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Year
Paper
2021
Achyutuni S, Nivarthi H, Majoros A, Hug E, Schueller C, Jia R, Varga C, Schuster M, Senekowitsch M, Tsiantoulas D, Kavirayani A, Binder CJ, Bock C, Zagrijtschuk O, Kralovics R. Hematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivo. Am J Hematol. 2021 Mar 24. doi: 10.1002/ajh.26171. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33761144/
2020
Mussbacher M, Salzmann M, Haigl B, Basílio J, Hochreiter B, Gleitsmann V, Moser B, Hoesel B, Suur BE, Puhm F, Ungerböck C, Kuttke M, Forteza MJ, Binder CJ, Ketelhuth DFJ, Assinger A, Schmid JA. Ikk2-mediated inflammatory activation of arterial endothelial cells promotes the development and progression of atherosclerosis. Atherosclerosis. 2020 Aug;307:21-31. doi: 10.1016/j.atherosclerosis.2020.06.005. Epub 2020 Jul 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32711212/
2020
Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt M, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Sci Immunol. 2020 Jul 10;5(49):eabc3979. doi: 10.1126/sciimmunol.abc3979.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32646852/
2020
Hofheinz K, Seibert F, Ackermann JA, Dietel B, Tauchi M, Oszvar-Kozma M, Kühn H, Schett G, Binder CJ, Krönke G. Formation of atherosclerotic lesions is independent of eosinophils in male mice. Atherosclerosis. 2020 Oct;311:67-72. doi: 10.1016/j.atherosclerosis.2020.08.030. Epub 2020 Sep 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32947200/
2020
Hendrikx T, Binder CJ. Oxidation-Specific Epitopes in Non-Alcoholic Fatty Liver Disease. Front Endocrinol (Lausanne). 2020 Dec 9;11:607011. doi: 10.3389/fendo.2020.607011.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33362721/
2019
Kiss MG, Ozsvár-Kozma M, Porsch F, Göderle L, Papac-Miličević N, Bartolini-Gritti B, Tsiantoulas D, Pickering MC, Binder CJ. Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production. Front Immunol. 2019;10:1607. Published 2019 Jul 11. doi:10.3389/fimmu.2019.01607
Abstract: https://pubmed.ncbi.nlm.nih.gov/31354740/
2019
Houben T, Magro Dos Reis I, Oligschlaeger Y, Steinbusch H, Gijbels MJJ, Hendrikx T, Binder CJ, Cassiman D, Westerterp M, Prickaerts J, Shiri-Sverdlov R. Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease. Front Immunol. 2019 Jan 7;9:3089. doi: 10.3389/fimmu.2018.03089. eCollection 2018.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30666257/
2019
Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH, Binder CJ, Kaser A, Mallat Z. Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice. Circ Res. 2019;125(11):1019–1034. doi:10.1161/CIRCRESAHA.119.315248
Abstract: https://pubmed.ncbi.nlm.nih.gov/31610723/
2019
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R1, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation. 2019 May 21;139(21):2466-2482. doi: 10.1161/CIRCULATIONAHA.118.038534.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30894016/
2019
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S,Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T,Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, HabenichtAJR. ApoE attenuates unresolvable inflammation by complex formation withactivated C1q. Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8.Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Feb 4;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692699
2019
Sage AP, Tsiantoulas D, Binder CJ, Mallat Z. The role of B cells inatherosclerosis. Nat Rev Cardiol. 2019 Mar;16(3):180-196. doi:10.1038/s41569-018-0106-9. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30410107
2019
Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M,Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N,Boilard E, Binder CJ. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells. Circ Res. 2019 Jun 21;125(1):43-52. doi:10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31219742
2019
Porsch F, Binder CJ. Impact of B-Cell-Targeted Therapies on Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Jul 18:ATVBAHA119311996. doi:10.1161/ATVBAHA.119.311996. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31315439
2019
McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L,Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M,Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb13.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30760925
2019
Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C,Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res. 2019 Jul 1;115(9):1385-1392. doi:10.1093/cvr/cvz166.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31228191
2019
Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M,Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, BinderCJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi:10.1161/ATVBAHA.118.312272. Epub 2019 May 16.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31092015
2018
Sage AP, Tsiantoulas D, Binder CJ, Mallat Z. The role of B cells in atherosclerosis. Nat Rev Cardiol. 2018 Nov 8. doi: 10.1038/s41569-018-0106-9. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30410107
2018
Puchner A, Saferding V, Bonelli M, Mikami Y, Hofmann M, Brunner JS, Caldera M, Goncalves-Alves E, Binder NB, Fischer A, Simader E, Steiner CW, Leiss H, Hayer S, Niederreiter B, Karonitsch T, Koenders MI, Podesser BK, O'Shea JJ, Menche J, Smolen JS, Redlich K, Blüml S. Non-classical monocytes as mediators of tissue destruction in arthritis. Ann Rheum Dis. 2018 Oct;77(10):1490-1497. doi: 10.1136/annrheumdis-2018-213250. Epub 2018 Jun 29.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29959183
2018
Afonyushkin T, Oskolkova OV, Bochkov VN. Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms. Angiogenesis. 2018 May;21(2):229-236. doi: 10.1007/s10456-017-9590-5. Epub 2018 Jan 12. PubMed PMID: 29330760; PubMed Central PMCID: PMC5878191.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29330760
2018
Clément M, Haddad Y, Raffort J, Lareyre F, Newland SA, Master L, Harrison J, Ozsvar-Kozma M, Bruneval P, Binder CJ, Taleb S, Mallat Z. Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity. Circ Res. 2018 Mar 16;122(6):813-820. doi: 10.1161/CIRCRESAHA.118.312713. Epub 2018 Feb 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29436389
2018
Tsiantoulas D, Sage AP, Göderle L, Ozsvar-Kozma M, Murphy D, Porsch F, Pasterkamp G, Menche J, Schneider P, Mallat Z, Binder CJ. BAFF Neutralization Aggravates Atherosclerosis. Circulation. 2018 Jun 1. pii: CIRCULATIONAHA.117.032790. doi: 10.1161/CIRCULATIONAHA.117.032790. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29858401
2018
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbit CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S. Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018 Jun 7. pii: ATVBAHA.118.310802. doi: 10.1161/ATVBAHA.118.310802. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29880490
2017
Tsiantoulas D, Bot I, Ozsvar-Kozma M, Göderle L, Perkmann T, Hartvigsen K, Conrad DH, Kuiper J, Mallat Z, Binder CJ. Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency. Circ Res. 2017 Jan 6;120(1):78-84. doi: 10.1161/CIRCRESAHA.116.309606. Epub 2016 Nov 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27903567
2017
Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017 Apr;65(4):1181-1195. doi: 10.1002/hep.28970. Epub 2017 Feb 3.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27981604
2017
Weißer J, Ctortecka C, Busch CJ, Austin SR, Nowikovsky K, Uchida K, Binder CJ, Bennett KL. A Comprehensive Analytical Strategy To Identify Malondialdehyde-Modified Proteins and Peptides. Anal Chem. 2017 Apr 4;89(7):3847-3852. doi: 10.1021/acs.analchem.6b05065. Epub 2017 Mar 15.h
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28248083
2017
Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28414328
2017
Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28572286
2017
Newland SA, Mohanta S, Clément M, Taleb S, Walker JA, Nus M, Sage AP, Yin C, Hu D, Kitt LL, Finigan AJ, Rodewald HR, Binder CJ, McKenzie ANJ, Habenicht AJ, Mallat Z. Type-2 innate lymphoid cells control the development of atherosclerosis in mice. Nat Commun. 2017 Jun 7;8:15781. doi: 10.1038/ncomms15781.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28589929
2017
Tsiantoulas D, Kiss M, Bartolini-Gritti B, Bergthaler A, Mallat Z, Jumaa H, Binder CJ. Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. Sci Rep. 2017 Jun 14;7(1):3540. doi: 10.1038/s41598-017-03688-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615655
