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Last author Jörg Menche and first author Christiane V.R. Hütter (© Klaus Pichler / CeMM).

New methods for network visualizations enable change of perspectives and views

When visualizing data using networks, the type of representation is crucial for extracting hidden information and relationships. The research group of Jörg Menche, Adjunct Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Professor at the University of Vienna, and Group leader at Max Perutz Labs, developed a new method for generating network layouts that allow for visualizing different information of a network in two- and three-dimensional virtual space and exploring different perspectives. The results could also facilitate future research on rare diseases by providing more…

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Gonçalo Oliveira, Joana Ferreira da Silva and Joanna Loizou ©Klaus Pichler, CeMM

Advancing genome editing through studying DNA repair mechanisms

Prime editing is an improved variant of the CRISPR/Cas system that can introduce alterations in DNA with exquisite precision. But the method is complex and inefficient. The research group of Joanna Loizou, at the Medical University of Vienna (MedUni Vienna) and CeMM, has now been able to show that the DNA mismatch repair process plays an essential role in prime editing.

Since the discovery of CRISPR/Cas9, also known as molecular scissors, scientists around the world have been working to improve the revolutionary technique for altering DNA that earned Emmanuelle Charpentier and Jennifer Doudna the Nobel Prize in 2020. The method enables deep…

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Monica Bettencourt-Dias and Giulio Superti-Furga.

Monica Bettencourt-Dias (IGC) and Giulio Superti-Furga (CeMM) appointed new chair and co-chair of EU-LIFE

Monica Bettencourt-Dias, Director of Instituto Gulbenkian de Ciência (IGC, Portugal), and Giulio Superti-Furga, Scientific Director of the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, have been appointed new Chair and Co-Chair respectively of EU-LIFE, the alliance of fifteen leading life science institutes in Europe, as of 1 January 2022.

During the next two years they will be working closely with Marta Agostinho, EU-LIFE Executive Director, to help shape the European research landscape, particularly with regard to excellent science. EU-LIFE’s priorities for the near future include the development of a…

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Andreas Bergthaler (© Franzi Kreis / CeMM).

Andreas Bergthaler becomes Professor for Molecular Immunology at MedUni Vienna, and CeMM Adjunct Principal Investigator

On 1 January 2022, Andreas Bergthaler and his team members will join the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna. There, Andreas will head the Institute for Hygiene and Applied Immunology. He will now become an Adjunct Principal Investigator at CeMM.

Andreas Bergthaler studied veterinary medicine at the University of Veterinary Medicine in Vienna. For his graduate studies, he joined the Institute of Experimental Immunology at the ETH and University of Zurich (Switzerland), with Profs. Hans Hengartner and Nobel Laureate Rolf Zinkernagel. After postdoctoral work in the laboratory of Prof.…

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Season Greetings

At the beginning of the pandemic, we optimistically hailed the "scientification of society” a so-called “Verwissenschaftlichung der Gesellschaft” as a positive Corona side effect. Multiple Covid vaccines within a year and tailored medicines represent a triumph for research and innovation. Yet, at a time in history when humanity's inventiveness is impressively evidenced, the status of science in society is surprisingly low. We would like to see a change in 2022. Never before has scientific and technical know-how been so important. Just think of climate change, the destruction of the environment and geo/biodiversity, famines, forced migration,…

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Tea Pemovska and Giulio Superti-Furga (© Klaus Pichler / CeMM)

Specific metabolic dependencies of cancer cells revealed by perturbation with tailored chemical library offer new therapeutic possibilities

Many types of cancer exhibit changes in their cellular metabolism. These contribute to the development and progression of cancer. Metabolic reprogramming has, thus, been recognized as a hallmark of cancer and may thus represent a vulnerability to be exploited by targeted cancer therapy. Scientists from the research group of Giulio Superti-Furga, Scientific Director at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor at the Medical University of Vienna, have now used a drug library of 243 compounds targeting a variety of metabolic pathways to identify sensitivities among 15 myeloid leukemia cell…

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CeMM Adjunct Principal Investigator Kaan Boztug (© Klaus Pichler / CeMM).

Kaan Boztug takes over professorship in the subject field Paediatrics and Inflammation Research in MedUni Vienna

CeMM Principal Investigator Kaan Boztug, consultant in paediatrics and adolescent medicine and internationally renowned expert in rare haematopoietic and immunological diseases, has accepted a professorship (§ 99 Para. 4 UG) in the subject field Paediatrics and Inflammation Research at the Medical University of Vienna's Department of Pediatrics and Adolescent Medicine with effect from 01 December 2021.

During the course of his medical and scientific work in the field of congenital immunodeficiencies and haematopoietic disorders, Kaan Boztug has played a leading role in the description and molecular characterisation of more than 15 previously…

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Tala Shahin and Kaan Boztug. Photo credit: St. Anna Children’s Cancer Research Institute, Ian Ehm

A disturbed Helios-dependent epigenetic regulation mechanism causes T and B cell defects in an inborn immune disease.

From the god of sun to immunodeficiency: international research team identifies new rare disease affecting hematopoiesis and immunity

A disturbed Helios-dependent epigenetic regulation mechanism causes T and B cell defects in an inborn immune disease. 

Together with international collaborators, scientists at the St. Anna Children’s Cancer Research Institute discover a new inborn error of hematopoiesis and immunity, caused by an inherited genetic defect of the transcription factor Helios. In their research project, the team was able to define previously unknown roles of Helios in immune activation and homeostasis. The study is now published in the high-ranked scientific journal Science Immunology.

The immune system is one of the most complex and fascinating networks in the…

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Simona Saluzzo and Georg Stary (©Laura Alvarez / CeMM).

Prompt initiation of antiretroviral therapy reduces cancer risk in HIV patients

HIV patients have an increased risk of developing skin and mucosal cancers, even though HIV is no longer detectable in their blood due to antiretroviral therapy. A new study by MedUni Vienna's Department of Dermatology, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) and the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences now shows that the time of starting antiretroviral therapy can influence tumour development. The results have recently been published in the specialist journal “Immunity”.

HIV (human immunodeficiency virus) infects and destroys immune cells that carry a specific…

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Last author Jörg Menche and first author Pisanu Buphamalai (©Laura Alvarez / CeMM).

Multiplex network improves diagnosis and analysis of rare diseases

Rare diseases are usually caused by a single genetic defect. Nevertheless, the search for the cause and the assessment of the effects is highly complex and difficult. Scientist Jörg Menche, Adjunct Principal Investigator at the CeMM, Professor at the University of Vienna and Research Group Leader at the Max Perutz Labs, and his team have now developed a multiplex network that maps all genes and their interactions on multiple levels and improves the identification of genetic defects and the assessment of their consequences.

 In contrast to common diseases, which are usually characterized by a complex interaction of multiple genetic and…

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