Publications
2020
Targeted protein degradation: current and future challenges.
Hanzl A,
Winter GE.
Curr Opin Chem Biol. 2020 Jun;56:35-41. doi: 10.1016/j.cbpa.2019.11.012. Epub 2020 Jan 2. PMID: 31901786.
2020
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis.
Bensimon A,
Pizzagalli MD,
Kartnig F,
Dvorak V,
Essletzbichler P,
Winter GE,
Superti-Furga G.
Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7.
2020
Selective Mediator dependence of cell-type-specifying transcription.
Jaeger MG,
Schwalb B,
Mackowiak SD,
Velychko T,
Hanzl A,
Imrichova H,
Brand M,
Agerer B,
Chorn S,
Nabet B,
Ferguson FM,
Müller AC,
Bergthaler A,
Gray NS,
Bradner JE,
Bock C,
Hnisz D,
Cramer P,
Winter GE.
Nat Genet. 2020 Jul;52(7):719-727. doi: 10.1038/s41588-020-0635-0. Epub 2020 Jun 1.
2020
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C,
Bauer S,
Brand M,
Kozicka Z,
Siklos M,
Imrichova H,
Kaltheuner IH,
Hahn E,
Seiler K,
Koren A,
Petzold G,
Fellner M,
Bock C,
Müller AC,
Zuber J,
Geyer M,
Thomä NH,
Kubicek S,
Winter GE.
Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Erratum in: Nat Chem Biol. 2021 Mar;17(3):361.
2020
Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr(701) phosphorylation.
Gaviraghi M,
Rabellino A,
Andolfo A,
Brand M,
Brombin C,
Bagnato P,
De Feudis G,
Raimondi A,
Locatelli A,
Tosoni D,
Mazza D,
Gianni L,
Tonon G,
Yarden Y,
Tacchetti C,
Daniele T.
Sci Rep. 2020 Oct 9;10(1):16906. doi: 10.1038/s41598-020-73835-1.
2020
Rational discovery of molecular glue degraders via scalable chemical profiling.
C Mayor-Ruiz,
S Bauer,
M Brand,
Z Kozicka,
M Siklos,
H Imrichova,
IH Kaltheuner,
E Hahn,
K Seiler,
A Koren,
G Petzold,
M Fellner,
C Bock,
AC Müller,
J Zuber,
M Geyer,
NH Thomä,
S Kubicek,
G E Winter.
Nat Chem Biol. 2020 Nov;16(11):1199-1207.doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3.
2020
Expanding the Degradable Proteome: Designing PROTACs by the Book.
Jaeger MG,
Winter GE.
Cell Chem Biol. 2020 Jan 16;27(1):14-16. doi: 10.1016/j.chembiol.2019.12.009.
2019
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Sdelci S,
Rendeiro AF,
Rathert P,
You W,
Lin JG,
Ringler A,
Hofstätter G,Moll HP,
Gürtl B,
Farlik M,
Schick S,
Klepsch F,
Oldach M,
Buphamalai P,Schischlik F,
Májek P,
Parapatics K,
Schmidl C,
Schuster M,
Penz T,
Buckley DL,Hudecz O,
Imre R,
Wang SY,
Maric HM,
Kralovics R,
Bennett KL,
Müller AC,
MechtlerK,
Menche J,
Bradner JE,
Winter GE,
Klavins K,
Casanova E,
Bock C,
Zuber J,Kubicek S.
Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
2019
Identification and characterization of cancer vulnerabilities via targeted protein degradation.
Mayor-Ruiz C,
Winter GE.
Drug Discov Today Technol. 2019Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.
2019
Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies.
Brand M,
Winter GE.
Methods Mol Biol. 2019;1953:105-119. doi:10.1007/978-1-4939-9145-7_7.