2017
Houben T, Oligschlaeger Y, Hendrikx T, Bitorina AV, Walenbergh SMA, van Gorp PJ, Gijbels MJJ, Friedrichs S, Plat J, Schaap FG, Lütjohann D, Hofker MH, Shiri-Sverdlov R. Cathepsin D regulates lipid metabolism in murine steatohepatitis. Sci Rep. 2017 Jun 14;7(1):3494. doi: 10.1038/s41598-017-03796-5.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615690
2017
Sage AP, Nus M, Bagchi Chakraborty J, Tsiantoulas D, Newland SA, Finigan AJ, Masters L, Binder CJ, Mallat Z. X-Box Binding Protein-1 Dependent Plasma Cell Responses Limit the Development of Atherosclerosis. Circ Res. 2017 Jul 21;121(3):270-281. doi: 10.1161/CIRCRESAHA.117.310884. Epub 2017 Jun 15.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28620068
2017
Ponnuswamy P, Joffre J, Herbin O, Esposito B, Laurans L, Binder CJ, Tedder TF, Zeboudj L, Loyer X, Giraud A, Zhang Y, Tedgui A, Mallat Z, Ait-Oufella H. Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. Sci Rep. 2017 Jun 23;7(1):4111. doi: 10.1038/s41598-017-04438-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28646220
2017
Puhm F, Binder CJ. Characterization of Natural IgM Antibodies Recognizing Oxidation-Specific Epitopes on Circulating Microvesicles. Methods Mol Biol. 2017;1643:147-154. doi: 10.1007/978-1-4939-7180-0_11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28667535
2017
Meeuwsen JAL, van Duijvenvoorde A, Gohar A, Kozma MO, van de Weg SM, Gijsberts CM, Haitjema S, Björkbacka H, Fredrikson GN, de Borst GJ, den Ruijter HM, Pasterkamp G, Binder CJ, Hoefer IE, de Jager SCA. High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease. J Am Heart Assoc. 2017 Sep 7;6(9). pii: e005747. doi: 10.1161/JAHA.117.005747.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28882820
2017
Houben T, Oligschlaeger Y, Bitorina AV, Hendrikx T, Walenbergh SMA, Lenders MH, Gijbels MJJ, Verheyen F, Lütjohann D, Hofker MH, Binder CJ, Shiri-Sverdlov R. Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation. Sci Rep. 2017 Oct 2;7(1):12550. doi: 10.1038/s41598-017-13058-z.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28970532
2016
Chéron M, Ademi M, Kraft F, Löffler-Stastka H. Case-based learning and multiple choice questioning methods favored by students. BMC Med Educ. 2016 Feb 2;16:41. doi: 10.1186/s12909-016-0564-x.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736609/
2016
Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2016 Dec 16. doi: 10.1002/hep.28970.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27981604
2016
Bartolini Gritti B, Binder CJ. Oxidation-specific epitopes are major targets of innate immunity in atherothrombosis. Hamostaseologie. 2016 May 10;36(2):89-96. doi: 10.5482/HAMO-14-11-0069.
Abstract: https://haemo.schattauer.de/inhalt/archiv/issue/2339/manuscript/24014.html
2016
Papac-Milicevic N, Busch CJ, Binder CJ. Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis. Adv Immunol. 2016;131:1-59. doi: 10.1016/bs.ai.2016.02.001. Epub 2016 Apr 5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27235680
2016
Hendrikx T, Watzenböck ML, Walenbergh SM, Amir S, Gruber S, Kozma MO, Grabsch HI, Koek GH, Pierik MJ, Staufer K, Trauner M, Kalhan SC, Jonkers D, Hofker MH, Binder CJ, Shiri-Sverdlov R. Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease. BMC Med. 2016 Jul 22;14(1):107. doi: 10.1186/s12916-016-0652-0.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27443391
2016
Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 2016 Mar 2. pii: S2211-1247(16)30130-9. doi: 10.1016/j.celrep.2016.02.027.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26947073
2016
Busch CJ, Binder CJ. Malondialdehyde epitopes as mediators of sterile inflammation. Biochim Biophys Acta. 2016 Jun 26. pii: S1388-1981(16)30168-8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27355566
2015
Grimm M, Tischner D, Troidl K, Albarrán Juárez J, Sivaraj KK, Ferreirós Bouzas N, Geisslinger G, Binder CJ, Wettschureck N. S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):37-48. doi: 10.1161/ATVBAHA.115.306066. Epub 2015 Nov 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26603156
2015
Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S. Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):25-36. doi: 10.1161/ATVBAHA.115.305990. Epub 2015 Nov 12.
