Publications
2026
Solute carrier membrane transporters: emerging targets in CNS disorders
Yee Kwan Law,
Selene Glück,
Enrico Girardi,
Ariel Bensimon,
S Andreas Angermayr,
Giulio Superti-Furga.
Nat Rev Drug Discov. 2026 Sep 1. doi: 10.1038/s41573-026-01513-4. Online ahead of print.
2026
Leukemia risk factor ARID5B coordinates HDAC-mediated transcriptional repression
Ana P Kutschat,
Fabian Frommelt,
Brianda L Santini,
Sophie Müller,
Paul Batty,
Animesh Awasthi,
Gerlinde Karbon,
Giulio Superti-Furga,
Davide Seruggia.
Nucleic Acids Res. 2026 Jun 22;54(12):gkag628. doi: 10.1093/nar/gkag628.
2026
Need for speed: advances in the era of high throughput interaction proteomics
Fabian Frommelt,
Uliana Federico,
Ruedi Aebersold,
Andrea Fossati.
Mol Omics. 2026 Mar 6;22(2):aaiag012. doi: 10.1093/molecular-omics/aaiag012.
2025
Inhibitors supercharge kinase turnover through native proteolytic circuits
Natalie S Scholes,
Martino Bertoni,
Arnau Comajuncosa-Creus,
Katharina Kladnik,
Xuefei Guo,
Fabian Frommelt,
Matthias Hinterndorfer,
Hlib Razumkov,
Polina Prokofeva,
Martin P Schwalm,
Florian Born,
Sandra Roehm,
Hana Imrichova,
Brianda L Santini,
Eleonora Barone,
Caroline Schätz,
Miquel Muñoz I Ordoño,
Severin Lechner,
Andrea Rukavina,
Iciar Serrano,
Miriam Abele,
Anna Koren,
Stefan Kubicek,
Stefan Knapp,
Nathanael S Gray,
Giulio Superti-Furga,
Bernhard Kuster,
Yigong Shi,
Patrick Aloy,
Georg E Winter.
Nature. 2026 Jan;649(8098):1032-1041. doi: 10.1038/s41586-025-09763-9. Epub 2025 Nov 26.
2025
Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML
Ben Haladik,
Margarita Maurer-Granofszky,
Peter Zoescher,
Raul Jimenez-Heredia,
Alexandra Frohne,
Anna Segarra-Roca,
Chloe Casey,
Felix Kartnig,
Sarah Giuliani,
Christina Rashkova,
Peter Repiscak,
Michael N Dworzak,
Giulio Superti-Furga,
Kaan Boztug.
Cell Rep Med. 2025 Sep 16;6(9):102304. doi: 10.1016/j.xcrm.2025.102304. Epub 2025 Aug 20.
2025
Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5
Wen-An Wang,
Evandro Ferrada,
Christoph Klimek,
Tanja Osthushenrich,
Aidan MacNamara,
Tabea Wiedmer,
Giulio Superti-Furga.
Sci Adv. 2025 Jun 27;11(26):eadx3011. doi: 10.1126/sciadv.adx3011. Epub 2025 Jun 27.
2025
Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1
Ashutosh Gulati,
Do-Hwan Ahn,
Albert Suades,
Yurie Hult,
Gernot Wolf,
So Iwata,
Giulio Superti-Furga,
Norimichi Nomura,
David Drew.
Nature. 2025 Jul;643(8072):855-864. doi: 10.1038/s41586-025-09069-w. Epub 2025 May 21.
2025
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Selina Troester,
Thomas Eder,
Nadja Wukowits,
Martin Piontek,
Pablo Fernández-Pernas,
Johannes Schmoellerl,
Ben Haladik,
Gabriele Manhart,
Melanie Allram,
Margarita Maurer-Granofszky,
Nastassja Scheidegger,
Karin Nebral,
Giulio Superti-Furga,
Roland Meisel,
Beat Bornhauser,
Peter Valent,
Michael N Dworzak,
Johannes Zuber,
Kaan Boztug,
Florian Grebien.
Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9.
2025
The solute carrier superfamily interactome
Fabian Frommelt,
Rene Ladurner,
Ulrich Goldmann,
Gernot Wolf,
Alvaro Ingles-Prieto,
Eva Lineiro-Retes,
Zuzana Gelová,
Ann-Katrin Hopp,
Eirini Christodoulaki,
Shao Thing Teoh,
Philipp Leippe,
Brianda L Santini,
Manuele Rebsamen,
Sabrina Lindinger,
Iciar Serrano,
Svenja Onstein,
Christoph Klimek,
Barbara Barbosa,
Anastasiia Pantielieieva,
Vojtech Dvorak,
Thomas J Hannich,
Julian Schoenbett,
Gilles Sansig,
Tamara A M Mocking,
Jasper F Ooms,
Adriaan P IJzerman,
Laura H Heitman,
Peter Sykacek,
Juergen Reinhardt,
André C Müller,
Tabea Wiedmer,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):632-675. doi: 10.1038/s44320-025-00109-1. Epub 2025 May 12.
2025
Data- and knowledge-derived functional landscape of human solute carriers
Ulrich Goldmann,
Tabea Wiedmer,
Andrea Garofoli,
Vitaly Sedlyarov,
Manuel Bichler,
Ben Haladik,
Gernot Wolf,
Eirini Christodoulaki,
Alvaro Ingles-Prieto,
Evandro Ferrada,
Fabian Frommelt,
Shao Thing Teoh,
Philipp Leippe,
Gabriel Onea,
Martin Pfeifer,
Mariah Kohlbrenner,
Lena Chang,
Paul Selzer,
Jürgen Reinhardt,
Daniela Digles,
Gerhard F Ecker,
Tanja Osthushenrich,
Aidan MacNamara,
Anders Malarstig,
David Hepworth,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):599-631. doi: 10.1038/s44320-025-00108-2. Epub 2025 May 12.
