Publications
2026
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Sofia Rossini,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Siska Führer,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Ciriana Orabona,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
Nat Chem. 2026 Jan 7. doi: 10.1038/s41557-025-02021-5. Online ahead of print.
2025
Inhibitors supercharge kinase turnover through native proteolytic circuits
Natalie S Scholes,
Martino Bertoni,
Arnau Comajuncosa-Creus,
Katharina Kladnik,
Xuefei Guo,
Fabian Frommelt,
Matthias Hinterndorfer,
Hlib Razumkov,
Polina Prokofeva,
Martin P Schwalm,
Florian Born,
Sandra Roehm,
Hana Imrichova,
Brianda L Santini,
Eleonora Barone,
Caroline Schätz,
Miquel Muñoz I Ordoño,
Severin Lechner,
Andrea Rukavina,
Iciar Serrano,
Miriam Abele,
Anna Koren,
Stefan Kubicek,
Stefan Knapp,
Nathanael S Gray,
Giulio Superti-Furga,
Bernhard Kuster,
Yigong Shi,
Patrick Aloy,
Georg E Winter.
Nature. 2025 Nov 26. doi: 10.1038/s41586-025-09763-9. Online ahead of print.
2025
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Artem Kalinichenko,
Jakob Huemer,
Theresa Humer,
Matthias Haimel,
Michael Svaton,
Nicolas Socquet-Juglard,
Giovanna Perinetti Casoni,
Celine Prakash,
Maximilian von der Linde,
Julia Pazmandi,
Cheryl van de Wetering,
Javier Nunez-Fontarnau,
Anton Kamnev,
Sarah Giuliani,
Martin G Jaeger,
Elisa Hahn,
Sarah Dobner,
Andrea Rukavina,
Elise Sylvander,
Jacqueline Seigner,
Christina Rashkova,
Birgit Hoeger,
Michael W Traxlmayr,
Manfred Lehner,
Yenan T Bryceson,
Janna Saarela,
Thomas Hannich,
Irinka Castanon,
Georg Winter,
Loïc Dupré,
Kaan Boztug.
Sci Immunol. 2025 Oct 17;10(112):eado3825. doi: 10.1126/sciimmunol.ado3825. Epub 2025 Oct 17.
2025
Opportunities in proximity modulation: Bridging academia and industry
Ivan Dikic,
Cristina Mayor-Ruiz,
Georg E Winter,
Kerstin Koch,
Alessio Ciulli,
Nicolas H Thomä.
Mol Cell. 2025 Aug 21;85(16):3012-3022. doi: 10.1016/j.molcel.2025.07.018.
2025
Targeted protein degradation for cancer therapy
Matthias Hinterndorfer,
Valentina A Spiteri,
Alessio Ciulli,
Georg E Winter.
Nat Rev Cancer. 2025 Jul;25(7):493-516. doi: 10.1038/s41568-025-00817-8. Epub 2025 Apr 25.
2024
Thoughts for the future
Lona M Alkhalaf,
Cheryl Arrowsmith,
Emily P Balskus,
Giovanna Bergamini,
Rashna Bhandari,
Christopher J Chang,
Peng Chen,
Xing Chen,
Alessio Ciulli,
Julia A Cricco,
Benjamin G Davis,
Martina Delbianco,
Natalia Dudareva,
Erin Dueber,
Fleur Ferguson,
Priscila Oliveira de Giuseppe,
Itaru Hamachi,
Ming Chen Hammond,
Stavroula K Hatzios,
Won Do Heo,
Jon Paul Janet,
Siddhesh S Kamat,
Stefan Knapp,
Yamuna Krishnan,
Kathrin Lang,
Luca Laraia,
Reuben B Leveson-Gower,
Xiang David Li,
David R Liu,
Mo-Fang Liu,
Nir London,
Nilkamal Mahanta,
Cristina Mayor-Ruiz,
Tom Muir,
Mário Tyago Murakami,
Hyun-Woo Rhee,
Matt Robers,
Alex Satz,
Brenda A Schulman,
Ben Shen,
Brian Shoichet,
Erick Strauss,
Tsutomu Suzuki,
Pratyush Tiwary,
Herbert Waldmann,
Thomas R Ward,
Amy Weeks,
Eranthie Weerapana,
Georg Winter.
Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2.
2024
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera
Adam G Bond,
Miquel Muñoz I Ordoño,
Celia M Bisbach,
Conner Craigon,
Nikolai Makukhin,
Elizabeth A Caine,
Manjula Nagala,
Marjeta Urh,
Georg E Winter,
Kristin M Riching,
Alessio Ciulli.
J Am Chem Soc. 2024 Dec 11;146(49):33675-33711. doi: 10.1021/jacs.4c11556. Epub 2024 Nov 28.
2024
Degradome analysis to identify direct protein substrates of small-molecule degraders
Marco Jochem,
Anna Schrempf,
Lina-Marie Wagner,
Dmitri Segal,
Jose Cisneros,
Amanda Ng,
Georg E Winter,
Jeroen Krijgsveld.
Cell Chem Biol. 2025 Jan 16;32(1):192-200.e6. doi: 10.1016/j.chembiol.2024.10.007. Epub 2024 Nov 12.
2024
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs
Georg E Winter.
ACS Chem Biol. 2024 Oct 18;19(10):2089-2102. doi: 10.1021/acschembio.4c00191. Epub 2024 Sep 12.
2024
Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857. doi: 10.1101/2024.07.10.602857.
