Publications
2025
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Gernot Wolf,
Conner Craigon,
Shao Thing Teoh,
Patrick Essletzbichler,
Svenja Onstein,
Diane Cassidy,
Esther C H Uijttewaal,
Vojtech Dvorak,
Yuting Cao,
Ariel Bensimon,
Ulrich Elling,
Alessio Ciulli,
Giulio Superti-Furga.
Cell Chem Biol. 2025 Feb 20;32(2):291-306.e6. doi: 10.1016/j.chembiol.2024.11.009. Epub 2025 Jan 3.
2024
Ex vivo imaging-based high content phenotyping of patients with rheumatoid arthritis
Felix Kartnig,
Michael Bonelli,
Ulrich Goldmann,
Noemi Mészáros,
Nikolaus Krall,
Daniel Aletaha,
Leonhard X Heinz,
Giulio Superti-Furga.
EBioMedicine. 2025 Jan;111:105522. doi: 10.1016/j.ebiom.2024.105522. Epub 2024 Dec 26.
2024
Membrane transporters modulating the toxicity of arsenic, cadmium, and mercury in human cells
Andrè Ferdigg,
Ann-Katrin Hopp,
Gernot Wolf,
Giulio Superti-Furga.
Life Sci Alliance. 2024 Nov 22;8(2):e202402866. doi: 10.26508/lsa.202402866. Print 2025 Feb.
2024
Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex
Sophie Piech,
Sven Brüschweiler,
Josepha Westphalen,
Katharina M Siess,
Julio García Murias,
Robert Konrat,
Johannes W Bigenzahn,
Giulio Superti-Furga.
ACS Chem Biol. 2024 Sep 20;19(9):1942-1952. doi: 10.1021/acschembio.4c00077. Epub 2024 Aug 28.
2024
Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist
Philipp Leippe,
Prashant Donthamsetti,
Tongil Ko,
Cherise Stanley,
Ehud Isacoff,
Dirk Trauner.
Angew Chem Int Ed Engl. 2024 Dec 2;63(49):e202411181. doi: 10.1002/anie.202411181. Epub 2024 Oct 29.
2024
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily
Daniela Digles,
Alvaro Ingles-Prieto,
Vojtech Dvorak,
Tamara A M Mocking,
Ulrich Goldmann,
Andrea Garofoli,
Evert J Homan,
Alberto Di Silvio,
Lucia Azzollini,
Francesca Sassone,
Mario Fogazza,
Felix Bärenz,
Antje Pommereau,
Yasmin Zuschlag,
Jasper F Ooms,
Jeppe Tranberg-Jensen,
Jesper S Hansen,
Josefina Stanka,
Hubert J Sijben,
Helena Batoulis,
Eckhard Bender,
Riccardo Martini,
Adriaan P IJzerman,
David B Sauer,
Laura H Heitman,
Vania Manolova,
Juergen Reinhardt,
Alexander Ehrmann,
Philipp Leippe,
Gerhard F Ecker,
Kilian V M Huber,
Thomas Licher,
Lia Scarabottolo,
Tabea Wiedmer,
Giulio Superti-Furga.
Front Pharmacol. 2024 Jul 9;15:1401599. doi: 10.3389/fphar.2024.1401599. eCollection 2024.
2024
Correction: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity
Marcello Polesel,
Alvaro Ingles-Prieto,
Eirini Christodoulaki,
Evandro Ferrada,
Cédric Doucerain,
Patrick Altermatt,
Michelle Knecht,
Michael Kuhn,
Anna-Lena Steck,
Maria Wilhelm,
Vania Manolova.
Biometals. 2024 Aug;37(4):1037-1038. doi: 10.1007/s10534-024-00615-z.
2024
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Marko Cigler,
Hana Imrichova,
Fabian Frommelt,
Lucie Caramelle,
Laura Depta,
Andrea Rukavina,
Chrysanthi Kagiou,
J Thomas Hannich,
Cristina Mayor-Ruiz,
Giulio Superti-Furga,
Sonja Sievers,
Alison Forrester,
Luca Laraia,
Herbert Waldmann,
Georg E Winter.
Nat Chem Biol. 2025 Feb;21(2):193-202. doi: 10.1038/s41589-024-01614-4. Epub 2024 Jun 21.
2024
Protein Binder Toolbox for Studies of Solute Carrier Transporters
Zuzana Gelová,
Alvaro Ingles-Prieto,
Tina Bohstedt,
Fabian Frommelt,
Gamma Chi,
Yung-Ning Chang,
Julio Garcia,
Gernot Wolf,
Lucia Azzollini,
Sara Tremolada,
Andreea Scacioc,
Jesper S Hansen,
Iciar Serrano,
Aida Droce,
Jenifer Cuesta Bernal,
Nicola A Burgess-Brown,
Elisabeth P Carpenter,
Katharina L Dürr,
Peter Kristensen,
Eric R Geertsma,
Saša Štefanić,
Lia Scarabottolo,
Tabea Wiedmer,
Vera Puetter,
David B Sauer,
Giulio Superti-Furga.
J Mol Biol. 2024 Aug 15;436(16):168665. doi: 10.1016/j.jmb.2024.168665. Epub 2024 Jun 13.
2024
Development of a live cell assay for the zinc transporter ZnT8
Lucia Azzollini,
Dolores Del Prete,
Gernot Wolf,
Christoph Klimek,
Mattia Saggioro,
Fernanda Ricci,
Eirini Christodoulaki,
Tabea Wiedmer,
Alvaro Ingles-Prieto,
Giulio Superti-Furga,
Lia Scarabottolo.
SLAS Discov. 2024 Jul;29(5):100166. doi: 10.1016/j.slasd.2024.100166. Epub 2024 Jun 5.
