2025
Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross-Over Study in Healthy Volunteers
Evette B M Hillman,
Maximilian Baumgartner,
Danielle Carson,
Gregory C A Amos,
Imad Wazir,
Haider A Khan,
Malik A Khan,
Sjoerd Rijpkema,
Julian R F Walters,
Elizabeth M H Wellington,
Ramesh Arasaradnam,
Stephen J Lewis.
Neurogastroenterol Motil. 2025 Oct;37(10):e70075. doi: 10.1111/nmo.70075. Epub 2025 May 20.
2025
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Selina Troester,
Thomas Eder,
Nadja Wukowits,
Martin Piontek,
Pablo Fernández-Pernas,
Johannes Schmoellerl,
Ben Haladik,
Gabriele Manhart,
Melanie Allram,
Margarita Maurer-Granofszky,
Nastassja Scheidegger,
Karin Nebral,
Giulio Superti-Furga,
Roland Meisel,
Beat Bornhauser,
Peter Valent,
Michael N Dworzak,
Johannes Zuber,
Kaan Boztug,
Florian Grebien.
Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9.
2025
The solute carrier superfamily interactome
Fabian Frommelt,
Rene Ladurner,
Ulrich Goldmann,
Gernot Wolf,
Alvaro Ingles-Prieto,
Eva Lineiro-Retes,
Zuzana Gelová,
Ann-Katrin Hopp,
Eirini Christodoulaki,
Shao Thing Teoh,
Philipp Leippe,
Brianda L Santini,
Manuele Rebsamen,
Sabrina Lindinger,
Iciar Serrano,
Svenja Onstein,
Christoph Klimek,
Barbara Barbosa,
Anastasiia Pantielieieva,
Vojtech Dvorak,
Thomas J Hannich,
Julian Schoenbett,
Gilles Sansig,
Tamara A M Mocking,
Jasper F Ooms,
Adriaan P IJzerman,
Laura H Heitman,
Peter Sykacek,
Juergen Reinhardt,
André C Müller,
Tabea Wiedmer,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):632-675. doi: 10.1038/s44320-025-00109-1. Epub 2025 May 12.
2025
Data- and knowledge-derived functional landscape of human solute carriers
Ulrich Goldmann,
Tabea Wiedmer,
Andrea Garofoli,
Vitaly Sedlyarov,
Manuel Bichler,
Ben Haladik,
Gernot Wolf,
Eirini Christodoulaki,
Alvaro Ingles-Prieto,
Evandro Ferrada,
Fabian Frommelt,
Shao Thing Teoh,
Philipp Leippe,
Gabriel Onea,
Martin Pfeifer,
Mariah Kohlbrenner,
Lena Chang,
Paul Selzer,
Jürgen Reinhardt,
Daniela Digles,
Gerhard F Ecker,
Tanja Osthushenrich,
Aidan MacNamara,
Anders Malarstig,
David Hepworth,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):599-631. doi: 10.1038/s44320-025-00108-2. Epub 2025 May 12.
2025
Metabolic mapping of the human solute carrier superfamily
Tabea Wiedmer,
Shao Thing Teoh,
Eirini Christodoulaki,
Gernot Wolf,
Chengzhe Tian,
Vitaly Sedlyarov,
Abigail Jarret,
Philipp Leippe,
Fabian Frommelt,
Alvaro Ingles-Prieto,
Sabrina Lindinger,
Barbara M G Barbosa,
Svenja Onstein,
Christoph Klimek,
Julio Garcia,
Iciar Serrano,
Daniela Reil,
Diana Santacruz,
Mary Piotrowski,
Stephen Noell,
Christoph Bueschl,
Huanyu Li,
Gamma Chi,
Stefan Mereiter,
Tiago Oliveira,
Josef M Penninger,
David B Sauer,
Claire M Steppan,
Coralie Viollet,
Kristaps Klavins,
J Thomas Hannich,
Ulrich Goldmann,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):560-598. doi: 10.1038/s44320-025-00106-4. Epub 2025 May 12.
2025
The genetic interaction map of the human solute carrier superfamily
Gernot Wolf,
Philipp Leippe,
Svenja Onstein,
Ulrich Goldmann,
Fabian Frommelt,
Shao Thing Teoh,
Enrico Girardi,
Tabea Wiedmer,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):531-559. doi: 10.1038/s44320-025-00105-5. Epub 2025 May 12.
2025
EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
Dana Krauß,
Veronica Moreno-Viedma,
Emi Adachi-Fernandez,
Cristiano de Sá Fernandes,
Jakob-Wendelin Genger,
Ourania Fari,
Bernadette Blauensteiner,
Dominik Kirchhofer,
Nikolina Bradaric,
Valeriya Gushchina,
Georgios Fotakis,
Thomas Mohr,
Ifat Abramovich,
Inbal Mor,
Martin Holcmann,
Andreas Bergthaler,
Arvand Haschemi,
Zlatko Trajanoski,
Juliane Winkler,
Eyal Gottlieb,
Maria Sibilia.
EMBO Mol Med. 2025 Jun;17(6):1355-1392. doi: 10.1038/s44321-025-00240-4. Epub 2025 May 6.
2025
Author's reply: "Aetiology-specific inflammation patterns in patients and rat models of compensated cirrhosis: New perspectives and recommendations"
Benedikt Silvester Hofer,
Thomas Reiberger.
Dig Liver Dis. 2025 Jun;57(6):1350-1351. doi: 10.1016/j.dld.2025.04.022. Epub 2025 May 2.
2025
Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation
Himadri B Thapa,
Christina A Passegger,
Dominik Fleischhacker,
Paul Kohl,
Yi-Chi Chen,
Ratchara Kalawong,
Carmen Tam-Amersdorfer,
Michael R Gerstorfer,
Jana Strahlhofer,
Kristina Schild-Prüfert,
Ellen L Zechner,
Andreas Blesl,
Lukas Binder,
Georg A Busslinger,
Leo Eberl,
Gregor Gorkiewicz,
Herbert Strobl,
Christoph Högenauer,
Stefan Schild.
Nat Commun. 2025 Apr 29;16(1):3995. doi: 10.1038/s41467-025-59354-5.
2025
Targeted protein degradation for cancer therapy
Matthias Hinterndorfer,
Valentina A Spiteri,
Alessio Ciulli,
Georg E Winter.
Nat Rev Cancer. 2025 Jul;25(7):493-516. doi: 10.1038/s41568-025-00817-8. Epub 2025 Apr 25.
