Publications
2024
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs
Georg E Winter.
ACS Chem Biol. 2024 Oct 18;19(10):2089-2102. doi: 10.1021/acschembio.4c00191. Epub 2024 Sep 12.
2024
Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857. doi: 10.1101/2024.07.10.602857.
2024
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
Chrysanthi Kagiou,
Jose A Cisneros,
Jakob Farnung,
Joanna Liwocha,
Fabian Offensperger,
Kevin Dong,
Ka Yang,
Gary Tin,
Christina S Horstmann,
Matthias Hinterndorfer,
Joao A Paulo,
Natalie S Scholes,
Juan Sanchez Avila,
Michaela Fellner,
Florian Andersch,
J Thomas Hannich,
Johannes Zuber,
Stefan Kubicek,
Steven P Gygi,
Brenda A Schulman,
Georg E Winter.
Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3.
2024
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Nianzhe He,
Laura Depta,
Cecilia Rossetti,
Lucie Caramelle,
Marko Cigler,
Hogan P Bryce-Rogers,
Marine Michon,
Oliver Rafn Dan,
Joseph Hoock,
Julien Barbier,
Daniel Gillet,
Alison Forrester,
Georg E Winter,
Luca Laraia.
Nat Chem Biol. 2025 Feb;21(2):203-214. doi: 10.1038/s41589-024-01653-x. Epub 2024 Jun 21.
2024
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Marko Cigler,
Hana Imrichova,
Fabian Frommelt,
Lucie Caramelle,
Laura Depta,
Andrea Rukavina,
Chrysanthi Kagiou,
J Thomas Hannich,
Cristina Mayor-Ruiz,
Giulio Superti-Furga,
Sonja Sievers,
Alison Forrester,
Luca Laraia,
Herbert Waldmann,
Georg E Winter.
Nat Chem Biol. 2025 Feb;21(2):193-202. doi: 10.1038/s41589-024-01614-4. Epub 2024 Jun 21.
2024
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins
Gary Tin,
Marko Cigler,
Matthias Hinterndorfer,
Kevin D Dong,
Hana Imrichova,
Steven P Gygi,
Georg E Winter.
Bioorg Med Chem Lett. 2024 Jul 15;107:129779. doi: 10.1016/j.bmcl.2024.129779. Epub 2024 May 9.
2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Fabian Offensperger,
Gary Tin,
Miquel Duran-Frigola,
Elisa Hahn,
Sarah Dobner,
Christopher W Am Ende,
Joseph W Strohbach,
Andrea Rukavina,
Vincenth Brennsteiner,
Kevin Ogilvie,
Nara Marella,
Katharina Kladnik,
Rodolfo Ciuffa,
Jaimeen D Majmudar,
S Denise Field,
Ariel Bensimon,
Luca Ferrari,
Evandro Ferrada,
Amanda Ng,
Zhechun Zhang,
Gianluca Degliesposti,
Andras Boeszoermenyi,
Sascha Martens,
Robert Stanton,
André C Müller,
J Thomas Hannich,
David Hepworth,
Giulio Superti-Furga,
Stefan Kubicek,
Monica Schenone,
Georg E Winter.
Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
2024
Targeted protein degradation via intramolecular bivalent glues
Oliver Hsia,
Matthias Hinterndorfer,
Angus D Cowan,
Kentaro Iso,
Tasuku Ishida,
Ramasubramanian Sundaramoorthy,
Mark A Nakasone,
Hana Imrichova,
Caroline Schätz,
Andrea Rukavina,
Koraljka Husnjak,
Martin Wegner,
Alejandro Correa-Sáez,
Conner Craigon,
Ryan Casement,
Chiara Maniaci,
Andrea Testa,
Manuel Kaulich,
Ivan Dikic,
Georg E Winter,
Alessio Ciulli.
Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21.
2023
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Bárbara M G Barbosa,
Aikaterini Sfyaki,
Sergi Rafael,
Ferran José-Duran,
Joan Pous,
Carolina Sánchez-Zarzalejo,
Carles Perez-Lopez,
Mar Vilanova,
Marko Cigler,
Marina Gay,
Marta Vilaseca,
Georg E Winter,
Antoni Riera,
Cristina Mayor-Ruiz.
Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202316730. doi: 10.1002/anie.202316730. Epub 2024 Jan 18.
2023
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling
Amanda Ng,
Fabian Offensperger,
Jose A Cisneros,
Natalie S Scholes,
Monika Malik,
Ludovica Villanti,
Andrea Rukavina,
Evandro Ferrada,
J Thomas Hannich,
Anna Koren,
Stefan Kubicek,
Giulio Superti-Furga,
Georg E Winter.
ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21.
