Publications
2016
Functional crosstalk between membrane lipids and TLR biology.
Köberlin MS,
Heinz LX,
Superti-Furga G.
Curr Opin Cell Biol. 2016 Feb 16;39:28-36. doi: 10.1016/j.ceb.2016.01.010.
2016
Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3A.
Gorelik A,
Illes K,
Superti-Furga G,
Nagar B.
J Biol Chem. 2016 Jan 20. pii: jbc.M115.711085.
2016
Crystal structure of mammalian acid sphingomyelinase.
Gorelik A,
Illes K,
Heinz LX,
Superti-Furga G,
Nagar B.
Nat Commun. 2016 Jul 20;7:12196. doi: 10.1038/ncomms12196.
2015
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.
Heinz LX,
Baumann CL,
Köberlin MS,
Snijder B,
Gawish R,
Shui G,
Sharif O,
Aspalter IM,
Müller AC,
Kandasamy RK,
Breitwieser FP,
Pichlmair A,
Bruckner M,
Rebsamen M,
Blüml S,
Karonitsch T,
Fauster A,
Colinge J,
Bennett KL,
Knapp S,
Wenk MR,
Superti-Furga G.
Cell Rep. 2015 Jun 30;11(12):1919-28. doi: 10.1016/j.celrep.2015.05.006.
2015
The promise and peril of chemical probes.
Arrowsmith CH,
Audia JE,
Austin C,
Baell J,
Bennett J,
Blagg J,
Bountra C,
Brennan PE,
Brown PJ,
Bunnage ME,
Buser-Doepner C,
Campbell RM,
Carter AJ,
Cohen P,
Copeland RA,
Cravatt B,
Dahlin JL,
Dhanak D,
Edwards AM,
Frederiksen M,
Frye SV,
Gray N,
Grimshaw CE,
Hepworth D,
Howe T,
Huber KV,
Jin J,
Knapp S,
Kotz JD,
Kruger RG,
Lowe D,
Mader MM,
Marsden B,
Mueller-Fahrnow A,
Müller S,
O'Hagan RC,
Overington JP,
Owen DR,
Rosenberg SH,
Roth B,
Ross R,
Schapira M,
Schreiber SL,
Shoichet B,
Sundström M,
Superti-Furga G,
Taunton J,
Toledo-Sherman L,
Walpole C,
Walters MA,
Willson TM,
Workman P,
Young RN,
Zuercher WJ.
Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added].
2015
Pharmacological targeting of the Wdr5-MLL interaction in C/EBP_ N-terminal leukemia.
Grebien F,
Vedadi M,
Getlik M,
Giambruno R,
Grover A,
Avellino R,
Skucha A,
Vittori S,
Kuznetsova E,
Smil D,
Barsyte-Lovejoy D,
Li F,
Poda G,
Schapira M,
Wu H,
Dong A,
Senisterra G,
Stukalov A,
Huber KV,
Schönegger A,
Marcellus R,
Bilban M,
Bock C,
Brown PJ,
Zuber J,
Bennett KL,
Al-Awar R,
Delwel R,
Nerlov C,
Arrowsmith CH,
Superti-Furga G.
Nat Chem Biol. 2015 Jul 13. doi: 10.1038/nchembio.1859.
2015
Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.
Royer-Bertrand B,
Castillo-Taucher S,
Moreno-Salinas R,
Cho TJ,
Chae JH,
Choi M,
Kim OH,
Dikoglu E,
Campos-Xavier B,
Girardi E,
Superti-Furga G,
Bonafé L,
Rivolta C,
Unger S,
Superti-Furga A.
Sci Rep. 2015 Nov 24;5:17154. doi: 10.1038/srep17154.
2015
SLC38A9: a lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.
Rebsamen M,
Superti-Furga G.
Autophagy. 2015 Oct 2:0.
2015
Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth.
Peter B,
Winter GE,
Blatt K,
Bennett KL,
Stefanzl G,
Rix U,
Eisenwort G,
Hadzijusufovic E,
Gridling M,
Dutreix C,
Hoermann G,
Schwaab J,
Radia D,
Roesel J,
Manley PW,
Reiter A,
Superti-Furga G,
Valent P.
Leukemia. 2015 Sep 9. doi: 10.1038/leu.2015.242.
2015
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
Licciardello MP,
Müllner MK,
Dürnberger G,
Kerzendorfer C,
Boidol B,
Trefzer C,
Sdelci S,
Berg T,
Penz T,
Schuster M,
Bock C,
Kralovics R,
Superti-Furga G,
Colinge J,
Nijman SM,
Kubicek S.
Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29.
