2024
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily
Daniela Digles,
Alvaro Ingles-Prieto,
Vojtech Dvorak,
Tamara A M Mocking,
Ulrich Goldmann,
Andrea Garofoli,
Evert J Homan,
Alberto Di Silvio,
Lucia Azzollini,
Francesca Sassone,
Mario Fogazza,
Felix Bärenz,
Antje Pommereau,
Yasmin Zuschlag,
Jasper F Ooms,
Jeppe Tranberg-Jensen,
Jesper S Hansen,
Josefina Stanka,
Hubert J Sijben,
Helena Batoulis,
Eckhard Bender,
Riccardo Martini,
Adriaan P IJzerman,
David B Sauer,
Laura H Heitman,
Vania Manolova,
Juergen Reinhardt,
Alexander Ehrmann,
Philipp Leippe,
Gerhard F Ecker,
Kilian V M Huber,
Thomas Licher,
Lia Scarabottolo,
Tabea Wiedmer,
Giulio Superti-Furga.
Front Pharmacol. 2024 Jul 9;15:1401599. doi: 10.3389/fphar.2024.1401599. eCollection 2024.
2024
Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857. doi: 10.1101/2024.07.10.602857.
2024
Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer
Carolina Mangana,
Barbara B Maier.
Cancer Cell. 2024 Aug 12;42(8):1329-1331. doi: 10.1016/j.ccell.2024.06.016. Epub 2024 Jul 18.
2024
Differential regulation of mitochondrial uncoupling protein 2 in cancer cells
Taraneh Beikbaghban,
Ludovica Proietti,
Jessica Ebner,
Roko Sango,
Thomas Rattei,
Thomas Weichhart,
Florian Grebien,
Felix Sternberg,
Elena E Pohl.
Biochim Biophys Acta Bioenerg. 2024 Nov 1;1865(4):149486. doi: 10.1016/j.bbabio.2024.149486. Epub 2024 Jul 8.
2024
Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection
Katja Knapp,
Romana Klasinc,
Anna Koren,
Magdalena Siller,
Ruth Dingelmaier-Hovorka,
Mathias Drach,
Juan Sanchez,
David Chromy,
Marlene Kranawetter,
Christoph Grimm,
Andreas Bergthaler,
Stefan Kubicek,
Hannes Stockinger,
Georg Stary.
Cell Rep Med. 2024 Jul 16;5(7):101643. doi: 10.1016/j.xcrm.2024.101643. Epub 2024 Jul 8.
2024
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
Chrysanthi Kagiou,
Jose A Cisneros,
Jakob Farnung,
Joanna Liwocha,
Fabian Offensperger,
Kevin Dong,
Ka Yang,
Gary Tin,
Christina S Horstmann,
Matthias Hinterndorfer,
Joao A Paulo,
Natalie S Scholes,
Juan Sanchez Avila,
Michaela Fellner,
Florian Andersch,
J Thomas Hannich,
Johannes Zuber,
Stefan Kubicek,
Steven P Gygi,
Brenda A Schulman,
Georg E Winter.
Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3.
2024
Correction: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity
Marcello Polesel,
Alvaro Ingles-Prieto,
Eirini Christodoulaki,
Evandro Ferrada,
Cédric Doucerain,
Patrick Altermatt,
Michelle Knecht,
Michael Kuhn,
Anna-Lena Steck,
Maria Wilhelm,
Vania Manolova.
Biometals. 2024 Aug;37(4):1037-1038. doi: 10.1007/s10534-024-00615-z.
2024
GPT-4 as a biomedical simulator
Moritz Schaefer,
Stephan Reichl,
Rob Ter Horst,
Adele M Nicolas,
Thomas Krausgruber,
Francesco Piras,
Peter Stepper,
Christoph Bock,
Matthias Samwald.
Comput Biol Med. 2024 Aug;178:108796. doi: 10.1016/j.compbiomed.2024.108796. Epub 2024 Jun 22.
2024
Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation
Vlad Taru,
Gyongyi Szabo,
Wajahat Mehal,
Thomas Reiberger.
J Hepatol. 2024 Nov;81(5):895-910. doi: 10.1016/j.jhep.2024.06.016. Epub 2024 Jun 20.
2024
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Nianzhe He,
Laura Depta,
Cecilia Rossetti,
Lucie Caramelle,
Marko Cigler,
Hogan P Bryce-Rogers,
Marine Michon,
Oliver Rafn Dan,
Joseph Hoock,
Julien Barbier,
Daniel Gillet,
Alison Forrester,
Georg E Winter,
Luca Laraia.
Nat Chem Biol. 2025 Feb;21(2):203-214. doi: 10.1038/s41589-024-01653-x. Epub 2024 Jun 21.
