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On the left, fluorescence microscopy images of the cell lines after treatment with solutions 1.5 μM in DMSO of quinoxalines (© Fabián Amaya Garcia & Miriam Unterlass). / On the right, authors of the study.

Successful collaboration among 3 CeMM groups results in the development of a novel synthesis for the quinoxaline functional group

The discipline of chemistry deals with understanding (analysis) and making and transforming (synthesis) of matter. The size-range with which chemistry is most concerned with is that of molecules as building blocks of matter. Molecules are nothing but connected atoms, and when aiming at making, i.e. synthesizing, them, it is useful to chemists to subdivide them into subsets, which are so-called "functions" or "functional groups". Although every type of molecule is unique, it's subsets - the functional groups - will eventually be found in many other molecules. Therefore, approaches of generating a particular functional group may eventually…

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Sylvia Knapp and Christoph Binder (© Klaus Pichler / CeMM).

CeMM bids farewell to Sylvia Knapp and Christoph Binder

Sylvia Knapp and Christoph Binder have been CeMM pioneers and have been associated with their groups with us for 15 years. On 31 March 2021 their CeMM research contracts end and we would like to say a big heartfelt thank you for the scientific contributions, the networking and personal engagement.

Both joined CeMM at the first round of Principal Investigator hiring and have been critical in setting the stage for future directions and hires at CeMM ever since. Both embodied the very essence of how CeMM was trying to position itself, as a bridge between hard-core frontier research in biomedicine and the clinical world. After their MDs, both…

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The image shows a part of the reaction pathway, in which the catalyst is attached to the reacting molecule. This was achieved through quantum chemical calculations of the reaction. (© Giovanni Di Mauro / CeMM)

Acids to drugs - catalytic access to paracetamol

Among the many pharmaceuticals in use every day, one of the most well-recognized substances is the century-old pain killer Paracetamol. Paracetamol is part of a family of compounds, the so-called para-aminophenols, which also includes other biologically active molecules, such as Diloxanide Furoate, which is used against amoeba infections, or the beta blocker Practolol. These molecules are typically synthesised using harsh acids, in processes that involve the formation of considerable amounts of waste (in the form of undesired byproducts).

The research group of Nuno Maulide, CeMM Adjunct Principal Investigator and Professor at the University…

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Pictured from left to right: Science Minister Heinz Faßmann, Andreas Bergthaler (Project Manager at CeMM), Giulio Superti-Furga (CeMM Scientific Director), Anna Schedl (Project Coordinator at CeMM), Anita Ender (CeMM Administrative Director) and Gregor Weihs (FWF President). (Photo credit: FWF/Novotny)

Andreas Bergthaler receives FWF Urgent Funding for further studies on SARS-CoV-2

CeMM congratulates our Principal Investigator Andreas Bergthaler: He is one of the four newly funded researchers who are further expanding their corona research with funding from the Austrian Science Fund (FWF).

With funding from the Austrian Science Fund (FWF), Austria’s top researchers have the opportunity to study the Corona pandemic and its consequences. In recent months, 19 research teams were able to get started under the SARS-CoV-2 urgent funding program, and now four more FWF-funded teams are joining them: physician Alice Assinger from the Medical University of Vienna, microbiologist Andreas Bergthaler from CeMM, educational…

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First authors Taras Afonyushkin (left) and Georg Obermayer (right) with Last author Christoph Binder (middle), © Laura Alvarez/CeMM.

New therapeutic approach discovered for reducing the risk of thrombosis

Thrombotic occlusion of blood vessels, which leads to myocardial infarctions, strokes and venous thromboembolisms, is the major cause of death in the western hemisphere. Therefore, it is of critical importance to understand mechanisms preventing thrombus formation. A new study by the research group of Christoph Binder, Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor at the Medical University of Vienna, now explains the important role of immunoglobulin-M (IgM) antibodies in preventing thrombosis. The study published in the journal Blood shows that these antibodies…

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From L to R: Venugopal Gudipati, Johannes B. Huppa, Judith H. Aberle, Maximilian Koblischke Andreas Bergthaler, Benedikt Agerer (© Laura Alvarez / CeMM).

SARS-CoV-2 mutations can complicate immune surveillance of human T-killer cells

The body’s immune response plays a crucial role in the course of a SARS-CoV-2 infection. In addition to antibodies, the so-called T-killer cells, are also responsible for detecting viruses in the body and eliminating them. Scientists from the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna have now shown that SARS-CoV-2 can make itself unrecognizable to the immune response by T-killer cells through mutations. The findings of the research groups of Andreas Bergthaler, Judith Aberle and Johannes Huppa provide important clues for the further development of vaccines and were…

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Solgate Co-Founders (from left to right): Georg Winter, Stefan Kubicek, Ariel Bensimon, Giulio Superti-Furga, Gaia Novarino (© Thomas Zauner / IST Austria).

Solgate closes its first financing round with IST cube and private investors

Joint CeMM-IST Austria start-up develops new class of drugs targeting solute carrier proteins

Solgate GmbH, an Austrian early-stage biotech company, announces the completion of its first financing round from a group of venture and private investors.

Solgate was incorporated in 2020 by a high-profile founding team and with intellectual property from the leading research institutions CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, and IST Austria (Institute of Science and Technology Austria), with support from the Austrian business agency (AWS). The company applies methods from chemistry, cell biology,…

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New research groups at CeMM: Barbara Maier, Georg Busslinger and Davide Seruggia

At the beginning of 2021, Barbara Maier, Georg Busslinger and Davide Seruggia joined CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences. Barbara Maier as Principal Investigator at CeMM, Georg Busslinger and Davide Seruggia as CeMM Adjunct Principal Investigators, Georg having his main affiliation at the Division of Gastroenterology and Hepatology of the Medical University of Vienna and Davide at St. Anna Children’s Cancer Research Institute. The three researchers strengthen CeMM’s expertise in the fields of tumor immunology, gastrointestinal biology and pediatric leukemia biology.

Barbara Maier studied…

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Artistic representation of the BAF complex interacting with DNA and nucleosomes (© CeMM)

Inhibition of the BAF complex causes rapid loss of DNA accessibility

When human cells have to adapt due to a wide variety of external influences, the BAF complex plays a central role because it controls the accessibility of the DNA and thus the information stored in it. In every fifth human cancer, a mutation is found in one of the BAF complex genes. Scientists from the research group of Principal Investigator Stefan Kubicek at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have now investigated this complex in more detail using novel techniques and were able to show how quickly changes in the BAF complex genes influence the accessibility of DNA. The study has now been…

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5th RESOLUTE Consortium Meeting (27-29 January 2021)

On 27 - 29 January 2021, the 5th RESOLUTE Consortium Meeting took place virtually. RESOLUTE is a public-private partnership, funded with a grant from the Innovative Medicines Initiative (IMI) and coordinated by CeMM and Pfizer, with 13 partners from academia and industry. Its mission is to increase the study of solute carriers for medical research and potential drug development, and it strives to become a reference hub for SLC research and open knowledge worldwide.

This year again virtually, more than 60 RESOLUTE partners joined the online event entitled “Abbey Road Studios” with a focus on different music genres. On the first day, featuring…

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