Publications
2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Fabian Offensperger,
Gary Tin,
Miquel Duran-Frigola,
Elisa Hahn,
Sarah Dobner,
Christopher W Am Ende,
Joseph W Strohbach,
Andrea Rukavina,
Vincenth Brennsteiner,
Kevin Ogilvie,
Nara Marella,
Katharina Kladnik,
Rodolfo Ciuffa,
Jaimeen D Majmudar,
S Denise Field,
Ariel Bensimon,
Luca Ferrari,
Evandro Ferrada,
Amanda Ng,
Zhechun Zhang,
Gianluca Degliesposti,
Andras Boeszoermenyi,
Sascha Martens,
Robert Stanton,
André C Müller,
J Thomas Hannich,
David Hepworth,
Giulio Superti-Furga,
Stefan Kubicek,
Monica Schenone,
Georg E Winter.
Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
2024
Targeted protein degradation via intramolecular bivalent glues
Oliver Hsia,
Matthias Hinterndorfer,
Angus D Cowan,
Kentaro Iso,
Tasuku Ishida,
Ramasubramanian Sundaramoorthy,
Mark A Nakasone,
Hana Imrichova,
Caroline Schätz,
Andrea Rukavina,
Koraljka Husnjak,
Martin Wegner,
Alejandro Correa-Sáez,
Conner Craigon,
Ryan Casement,
Chiara Maniaci,
Andrea Testa,
Manuel Kaulich,
Ivan Dikic,
Georg E Winter,
Alessio Ciulli.
Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21.
2023
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Bárbara M G Barbosa,
Aikaterini Sfyaki,
Sergi Rafael,
Ferran José-Duran,
Joan Pous,
Carolina Sánchez-Zarzalejo,
Carles Perez-Lopez,
Mar Vilanova,
Marko Cigler,
Marina Gay,
Marta Vilaseca,
Georg E Winter,
Antoni Riera,
Cristina Mayor-Ruiz.
Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202316730. doi: 10.1002/anie.202316730. Epub 2024 Jan 18.
2023
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling
Amanda Ng,
Fabian Offensperger,
Jose A Cisneros,
Natalie S Scholes,
Monika Malik,
Ludovica Villanti,
Andrea Rukavina,
Evandro Ferrada,
J Thomas Hannich,
Anna Koren,
Stefan Kubicek,
Giulio Superti-Furga,
Georg E Winter.
ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21.
2023
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Gang Xue,
Jianing Xie,
Matthias Hinterndorfer,
Marko Cigler,
Lara Dötsch,
Hana Imrichova,
Philipp Lampe,
Xiufen Cheng,
Soheila Rezaei Adariani,
Georg E Winter,
Herbert Waldmann.
Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6.
2023
Proximity-inducing pharmacology
Georg E Winter,
Cristina Mayor-Ruiz.
Nat Chem Biol. 2024 Jan;20(1):13-14. doi: 10.1038/s41589-023-01492-2.
2023
Design principles for cyclin K molecular glue degraders
Zuzanna Kozicka,
Dakota J Suchyta,
Vivian Focht,
Georg Kempf,
Georg Petzold,
Marius Jentzsch,
Charles Zou,
Cristina Di Genua,
Katherine A Donovan,
Seemon Coomar,
Marko Cigler,
Cristina Mayor-Ruiz,
Jonathan L Schmid-Burgk,
Daniel Häussinger,
Georg E Winter,
Eric S Fischer,
Mikołaj Słabicki,
Dennis Gillingham,
Benjamin L Ebert,
Nicolas H Thomä.
Nat Chem Biol. 2024 Jan;20(1):93-102. doi: 10.1038/s41589-023-01409-z. Epub 2023 Sep 7.
2023
Pharmacological perturbation of the phase-separating protein SMNDC1
Lennart Enders,
Marton Siklos,
Jan Borggräfe,
Stefan Gaussmann,
Anna Koren,
Monika Malik,
Tatjana Tomek,
Michael Schuster,
Jiří Reiniš,
Elisa Hahn,
Andrea Rukavina,
Andreas Reicher,
Tamara Casteels,
Christoph Bock,
Georg E Winter,
J Thomas Hannich,
Michael Sattler,
Stefan Kubicek.
Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0.
2023
Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence
Miquel Duran-Frigola,
Marko Cigler,
Georg E Winter.
J Am Chem Soc. 2023 Feb 8;145(5):2711-2732. doi: 10.1021/jacs.2c11098. Epub 2023 Jan 27.
2023
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance
Alexander Hanzl,
Eleonora Barone,
Sophie Bauer,
Hong Yue,
Radosław P Nowak,
Elisa Hahn,
Eugenia V Pankevich,
Anna Koren,
Stefan Kubicek,
Eric S Fischer,
Georg E Winter.
J Am Chem Soc. 2023 Jan 18;145(2):1176-1184. doi: 10.1021/jacs.2c10784. Epub 2023 Jan 5.
