2025
Hepatic Recompensation Before Systemic Therapy for Hepatocellular Carcinoma Yields Comparable Survival to Compensated Cirrhosis
Lorenzo Lani,
Bernhard Scheiner,
Matthias Pinter,
Thomas Reiberger.
Liver Int. 2025 Dec;45(12):e70413. doi: 10.1111/liv.70413.
2025
Ileal Biofilms Confirm SIBO-IBS Hypothesis: Comment on PMID 38798120
Maximilian Baumgartner,
Christoph Gasche.
Neurogastroenterol Motil. 2025 Dec;37(12):e70183. doi: 10.1111/nmo.70183. Epub 2025 Oct 24.
2025
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard
Yu-Yu Lin,
Kersten Breuer,
Dieter Weichenhan,
Pascal Lafrenz,
Antonella Sarnataro,
Agata Wilk,
Maryna Chepeleva,
Oliver Mücke,
Maximilian Schönung,
Franziska Petermann,
Philip Reiner Kensche,
Lena Weiser,
Frank Thommen,
Gideon Giacomelli,
Karl Nordstroem,
Edahi Gonzalez-Avalos,
Angelika Merkel,
Helene Kretzmer,
Jonas Fischer,
Stephen Krämer,
Murat Iskar,
Stephan Wolf,
Ivo Buchhalter,
Manel Esteller,
Christian Lawerenz,
Sven Twardziok,
Marc Zapatka,
Volker Hovestadt,
Matthias Schlesner,
Marcel H Schulz,
Steve Hoffmann,
Clarissa Gerhauser,
Jörn Walter,
Mark Hartmann,
Daniel B Lipka,
Yassen Assenov,
Christoph Bock,
Christoph Plass,
Reka Toth,
Pavlo Lutsik.
Nucleic Acids Res. 2025 Oct 14;53(19):gkaf970. doi: 10.1093/nar/gkaf970.
2025
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Artem Kalinichenko,
Jakob Huemer,
Theresa Humer,
Matthias Haimel,
Michael Svaton,
Nicolas Socquet-Juglard,
Giovanna Perinetti Casoni,
Celine Prakash,
Maximilian von der Linde,
Julia Pazmandi,
Cheryl van de Wetering,
Javier Nunez-Fontarnau,
Anton Kamnev,
Sarah Giuliani,
Martin G Jaeger,
Elisa Hahn,
Sarah Dobner,
Andrea Rukavina,
Elise Sylvander,
Jacqueline Seigner,
Christina Rashkova,
Birgit Hoeger,
Michael W Traxlmayr,
Manfred Lehner,
Yenan T Bryceson,
Janna Saarela,
Thomas Hannich,
Irinka Castanon,
Georg Winter,
Loïc Dupré,
Kaan Boztug.
Sci Immunol. 2025 Oct 17;10(112):eado3825. doi: 10.1126/sciimmunol.ado3825. Epub 2025 Oct 17.
2025
The metabolic organ connectome: A novel approach to measure allostatic load during health-to-disease transition
Barbara Katharina Geist,
Julia Guthrie,
Hunor Kertesz,
Florian W Kiefer,
Oana C Kulterer,
Thomas Nakuz,
Lukas Nics,
Eva-Maria Patronas,
Andre Rendeiro,
Chrysoula Vraka,
Josef Yu,
Stefan Grünert,
Marcus Hacker.
Med. 2025 Dec 12;6(12):100881. doi: 10.1016/j.medj.2025.100881. Epub 2025 Oct 14.
2025
Systematic mapping of human tissue microanatomy reveals age-associated remodeling and resilience
Iva Buljan,
Zsuzsanna Bagó-Horváth,
André F. Rendeiro.
bioRxiv [Preprint]. 2025 Oct 14:2025.10.13.682110. doi: 110.1101/2025.10.13.682110.
2025
Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease
Benedikt Simbrunner,
Ida Falk Villesen,
Georg Semmler,
Lorenz Balcar,
Georg Kramer,
Joana Almeida Calvão,
Benedikt Silvester Hofer,
Mathias Jachs,
Lukas Hartl,
Jurij Maurer,
Bernhard Scheiner,
Kerstin Zinober,
Rodrig Marculescu,
Michael Trauner,
Morten Karsdal,
Thomas Reiberger,
Mattias Mandorfer,
Diana Julie Leeming.
Aliment Pharmacol Ther. 2025 Oct 12. doi: 10.1111/apt.70407. Online ahead of print.
2025
T cell receptor associated transmembrane adaptor 1 (TRAT1) modulates human Th17 and Treg responses via PI3-kinase and STAT dependent mechanisms
Tobias Frey,
Christina Kandolf-Zumpf,
Anna Kaempf,
Kristin Schaffer,
Marlene Hollenstein,
Annika Lampl,
Johannes J Kovarik,
Johanna Strobl,
Georg Stary,
Julia Eckl-Dorna,
Ralf Schmidt,
Klaus G Schmetterer.
Cell Commun Signal. 2025 Oct 10;23(1):431. doi: 10.1186/s12964-025-02429-z.
2025
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
Jordan C J Wilson,
JiaYi Zhu,
Vanesa Vinciauskaite,
Eloise G Lloyd,
Simon Lam,
Alexandra Hart,
Chen Gang Goh,
Fadia Bou-Dagher,
Hlib Razumkov,
Lena Kobel,
Zacharias Kontarakis,
John Fielden,
Moritz F Schlapansky,
Joanna I Loizou,
Andreas Villunger,
Jacob E Corn,
Giulia Biffi,
Glenn R Masson,
Stefan J Marciniak,
Aldo S Bader,
Stephen P Jackson.
Nat Commun. 2025 Oct 9;16(1):8983. doi: 10.1038/s41467-025-64050-5.
2025
Defining the vascular niche of human adipose tissue across metabolic states
Ibrahim AlZaim,
Mohamed N Hassan,
Maja Schröter,
Luca Mannino,
Katarina Dragicevic,
Marie Balle Sjogaard,
Joseph Festa,
Lolita Dokshokova,
Sophie Weinbrenner,
Blanca Tardajos Ayllon,
Bettina Hansen,
Rikke Kongsgaard Rasmussen,
Julie N Christensen,
Olivia Wagman,
Ruby Schipper,
Min Cai,
Wouter Dheedene,
Anja Bille Bohn,
Jean Farup,
Lin Lin,
Samuele Soraggi,
Anna Dalsgaard Thorsen,
Amanda Bæk,
Henrik Holm Thomsen,
Maximilian von Heesen,
Lena-Christin Conradi,
Paul Evans,
Carolina E Hagberg,
None Joerg Heeren,
Margo Emont,
Evan D Rosen,
Aernout Luttun,
Anders Etzerodt,
Lucas Massier,
Mikael Rydén,
Niklas Mejhert,
Matthias Blüher,
Konstantin Khodosevich,
Robert A Fenton,
Bilal N Sheikh,
Niels Jessen,
Laura P M H de Rooij,
Joanna Kalucka.
bioRxiv [Preprint]. 2025 Sep 22:2024.09.22.610444. doi: 10.1101/2024.09.22.610444.
