Publications
2023
A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
Andras Boeszoermenyi,
Léa Bernaleau,
Xudong Chen,
Felix Kartnig,
Min Xie,
Haobo Zhang,
Sensen Zhang,
Maeva Delacrétaz,
Anna Koren,
Ann-Katrin Hopp,
Vojtech Dvorak,
Stefan Kubicek,
Daniel Aletaha,
Maojun Yang,
Manuele Rebsamen,
Leonhard X Heinz,
Giulio Superti-Furga.
Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3.
2023
Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
Xudong Chen,
Min Xie,
Sensen Zhang,
Marta Monguió-Tortajada,
Jian Yin,
Chang Liu,
Youqi Zhang,
Maeva Delacrétaz,
Mingyue Song,
Yixue Wang,
Lin Dong,
Qiang Ding,
Boda Zhou,
Xiaolin Tian,
Haiteng Deng,
Lina Xu,
Xiaohui Liu,
Zi Yang,
Qing Chang,
Jie Na,
Wenwen Zeng,
Giulio Superti-Furga,
Manuele Rebsamen,
Maojun Yang.
Nat Commun. 2023 Oct 20;14(1):6627. doi: 10.1038/s41467-023-42210-9.
2023
Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels
Anka Güldenpfennig,
Ann-Katrin Hopp,
Lukas Muskalla,
Patrick Manetsch,
Fabio Raith,
Lars Hellweg,
Cyril Dördelmann,
Deena M Leslie Pedrioli,
Kai Johnsson,
Giulio Superti-Furga,
Michael O Hottiger.
Nucleic Acids Res. 2023 Sep 22;51(17):9248-9265. doi: 10.1093/nar/gkad659.
2023
Structural and functional annotation of solute carrier transporters: implication for drug discovery
Vojtech Dvorak,
Giulio Superti-Furga.
Expert Opin Drug Discov. 2023 Jul-Dec;18(10):1099-1115. doi: 10.1080/17460441.2023.2244760. Epub 2023 Aug 10.
2023
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
Vojtech Dvorak,
Andrea Casiraghi,
Claire Colas,
Anna Koren,
Tatjana Tomek,
Fabian Offensperger,
Andrea Rukavina,
Gary Tin,
Elisa Hahn,
Sarah Dobner,
Fabian Frommelt,
Andras Boeszoermenyi,
Viktoriia Bernada,
J Thomas Hannich,
Gerhard F Ecker,
Georg E Winter,
Stefan Kubicek,
Giulio Superti-Furga.
Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28.
2023
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma
Hamed Alborzinia,
Zhiyi Chen,
Umut Yildiz,
Florencio Porto Freitas,
Felix C E Vogel,
Julianna Patricia Varga,
Jasmin Batani,
Christoph Bartenhagen,
Werner Schmitz,
Gabriele Büchel,
Bernhard Michalke,
Jashuo Zheng,
Svenja Meierjohann,
Enrico Girardi,
Elisa Espinet,
Andrés F Flórez,
Ancely Ferreira Dos Santos,
Nesrine Aroua,
Tasneem Cheytan,
Julie Haenlin,
Lisa Schlicker,
Thamara N Xavier da Silva,
Adriana Przybylla,
Petra Zeisberger,
Giulio Superti-Furga,
Martin Eilers,
Marcus Conrad,
Marietta Fabiano,
Ulrich Schweizer,
Matthias Fischer,
Almut Schulze,
Andreas Trumpp,
José Pedro Friedmann Angeli.
EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12.
2023
Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis
Maximilian Kugler,
Mirjam Dellinger,
Felix Kartnig,
Lena Müller,
Teresa Preglej,
Leonhard X Heinz,
Elisabeth Simader,
Lisa Göschl,
Stephan E Puchner,
Sebastian Weiss,
Lisa E Shaw,
Matthias Farlik,
Wolfgang Weninger,
Giulio Superti-Furga,
Josef S Smolen,
Guenter Steiner,
Daniel Aletaha,
Hans P Kiener,
Myles J Lewis,
Costantino Pitzalis,
Anela Tosevska,
Thomas Karonitsch,
Michael Bonelli.
Ann Rheum Dis. 2023 Sep;82(9):1142-1152. doi: 10.1136/ard-2022-223396. Epub 2023 Jun 21.
2023
Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
Domagoj Cikes,
Kareem Elsayad,
Erdinc Sezgin,
Erika Koitai,
Ferenc Torma,
Michael Orthofer,
Rebecca Yarwood,
Leonhard X Heinz,
Vitaly Sedlyarov,
Nasser Darwish Miranda,
Adrian Taylor,
Sophie Grapentine,
Fathiya Al-Murshedi,
Anne Abot,
Adelheid Weidinger,
Candice Kutchukian,
Colline Sanchez,
Shane J F Cronin,
Maria Novatchkova,
Anoop Kavirayani,
Thomas Schuetz,
Bernhard Haubner,
Lisa Haas,
Astrid Hagelkruys,
Suzanne Jackowski,
Andrey V Kozlov,
Vincent Jacquemond,
Claude Knauf,
Giulio Superti-Furga,
Eric Rullman,
Thomas Gustafsson,
John McDermot,
Martin Lowe,
Zsolt Radak,
Jeffrey S Chamberlain,
Marica Bakovic,
Siddharth Banka,
Josef M Penninger.
Nat Metab. 2023 Apr;5(4):711. doi: 10.1038/s42255-023-00791-1.
2023
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
Domagoj Cikes,
Kareem Elsayad,
Erdinc Sezgin,
Erika Koitai,
Ferenc Torma,
Michael Orthofer,
Rebecca Yarwood,
Leonhard X Heinz,
Vitaly Sedlyarov,
Nasser Darwish Miranda,
Adrian Taylor,
Sophie Grapentine,
Fathiya Al-Murshedi,
Anne Abot,
Adelheid Weidinger,
Candice Kutchukian,
Colline Sanchez,
Shane J F Cronin,
Maria Novatchkova,
Anoop Kavirayani,
Thomas Schuetz,
Bernhard Haubner,
Lisa Haas,
Astrid Hagelkruys,
Suzanne Jackowski,
Andrey V Kozlov,
Vincent Jacquemond,
Claude Knauf,
Giulio Superti-Furga,
Eric Rullman,
Thomas Gustafsson,
John McDermot,
Martin Lowe,
Zsolt Radak,
Jeffrey S Chamberlain,
Marica Bakovic,
Siddharth Banka,
Josef M Penninger.
Nat Metab. 2023 Mar;5(3):495-515. doi: 10.1038/s42255-023-00766-2. Epub 2023 Mar 20.
2023
A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
Patrick Essletzbichler,
Vitaly Sedlyarov,
Fabian Frommelt,
Didier Soulat,
Leonhard X Heinz,
Adrijana Stefanovic,
Benedikt Neumayer,
Giulio Superti-Furga.
Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr.
