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Andreas Bergthaler (© Franzi Kreis / CeMM).

Andreas Bergthaler becomes Professor for Molecular Immunology at MedUni Vienna, and CeMM Adjunct Principal Investigator

On 1 January 2022, Andreas Bergthaler and his team members will join the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna. There, Andreas will head the Institute for Hygiene and Applied Immunology. He will now become an Adjunct Principal Investigator at CeMM.

Andreas Bergthaler studied veterinary medicine at the University of Veterinary Medicine in Vienna. For his graduate studies, he joined the Institute of Experimental Immunology at the ETH and University of Zurich (Switzerland), with Profs. Hans Hengartner and Nobel Laureate Rolf Zinkernagel. After postdoctoral work in the laboratory of Prof.…

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Season Greetings

At the beginning of the pandemic, we optimistically hailed the "scientification of society” a so-called “Verwissenschaftlichung der Gesellschaft” as a positive Corona side effect. Multiple Covid vaccines within a year and tailored medicines represent a triumph for research and innovation. Yet, at a time in history when humanity's inventiveness is impressively evidenced, the status of science in society is surprisingly low. We would like to see a change in 2022. Never before has scientific and technical know-how been so important. Just think of climate change, the destruction of the environment and geo/biodiversity, famines, forced migration,…

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Tea Pemovska and Giulio Superti-Furga (© Klaus Pichler / CeMM)

Specific metabolic dependencies of cancer cells revealed by perturbation with tailored chemical library offer new therapeutic possibilities

Many types of cancer exhibit changes in their cellular metabolism. These contribute to the development and progression of cancer. Metabolic reprogramming has, thus, been recognized as a hallmark of cancer and may thus represent a vulnerability to be exploited by targeted cancer therapy. Scientists from the research group of Giulio Superti-Furga, Scientific Director at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor at the Medical University of Vienna, have now used a drug library of 243 compounds targeting a variety of metabolic pathways to identify sensitivities among 15 myeloid leukemia cell…

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CeMM Adjunct Principal Investigator Kaan Boztug (© Klaus Pichler / CeMM).

Kaan Boztug takes over professorship in the subject field Paediatrics and Inflammation Research in MedUni Vienna

CeMM Principal Investigator Kaan Boztug, consultant in paediatrics and adolescent medicine and internationally renowned expert in rare haematopoietic and immunological diseases, has accepted a professorship (§ 99 Para. 4 UG) in the subject field Paediatrics and Inflammation Research at the Medical University of Vienna's Department of Pediatrics and Adolescent Medicine with effect from 01 December 2021.

During the course of his medical and scientific work in the field of congenital immunodeficiencies and haematopoietic disorders, Kaan Boztug has played a leading role in the description and molecular characterisation of more than 15 previously…

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Tala Shahin and Kaan Boztug. Photo credit: St. Anna Children’s Cancer Research Institute, Ian Ehm

A disturbed Helios-dependent epigenetic regulation mechanism causes T and B cell defects in an inborn immune disease.

From the god of sun to immunodeficiency: international research team identifies new rare disease affecting hematopoiesis and immunity

A disturbed Helios-dependent epigenetic regulation mechanism causes T and B cell defects in an inborn immune disease. 

Together with international collaborators, scientists at the St. Anna Children’s Cancer Research Institute discover a new inborn error of hematopoiesis and immunity, caused by an inherited genetic defect of the transcription factor Helios. In their research project, the team was able to define previously unknown roles of Helios in immune activation and homeostasis. The study is now published in the high-ranked scientific journal Science Immunology.

The immune system is one of the most complex and fascinating networks in the…

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Simona Saluzzo and Georg Stary (©Laura Alvarez / CeMM).

Prompt initiation of antiretroviral therapy reduces cancer risk in HIV patients

HIV patients have an increased risk of developing skin and mucosal cancers, even though HIV is no longer detectable in their blood due to antiretroviral therapy. A new study by MedUni Vienna's Department of Dermatology, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) and the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences now shows that the time of starting antiretroviral therapy can influence tumour development. The results have recently been published in the specialist journal “Immunity”.

HIV (human immunodeficiency virus) infects and destroys immune cells that carry a specific…

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Last author Jörg Menche and first author Pisanu Buphamalai (©Laura Alvarez / CeMM).

Multiplex network improves diagnosis and analysis of rare diseases

Rare diseases are usually caused by a single genetic defect. Nevertheless, the search for the cause and the assessment of the effects is highly complex and difficult. Scientist Jörg Menche, Adjunct Principal Investigator at the CeMM, Professor at the University of Vienna and Research Group Leader at the Max Perutz Labs, and his team have now developed a multiplex network that maps all genes and their interactions on multiple levels and improves the identification of genetic defects and the assessment of their consequences.

 In contrast to common diseases, which are usually characterized by a complex interaction of multiple genetic and…

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Participants at the virtual 1st REsolution Consortium Meeting (© CeMM).

1st REsolution Consortium Meeting 21 October 2021

On 21 October 2021, the REsolution consortium held its first consortium meeting online with 30 participants. The REsolution consortium is a public-private research partnership supported by the Innovative Medicines Initiative (IMI), the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA), with nine partners from academia and the pharmaceutical industry. With a duration of two years, the project aims at understanding how genetic variants in humans affect the function of cellular solute carrier transporters (SLCs).

Scientists from different work packages described the progress on the collection and…

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Artist Adriana Czernin with CeMM PhD students in the inauguration event (© Franzi Kreis / CeMM).

Artist Adriana Czernin designed chair’s backrest for CeMM’s Brain Lounge

On 19 October 2021, CeMM welcomed artist Adriana Czernin for the inauguration of the new chair’s backrest that she has specially designed for CeMM’s Brain Lounge. During the event, Adriana Czernin presented her piece of art entitled “4-sided 3-angle”, and discussed with CeMM PhD students the design process, and the combination of abstract art with the idea of perspective in her work. 
 
CeMM’s Brain Lounge is located on the 8th floor of CeMM’s building, overlooking the impressive Vienna’s skyline. It was originally built as a special space where participants can abandon their daily professional routine and embark on a new journey to ignite…

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Prof. David M. Livingston (© Michael Sazel / CeMM).

Obituary David M. Livingston

It is with great sadness that we learn of the decease of Prof. David M. Livingston, former Deputy Director, Dana-Farber/Harvard Cancer Center, Boston, USA. David Livingston was the Chair of the Scientific Advisory Board of CeMM from its very beginning until 2018, and had a huge influence on the development and success of our institute. We lose an extraordinary scientist and highly esteemed advisor. His constructive criticism, encouraging words and his humor and good spirit will be dearly missed by the CeMM Directors and by the entire CeMM community. Our thoughts are with his wife Emily, his family, friends and collaborators.

David Livingston…

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