Publications
2026
Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing
Basheer Becerra,
Sandra Wittibschlager,
Zain M Patel,
Ana P Kutschat,
Justin Delano,
Eric Che,
Anzhelika Tauber,
Ting Wu,
Marlena Starrs,
Christina S Horstmann,
Sophie Müller,
Madelynn N Whittaker,
Elise Sylvander,
Manfred Lehner,
Michael I Love,
Benjamin P Kleinstiver,
Martin Jankowiak,
Daniel E Bauer,
Davide Seruggia,
Luca Pinello.
Nat Commun. 2026 Mar 3;17(1):3398. doi: 10.1038/s41467-026-69918-8.
2026
Directing stem cell differentiation by chromatin state approximation
Luis F Montano-Gutierrez,
Sophie Müller,
Ana P Kutschat,
Igor Adameyko,
Davide Seruggia,
Florian Halbritter.
Nucleic Acids Res. 2026 Feb 24;54(5):gkag124. doi: 10.1093/nar/gkag124.
2025
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
Ramona Rica,
Monika Waldherr,
Emi Miyakoda,
Ana Patricia Kutschat,
Marlene Schülein,
Jing Zhang,
Ricardo Alfredo Orbegozo-Medina,
Lisa Sandner,
Valentina Stolz,
Darina Waltenberger,
Thomas Krausgruber,
Christoph Bock,
Nicole Boucheron,
Davide Seruggia,
Wilfried Ellmeier,
Shinya Sakaguchi.
J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4.
2025
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation
Teresa Neuwirth,
Daniel Malzl,
Katja Knapp,
Panagiota Tsokkou,
Lisa Kleissl,
Anna Gabriel,
Baerbel Reininger,
Christian Freystätter,
Nara Marella,
Ana P Kutschat,
Elisabeth Ponweiser,
Arvand Haschemi,
Davide Seruggia,
Jörg Menche,
Erwin F Wagner,
Georg Stary.
Immunity. 2025 Mar 11;58(3):632-647.e12. doi: 10.1016/j.immuni.2025.02.011. Epub 2025 Feb 28.
2024
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6
Thibault Viennet,
Maolu Yin,
Abhilash Jayaraj,
Woojin Kim,
Zhen-Yu J Sun,
Yuko Fujiwara,
Kevin Zhang,
Davide Seruggia,
Hyuk-Soo Seo,
Sirano Dhe-Paganon,
Stuart H Orkin,
Haribabu Arthanari.
Structure. 2024 Dec 5;32(12):2276-2286.e4. doi: 10.1016/j.str.2024.09.022. Epub 2024 Oct 17.
2024
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing
Basheer Becerra,
Sandra Wittibschlager,
Zain M Patel,
Ana P Kutschat,
Justin Delano,
Eric Che,
Anzhelika Karjalainen,
Ting Wu,
Marlena Starrs,
Martin Jankowiak,
Daniel E Bauer,
Davide Seruggia,
Luca Pinello.
bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612085. doi: 10.1101/2024.09.09.612085.
2024
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
Cristiano De Sá Fernandes,
Philipp Novoszel,
Tommaso Gastaldi,
Dana Krauß,
Magdalena Lang,
Ramona Rica,
Ana P Kutschat,
Martin Holcmann,
Wilfried Ellmeier,
Davide Seruggia,
Herbert Strobl,
Maria Sibilia.
Cell Rep. 2024 Jun 25;43(6):114308. doi: 10.1016/j.celrep.2024.114308. Epub 2024 Jun 2.
2023
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche
Elisa Manieri,
Guodong Tie,
Ermanno Malagola,
Davide Seruggia,
Shariq Madha,
Adrianna Maglieri,
Kun Huang,
Yuko Fujiwara,
Kevin Zhang,
Stuart H Orkin,
Timothy C Wang,
Ruiyang He,
Neil McCarthy,
Ramesh A Shivdasani.
Nat Commun. 2023 Dec 2;14(1):7978. doi: 10.1038/s41467-023-43619-y.
2023
In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice
Bin E Li,
Grace Y Li,
Wenqing Cai,
Qian Zhu,
Davide Seruggia,
Yuko Fujiwara,
Christopher R Vakoc,
Stuart H Orkin.
Blood Adv. 2023 Sep 26;7(18):5281-5293. doi: 10.1182/bloodadvances.2022009455.
2022
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Stuti Mehta,
Altantsetseg Buyanbat,
Yan Kai,
Ozge Karayel,
Seth Raphael Goldman,
Davide Seruggia,
Kevin Zhang,
Yuko Fujiwara,
Katherine A Donovan,
Qian Zhu,
Huan Yang,
Behnam Nabet,
Nathanael S Gray,
Matthias Mann,
Eric S Fischer,
Karen Adelman,
Stuart H Orkin.
Cell Chem Biol. 2022 Aug 18;29(8):1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. Epub 2022 Jul 14.
