Publications
2025
Probing condensate microenvironments with a micropeptide killswitch
Yaotian Zhang,
Ida Stöppelkamp,
Pablo Fernandez-Pernas,
Melanie Allram,
Matthew Charman,
Alexandre P Magalhaes,
Melanie Piedavent-Salomon,
Gregor Sommer,
Yu-Chieh Sung,
Katrina Meyer,
Nicholas Grams,
Edwin Halko,
Shivali Dongre,
David Meierhofer,
Michal Malszycki,
Ibrahim A Ilik,
Tugce Aktas,
Matthew L Kraushar,
Nadine Vastenhouw,
Matthew D Weitzman,
Florian Grebien,
Henri Niskanen,
Denes Hnisz.
Nature. 2025 Jun 4. doi: 10.1038/s41586-025-09141-5. Online ahead of print.
2025
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Selina Troester,
Thomas Eder,
Nadja Wukowits,
Martin Piontek,
Pablo Fernández-Pernas,
Johannes Schmoellerl,
Ben Haladik,
Gabriele Manhart,
Melanie Allram,
Margarita Maurer-Granofszky,
Nastassja Scheidegger,
Karin Nebral,
Giulio Superti-Furga,
Roland Meisel,
Beat Bornhauser,
Peter Valent,
Michael N Dworzak,
Johannes Zuber,
Kaan Boztug,
Florian Grebien.
Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9.
2025
DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes
Fadimana Kaya,
Findlay Bewicke-Copley,
Juho J Miettinen,
Pedro Casado,
Eve Leddy,
Özgen Deniz,
Vincent-Philippe Lavallée,
Celine Philippe,
Jiexin Zheng,
Florian Grebien,
Naeem Khan,
Szilvia Krizsán,
Joseph Saad,
Alexis Nolin-Lapalme,
Josée Hébert,
Sébastien Lemieux,
Eric Audemard,
Janet Matthews,
Marianne Grantham,
Doriana Di Bella,
Krister Wennerberg,
Alun Parsons,
John Gribben,
James D Cavenagh,
Sylvie D Freeman,
Csaba Bödör,
Guy Sauvageau,
Jun Wang,
Pilar Llamas-Sillero,
Jean-Baptiste Cazier,
David C Taussig,
Dominique Bonnet,
Pedro R Cutillas,
Caroline A Heckman,
Jude Fitzgibbon,
Kevin Rouault-Pierre,
Ana Rio-Machin.
Leukemia. 2025 Jun;39(6):1526-1531. doi: 10.1038/s41375-025-02593-8. Epub 2025 Apr 9.
2024
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors
Marco Tarullo,
Guillermo Fernandez Rodriguez,
Alessia Iaiza,
Sara Venezia,
Alberto Macone,
Alessio Incocciati,
Silvia Masciarelli,
Marcella Marchioni,
Marta Giorgis,
Marco Lucio Lolli,
Federico Fornaseri,
Ludovica Proietti,
Florian Grebien,
Serena Rosignoli,
Alessandro Paiardini,
Dante Rotili,
Antonello Mai,
Elena Bochenkova,
Amedeo Caflisch,
Francesco Fazi,
Alessandro Fatica.
ACS Pharmacol Transl Sci. 2024 Nov 26;7(12):4096-4111. doi: 10.1021/acsptsci.4c00533. eCollection 2024 Dec 13.
2024
The adsorption of drugs on nanoplastics has severe biological impact
Leonard Dick,
Patrick R Batista,
Paul Zaby,
Gabriele Manhart,
Verena Kopatz,
Lukas Kogler,
Verena Pichler,
Florian Grebien,
Vince Bakos,
Benedek G Plósz,
Nikola Zlatkov Kolev,
Lukas Kenner,
Barbara Kirchner,
Oldamur Hollóczki.
Sci Rep. 2024 Oct 28;14(1):25853. doi: 10.1038/s41598-024-75785-4.
2024
NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities
Milad Rasouli,
Selina Troester,
Florian Grebien,
Bianca F Goemans,
C Michel Zwaan,
Olaf Heidenreich.
Hemasphere. 2024 Sep 25;8(9):e70013. doi: 10.1002/hem3.70013. eCollection 2024 Sep.
2024
RNA sequestration in P-bodies sustains myeloid leukaemia
Srikanth Kodali,
Ludovica Proietti,
Gemma Valcarcel,
Anna V López-Rubio,
Patrizia Pessina,
Thomas Eder,
Junchao Shi,
Annie Jen,
Núria Lupión-Garcia,
Anne C Starner,
Mason D Bartels,
Yingzhi Cui,
Caroline M Sands,
Ainoa Planas-Riverola,
Alba Martínez,
Talia Velasco-Hernandez,
Laureano Tomás-Daza,
Bernhard Alber,
Gabriele Manhart,
Isabella Maria Mayer,
Karoline Kollmann,
Alessandro Fatica,
Pablo Menendez,
Evgenia Shishkova,
Rachel E Rau,
Biola M Javierre,
Joshua Coon,
Qi Chen,
Eric L Van Nostrand,
Jose L Sardina,
Florian Grebien,
Bruno Di Stefano.
Nat Cell Biol. 2024 Oct;26(10):1745-1758. doi: 10.1038/s41556-024-01489-6. Epub 2024 Aug 21.
2024
Differential regulation of mitochondrial uncoupling protein 2 in cancer cells
Taraneh Beikbaghban,
Ludovica Proietti,
Jessica Ebner,
Roko Sango,
Thomas Rattei,
Thomas Weichhart,
Florian Grebien,
Felix Sternberg,
Elena E Pohl.
Biochim Biophys Acta Bioenerg. 2024 Nov 1;1865(4):149486. doi: 10.1016/j.bbabio.2024.149486. Epub 2024 Jul 8.
2024
A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
Sophie Edtmayer,
Agnieszka Witalisz-Siepracka,
Bernhard Zdársky,
Kerstin Heindl,
Stefanie Weiss,
Thomas Eder,
Sayantanee Dutta,
Uwe Graichen,
Sascha Klee,
Omar Sharif,
Rotraud Wieser,
Balázs Győrffy,
Valeria Poli,
Emilio Casanova,
Heinz Sill,
Florian Grebien,
Dagmar Stoiber.
Cell Death Dis. 2024 May 28;15(5):369. doi: 10.1038/s41419-024-06749-9.
2024
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
Tobias Suske,
Helena Sorger,
Gabriele Manhart,
Frank Ruge,
Nicole Prutsch,
Mark W Zimmerman,
Thomas Eder,
Diaaeldin I Abdallah,
Barbara Maurer,
Christina Wagner,
Susann Schönefeldt,
Katrin Spirk,
Alexander Pichler,
Tea Pemovska,
Carmen Schweicker,
Daniel Pölöske,
Emina Hubanic,
Dennis Jungherz,
Tony Andreas Müller,
Myint Myat Khine Aung,
Anna Orlova,
Ha Thi Thanh Pham,
Kerstin Zimmel,
Thomas Krausgruber,
Christoph Bock,
Mathias Müller,
Maik Dahlhoff,
Auke Boersma,
Thomas Rülicke,
Roman Fleck,
Elvin Dominic de Araujo,
Patrick Thomas Gunning,
Tero Aittokallio,
Satu Mustjoki,
Takaomi Sanda,
Sylvia Hartmann,
Florian Grebien,
Gregor Hoermann,
Torsten Haferlach,
Philipp Bernhard Staber,
Heidi Anne Neubauer,
Alfred Thomas Look,
Marco Herling,
Richard Moriggl.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
