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2020

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM.
Immunity. 2021 Jan 12;54(1):132-150.e9. doi: 10.1016/j.immuni.2020.11.003. Epub 2020 Dec 2. Erratum in: Immunity. 2021 Feb 9;54(2):387.
2020

Rational discovery of molecular glue degraders via scalable chemical profiling.

C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, IH Kaltheuner, E Hahn, K Seiler, A Koren, G Petzold, M Fellner, C Bock, AC Müller, J Zuber, M Geyer, NH Thomä, S Kubicek, G E Winter.
Nat Chem Biol. 2020 Nov;16(11):1199-1207.doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3.
2020

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL.

Rendeiro AF, Krausgruber T, Fortelny N, Zhao F, Penz T, Farlik M, Schuster LC, Nemc A, Tasnády S, Réti M, Mátrai Z, Alpár D, Bödör C, Schmidl C, Bock C.
Nat Commun. 2020 Jan 29;11(1):577. doi: 10.1038/s41467-019-14081-6.
2020

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time.

Reicher A, Koren A, Kubicek S.
Genome Res. 2020 Dec;30(12):1846-1855. doi: 10.1101/gr.261503.120. Epub 2020 Nov 17.
2020

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.

Ghosh S, Köstel Bal S, Edwards E S J, Pillay B, Jimenez-Heredia R, Rao G, Erol Cipe F, Salzer E, Zoghi S, Abolhassani H, Momen T, Gostick E, Price D A, Zhang Y, Oler A J, Gonzaga-Jauregui C, Erman B, Metin A, Ilhan I, Haskologlu S, Islamoglu C, Baskin K, Ceylaner S, Yilmaz E, Unal E, Karakukcu M, Berghuis D, Cole T, Kumar Gupta A, Hauck F, Hoepelman A, Baris S, Karakoc-Aydiner E, Ozen A, Kager L, Holzinger D, Paulussen M, Krüger, R, Meisel R, Thomas Oommen P, Morris E C, Neven B, Worth A J J, van Montfrans J M, Fraaij P, Choo S, Dogu F, Davies E G, Burns S, Dueckers G, Perez Becker R, von Bernuth H, Latour S, Faraci M, Gattorno M, Su H, Pan-Hammarström, Q, Hammarström L, Lenardo M J, Ma C S, Niehues T, Aghamohammadi A, Rezaei N, Ikinciogullari A, Tangye S G, Lankester A C, Boztug K.
Blood. 2020 Dec 3;136(23):2638-2655. Doi: 10.1182/blood.2020006738.
2020

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.

Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole A, Pereyaslov D, WHO European Region sequencing laboratories and GISAID EpiCoV group; WHO European Region sequencing laboratories and GISAID EpiCoV group*.
Euro Surveill. 2020 Aug;25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
2020

Structural cells are key regulators of organ-specific immune responses.

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C.
Nature. 2020 Jul;583(7815):296-302. doi: 10.1038/s41586-020-2424-4. Epub 2020 Jul 1.
2020

Environmental arginine controls multinuclear giant cell metabolism and formation.

Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G.
Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1.
2020

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation.

Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W.
Cell Rep. 2020 Feb 4;30(5):1542-1552.e7. doi: 10.1016/j.celrep.2020.01.011.
2020

Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease.

Brunner SB, Marculescu R, Scheiner B, Schwabl P, Bucsics T, Stadlmann A, Bauer DJM, Paternostro R, Eigenbauer E, Pinter M, Stättermayer AF, Trauner M, Mandorfer M, Reiberger T.
Liver Int. 2020 May 2. doi: 10.1111/liv.14498. Epub ahead of print.