On 18 May 2020, Proxygen GmbH, a startup company by CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, Georg Winter, Giulio Superti-Furga, Stefan Kubicek and Matthias Brand has been founded.

Proxygen GmbH will develop therapies against cancer and other life-threatening diseases by reprogramming the cellular protein quality control system. Proxygen is focused on particular small molecules called “molecular glue degraders” which induce proximity between a disease-causing protein and an ubiquitin ligase. Consequently, the target protein is ubiquitinated and directed to the proteasome for degradation. Instead…

How cells recognize pathogens and alert the immune system swiftly is a fundamental process of high importance for the survival of any species, including humans. A key role is ascribed to so-called adapters, that equal little molecular platforms inside cells where signals from pathogen detectors are integrated for safety and accuracy and conveyed to lasting signals leading to the activation of the major “red alarm” genes, like interferons. Researchers from the lab of Giulio Superti-Furga at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in collaboration with Boehringer Ingelheim have identified a new key…

Researchers from Stefan Kubicek's and Christoph Bock’s groups, at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, have developed a method to accurately assess the effect of specific drugs in isolated pancreatic tissue by using a refined single-cell RNA sequencing method. Their study published in Genome Biology describes the technique that they have developed to overcome the problem of contaminating RNA molecules in single-cell transcriptomics, which allowed for accurate results of dynamic drug responses in pancreatic cells. These findings will support the development of targeted drug therapies…

CeMM Adjunct PI Nuno Maulide’s group at the University of Vienna has developed an efficient reaction sequence to increase the oxidation state in oleanolic acid in the lab. In collaboration with the Georg Winter group at CeMM, the researchers also evaluated the antileukemic activity of the prepared compounds, revealing pronounced antiproliferative activity of a synthetic intermediate. The study, published in the renowned journal Chem, illustrates the value of interdisciplinary collaboration in basic research, when synthetic organic chemistry and cancer biology are harnessed to deliver a synergistic outcome.

Terpenes are a large class of…

Today CeMM is launching the official Alumni LinkedIn group to provide CeMM Alumni for a space where they can come together with their former colleagues and friends and stay connected. In this private platform, former CeMMies can keep up to date with what is happening at CeMM, as well as post news, relevant job openings and announce events.

The CeMM Alumni Network was established back in 2017 with the aim of connecting or re-connecting with former CeMM colleagues. Currently, the Alumni Network has over 170 members living in 22 different countries and distributed across four continents.

The CeMM Alumni Network is represented by the Alumni…

Researchers love music and listen to music all the time. The new CeMM Research Report has a musical backbone. Like in science, where people from different countries and with different cultural backgrounds share a common goal to search truth and to advance knowledge, music brings together individuals with different background. Music is a universal language that speaks to our brain, melts our hearts, goes under our skin and so on. As soundtrack to our 2019 Research Report, we have chosen six pop songs, which by lyrics and mood are suitable to connect you to CeMM’s areas of research.

Nuno Maulide, Adjunct Principal Investigator at CeMM and…

The first 21 SARS-CoV-2 genomes in Austria have now been completed and published within the scope of the “Mutational Dynamics of SARS-CoV-2” project recently launched by CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, in close collaboration with the Medical University of Vienna. The project aims at sequencing 1,000 viral genomes obtained from Austrian patient-derived samples, in order to learn more about the molecular understanding of the COVID-19 pandemic and the causative pathogen. The project results will integrate Austrian viral genome data into a global map of SARS-CoV-2 mutations, which will help…

The CeMM community was shocked to hear the tragic news of the passing of Michael Wakelam, Director of The Babraham Institute, Cambridge, U.K.

Since the foundation of the EU-Life Alliance, he was committed to building a community of excellence and promoting science. We will remember him from his visits to CeMM and collaborating with him at EU-Life meetings. Those who met him, even briefly, will remember him as friendly and open, always available for a chat or an in-depth discussion.  His dedication to The Babraham, to EU-Life, to science and science education was immense. His loss will be deeply felt across the European science community.

O…

As a leading biomedical research institute, CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, is committed to advancing our molecular understanding of the COVID-19 pandemic and the causative pathogen, SARS-CoV-2. Biomedical research on the virus and the disease will contribute substantially to informed policy decisions and, ultimately, the development of new treatments.

An interdisciplinary team at CeMM under the project leadership of virologist Andreas Bergthaler and computational biologist Christoph Bock will investigate SARS-CoV-2 genome evolution in patients by deep sequencing and sophisticated…

Due to the latest developments in the corona virus (COVID-19) and as a preventive health measure, CeMM has decided to cancel all public events and seminars until 13 April 2020. Events will be rescheduled to a later date.

Please check the CeMM website where the new dates will be announced.

Should you have any questions, do not hesitate to contact us at info@cemm.at