Publications
2025
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions
Anzhelika Karjalainen,
Agnieszka Witalisz-Siepracka,
Michaela Prchal-Murphy,
David Martin,
Felix Sternberg,
Milica Krunic,
Marlies Dolezal,
Nikolaus Fortelny,
Matthias Farlik,
Sabine Macho-Maschler,
Caroline Lassnig,
Katrin Meissl,
Lena Amenitsch,
Therese Lederer,
Elena Pohl,
Dagmar Gotthardt,
Christoph Bock,
Thomas Decker,
Birgit Strobl,
Mathias Müller.
Cell Mol Life Sci. 2025 Mar 2;82(1):98. doi: 10.1007/s00018-025-05625-9.
2025
Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring
Takaya Saito,
Marit Espe,
Maren Mommens,
Christoph Bock,
Jorge M O Fernandes,
Kaja Helvik Skjærven.
PLoS One. 2025 Feb 24;20(2):e0317770. doi: 10.1371/journal.pone.0317770. eCollection 2025.
2025
Single-cell CRISPR screening in mouse brain
Eugenia V Pankevich,
Christoph Bock.
Nat Protoc. 2025 Jul;20(7):1731-1732. doi: 10.1038/s41596-024-01128-2.
2024
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Valentina Stolz,
Rafael de Freitas E Silva,
Ramona Rica,
Ci Zhu,
Teresa Preglej,
Patricia Hamminger,
Daniela Hainberger,
Marlis Alteneder,
Lena Müller,
Monika Waldherr,
Darina Waltenberger,
Anastasiya Hladik,
Benedikt Agerer,
Michael Schuster,
Tobias Frey,
Thomas Krausgruber,
Sylvia Knapp,
Clarissa Campbell,
Klaus Schmetterer,
Michael Trauner,
Andreas Bergthaler,
Christoph Bock,
Nicole Boucheron,
Wilfried Ellmeier.
Elife. 2024 Oct 28;13:e78738. doi: 10.7554/eLife.78738.
2024
Insights into the multifaceted role of interleukin-37 on human immune cell regulation
Lisa U Teufel,
Vasiliki Matzaraki,
Lukas Folkman,
Rob Ter Horst,
Simone J C F M Moorlag,
Catharina M Mulders-Manders,
Mihai G Netea,
Thomas Krausgruber,
Leo A B Joosten,
Rob J W Arts.
Clin Immunol. 2024 Nov;268:110368. doi: 10.1016/j.clim.2024.110368. Epub 2024 Sep 20.
2024
GPT-4 as a biomedical simulator
Moritz Schaefer,
Stephan Reichl,
Rob Ter Horst,
Adele M Nicolas,
Thomas Krausgruber,
Francesco Piras,
Peter Stepper,
Christoph Bock,
Matthias Samwald.
Comput Biol Med. 2024 Aug;178:108796. doi: 10.1016/j.compbiomed.2024.108796. Epub 2024 Jun 22.
2024
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
Leon U B Enk,
Malte Hellmig,
Kristoffer Riecken,
Christoph Kilian,
Paul Datlinger,
Saskia L Jauch-Speer,
Tobias Neben,
Zeba Sultana,
Varshi Sivayoganathan,
Alina Borchers,
Hans-Joachim Paust,
Yu Zhao,
Nariaki Asada,
Shuya Liu,
Theodora Agalioti,
Penelope Pelczar,
Thorsten Wiech,
Christoph Bock,
Tobias B Huber,
Samuel Huber,
Stefan Bonn,
Nicola Gagliani,
Boris Fehse,
Ulf Panzer,
Christian F Krebs.
Sci Immunol. 2024 Jun 14;9(96):eadd6774. doi: 10.1126/sciimmunol.add6774. Epub 2024 Jun 14.
2024
Mapping the brain's gene-regulatory maze
Gaia Novarino,
Christoph Bock.
Science. 2024 May 24;384(6698):860-861. doi: 10.1126/science.adp4663. Epub 2024 May 23.
2024
JAK-STAT signaling maintains homeostasis in T cells and macrophages
Nikolaus Fortelny,
Matthias Farlik,
Victoria Fife,
Anna-Dorothea Gorki,
Caroline Lassnig,
Barbara Maurer,
Katrin Meissl,
Marlies Dolezal,
Laura Boccuni,
Aarathy Ravi Sundar Jose Geetha,
Mojoyinola Joanna Akagha,
Anzhelika Karjalainen,
Stephen Shoebridge,
Asma Farhat,
Ulrike Mann,
Rohit Jain,
Shweta Tikoo,
Nina Zila,
Wolfgang Esser-Skala,
Thomas Krausgruber,
Katarzyna Sitnik,
Thomas Penz,
Anastasiya Hladik,
Tobias Suske,
Sophie Zahalka,
Martin Senekowitsch,
Daniele Barreca,
Florian Halbritter,
Sabine Macho-Maschler,
Wolfgang Weninger,
Heidi A Neubauer,
Richard Moriggl,
Sylvia Knapp,
Veronika Sexl,
Birgit Strobl,
Thomas Decker,
Mathias Müller,
Christoph Bock.
Nat Immunol. 2024 May;25(5):847-859. doi: 10.1038/s41590-024-01804-1. Epub 2024 Apr 24.
2024
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
Tobias Suske,
Helena Sorger,
Gabriele Manhart,
Frank Ruge,
Nicole Prutsch,
Mark W Zimmerman,
Thomas Eder,
Diaaeldin I Abdallah,
Barbara Maurer,
Christina Wagner,
Susann Schönefeldt,
Katrin Spirk,
Alexander Pichler,
Tea Pemovska,
Carmen Schweicker,
Daniel Pölöske,
Emina Hubanic,
Dennis Jungherz,
Tony Andreas Müller,
Myint Myat Khine Aung,
Anna Orlova,
Ha Thi Thanh Pham,
Kerstin Zimmel,
Thomas Krausgruber,
Christoph Bock,
Mathias Müller,
Maik Dahlhoff,
Auke Boersma,
Thomas Rülicke,
Roman Fleck,
Elvin Dominic de Araujo,
Patrick Thomas Gunning,
Tero Aittokallio,
Satu Mustjoki,
Takaomi Sanda,
Sylvia Hartmann,
Florian Grebien,
Gregor Hoermann,
Torsten Haferlach,
Philipp Bernhard Staber,
Heidi Anne Neubauer,
Alfred Thomas Look,
Marco Herling,
Richard Moriggl.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