2015
Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H. Responsiveness of B cells is regulated by the hinge region of IgD. Nat Immunol. 2015 May;16(5):534-43. doi: 10.1038/ni.3141. Epub 2015 Apr 6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25848865
2015
Bartolini-Gritti B, Binder CJ. Oxidation-specific epitopes are major targets of innate immunity in atherothrombosis. Hamostaseologie. 2015 Feb 16;35(2).
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25682990
2015
Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol. 2015 Feb 7. pii: S0020-7519(15)00020-X. doi: 10.1016/j.ijpara.2014.12.006.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25666929
2014
Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. B cells and humoral immunity in atherosclerosis. Circ Res. 2014 May 23;114(11):1743-56. doi: 10.1161/CIRCRESAHA.113.301145.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24855199
2014
Schuh C, Wimmer I, Hametner S, Haider L, Van Dam AM, Liblau RS, Smith KJ, Probert L, Binder CJ, Bauer J, Bradl M, Mahad D, Lassmann H. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol. 2014 Aug;128(2):247-66. doi: 10.1007/s00401-014-1263-5. Epub 2014 Mar 13.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24622774
2014
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Atheroprotective immunization with malondialdehyde modified LDL is hapten-specific and dependent on advanced MDA-adducts: Implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct;55(10):2137-55. doi: 10.1194/jlr.M053256. Epub 2014 Aug 20.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25143462
2014
Wolf D, Jehle F, Michel NA, Bukosza N, Rivera J, Chen YC, Hoppe N, Dufner B, Ortiz Rodriguez A, Colberg C, Nieto L, Rupprecht B, Wiedemann A, Schulte L, Peikert A, Bassler N, Lozhkin A, Hergeth SP, Stachon P, Hilgendorf I, Willecke F, von zur Muhlen C, von Elverfeld D, Binder CJ, Aichele P, Varo N, Febbraio M, Libby P, Bode C, Peter K and Zirlik A. Co-inhibitory suppression of T cell activation by CD40 protects from obesity and adipose tissue inflammation in mice. Circulation. Circulation. 2014 Jun 10;129(23):2414-25. doi: 10.1161/CIRCULATIONAHA.113.008055. Epub 2014 Mar 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24664276
2013
Karper JC, de Jager SC, Ewing MM, de Vries MR, Bot I, van Santbrink PJ, Redeker A, Mallat Z, Binder CJ, Arens R, Jukema JW, Kuiper J, Quax PH. An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2810-7. doi: 10.1161/ATVBAHA.113.301882. Epub 2013 Oct 10.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24115036
2013
Hendrikx T, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Jeurissen ML, Steinbusch MM, Vaes N, Binder CJ, Koek GH, Stienstra R, Netea MG, Hofker MH, Shiri-Sverdlov R. Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice. PLoS One. 2013 Dec 2;8(12):e78792. doi: 10.1371/journal.pone.0078792.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24312444
2013
Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat Med. 2013 Oct;19(10):1273-1280.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24037091
2013
Que X, Widhopf II GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde–Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope. PLoS One. 2013; 8(6): e65203.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23840319
2013
Montano EN, Boullier A, Almazan F, Binder CJ, Witztum JL, Hartvigsen K. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res. 2013 Nov;54(11):3206-3214.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23997238
2013
Lichtman AH, Binder CJ, Tsimikas S, Witztum JL. Adaptive immunity in atherogenesis: new insights and therapeutic approaches. J Clin Invest. 2013 Jan 2;123(1):27-36.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23281407
2013
Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain. 2013 June; 136(6): 1799–1815.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23687122
2013
Bieghs V, Walenbergh SM, Hendrikx T, van Gorp PJ, Verheyen F, Olde Damink SW, Masclee AA, Koek GH, Hofker MH, Binder CJ, Shiri-Sverdlov R. Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. Liver Int. 2013 Aug;33(7):1056-61.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23617943
2012
Wolf D, Jehle F, Ortiz Rodriguez A, Dufner B, Hoppe N, Colberg C, Lozhkin A, Bassler N, Rupprecht B, Wiedemann A, Hilgendorf I, Stachon P, Willecke F, Febbraio M, von zur Muhlen C, Binder CJ, Bode C, Zirlik A, Peter K. CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulations and production of pathogenic IdG-antibodies. PLoS One. 2012;7(3):e33026. Epub 2012 Mar 8. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/84102aae-770a-41ae-9c15-4736ed129c17. von zur Muhlen, Constantin [added].
