS, Schapira M, Scholten C, Sharma S, Simeonov A, Sundström M, Superti-Furga G, Todd MH, Tredup C, Vedadi M, von Delft F, Willson TM, Winter GE, Workman P, Arrowsmith CH.
RSC Med Chem. 2021 Dec 3;13(1):13-21. doi: 10.1039/d1md00228g. eCollection 2022 Jan 27.
2021

The 2(nd) Alpine Winter Conference on Medicinal and Synthetic Chemistry.

Ciulli A, Hamann L, Jahnke W, Kalgutkar AS, Magauer T, Ritter T, Steadman V, Williams SD, Winter G, Hoegenauer K, Krawinkler KH, Stepan AF.
ChemMedChem. 2021 Aug 5;16(15):2417-2423. doi: 10.1002/cmdc.202100372. Epub 2021 Jun 10.
2021

Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.

Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P..
Mol Cell. 2021 Aug 5;81(15):3096-3109.e8. doi: 10.1016/j.molcel.2021.05.028. Epub 2021 Jun 18.
2022

Target 2035 - update on the quest for a probe for every protein

Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Jonathan B Baell, Hartmut Beck, Shaunna Beedie, Ulrich A K Betz, Gustavo Arruda Bezerra, Paul E Brennan, David Brown, Peter J Brown, Alex N Bullock, Adrian J Carter, Apirat Chaikuad, Mathilde Chaineau, Alessio Ciulli, Ian Collins, Jan Dreher, David Drewry, Kristina Edfeldt, Aled M Edwards, Ursula Egner, Stephen V Frye, Stephen M Fuchs, Matthew D Hall, Ingo V Hartung, Alexander Hillisch, Stephen H Hitchcock, Evert Homan, Natarajan Kannan, James R Kiefer, Stefan Knapp, Milka Kostic, Stefan Kubicek, Andrew R Leach, Sven Lindemann, Brian D Marsden, Hisanori Matsui, Jordan L Meier, Daniel Merk, Maurice Michel, Maxwell R Morgan, Anke Mueller-Fahrnow, Dafydd R Owen, Benjamin G Perry, Saul H Rosenberg, Kumar Singh Saikatendu, Matthieu Schapira, Cora Scholten, Sujata Sharma, Anton Simeonov, Michael Sundström, Giulio Superti-Furga, Matthew H Todd, Claudia Tredup, Masoud Vedadi, Frank von Delft, Timothy M Willson, Georg E Winter, Paul Workman, Cheryl H Arrowsmith.
RSC Med Chem. 2021 Dec 3;13(1):13-21. doi: 10.1039/d1md00228g. eCollection 2022 Jan 27.
2020

Targeted protein degradation: current and future challenges.

Hanzl A, Winter GE.
Curr Opin Chem Biol. 2020 Jun;56:35-41. doi: 10.1016/j.cbpa.2019.11.012. Epub 2020 Jan 2. PMID: 31901786.
2020

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis.

Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G.
Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7.
2020

Selective Mediator dependence of cell-type-specifying transcription.

Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GE.
Nat Genet. 2020 Jul;52(7):719-727. doi: 10.1038/s41588-020-0635-0. Epub 2020 Jun 1.