Publications
2025
The genetic interaction map of the human solute carrier superfamily
Gernot Wolf,
Philipp Leippe,
Svenja Onstein,
Ulrich Goldmann,
Fabian Frommelt,
Shao Thing Teoh,
Enrico Girardi,
Tabea Wiedmer,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):531-559. doi: 10.1038/s44320-025-00105-5. Epub 2025 May 12.
2025
Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell
Wen-An Wang,
Andrea Garofoli,
Evandro Ferrada,
Christoph Klimek,
Barbara Steurer,
Alvaro Ingles-Prieto,
Tanja Osthushenrich,
Aidan MacNamara,
Anders Malarstig,
Tabea Wiedmer,
Giulio Superti-Furga.
Life Sci Alliance. 2025 Jan 30;8(4):e202403028. doi: 10.26508/lsa.202403028. Print 2025 Apr.
2025
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Huanyu Z Li,
Ashley C W Pike,
Yung-Ning Chang,
Dheeraj Prakaash,
Zuzana Gelova,
Josefina Stanka,
Christophe Moreau,
Hannah C Scott,
Frank Wunder,
Gernot Wolf,
Andreea Scacioc,
Gavin McKinley,
Helena Batoulis,
Shubhashish Mukhopadhyay,
Andrea Garofoli,
Adán Pinto-Fernández,
Benedikt M Kessler,
Nicola A Burgess-Brown,
Saša Štefanić,
Tabea Wiedmer,
Katharina L Dürr,
Vera Puetter,
Alexander Ehrmann,
Syma Khalid,
Alvaro Ingles-Prieto,
Giulio Superti-Furga,
David B Sauer.
Nat Commun. 2025 Jan 16;16(1):721. doi: 10.1038/s41467-025-55942-7.
2025
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Gernot Wolf,
Conner Craigon,
Shao Thing Teoh,
Patrick Essletzbichler,
Svenja Onstein,
Diane Cassidy,
Esther C H Uijttewaal,
Vojtech Dvorak,
Yuting Cao,
Ariel Bensimon,
Ulrich Elling,
Alessio Ciulli,
Giulio Superti-Furga.
Cell Chem Biol. 2025 Feb 20;32(2):291-306.e6. doi: 10.1016/j.chembiol.2024.11.009. Epub 2025 Jan 3.
2024
Ex vivo imaging-based high content phenotyping of patients with rheumatoid arthritis
Felix Kartnig,
Michael Bonelli,
Ulrich Goldmann,
Noemi Mészáros,
Nikolaus Krall,
Daniel Aletaha,
Leonhard X Heinz,
Giulio Superti-Furga.
EBioMedicine. 2025 Jan;111:105522. doi: 10.1016/j.ebiom.2024.105522. Epub 2024 Dec 26.
2024
Membrane transporters modulating the toxicity of arsenic, cadmium, and mercury in human cells
Andrè Ferdigg,
Ann-Katrin Hopp,
Gernot Wolf,
Giulio Superti-Furga.
Life Sci Alliance. 2024 Nov 22;8(2):e202402866. doi: 10.26508/lsa.202402866. Print 2025 Feb.
2024
Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex
Sophie Piech,
Sven Brüschweiler,
Josepha Westphalen,
Katharina M Siess,
Julio García Murias,
Robert Konrat,
Johannes W Bigenzahn,
Giulio Superti-Furga.
ACS Chem Biol. 2024 Sep 20;19(9):1942-1952. doi: 10.1021/acschembio.4c00077. Epub 2024 Aug 28.
2024
Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist
Philipp Leippe,
Prashant Donthamsetti,
Tongil Ko,
Cherise Stanley,
Ehud Isacoff,
Dirk Trauner.
Angew Chem Int Ed Engl. 2024 Dec 2;63(49):e202411181. doi: 10.1002/anie.202411181. Epub 2024 Oct 29.
2024
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily
Daniela Digles,
Alvaro Ingles-Prieto,
Vojtech Dvorak,
Tamara A M Mocking,
Ulrich Goldmann,
Andrea Garofoli,
Evert J Homan,
Alberto Di Silvio,
Lucia Azzollini,
Francesca Sassone,
Mario Fogazza,
Felix Bärenz,
Antje Pommereau,
Yasmin Zuschlag,
Jasper F Ooms,
Jeppe Tranberg-Jensen,
Jesper S Hansen,
Josefina Stanka,
Hubert J Sijben,
Helena Batoulis,
Eckhard Bender,
Riccardo Martini,
Adriaan P IJzerman,
David B Sauer,
Laura H Heitman,
Vania Manolova,
Juergen Reinhardt,
Alexander Ehrmann,
Philipp Leippe,
Gerhard F Ecker,
Kilian V M Huber,
Thomas Licher,
Lia Scarabottolo,
Tabea Wiedmer,
Giulio Superti-Furga.
Front Pharmacol. 2024 Jul 9;15:1401599. doi: 10.3389/fphar.2024.1401599. eCollection 2024.
2024
Correction: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity
Marcello Polesel,
Alvaro Ingles-Prieto,
Eirini Christodoulaki,
Evandro Ferrada,
Cédric Doucerain,
Patrick Altermatt,
Michelle Knecht,
Michael Kuhn,
Anna-Lena Steck,
Maria Wilhelm,
Vania Manolova.
Biometals. 2024 Aug;37(4):1037-1038. doi: 10.1007/s10534-024-00615-z.
