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Participants at the virtual 1st REsolution Consortium Meeting (© CeMM).

1st REsolution Consortium Meeting 21 October 2021

On 21 October 2021, the REsolution consortium held its first consortium meeting online with 30 participants. The REsolution consortium is a public-private research partnership supported by the Innovative Medicines Initiative (IMI), the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA), with nine partners from academia and the pharmaceutical industry. With a duration of two years, the project aims at understanding how genetic variants in humans affect the function of cellular solute carrier transporters (SLCs).

Scientists from different work packages described the progress on the collection and…

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Artist Adriana Czernin with CeMM PhD students in the inauguration event (© Franzi Kreis / CeMM).

Artist Adriana Czernin designed chair’s backrest for CeMM’s Brain Lounge

On 19 October 2021, CeMM welcomed artist Adriana Czernin for the inauguration of the new chair’s backrest that she has specially designed for CeMM’s Brain Lounge. During the event, Adriana Czernin presented her piece of art entitled “4-sided 3-angle”, and discussed with CeMM PhD students the design process, and the combination of abstract art with the idea of perspective in her work. 
 
CeMM’s Brain Lounge is located on the 8th floor of CeMM’s building, overlooking the impressive Vienna’s skyline. It was originally built as a special space where participants can abandon their daily professional routine and embark on a new journey to ignite…

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Prof. David M. Livingston (© Michael Sazel / CeMM).

Obituary David M. Livingston

It is with great sadness that we learn of the decease of Prof. David M. Livingston, former Deputy Director, Dana-Farber/Harvard Cancer Center, Boston, USA. David Livingston was the Chair of the Scientific Advisory Board of CeMM from its very beginning until 2018, and had a huge influence on the development and success of our institute. We lose an extraordinary scientist and highly esteemed advisor. His constructive criticism, encouraging words and his humor and good spirit will be dearly missed by the CeMM Directors and by the entire CeMM community. Our thoughts are with his wife Emily, his family, friends and collaborators.

David Livingston…

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From left to right: Laura Marie Gail, Georg Stary and Johanna Strobl (©Laura Alvarez / CeMM).

Stem cell transplant: How skin-derived T cells can damage other organs

More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system. Very often, the so-called graft-versus-host reaction occurs, an inflammatory disease that can affect different organs and is caused by an unwanted defense reaction of the donor cells and the body’s own T cells. Scientists at CeMM, Medical University of Vienna and LBI-RUD, led by Georg Stary, now show how these endogenous, tissue-derived T cells enter other organs, such as the intestine, via the blood and contribute to inflammation there. The study

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Philipp Staber and Giulio Superti-Furga (c) CeMM

First worldwide personalized-medicine study using a functional test demonstrates clinical feasibility and efficacy of individualized therapy in leukemia and lymphoma patients

Standard therapy for advanced recurring aggressive, hematological malignancies, such as leukemias and lymphomas, have a limited effect with patients experiencing short survival times. A study at the Vienna General Hospital conducted by physicians and scientists from Medical University Vienna and CeMM, as well as ETH Zurich for the first time demonstrated that therapy selection based on results from a functional test is clinically possible and effective in patients with recurrent hematologic cancers. The researchers quantified drug effects on single cells from real-time patient biopsies using a novel experimental technique, resulting in 56…

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The RESOLUTE consortium in Basel (c) Michael Nyffenegger;

6th RESOLUTE Consortium Meeting in Basel

RESOLUTE is a public-private partnership with 13 partners from academia and industry with an overarching goal: To trigger an escalation in the appreciation and intensity of research on solute carriers (SLCs) worldwide and to establish SLCs as a tractable target class for medical research and development. The project is coordinated by CeMM and Pfizer. 
From 4th to 7th October 2021, Novartis and Vifor Pharma hosted the 6th RESOLUTE Consortium Meeting in Basel (Switzerland) and virtually. Around 100 participants joined the hybrid event and discussed their projects and publication strategies.

Participants were welcomed at the Novartis campus and…

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Cachexia: How do immune responses contribute to weight loss?

Cachexia is the name of a syndrome that is associated with numerous chronic diseases. It refers to weight loss induced by shrinkage of both fat reserves and muscle tissue. Although the occurrence of cachexia can have serious implications on patients’ health and survival, there are many aspects of this syndrome that are unknown and therapeutic options remain very limited. Scientists from Andreas Bergthaler's research group at  CeMM emphasize the need for more research into cachexia in their recent publication in Nature Reviews Immunology. In order to counteract cachexia and numerous other diseases, a better understanding of the interplay…

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From L to R: Thomas Hannich, Anna Koren, Prudence Donovan, Stefan Kubicek, André Müller and Christoph Bock (© Laura Alvarez / CeMM).

Meet CeMM at BIO-Europe Digital on 25-28 October 2021

As a pioneering institute with the goal of achieving maximum scientific innovation in molecular medicine to improve healthcare, CeMM is fully committed to identifying, supporting, and developing its research discoveries into impactful solutions for society. In line with this, once again this year on 25-28 October, CeMM will be joining the BIO-Europe Digital conference, the meeting point for global biopharma and investment leaders to build partnerships that facilitate innovation and medical breakthroughs. 

CeMM IP and Technology Transfer Manager, Prudence Donovan, together with the heads of CeMM services and facilities, Christoph Bock,…

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Colored microscopy image of the monolith, © Lahnsteiner M, Unterlass M, published in the Royal Society of Chemistry's peer-reviewed Journal of Materials Chemistry A, 2021.

Eco-friendly process for synthesizing organic materials developed for high-performance materials industry

Until now, the production of materials from organic substances was only possible with the use of highly toxic solvents. A team led by chemist Miriam Unterlass, Professor at the University of Konstanz and Adjunct Principal Investigator at CeMM, has now developed a method for making organic substances suitable for use as high-performance materials in an eco-friendly and completely non-toxic way by generating them in only hot water. The study represents an important milestone in the green production of organic materials and thus also provides an important incentive to switch from inorganic to organic, renewable materials. Beside that the method…

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RESOLUTE Scientific Project Manager Tabea Wiedmer, Schoolteacher Alexandra Schmidl and RESOLUTE Senior Scientist Gernot Wolf / Laura Alvarez, CeMM

Seitenwechsel candidate Alexandra Schmidl joins CeMM for a year

On 6 September 2021, schoolteacher Alexandra Schmidl joins CeMM as part of the Seitenwechsel program, which fosters fruitful exchanges among companies and teachers in Austria. During the next year, she will have a full immersion in the scientific environment at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, where she will benefit from daily interactions with CeMM researchers. The knowledge and new techniques that she acquires, will be then applied in her teaching when she goes back to her classroom next year. CeMM will not only profit from her everyday school life know-how, but will also gain further…

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