2025
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Huanyu Z Li,
Ashley C W Pike,
Yung-Ning Chang,
Dheeraj Prakaash,
Zuzana Gelova,
Josefina Stanka,
Christophe Moreau,
Hannah C Scott,
Frank Wunder,
Gernot Wolf,
Andreea Scacioc,
Gavin McKinley,
Helena Batoulis,
Shubhashish Mukhopadhyay,
Andrea Garofoli,
Adán Pinto-Fernández,
Benedikt M Kessler,
Nicola A Burgess-Brown,
Saša Štefanić,
Tabea Wiedmer,
Katharina L Dürr,
Vera Puetter,
Alexander Ehrmann,
Syma Khalid,
Alvaro Ingles-Prieto,
Giulio Superti-Furga,
David B Sauer.
Nat Commun. 2025 Jan 16;16(1):721. doi: 10.1038/s41467-025-55942-7.
2025
Restimulation by macrophages exhausts T cells
Fernando Fernández-García,
Barbara B Maier.
Immunity. 2025 Jan 14;58(1):12-14. doi: 10.1016/j.immuni.2024.12.010.
2025
Mitotic lethality prevents inflammation
Christian Zierhut,
Andreas Villunger.
Nat Cell Biol. 2025 Jan;27(1):7-8. doi: 10.1038/s41556-024-01529-1.
2025
Marsilea: an intuitive generalized paradigm for composable visualizations
Yimin Zheng,
Zhihang Zheng,
André F Rendeiro,
Edwin Cheung.
Genome Biol. 2025 Jan 6;26(1):5. doi: 10.1186/s13059-024-03469-3.
2025
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Gernot Wolf,
Conner Craigon,
Shao Thing Teoh,
Patrick Essletzbichler,
Svenja Onstein,
Diane Cassidy,
Esther C H Uijttewaal,
Vojtech Dvorak,
Yuting Cao,
Ariel Bensimon,
Ulrich Elling,
Alessio Ciulli,
Giulio Superti-Furga.
Cell Chem Biol. 2025 Feb 20;32(2):291-306.e6. doi: 10.1016/j.chembiol.2024.11.009. Epub 2025 Jan 3.
2024
Ex vivo imaging-based high content phenotyping of patients with rheumatoid arthritis
Felix Kartnig,
Michael Bonelli,
Ulrich Goldmann,
Noemi Mészáros,
Nikolaus Krall,
Daniel Aletaha,
Leonhard X Heinz,
Giulio Superti-Furga.
EBioMedicine. 2025 Jan;111:105522. doi: 10.1016/j.ebiom.2024.105522. Epub 2024 Dec 26.
2024
Thoughts for the future
Lona M Alkhalaf,
Cheryl Arrowsmith,
Emily P Balskus,
Giovanna Bergamini,
Rashna Bhandari,
Christopher J Chang,
Peng Chen,
Xing Chen,
Alessio Ciulli,
Julia A Cricco,
Benjamin G Davis,
Martina Delbianco,
Natalia Dudareva,
Erin Dueber,
Fleur Ferguson,
Priscila Oliveira de Giuseppe,
Itaru Hamachi,
Ming Chen Hammond,
Stavroula K Hatzios,
Won Do Heo,
Jon Paul Janet,
Siddhesh S Kamat,
Stefan Knapp,
Yamuna Krishnan,
Kathrin Lang,
Luca Laraia,
Reuben B Leveson-Gower,
Xiang David Li,
David R Liu,
Mo-Fang Liu,
Nir London,
Nilkamal Mahanta,
Cristina Mayor-Ruiz,
Tom Muir,
Mário Tyago Murakami,
Hyun-Woo Rhee,
Matt Robers,
Alex Satz,
Brenda A Schulman,
Ben Shen,
Brian Shoichet,
Erick Strauss,
Tsutomu Suzuki,
Pratyush Tiwary,
Herbert Waldmann,
Thomas R Ward,
Amy Weeks,
Eranthie Weerapana,
Georg Winter.
Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2.
2024
Inflammation remains a dynamic component of portal hypertension in regressive alcohol-related cirrhosis
Benedikt Silvester Hofer,
Benedikt Simbrunner,
Philipp Königshofer,
Ksenia Brusilovskaya,
Oleksandr Petrenko,
Vlad Taru,
Thomas Sorz-Nechay,
Kerstin Zinober,
Katharina Regnat,
Georg Semmler,
Carolin Lackner,
Michael Trauner,
Mattias Mandorfer,
Philipp Schwabl,
Thomas Reiberger.
United European Gastroenterol J. 2025 Apr;13(3):317-329. doi: 10.1002/ueg2.12643. Epub 2024 Dec 21.
2024
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors
Marco Tarullo,
Guillermo Fernandez Rodriguez,
Alessia Iaiza,
Sara Venezia,
Alberto Macone,
Alessio Incocciati,
Silvia Masciarelli,
Marcella Marchioni,
Marta Giorgis,
Marco Lucio Lolli,
Federico Fornaseri,
Ludovica Proietti,
Florian Grebien,
Serena Rosignoli,
Alessandro Paiardini,
Dante Rotili,
Antonello Mai,
Elena Bochenkova,
Amedeo Caflisch,
Francesco Fazi,
Alessandro Fatica.
ACS Pharmacol Transl Sci. 2024 Nov 26;7(12):4096-4111. doi: 10.1021/acsptsci.4c00533. eCollection 2024 Dec 13.
2024
Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia
Sabrina Grundtner,
Julia R Sondermann,
Feng Xian,
Daniel Malzl,
Daniel Segelcke,
Esther M Pogatzki-Zahn,
Jörg Menche,
David Gómez-Varela,
Manuela Schmidt.
Pharmacol Res. 2025 Jan;211:107552. doi: 10.1016/j.phrs.2024.107552. Epub 2024 Dec 16.
