Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP. Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells. Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27820796

Smida M, Fece de la Cruz F, Kerzendorfer C, Uras IZ, Mair B, Mazouzi A, Suchankova T, Konopka T, Katz AM, Paz K, Nagy-Bojarszky K, Muellner MK, Bago-Horvath Z, Haura EB, Loizou JI, Nijman SM. MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated. Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701.
Abstract: http://www.nature.com/articles/ncomms13701

Mair B, Konopka T, Kerzendorfer C, Sleiman K, Salic S, Serra V, Muellner MK, Theodorou V, Nijman SM. Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PLoS Genet. 2016 Sep 2;12(9):e1006279. doi: 10.1371/journal.pgen.1006279.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010247/

Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP. Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells. Nat Chem Biol. 2016 Oct 31. doi: 10.1038/nchembio.2226.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27820796

Nijman SM. Functional genomics to uncover drug mechanism of action. Nat Chem Biol. 2015 Dec;11(12):942-8. doi: 10.1038/nchembio.1963. Epub 2015 Nov 17. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26575241

Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S. NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25263445

Inglés-Prieto Á, Reichhart E, Muellner MK, Nowak M, Nijman SM, Grusch M, Janovjak H. Light-assisted small-molecule screening against protein kinases. Nat Chem Biol. 2015 Dec;11(12):952-4. doi: 10.1038/nchembio.1933. Epub 2015 Oct 12.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26457372

Kerzendorfer C, Konopka T, Nijman SM. A thesaurus of genetic variation for interrogation of repetitive genomic regions. Nucleic Acids Res. 2015 May 26;43(10):e68. doi: 10.1093/nar/gkv178. Epub 2015 Mar 27.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25820428

Muellner MK, Duernberger G, Ganglberger F, Kerzendorfer C, Uras IZ, Schoenegger A, Bagienski K, Colinge J, Nijman SM. TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens. BMC Bioinformatics. 2014 Apr 8;15:98. doi: 10.1186/1471-2105-15-98.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24712852

Mair B, Kubicek S, Nijman SM. Exploiting epigenetic vulnerabilities for cancer therapeutics. Trends Pharmacol Sci. 2014 Mar;35(3):136-145. doi: 10.1016/j.tips.2014.01.001. Epub 2014 Feb 12. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24529765

Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods. 2013 Oct;10(10):965-71.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24161985

Nijman SM, Friend SH. Cancer. Potential of the synthetic lethality principle. Science. 2013 Nov 15;342(6160):809-11. doi: 10.1126/science.1244669.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24233712

Kretschy N, Teichmann M, Kopf S, Atanasov AG, Saiko P, Vonach C, Viola K, Giessrigl B, Huttary N, Raab I, Krieger S, Jäger W, Szekeres T, Nijman SM, Mikulits W, Dirsch VM, Dolznig H, Grusch M, Krupitza G. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23299527

Uras IZ, List T, Nijman SM. Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1. PloS One 2012;7(2):e31003.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22347420

Smida M, Nijman SM. Functional drug-gene interactions in lung cancer. Expert Rev. Mol. Diagn. 2012 Apr;12(3):291-302.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22468819

Schneller D, Machat G, Sousek A, Proell V, van Zijl F, Zulehner G, Huber H, Mair M, Muellner MK, Nijman SM, Eferl R, Moriggl R, Mikulits W. p19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma. Hepatology. 2011 Jul;54(1):164-72.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21452288

Nijman SM. Synthetic lethality: general principles, utility and detection using genetic screens in human cells. FEBS Lett. 2011 Jan 3;585(1):1-6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21094158

Muellner MK, Uras IZ, Gapp BV, Kerzendorfer C, Smida M, Lechtermann H, Craig-Mueller N, Colinge J, Duernberger G, Nijman SM. A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer. Nat Chem Biol. 2011 Nov;7(11):787-93.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21946274

Hoermann G, Cerny-Reiterer S, Perne A, Klauser M, Hoetzenecker K, Klein K, Mullauer L, Groger M, Nijman SM, Klepetko W, Valent P, Mayerhofer M. Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis. Am J Pathol. 2011 May;178(5):2344-56.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21457934

Nijman SM. Syntehtic lethality: General principles, utility and detection using genetic screens in human cells. FEBS Lett. 2010 Nov 19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21094158

Muellner MK and Nijman SM. Giving Rho(d) Directions. Nat Chem Biol. 2010 Jun;6(6):397-8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20479746

Perne A, Muellner MK, Steinrueck M, Craig- Mueller N, Mayerhofer J, Schwarzinger I, Sloane M, Uras IZ, Hoermann G, Nijman SM, Mayerhofer M. Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. PLoS One, 2009 Dec 16; 4(12):e8292.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20016840

Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res, 2009 Sep 15; 69(18):7385-92. Epub 2009 Sep 1.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19723656