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22412980
2012
Weismann D, Binder CJ. The innate immune response to products of phospholipid peroxidation. Biochim Biophys Acta. 2012 Oct;1818(10):2465-75.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22305963
2012
Tsiantoulas D, Binder CJ. Natural Antibodies and Atherosclerosis; pp. 289-304 in Inflammation and Atherosclerosis; Springer; Edited by Georg Wick & Cecilia Grundtman.
2012
Sage AP, Tsiantoulas D, Baker L, Harrison J, Masters L, Binder CJ, Mallat Z. BAFF (B Cell Activating Factor) Receptor Deficiency Reduces the Development of Atherosclerosis in Mice. Arterioscl Thromb Vasc Biol. 2012 Jul;32(7):1573-6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22426131
2012
Papac-Milicevic N, Breuss JM, Zaujec J, Ryban L, Plyushch T, Wagner GA, Fenzl S, Dremsek P, Cabaravic M, Steiner M, Glass CK, Binder CJ, Uhrin P, Binder BR. The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. Circulation Research. 2012 Apr 13;110(8):e50-63.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22427340
2012
Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E. Abrogated transforming growth factor beta receptor II (TGF_RII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. Eur Heart J. 2012 May 21.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22613345
2012
Elsoe S, Ahnstrom J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW, Binder CJ, Bjorkbacka H, Dahlback B, Nielsen LB. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis 221:91-97.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22204862
2012
Doring Y, Manthey H, Drechsler M, Lievens D, Megens R, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E, Zenke M, Binder CJ, Weber C, Zernecke A. Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis. Circulation 2012 Apr 3;125(13):1673-83.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22388324
2012
Bieghs V, Verheyen F, van Gorp PJ, Hendrikx T, Wouters K, Lütjohann D, Gijbels MJ, Febbraio M, Binder CJ, Hofker MH, Shiri-Sverdlov R. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS One. 2012;7(3):e34378. Epub 2012 Mar 28.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22470565
2012
Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lutjohann D, Staels B, Hofker MH, Shiri-Sverdlov R. LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease. PLoS One 7:e30668.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22295101
2012
Bieghs V, van Gorp PJ, Walenbergh SM, Gijbels MJ, Verheyen F, Buurman WA, Briles DE, Hofker MH, Binder CJ, Shiri-Sverdlov R. Specific immunization strategies against oxidized low-density lipoprotein: A novel way to reduce nonalcoholic steatohepatitis in mice. Hepatology. 2012 Sep;56(3):894-903. doi: 10.1002/hep.25660. Epub 2012 Jul 6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22334337
2012
Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul;53(7):1316-26. Epub 2012 Apr 16.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22508944
2011
Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan;25(1):290-300.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20876212
2011
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstatter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 6;478(7367):76-81.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21979047
2011
Weber C, Meiler S, Doring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Forster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011 Jul;121(7):2898-910.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21633167
2011
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21;108(2):235-48.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21252151
2011
Lutgens E, Binder CJ. Immunology of atherosclerosis. Thromb Haemost. 2011 Nov;106(5):755-6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22011700
2011
Haider L, Fischer MT, Frischer JM, Bauer J, Hoftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H. Oxidative damage in multiple sclerosis lesions. Brain. 2011 Jul;134(Pt 7):1914-24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21653539
2011
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Ozturk M, Palkonen S, Prefaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schunemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski- Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med. 2011;3(7):43.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21745417
2011
Binder CJ, Witztum JL. Is atherosclerosis an allergic disease? Circ Res. 2011 Oct 28;109(10):1103-4.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22034478
2010
Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2010 Sep 27.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20876212
2010
Pedersen TX, Binder CJ, Fredrikson GN, Nilsson J, Bro S, Nielsen LB. The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice. Nephrol Dial Transplant. 2010 Aug;25(8):2486-91. Epub 2010 Feb 17.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20164045
