Publications
2023
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling
Amanda Ng,
Fabian Offensperger,
Jose A Cisneros,
Natalie S Scholes,
Monika Malik,
Ludovica Villanti,
Andrea Rukavina,
Evandro Ferrada,
J Thomas Hannich,
Anna Koren,
Stefan Kubicek,
Giulio Superti-Furga,
Georg E Winter.
ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21.
2023
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Gang Xue,
Jianing Xie,
Matthias Hinterndorfer,
Marko Cigler,
Lara Dötsch,
Hana Imrichova,
Philipp Lampe,
Xiufen Cheng,
Soheila Rezaei Adariani,
Georg E Winter,
Herbert Waldmann.
Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6.
2023
Proximity-inducing pharmacology
Georg E Winter,
Cristina Mayor-Ruiz.
Nat Chem Biol. 2024 Jan;20(1):13-14. doi: 10.1038/s41589-023-01492-2.
2023
Design principles for cyclin K molecular glue degraders
Zuzanna Kozicka,
Dakota J Suchyta,
Vivian Focht,
Georg Kempf,
Georg Petzold,
Marius Jentzsch,
Charles Zou,
Cristina Di Genua,
Katherine A Donovan,
Seemon Coomar,
Marko Cigler,
Cristina Mayor-Ruiz,
Jonathan L Schmid-Burgk,
Daniel Häussinger,
Georg E Winter,
Eric S Fischer,
Mikołaj Słabicki,
Dennis Gillingham,
Benjamin L Ebert,
Nicolas H Thomä.
Nat Chem Biol. 2024 Jan;20(1):93-102. doi: 10.1038/s41589-023-01409-z. Epub 2023 Sep 7.
2023
Pharmacological perturbation of the phase-separating protein SMNDC1
Lennart Enders,
Marton Siklos,
Jan Borggräfe,
Stefan Gaussmann,
Anna Koren,
Monika Malik,
Tatjana Tomek,
Michael Schuster,
Jiří Reiniš,
Elisa Hahn,
Andrea Rukavina,
Andreas Reicher,
Tamara Casteels,
Christoph Bock,
Georg E Winter,
J Thomas Hannich,
Michael Sattler,
Stefan Kubicek.
Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0.
2023
Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence
Miquel Duran-Frigola,
Marko Cigler,
Georg E Winter.
J Am Chem Soc. 2023 Feb 8;145(5):2711-2732. doi: 10.1021/jacs.2c11098. Epub 2023 Jan 27.
2023
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance
Alexander Hanzl,
Eleonora Barone,
Sophie Bauer,
Hong Yue,
Radosław P Nowak,
Elisa Hahn,
Eugenia V Pankevich,
Anna Koren,
Stefan Kubicek,
Eric S Fischer,
Georg E Winter.
J Am Chem Soc. 2023 Jan 18;145(2):1176-1184. doi: 10.1021/jacs.2c10784. Epub 2023 Jan 5.
2022
CIDE-stepping E3s
Gary Tin,
Georg E Winter.
Nat Chem Biol. 2023 Jan;19(1):3-4. doi: 10.1038/s41589-022-01217-x.
2022
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Alexander Hanzl,
Ryan Casement,
Hana Imrichova,
Scott J Hughes,
Eleonora Barone,
Andrea Testa,
Sophie Bauer,
Jane Wright,
Matthias Brand,
Alessio Ciulli,
Georg E Winter.
Nat Chem Biol. 2023 Mar;19(3):323-333. doi: 10.1038/s41589-022-01177-2. Epub 2022 Nov 3.
2022
BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia
Barbara Peter,
Gregor Eisenwort,
Irina Sadovnik,
Karin Bauer,
Michael Willmann,
Thomas Rülicke,
Daniela Berger,
Gabriele Stefanzl,
Georg Greiner,
Gregor Hoermann,
Alexandra Keller,
Dominik Wolf,
Martin Čulen,
Georg E Winter,
Thomas Hoffmann,
Ana-Iris Schiefer,
Wolfgang R Sperr,
Johannes Zuber,
Jiří Mayer,
Peter Valent.
Am J Hematol. 2022 Sep;97(9):1215-1225. doi: 10.1002/ajh.26650. Epub 2022 Jul 18.
