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CeMM Adjunct Principal Investigator

Nuno Maulide

Precision design enabled by organic synthesis

University of Vienna
Institute of Organic Chemistry

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Selected Papers

The research of Nuno Maulide's group has mostly focused on unusual or "unconventional" reactivity profiles of organic compounds. His group has taken particular interest in high-energy reactive intermediates that can be generated under mild conditions and subsequently lead to rearrangements, domino reaction sequences or catalytic asymmetric transformations. A broad scope of activities has resulted from these efforts, spanning a large subset of areas within organic chemistry.

Main Research Interests:

  • Development of new synthetic methodology
  • Total synthesis of natural products
  • "Precision modification" of C-H bonds, with the vision of systematically exploiting such modifications in particular contexts
  • Design of new chemical probes in close collaboration with computational methods
  • Drug design and synthesis


Nuno Maulide is a trained chemist. He underwent doctoral studies in the Université Catholique de Louvain and, in 2007, obtained his PhD under the supervision of Prof. István Markó, working on the application of functionalized orthoesters in organic synthesis. He then moved to Stanford University for a postdoctoral stay in the group of Prof. Barry Trost. Nuno started his independent career in 2009, when he was appointed group leader at the Max- Planck-Institut für Kohlenforschung in Mülheim an der Ruhr. In 2013, at age 33, he was appointed Full Professor of Organic Synthesis at the University of Vienna and is currently Head of the Institute of Organic Chemistry. He is the holder of an ERC Consolidator Grant (2017–2021)   and an ERC Proof of Concept Grant (awarded 2018), after having held an ERC Starting Grant (2011–2016). Nuno also leads the Christian Doppler Laboratory for Entropy-Oriented Drug Design and was named “Austria’s Scientist of the  Year 2018”. Nuno Maulide joined CeMM as Adjunct PI in November 2018 and has since been awarded the Ignaz L. Lieben Award of the Austrian Academy of Sciences (2019) as well as the 2020 Tetrahedron Young Investigator Award.

Selected Papers

Klose I et al. Inverse hydride shuttle catalysis enables the stereoselective one-step synthesis of complex frameworks. Nat Chem. 2022 Nov;14(11):1306-1310. (abstract)

Berger M et al. Application of Relay C-H Oxidation Logic to Polyhydroxylated Oleanane Triterpenoids. Chem. 2020; 6, 1183-1189. (abstract)

Kaiser D, et al. A general acid-mediated hydroaminomethylation of unactivated alkenes and alkynes. Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14639-14643. (abstract)

Chen Y, et al. A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants. J Am Chem Soc. 2019 Sep 4;141(35):13772-13777. (abstract)

Adler P, et al. α-Fluorination of carbonyls with nucleophilic fluorine. Nat Chem. 2019 Apr;11(4):329-334. (abstract)

Adler P, Pons A, Li J, Heider J, Brutiu BR, Maulide N. Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13330-13334. (abstract)

Kaldre D, Klose I, Maulide N. Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge-accelerated sulfonium rearrangement. Science. 2018 Aug 17;361(6403):664-667.(abstract)

O' Donovan DH, Aillard P, Berger M, de la Torre A, Petkova D, Knittl-Frank C, Geerdink D, Kaiser M, Maulide N. C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity. Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10737-10741. (abstract)

de la Torre A, Kaiser D, Maulide N. Flexible and Chemoselective Oxidation of Amides to α-Keto Amides and α-Hydroxy Amides. J Am Chem Soc. 2017 May 17;139(19):6578-6581. (abstract)

Xie LG, Niyomchon S, Mota AJ, González L, Maulide N. Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles. Nat Commun. 2016 Mar 15;7:10914. (abstract)