Publications
2018
Pharmacologic inhibition of STAT5 in acute myeloid leukemia
Bettina Wingelhofer,
Barbara Maurer,
Elizabeth C Heyes,
Abbarna A Cumaraswamy,
Angelika Berger-Becvar,
Elvin D de Araujo,
Anna Orlova,
Patricia Freund,
Frank Ruge,
Jisung Park,
Gary Tin,
Siawash Ahmar,
Charles-Hugues Lardeau,
Irina Sadovnik,
Dávid Bajusz,
György Miklós Keserű,
Florian Grebien,
Stefan Kubicek,
Peter Valent,
Patrick T Gunning,
Richard Moriggl.
Leukemia. 2018 May;32(5):1135-1146. doi: 10.1038/s41375-017-0005-9. Epub 2018 Feb 2.
2017
STAT5BN642H is a driver mutation for T cell neoplasia
Ha Thi Thanh Pham,
Barbara Maurer,
Michaela Prchal-Murphy,
Reinhard Grausenburger,
Eva Grundschober,
Tahereh Javaheri,
Harini Nivarthi,
Auke Boersma,
Thomas Kolbe,
Mohamed Elabd,
Florian Halbritter,
Jan Pencik,
Zahra Kazemi,
Florian Grebien,
Markus Hengstschläger,
Lukas Kenner,
Stefan Kubicek,
Matthias Farlik,
Christoph Bock,
Peter Valent,
Mathias Müller,
Thomas Rülicke,
Veronika Sexl,
Richard Moriggl.
J Clin Invest. 2018 Jan 2;128(1):387-401. doi: 10.1172/JCI94509. Epub 2017 Dec 4.
2017
Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site
E Hadzijusufovic,
K Albrecht-Schgoer,
K Huber,
G Hoermann,
F Grebien,
G Eisenwort,
W Schgoer,
S Herndlhofer,
C Kaun,
M Theurl,
W R Sperr,
U Rix,
I Sadovnik,
B Jilma,
G H Schernthaner,
J Wojta,
D Wolf,
G Superti-Furga,
R Kirchmair,
P Valent.
Leukemia. 2017 Nov;31(11):2388-2397. doi: 10.1038/leu.2017.245. Epub 2017 Jul 31.
2016
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Tahereh Javaheri,
Zahra Kazemi,
Jan Pencik,
Ha Tt Pham,
Maximilian Kauer,
Rahil Noorizadeh,
Barbara Sax,
Harini Nivarthi,
Michaela Schlederer,
Barbara Maurer,
Maximillian Hofbauer,
Dave Nt Aryee,
Marc Wiedner,
Eleni M Tomazou,
Malcolm Logan,
Christine Hartmann,
Jan P Tuckermann,
Lukas Kenner,
Mario Mikula,
Helmut Dolznig,
Aykut Üren,
Günther H Richter,
Florian Grebien,
Heinrich Kovar,
Richard Moriggl.
Cell Death Dis. 2016 Oct 13;7(10):e2419. doi: 10.1038/cddis.2016.268.
2015
STAT3 regulated ARF expression suppresses prostate cancer metastasis
Jan Pencik,
Michaela Schlederer,
Wolfgang Gruber,
Christine Unger,
Steven M Walker,
Athena Chalaris,
Isabelle J Marié,
Melanie R Hassler,
Tahereh Javaheri,
Osman Aksoy,
Jaine K Blayney,
Nicole Prutsch,
Anna Skucha,
Merima Herac,
Oliver H Krämer,
Peter Mazal,
Florian Grebien,
Gerda Egger,
Valeria Poli,
Wolfgang Mikulits,
Robert Eferl,
Harald Esterbauer,
Richard Kennedy,
Falko Fend,
Marcus Scharpf,
Martin Braun,
Sven Perner,
David E Levy,
Tim Malcolm,
Suzanne D Turner,
Andrea Haitel,
Martin Susani,
Ali Moazzami,
Stefan Rose-John,
Fritz Aberger,
Olaf Merkel,
Richard Moriggl,
Zoran Culig,
Helmut Dolznig,
Lukas Kenner.
Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736.
2015
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
Florian Grebien,
Masoud Vedadi,
Matthäus Getlik,
Roberto Giambruno,
Amit Grover,
Roberto Avellino,
Anna Skucha,
Sarah Vittori,
Ekaterina Kuznetsova,
David Smil,
Dalia Barsyte-Lovejoy,
Fengling Li,
Gennadiy Poda,
Matthieu Schapira,
Hong Wu,
Aiping Dong,
Guillermo Senisterra,
Alexey Stukalov,
Kilian V M Huber,
Andreas Schönegger,
Richard Marcellus,
Martin Bilban,
Christoph Bock,
Peter J Brown,
Johannes Zuber,
Keiryn L Bennett,
Rima Al-Awar,
Ruud Delwel,
Claus Nerlov,
Cheryl H Arrowsmith,
Giulio Superti-Furga.
Nat Chem Biol. 2015 Aug;11(8):571-578. doi: 10.1038/nchembio.1859. Epub 2015 Jul 13.
2013
Affinity purification strategies for proteomic analysis of transcription factor complexes
Roberto Giambruno,
Florian Grebien,
Alexey Stukalov,
Christian Knoll,
Melanie Planyavsky,
Elena L Rudashevskaya,
Jacques Colinge,
Giulio Superti-Furga,
Keiryn L Bennett.
J Proteome Res. 2013 Sep 6;12(9):4018-27. doi: 10.1021/pr4003323. Epub 2013 Aug 22.
2012
Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
Georg E Winter,
Uwe Rix,
Scott M Carlson,
Karoline V Gleixner,
Florian Grebien,
Manuela Gridling,
André C Müller,
Florian P Breitwieser,
Martin Bilban,
Jacques Colinge,
Peter Valent,
Keiryn L Bennett,
Forest M White,
Giulio Superti-Furga.
Nat Chem Biol. 2012 Nov;8(11):905-912. doi: 10.1038/nchembio.1085. Epub 2012 Sep 30.
2012
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
Oliver Hantschel,
Wolfgang Warsch,
Eva Eckelhart,
Ines Kaupe,
Florian Grebien,
Kay-Uwe Wagner,
Giulio Superti-Furga,
Veronika Sexl.
Nat Chem Biol. 2012 Jan 29;8(3):285-93. doi: 10.1038/nchembio.775.
2010
Using iTRAQ combined with tandem affinity purification to enhance low-abundance proteins associated with somatically mutated EGFR core complexes in lung cancer
Eric B Haura,
André Müller,
Florian P Breitwieser,
Jiannong Li,
Florian Grebien,
Jacques Colinge,
Keiryn L Bennett.
J Proteome Res. 2011 Jan 7;10(1):182-90. doi: 10.1021/pr100863f. Epub 2010 Nov 9.
