Publications
2024
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
Tobias Suske,
Helena Sorger,
Gabriele Manhart,
Frank Ruge,
Nicole Prutsch,
Mark W Zimmerman,
Thomas Eder,
Diaaeldin I Abdallah,
Barbara Maurer,
Christina Wagner,
Susann Schönefeldt,
Katrin Spirk,
Alexander Pichler,
Tea Pemovska,
Carmen Schweicker,
Daniel Pölöske,
Emina Hubanic,
Dennis Jungherz,
Tony Andreas Müller,
Myint Myat Khine Aung,
Anna Orlova,
Ha Thi Thanh Pham,
Kerstin Zimmel,
Thomas Krausgruber,
Christoph Bock,
Mathias Müller,
Maik Dahlhoff,
Auke Boersma,
Thomas Rülicke,
Roman Fleck,
Elvin Dominic de Araujo,
Patrick Thomas Gunning,
Tero Aittokallio,
Satu Mustjoki,
Takaomi Sanda,
Sylvia Hartmann,
Florian Grebien,
Gregor Hoermann,
Torsten Haferlach,
Philipp Bernhard Staber,
Heidi Anne Neubauer,
Alfred Thomas Look,
Marco Herling,
Richard Moriggl.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
2021
Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions
Peter Valent,
Alberto Orfao,
Stefan Kubicek,
Philipp Staber,
Torsten Haferlach,
Michael Deininger,
Karoline Kollmann,
Thomas Lion,
Irene Virgolini,
Georg Winter,
Oliver Hantschel,
Lukas Kenner,
Johannes Zuber,
Florian Grebien,
Richard Moriggl,
Gregor Hoermann,
Olivier Hermine,
Michael Andreeff,
Christoph Bock,
Tariq Mughal,
Stefan N Constantinescu,
Robert Kralovics,
Veronika Sexl,
Radek Skoda,
Giulio Superti-Furga,
Ulrich Jäger.
Hemasphere. 2021 Feb 17;5(3):e536. doi: 10.1097/HS9.0000000000000536. eCollection 2021 Mar.
2021
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression
Stefan Terlecki-Zaniewicz,
Theresa Humer,
Thomas Eder,
Johannes Schmoellerl,
Elizabeth Heyes,
Gabriele Manhart,
Natalie Kuchynka,
Katja Parapatics,
Fabio G Liberante,
André C Müller,
Eleni M Tomazou,
Florian Grebien.
Nat Struct Mol Biol. 2021 Feb;28(2):190-201. doi: 10.1038/s41594-020-00550-w. Epub 2021 Jan 21.
2019
Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Tahereh Javaheri,
Zahra Kazemi,
Jan Pencik,
Ha T T Pham,
Maximilian Kauer,
Rahil Noorizadeh,
Barbara Sax,
Harini Nivarthi,
Michaela Schlederer,
Barbara Maurer,
Maximillian Hofbauer,
Dave N T Aryee,
Marc Wiedner,
Eleni M Tomazou,
Malcolm Logan,
Christine Hartmann,
Jan P Tuckermann,
Lukas Kenner,
Mario Mikula,
Helmut Dolznig,
Aykut Üren,
Günther H Richter,
Florian Grebien,
Heinrich Kovar,
Richard Moriggl.
Cell Death Dis. 2019 Aug 13;10(8):605. doi: 10.1038/s41419-019-1853-1.
2019
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
Barbara Maurer,
Harini Nivarthi,
Bettina Wingelhofer,
Ha Thi Thanh Pham,
Michaela Schlederer,
Tobias Suske,
Reinhard Grausenburger,
Ana-Iris Schiefer,
Michaela Prchal-Murphy,
Doris Chen,
Susanne Winkler,
Olaf Merkel,
Christoph Kornauth,
Maximilian Hofbauer,
Birgit Hochgatterer,
Gregor Hoermann,
Andrea Hoelbl-Kovacic,
Jana Prochazkova,
Cosimo Lobello,
Abbarna A Cumaraswamy,
Johanna Latzka,
Melitta Kitzwögerer,
Andreas Chott,
Andrea Janikova,
Šárka Pospíšilova,
Joanna I Loizou,
Stefan Kubicek,
Peter Valent,
Thomas Kolbe,
Florian Grebien,
Lukas Kenner,
Patrick T Gunning,
Robert Kralovics,
Marco Herling,
Mathias Müller,
Thomas Rülicke,
Veronika Sexl,
Richard Moriggl.
Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986. Print 2020.
2019
The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis
Afsar A Mian,
Ines Baumann,
Marcus Liebermann,
Florian Grebien,
Giulio Superti-Furga,
Martin Ruthardt,
Oliver G Ottmann,
Oliver Hantschel.
Leukemia. 2019 Sep;33(9):2319-2323. doi: 10.1038/s41375-019-0468-y. Epub 2019 Apr 8.
2019
Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond
Anna Skucha,
Jessica Ebner,
Florian Grebien.
Int J Mol Sci. 2019 Feb 27;20(5):1029. doi: 10.3390/ijms20051029.
2018
SETD2 in MLL-rearranged leukemia - a complex case
Anna Skucha,
Jessica Ebner,
Florian Grebien.
Mol Cell Oncol. 2018 Aug 13;5(4):e1503492. doi: 10.1080/23723556.2018.1503492. eCollection 2018.
2018
Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Tahereh Javaheri,
Zahra Kazemi,
None Jan Pencik,
Ha T T Pham,
Maximilian Kauer,
Rahil Noorizadeh,
Barbara Sax,
Harini Nivarthi,
Michaela Schlederer,
Barbara Maurer,
Maximillian Hofbauer,
Dave N T Aryee,
Marc Wiedner,
Eleni M Tomazou,
Malcolm Logan,
Christine Hartmann,
Jan P Tuckermann,
Lukas Kenner,
Mario Mikula,
Helmut Dolznig,
Aykut Üren,
Günther H Richter,
Florian Grebien,
Heinrich Kovar,
Richard Moriggl.
Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9.
2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
Anna Skucha,
Jessica Ebner,
Johannes Schmöllerl,
Mareike Roth,
Thomas Eder,
Adrián César-Razquin,
Alexey Stukalov,
Sarah Vittori,
Matthias Muhar,
Bin Lu,
Martin Aichinger,
Julian Jude,
André C Müller,
Balázs Győrffy,
Christopher R Vakoc,
Peter Valent,
Keiryn L Bennett,
Johannes Zuber,
Giulio Superti-Furga,
Florian Grebien.
Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y.