2010
Jellusova J, Duber S, Guckel E, Binder CJ, Weiss S, Voll R, Nitschke L. Siglec-G Regulates B1 Cell Survival and Selection. J Immunol. 2010 Sep 15;185(6):3277-84. Epub 2010 Aug 20.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20729333
2010
Cardilo-Reis L, Witztum JL, Binder CJ. When monocytes come (too) close to our hearts. J Am Coll Cardiol. 2010 Apr 13;55(15):1639-41.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20378084
2010
Binder CJ. Natural IgM Antibodies Against Oxidation-Specific Epitopes. J Clin Immunol. 2010 May;30 Suppl 1:S56-60.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20387104
2010
Bieghs V, Wouters K, Van Gorp PJ, Gijbels MJ, De Winther MP, Binder CJ, Lutjohann D, Febbraio M, Moore KJ, Van Bilsen M, Hofker MH, Shiri-Sverdlov R. Role of Scavenger Receptor A and CD36 in Diet-induced Non-alcoholic Steatohepatitis in Hyperlipidemic Mice. Gastroenterology. 2010 Jun;138(7):2477-86, 2486.e1-3. Epub 2010 Mar 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20206177
2010
Ait-Oufella H, Herbin O, Bouaziz JD, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vre E, Esposito B, Vilar J, Sirvent J, Van Snick J, Tedgui A, Tedder TF, Mallat Z. B cell depletion reduces the development of atherosclerosis in mice. J Exp Med. 2010 Aug 2;207(8):1579-87. Epub 2010 Jul 5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20603314
2009
Schwartz-Albiez R, Monteiro RC, Rodriguez M, Binder CJ, Shoenfeld Y. Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation. Clin Exp Immunol, 2009 Dec;158 Suppl 1:43-50.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19883423
2009
Lutz HU, Binder CJ, Kaveri S. Naturally occurring auto-antibodies in homeostasis and disease. Trends Immunol, 2009 Jan;30(1):43-51.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19058756
2009
Kelly JA, Griffifin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM. Inhibition of arterial lesion progression in CD16-defificient mice: evidence for altered immunity and the role of IL-10. Cardiovasc Res, Epub 2009 Sep 19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19720605
2009
Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. The role of innate immunity in atherogenesis. J Lipid Res, 2009 Apr;50 Suppl:S388-93.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19106070
2009
Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest, 2009 May;119(5):1335-49. Epub 2009 Apr 13.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19363291
2009
Bochkov VN, Oskolkova OV, Birukov KG, Levonen AL, Binder CJ, Stöckl J. Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal, Epub 2009 Aug 17.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19686040
2009
Amir S, Binder CJ. Experimental immunotherapeutic approaches for atherosclerosis. Clin Immunol, Epub 2009 Aug 8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19666239
2008
Sämpi M, Ukkola O, Päivänsalo M, Kesäniemi YA, Binder CJ, Hörkkö S. Plasma interleukin – 5 levels are related to antibodies binding to oxidized low-density lipoprotein and to decreased subclinical atherosclerosis. J Am Coll Cardiol. 2008, Oct 21;52(17):1370–8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18940525
2008
Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008, Apr 18;133(2):235–49.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18423196
2008
Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. Oxidation-specific epitopes are important targets of innate immunity. J Intern Med. 2008, May;263(5):479–88. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18410591
2008
Bro S, Flyvbjerg A, Binder CJ, Bang CA, Denner L, Olgaard K, Nielsen LB. A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice. Atherosclerosis. 2008, Dec;201(2):274–80.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18371970
2008
Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008, Mar;9(3):190–5. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18336236
2008
Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008, Oct;49(10):2230–9.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18594118
2007
Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, et al. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscl Thromb Vasc Biol. 2007, 27(4):878–85.
Abstract: http://atvb.ahajournals.org/content/27/4/878.long
2007
Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB. Inhibition of the Renin-Angiotensin System Abolishes the Proatherogenic Effect of Uremia in Apolipoprotein E-Deficient Mice. Arterioscl Thromb Vasc Biol. 2007, 27(5):1080–6. 
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17347482
2007
Binder CJ, Hartvigsen K, Witztum JL. Promise of immune modulation to inhibit atherogenesis. J Am Coll Cardiol. 2007, 50(6):547–50. 
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17678739