Publications
2014
Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.
Dancík V,
Carrel H,
Bodycombe NE,
Seiler KP,
Fomina-Yadlin D,
Kubicek ST,
Hartwell K,
Shamji AF,
Wagner BK,
Clemons PA.
J Biomol Screen. 2014 Jan 24;19(5):771-781. [Epub ahead of print]
2013
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
Berger A,
Hoelbl-Kovacic A,
Bourgeais J,
Hoefling L,
Warsch W,
Grundschober E,
Uras IZ,
Menzl I,
Putz EM,
Hoermann G,
Schuster C,
Fajmann S,
Leitner E,
Kubicek S,
Moriggl R,
Gouilleux F,
Sexl V.
Leukemia. 2013 Nov 22. doi: 10.1038/leu.2013.351. [Epub ahead of print]
2012
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.
Yuan Y,
Wang Q,
Paulk J,
Kubicek S,
Kemp MM,
Adams DJ,
Shamji AF,
Wagner BK,
Schreiber SL.
ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
2012
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Kubicek S,
Gilbert JC,
Fomina-Yadlin D,
Gitlin AD,
Yuan Y,
Wagner FF,
Holson EB,
Luo T,
Lewis TA,
Taylor B,
Gupta S,
Shamji A,
Wagner BK,
Clemons PA,
Schreiber S.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. PNAS 2012 Apr 3;109(14):5364-9.
2012
Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation.
Frogne T,
Sylvestersen KB,
Kubicek S,
Nielsen ML,
Hecksher-Sørensen J.
PLoS One. 2012;7(4):e35233.
2012
GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.
Fomina-Yadlin D,
Kubicek S,
Vetere A,
Hu He K,
Schreiber SL,
Wagner BK.
PLOS one7(1): e28808.
2011
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.
Luo X,
Liu Y,
Kubicek S,
Myllyharju J,
Tumber A,
Ng S,
Che KH,
Podoll J,
Heightman TD,
Oppermann U,
Schreiber SL,
Wang X.
J Am Chem Soc. 2011 Jun 22;133(24):9451-6.
2010
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres.
O’Sullivan RJ,
Kubicek S,
Schreiber SL,
Karlseder J.
Nat Struct Mol Biol. 2010 Oct;17(10):1218-25. Epub 2010 Oct 3.
